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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Pharmacoscript Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Current Research on Biosciences and Biotechnology Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Farmasi Sains dan Praktis Pharmaceutical Reports Molekul: Jurnal Ilmiah Kimia Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Jurnal Sains dan Teknologi Pangan
Yodha, Agung Wibawa Mahatva
Politeknik Bina Husada Kendari
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Metabolite Profiling and Anti-Inflammatory Potential of East Kolaka Forest Honey: Targeting Protein Denaturation through GC-MS/MS Characterization Hariana, Hariana; Wahyuni, Wahyuni; Irnawati, Irnawati; Fitrawan, La Ode Muhammad; Munasari, Dian; Yodha, Agung Wibawa Mahatva; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.860

Abstract

Forest honey is a natural product produced by wild bees that gather nectar from various types of flowers, creating a unique chemical composition influenced by the biodiversity of the surrounding environment. This honey contains bioactive compounds such as phenolics, flavonoids, terpenoids, and volatile substances that contribute to its pharmacological properties, particularly as an anti-inflammatory agent. This study aimed to identify bioactive compounds in forest honey from East Kolaka using Gas Chromatography-Mass Spectrometry (GC-MS) and to evaluate its anti-inflammatory activity through in vitro assays, including red blood cell (RBC) membrane stabilization, protein denaturation inhibition, and nitric oxide (NO) production inhibition. GC-MS analysis revealed several volatile compounds with antioxidant, antimicrobial, and anti-inflammatory properties. The RBC membrane stabilization assay showed increased membrane stability as honey concentration increased, reaching 92.55% at 100 mg/L compared to 97.00% for sodium diclofenac. In the protein denaturation assay, East Kolaka forest honey had an IC?? value of 12.70?±?0.02?mg/L, categorized as moderate, while the NO inhibition assay recorded an IC?? of 2.97?±?1.34?mg/L, indicating strong activity, approaching that of vitamin C (1.07?±?0.39?mg/L). Statistical tests showed significant differences (p < 0.05) in all tested parameters compared to positive controls. These results support the potential of East Kolaka forest honey as a natural anti-inflammatory agent through mechanisms involving membrane stabilization, protein protection, and nitric oxide suppression.
In Vitro Anti-Inflammatory Potential of Buton Forest Honey through Nitric Oxide Inhibition in RAW 264.7 Macrophage Cells Hariana, Hariana; Wahyuni, Wahyuni; Suryani, Suryani; Sartinah, Ari; Maulidyah, Maulidyah; Yodha, Agung Wibawa Mahatva; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.396

Abstract

Inflammation is a physiological defense response to injury, infection, or stress, mediated by various signaling molecules, including nitric oxide (NO). However, excessive NO production can contribute to tissue damage and the progression of inflammatory conditions. Honey, a natural product derived from floral nectar by bees, contains diverse bioactive compounds with potential pharmacological properties, including anti-inflammatory activity. Buton Regency, located in Southeast Sulawesi, is a major producer of forest honey, making it a promising source of bioactive honey with therapeutic potential. This study aimed to evaluate the in vitro anti-inflammatory activity of Buton forest honey by assessing its ability to inhibit NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results demonstrated that Buton forest honey significantly suppressed NO production in a concentration-dependent manner. At concentrations of 500, 250, 125, 62.5, 31.25, 15.63, 7.81, and 3.91 mg/L, the percentages of inhibition were 94.69 ± 2.94%, 74.03 ± 2.43%, 67.40 ± 2.34%, 62.72 ± 3.09%, 51.80 ± 4.73%, 44.40 ± 4.73%, 19.06 ± 1.79%, and 12.82 ± 0.68%, respectively. Statistical analysis using one-way ANOVA followed by post hoc testing revealed significant differences among the tested concentrations (p 0.05). In conclusion, Buton forest honey exhibits significant anti-inflammatory activity by inhibiting NO production in macrophage cells, suggesting its potential as a natural source for the development of anti-inflammatory agents.
Education on the Dangers of Environmental Chemical Exposure and Urine Protein Examination as Risk Factors for Impaired Renal Function Among Students at SDN 6 Kendari Yanti, Firda; Umar, Ani; Jung, Jeoun; Tantrakarnapa, Kraichat; Idris, Sri Aprilianti; Susanti, Susanti; Setiawan, Muhammad Azdar; Aulya, Muhammad Sultanul; Balaka, Kemal Idris; Tosepu, Ramadhan; Dharmawati, Tuti; Fusvita, Angriani; Yodha, Agung Wibawa Mahatva
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 12, No 1 (2026): Maret
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.103358

Abstract

This community service activity aimed to improve primary school students’ knowledge regarding environmental chemical exposure and kidney health while introducing a simple renal screening approach as an educational awareness tool. The program was conducted in 2023 at Sekolah Dasar Negeri 6 Kendari and involved 30 grade 5 and grade 6 students selected using accidental sampling. The activities consisted of interactive, age-appropriate education sessions and preliminary screening using urine protein dipstick testing, together with serum urea and creatinine measurements. Knowledge scores increased from a mean of 3.13 (SD 1.93) before the education sessions to 8.83 (SD 1.02) after the sessions (p < 0.001), indicating substantial short-term improvement in understanding. Most participants had negative urine protein findings, with a small proportion showing low-level positivity, whereas biochemical values were generally within expected ranges. The screening results are presented descriptively to support awareness and should not be interpreted as a clinical diagnosis or as evidence of impaired renal function. Overall, the activity demonstrates the feasibility of integrating school-based health education with simple screening to promote awareness and engagement, providing a practical model for community health promotion while avoiding overstatement of clinical implications.
Co-Authors Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Arfan Arfan Ari Sartinah, Ari Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Aulya, Muhammad Sultanul Austin Tee, Selfyana Azdar Setiawan, Muh. Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Balaka, Kemal Idris Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dharmawati, Tuti Dhea, Alisha Dian Munasari Elfahmi Elfahmi, Elfahmi Eny Nurhikma Esti Badia Esti Badia Fadhliyah Malik Fauziah, Yulianti Firasmi Sangadji Firda yanti, Firda Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Frangky Sangande Fristiohady, Adryan Fusvita, Angriani Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Hariana Hariana, Hariana Harnita, Wa Ode Haruna, Lidya Agriningsih Haslianti Haslianti, Haslianti I Sahidin I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Idris, Sri Aprilianti Ilyas Y, Muhammad Irnawati Irnawati Irnawati Irvan Anwar Jafriati Jumadil Jung, Jeoun Junli Hong Karmilah Karmilah Karmilah Karmilah, Karmilah La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama Lisa Wulansari Siregar Loly Subhiaty Idrus Loly Subhiaty Idrus Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Maulidyah, Maulidyah Muamar Abdillah Muh. Arnas Muh. Azdar Setiawan Muhammad Azhar Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Munasari, Dian Murtafia Murtafia Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah, Musdalipah NASRUDIN Nirwati Rusli Nur Af’idah Anas Nur Illiyyin Akib Nur Saadah Daud Nur Saadah Daud Nur Syifa Rahmatika Nur Syifa Rahmatika Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Pascayantri, Asniar Pryangan, Wulandari Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian RAHMAT MULIADI, RAHMAT Ramadhan Tosepu Randa Wulaisfan Reymon Reymon Rina Andryani Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin Selfyana Austin Tee Sernita Sernita Setiawan, Muh. Azdar Setiawan, Muhammad Azdar Sitti Raodah Nurul Jannah Solo, Dian Munasari Sukrasno Sukrasno SURYANI Suryani Suryani Susanti Susanti Syaikhul Aziz Syamsu Alam Syarul Nataqain Baharum Tantrakarnapa, Kraichat Tee, Selfyana Austin Umar, Ani WAHYUNI Wahyuni Wahyuni wahyuni wahyuni Wenty, Darmayanita Yulianti Fauziah Zeptiano, Zeptiano