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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences Journal of Marine Research Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Pharmacoscript Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Current Research on Biosciences and Biotechnology Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Farmasi Sains dan Praktis Pharmaceutical Reports Molekul: Jurnal Ilmiah Kimia Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Jurnal Vokasi Indonesia Borneo Journal of Pharmacy Jurnal Sains dan Teknologi Pangan Biodiversitas Journal of Biological Diversity
Agung Wibawa Mahatva Yodha
Politeknik Bina Husada Kendari
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STUDI IN VITRO: POTENSI ANTIINFLAMASI EKSTRAK RIMPANG TANAMAN WUNDU WATU (Alpinia monopleura) MELALUI PENGHAMBATAN NITRIC OXIDE Nur Af’idah Anas; Wahyuni; Irnawati; Loly Subhiaty Idrus; Agung Wibawa Mahatva Yodha
Jurnal Sains dan Teknologi Pangan Vol. 10 No. 5 (2025): Jurnal Sains dan Teknologi Pangan
Publisher : Jurusan Ilmu dan Teknologi Pangan Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63071/y40jt323

Abstract

Wundu watu (Alpinia monopleura) merupakan tanaman yang banyak ditemukan di Sulawesi. Secara empiris, rimpangnya dimanfaatkan sebagai obat tradisional untuk meredakan pegal-pegal dan sebagai bahan tambahan dalam kuliner. Namun, laporan ilmiah mengenai aktivitas biologis dan kandungan aktif tanaman ini masih terbatas. Berdasarkan pendekatan etnofarmakologis dan kesamaan genus, tanaman ini diperkirakan berpotensi sebagai antiinflamasi. Inflamasi merupakan mekanisme pertahanan biologis akibat cedera jaringan atau infeksi, ditandai dengan aktivasi sel imun dan peningkatan mediator inflamasi, salah satunya nitric oxide (NO). Penelitian ini bertujuan mengevaluasi potensi antiinflamasi ekstrak metanol rimpang wundu watu (EMRWW) melalui penghambatan NO secara in vitro. Uji antiinflamasi dilakukan menggunakan metode Griess pada seri konsentrasi 6,25; 12,25; 25; 50; dan 100 mg/L dengan asam askorbat sebagai kontrol positif. Pengukuran kadar NO dilakukan menggunakan microplate reader. Hasil penelitian menunjukkan bahwa EMRWW memiliki nilai IC₅₀ sebesar 33,01±5,6 mg/L yang tergolong kuat, sementara asam askorbat memberikan nilai IC₅₀ 6,83±2,3 mg/L dan termasuk kategori sangat kuat. Temuan ini mengindikasikan bahwa ekstrak rimpang wundu watu berpotensi sebagai agen antiinflamasi melalui mekanisme penghambatan produksi NO. 
Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast Daud, Nur Saadah; Yodha, Agung Wibawa Mahatva; Musdalipah, Musdalipah; Fusvita, Angriani; Firdayanti, Firdayanti; Sahidin, Sahidin; Arfan, Arfan; Fristiohady, Adryan; Sadarun, Baru
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 3 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.3.453-464

Abstract

Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5),  (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.
Aktivitas Antibakteri Rimpang Meistera chinensis terhadap Bakteri Staphylococcus aureus ATCC 25023 dan Eschericia coli ATCC 35218 Secara Difusi Agar Karmilah; Reymon; Daud, Nur Saadah; Badia, Esti; Yodha, Agung Wibawa Mahatva; Setiawan, Muh. Azdar; Tee, Selfyana Austin; Musdalipah
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 1 (2023): February 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i1.5651

Abstract

Meistera chinensis merupakan generasi baru famili Zingiberaceae yang tumbuh di Sulawesi Tenggara. Ekstrak buah mengandung metabolit sekunder seperti flavonoid, terpenoid, alkaloid, steroid, dan tanin yang memiliki efektivitas sebagai antioksidan dan antibakteri. Namun, belum ada laporan tentang antibakteri pada bagian rimpang. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri ekstrak etanol rimpang M. chinensis. Serbuk kering rimpang M. chinensis diekstraksi dengan maserasi menggunakan pelarut etanol 96%. Ekstrak dipekatkan menggunakan rotary vacuum evaporator. Metode analisis aktivitas antibakteri menggunakan difusi agar dengan konsentrasi ekstrak 10%, 20%, 30%, dan kontrol positif (Ciprofloxacin 30µg) terhadap Staphylococcus aureus ACTT 25023 dan Escherichia coli ACTT 35218 selama 24 jam. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang M. chinensis mengandung flavonoid, saponin, alkaloid, steroid, dan fenol, Ekstrak terbukti menghambat pertumbuhan E. coli dengan diameter zona hambat rata-rata secara berturut-turut pada konsentrasi 10%, 20%, dan 30% sebesar 6,08±1,79; 8,16±0,11 dan  10,57±1,34 mm. Pada S. aureus, zona hambat masing-masing konsentrasi 10%, 20%, dan  30% sebesar 5,02±0,79; 6,01±0,69; 8,03±0,76. Analisis One Way ANOVA menunjukkan perbedaan aktivitas antibakteri yang signifikan antar konsentrasi ekstrak pada E. coli dan S. aureus. Dapat disimpulkan rimpang M. chinensis memiliki aktivitas sebagai antibakteri. 
Pembuatan Teh Kombucha dengan Tambahan Tanaman Herbal sebagai Minuman Probiotik Kesehatan di Desa Soropia Idris, Sri Aprilianti; Pryangan, Wulandari; Karmilah, Karmilah; Firdayanti, Firdayanti; Fusvita, Angriani; Yodha, Agung Wibawa Mahatva; Wenty, Darmayanita; Susanti, Susanti; Zeptiano, Zeptiano; Dhea, Alisha
Jurnal Pengabdian Masyarakat: Pemberdayaan, Inovasi dan Perubahan Vol 5, No 6 (2025): JPM: Pemberdayaan, Inovasi dan Perubahan
Publisher : Penerbit Widina, Widina Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59818/jpm.v5i6.2226

Abstract

Kombucha tea is the result of the fermentation of tea and sugar solution using Symbiotic Culture of Bacteria and Yeast (SCOBY) which produces a drink with a fresh taste, distinctive aroma, and contains various bioactive compounds, such as organic acids, vitamins, and probiotics. The addition of herbal ingredients to kombucha tea, such as ginger, lemongrass, or mint leaves, can enhance the taste and improve health. Soropia Village as a coastal area has great potential in the development of products based on natural ingredients. However, limited knowledge and skills of the community in processing ingredients into value-added products remain a barrier. The purpose of community service is to increase knowledge and training to the community in Soropia Village on making kombucha tea with the addition of herbs as a health drink rich in probiotics. The methods used are socialization, education, training and evaluation. This activity was carried out in Soropia Village with the target group of the Soropia Village Family Welfare Movement (PKK). This training enables the community to know and understand how to make kombucha tea with the addition of herbal plants as a health drink that can be made into a product. The training and interviews following teh kombucha tea-making workshop demonstrated that all participants understood the material, with nearly 30 participants answering the questionnaire correctly. After the training, participants were able to independently make kombucha tea with ginger at home.ABSTRAKTeh kombucha merupakan hasil fermentasi larutan teh dan gula menggunakan Symbiotic Culture of Bacteria and Yeast (SCOBY) yang menghasilkan minuman dengan cita rasa segar, beraroma khas, serta mengandung berbagai senyawa bioaktif, seperti asam organik, vitamin, dan probiotik. Penambahan bahan herbal pada teh kombucha, seperti jahe, serai, atau daun mint, dapat meningkatkan cita rasa sekaligus dapat meningkatkan kesehatan. Desa Soropia sebagai salah satu wilayah pesisir memiliki potensi besar dalam pengembangan produk berbasis bahan alami. Namun, keterbatasan pengetahuan dan keterampilan masyarakat dalam mengolah bahan menjadi produk bernilai tambah masih menjadi kendala. Tujuan pengabdian untuk meningkatkan pengetahuan dan pelatihan kepada masyarakat di desa soropia tentang pembuatan teh kombucha dengan tambahan herbal  sebagai minuman kesehatan yang kaya probiotik. Metode yang digunakan adalah sosialisasi, edukasi, pelatihan dan evaluasi. Kegiatan ini dilaksanakan di desa soropia dengan target kelompok PKK desa Soropia. Pelatihan ini membuat masyarakat dapat mengetahui dan memahami bagaimana cara pembuatan teh kombucha dengan tambahan tanaman herbal sebagai minuman kesehatan yang dapat dijadikan produk. Hasil pelatihan dan wawancara setelah dilakukan pengabdian pembuatan teh kombucha, seluruh peserta memahami materi yang diberikan dengan hasil jawaban hampir 30 peserta menjawab kuesioner dengan benar. Setelah pelatihan, peserta dapat membuat teh kombucha dengan tambahan jahe secara mandiri dirumah.
Metabolite Profiling and Anti-Inflammatory Potential of East Kolaka Forest Honey: Targeting Protein Denaturation through GC-MS/MS Characterization Hariana, Hariana; Wahyuni, Wahyuni; Irnawati, Irnawati; Fitrawan, La Ode Muhammad; Munasari, Dian; Yodha, Agung Wibawa Mahatva; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.860

Abstract

Forest honey is a natural product produced by wild bees that gather nectar from various types of flowers, creating a unique chemical composition influenced by the biodiversity of the surrounding environment. This honey contains bioactive compounds such as phenolics, flavonoids, terpenoids, and volatile substances that contribute to its pharmacological properties, particularly as an anti-inflammatory agent. This study aimed to identify bioactive compounds in forest honey from East Kolaka using Gas Chromatography-Mass Spectrometry (GC-MS) and to evaluate its anti-inflammatory activity through in vitro assays, including red blood cell (RBC) membrane stabilization, protein denaturation inhibition, and nitric oxide (NO) production inhibition. GC-MS analysis revealed several volatile compounds with antioxidant, antimicrobial, and anti-inflammatory properties. The RBC membrane stabilization assay showed increased membrane stability as honey concentration increased, reaching 92.55% at 100 mg/L compared to 97.00% for sodium diclofenac. In the protein denaturation assay, East Kolaka forest honey had an IC?? value of 12.70?±?0.02?mg/L, categorized as moderate, while the NO inhibition assay recorded an IC?? of 2.97?±?1.34?mg/L, indicating strong activity, approaching that of vitamin C (1.07?±?0.39?mg/L). Statistical tests showed significant differences (p < 0.05) in all tested parameters compared to positive controls. These results support the potential of East Kolaka forest honey as a natural anti-inflammatory agent through mechanisms involving membrane stabilization, protein protection, and nitric oxide suppression.
Isolation of Secondary Metabolite Compounds from the Soft Coral Isis sp., Antimicrobial Testing and Molecular Docking Studies Imran; Fajri Fitra Amalia; Sahidin; Agung Wibawa Mahatva Yodha; Nohong; I Wayan Sutapa; Thamrin Azis
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.10830

Abstract

Soft coral Isis sp. is a type of soft coral that contains many chemical compounds with various benefits that have not been widely studied. This study aims to identify and isolate secondary metabolite compounds contained in the ethyl acetate extract fraction of Isis sp. soft coral, determine of antimicrobial activity, and molecular docking study. Compound separation was carried out by maceration followed by fractionation using Liquid Vacuum Chromatography (LVC). The fractions obtained were identified by Liquid Chromatography Tandem-Mass Spectrometry (LC-MS/MS) technique. Four compounds were successfully identified through LC-MS/MS analysis namely Deoxyadenosine (C10H13N5O3), Spinasterol (C29H48O), Pseudoionone (C11H16O) and Isosalsoline (C11H15NO2). Antimicrobial activity test was conducted against Staphylococcus aureus, and Escherichia coli. The results of the antimicrobial activity test showed strong activity against S.aureus bacteria and E. coli bacteria with the same MIC value of 2 µg/mL. Based on molecular docking analysis can be predicted that compounds isolated from soft coral Isis sp., namely pseudoinone compounds have a role as anti-bacterial S. aureus (PDB: 6KVS). This compound also shows a strong ability as an anti- gram positive bacteria than gram negative. Isosalsoline compounds have a role as anti-bacterial E. coli (PDB: 5BNM). This compound also shows a strong ability as an anti-gram negative bacteria rather than gram positive.
Skrining Senyawa Metabolit Sekunder Ekstrak Daun dan Kulit Batang Bruguiera gymnorrhiza dari Laguna Anano Te’i, Buton Tengah Maharani Maharani; La Ode Abdul Fajar Hasidu; Raodatul Jannah; Melati Octapian Simanjuntak; Kasnia Kaatu; Indra Ardiansyah; Sri Aprilianti Idris; Agung Wibawa Mahatva Yodha
Journal of Marine Research Vol 14, No 4 (2025): Journal of Marine Research
Publisher : Departemen Ilmu Kelautan, Fakultas PerikanJurusan Ilmu Kelautan, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmr.v14i4.53760

Abstract

Ekosistem mangrove kaya akan senyawa metabolit sekunder yang memiliki nilai ekologis dan farmakologis. Bruguiera gymnorrhiza merupakan salah satu spesies mangrove dominan yang telah lama dimanfaatkan dalam pengobatan tradisional, namun profil bioaktifnya pada habitat unik masih jarang dikaji. Penelitian ini bertujuan mengetahui komposisi kualitatif dan kuantitatif bioaktif pada daun dan batang B. gymnorrhiza dari Laguna Anano Te’i, Buton Tengah. Sampel diekstraksi dengan metode maserasi menggunakan etanol, kemudian dilakukan skrining fitokimia dan kuantifikasi spektrofotometri. Analisis kualitatif menunjukkan keberadaan alkaloid, flavonoid, steroid, dan fenolik pada kedua bagian tanaman. Secara kuantitatif, daun mengandung fenolik sebesar 465,596 mg GAE/g ekstrak, steroid 275,794 mg CE/g, alkaloid 83,944 mg CE/g, dan flavonoid 6,501 mg QE/g. Kulit batang didominasi oleh steroid sebesar 362,745 mg CE/g, diikuti fenolik 149,807 mg GAE/g, alkaloid 25,889 mg CE/g, dan flavonoid 6,419 mg QE/g. Variasi ini menunjukkan adanya pengaruh lingkungan laguna terhadap biosintesis senyawa metabolit sekunder, dengan daun memiliki potensi lebih besar sebagai antioksidan dan antimikroba. 
In Vitro Anti-Inflammatory Potential of Buton Forest Honey through Nitric Oxide Inhibition in RAW 264.7 Macrophage Cells Hariana Hariana; Wahyuni Wahyuni; Suryani Suryani; Ari Sartinah; Maulidyah Maulidyah; Agung Wibawa Mahatva Yodha; La Ode Muhammad Julian Purnama; Adryan Fristiohady
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.396

Abstract

Inflammation is a physiological defense response to injury, infection, or stress, mediated by various signaling molecules, including nitric oxide (NO). However, excessive NO production can contribute to tissue damage and the progression of inflammatory conditions. Honey, a natural product derived from floral nectar by bees, contains diverse bioactive compounds with potential pharmacological properties, including anti-inflammatory activity. Buton Regency, located in Southeast Sulawesi, is a major producer of forest honey, making it a promising source of bioactive honey with therapeutic potential. This study aimed to evaluate the in vitro anti-inflammatory activity of Buton forest honey by assessing its ability to inhibit NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results demonstrated that Buton forest honey significantly suppressed NO production in a concentration-dependent manner. At concentrations of 500, 250, 125, 62.5, 31.25, 15.63, 7.81, and 3.91 mg/L, the percentages of inhibition were 94.69 ± 2.94%, 74.03 ± 2.43%, 67.40 ± 2.34%, 62.72 ± 3.09%, 51.80 ± 4.73%, 44.40 ± 4.73%, 19.06 ± 1.79%, and 12.82 ± 0.68%, respectively. Statistical analysis using one-way ANOVA followed by post hoc testing revealed significant differences among the tested concentrations (p 0.05). In conclusion, Buton forest honey exhibits significant anti-inflammatory activity by inhibiting NO production in macrophage cells, suggesting its potential as a natural source for the development of anti-inflammatory agents.
Identification of Bioactive Constituents in Forest Honey Using GC-MS and Anti-Inflammatory Activity Through Protein Denaturation Hariana, Hariana; Fristiohady, Adryan; Purnama, La Ode Muhammad Julian; Yodha, Agung Wibawa Mahatva; Irnawati, Irnawati; Wahyuni, Wahyuni; Jumriani, Jumriani
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.62972

Abstract

Honey is a natural product rich in bioactive compounds with various pharmacological and anti-inflammatory effects. Bee species and nectar sources influence the composition of bioactive compounds in honey. This study aimed to identify bioactive compounds and evaluate the anti-inflammatory activity of honey from Apis mellifera and Apis dorsata. Compound identification from both honey types was performed using Gas Chromatography-Mass Spectrometry (GC-MS). At the same time, anti-inflammatory activity was assessed through the human red blood cell (HRBC) membrane stabilization method and protein denaturation inhibition assay, with sodium diclofenac as a positive control. GC-MS analysis revealed various bioactive compounds, notably 2-Propenoic acid, 3-(4-methoxyphenyl)-2-ethylhexyl ester, consistently present in both honey types. In the HRBC assay, Apis mellifera honey showed the highest stabilization value of 94.14% at a concentration of 6.25 mg/L honey solution, surpassing sodium diclofenac (87.96%), while Apis dorsata honey reached 85.21%. All samples achieved over 95% stabilization at 100 mg/L. In the protein denaturation assay, Apis dorsata honey exhibited stronger anti-inflammatory potential with an IC₅₀ of 12.85 ± 1.477 mg/L compared to Apis mellifera (25.35 ± 0.024 mg/L). In conclusion, both types of honey possess promising natural anti-inflammatory potential through membrane stabilization and protein protection mechanisms.
In Vivo Evaluation of the Anti-Inflammatory Activity of Wild Forest Honey from Konawe and Its Potential as a Nitric Oxide Inhibitor in Macrophage Cells Hariana Hariana; Wahyuni Wahyuni; Suryani Suryani; Ari Sartinah; Maulidyah Maulidyah; Agung Wibawa Mahatva Yodha; La Ode Muhammad Julian Purnama; Nuralifah Nuralifah; Arfan; Adryan Fristiohady; Jumriani Jumriani
Jurnal Mandala Pharmacon Indonesia Vol. 12 No. 1 (2026): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v12i1.1192

Abstract

Forest honey is a natural product derived from nectar of wild plants, rich in bioactive compounds such as flavonoids and phenolics, with potential antioxidant and anti-inflammatory properties.  Konawe Regency, Southeast Sulawesi, is known for forest honey production, yet its biological activity has been scarcely studied. This study aimed to evaluate the in vivo anti-inflammatory effect of Konawe forest honey and its potential as a nitric oxide (NO) inhibitor in macrophage cells. In vivo activity was assessed using a xylene-induced mouse ear edema model, while NO inhibition was evaluated in LPS-stimulated RAW 264.7 macrophage cells.  Results showed that forest honey significantly reduced ear edema. At 45 minutes, ear thickness was 0.967 ± 0.115 mm for the negative control, 0.233 ± 0.058 mm for the positive control, and 0.300 ± 0.100, 0.333 ± 0.058, and 0.267 ± 0.058 mm for doses of 25, 50, and 100 mg/kg body weight, respectively, with inflammation inhibition percentages of 43.91%, 43.70%, and 32.81%. ANOVA followed by Tukey’s post hoc test indicated significant differences among treatments (p < 0.05). In the NO assay, forest honey showed inhibition up to 94.35 ± 5.40%, with significant concentration-dependent effects (p < 0.05).  Konawe forest honey shows promising potential as a natural anti-inflammatory agent through suppression of edema formation and nitric oxide production in macrophage cells.
Co-Authors Abdulkadir Kamaluddin Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Ajeng Diantini, Ajeng Anas Subarnas Andini Sundowo Andini Sundowo Andini Sundowo Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Angriani Fusvita Ani Umar Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Arfan Arfan Arfan ARFAN ARFAN Ari Sartinah Ari Sartinah ARMAN FASLIH, ARMAN Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Austin Tee, Selfyana Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Baru Sadarun Baru Sadarun Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dhea, Alisha Dian Munasari Diasty Nuraisya Dzaky Aulia Rahman Elfahmi Elfahmi, Elfahmi Eny Nurhikma Euis Julaeha Fadhliyah Malik Fajri Fitra Amalia Fauzia Azzahra, Fauzia Fauziah, Yulianti Firasmi Sangadji Firda Yanti Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Frangky Sangande Fristiohady, Adryan Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Hariana Hariana Hariana Hariana Hariana Hariana Hariana Hariana, Hariana Harnita, Wa Ode Haruna, Lidya A. Haruna, Lidya Agriningsih Hasidu, La Ode Abdul Fajar Haslianti Haslianti, Haslianti I Sahidin I W. Sutapa I. Sahidin I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Idris, Sri Aprilianti Ikhsan, Ainussalbi Al Ilyas Y, Muhammad Imran Indra Ardiansyah Iren Meylani Irnawati Irnawati Irnawati Irvan Anwar Jafriati Jeoun Jung Jumadil Jumriani Jumriani Jumriani, Jumriani Junli Hong Karmilah KARMILAH KARMILAH Karmilah, Karmilah Kasnia Kaatu Kemal Idris Balaka Kraichat Tantrakarnapa La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Lidya Agriningsih Haruna Lidya Agriningsih Haruna Lisa Wulansari Siregar Loly Subhiaty Idrus Loly Subhiaty Idrus M. Hajrul Malaka Maharani Maharani Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Marianti A Manggau Marianti A. Manggau Masrika, Nur Upik En Maulidyah Maulidyah Maulidyah Maulidyah Mega Fatimah Rosana Melati Octapian Simanjuntak Mentarry Bafadal Mohammad Ghozali Muamar Abdillah Muh. Arnas MUH. AZDAR SETIAWAN Muhammad Azdar Setiawan Muhammad Azhar MUHAMMAD HAJRUL MALAKA Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Muhammad Sultanul Aulya Muktiarni, Muktiarni Munasari, Dian Murtafia Murtafia Musdalipah MUSDALIPAH MUSDALIPAH MUSDALIPAH MUSDALIPAH N. Nohong NASRUDIN Nirwati Rusli Nohong Nur Af’idah Anas Nur Illiyyin Akib Nur Indri Rahayu NUR SAADAH DAUD Nur Syifa Rahmatika Nur Syifa Rahmatika Nur Syifa Rahmatika Nuralifah Nuralifah Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Parawansah Parawansah Pascayantri, Asniar Pryangan, Wulandari Purnama, La O. M. J. Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Raden Maya Febrianti RAHMAT MULIADI, RAHMAT Rahmatika, Nur S. Ramadhan Tosepu Randa Wulaisfan Raodatul Jannah Rathapon Asasutjarit Rathapon Asasutjarit REYMON REYMON Reymon, Reymon Riezki Amalia Rina Andryani Rina Maryanti RINI HAMSIDI Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin SAHIDIN SAHIDIN Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin SELFYANA AUSTIN TEE Selfyana Austin Tee Sernita Seren Setiawan, Muh. Azdar Sitti Raodah Nurul Jannah Sofa Fajriah Sofa Fajriah Sofa Fajriah Solo, Dian Munasari Sri Aprilianti Idris Sukrasno Sukrasno SURYANI Suryani Suryani Suryani Suryani Susanti Susanti Susanti Susanti Syaikhul Aziz SYAMSU ALAM Syamsu Alam Syarul Nataqain Baharum Tee, Selfyana Austin Thamrin Azis Tien Tien Tuti Dharmawati W. Wahyuni Wa Ode Mutiara WAHYUNI wahyuni wahyuni Wahyuni Wahyuni Wahyuni Wahyuni Wenty, Darmayanita Yuni Elsa Hadisaputri YURIKA SASTYARINA Zeptiano, Zeptiano