Article Per Year (5 Year)
p-Index From 2021 - 2026
4.865
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences Journal of Marine Research Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Pharmacoscript Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Current Research on Biosciences and Biotechnology Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Farmasi Sains dan Praktis Pharmaceutical Reports Molekul: Jurnal Ilmiah Kimia Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Jurnal Sains dan Teknologi Pangan
Yodha, Agung Wibawa Mahatva
Politeknik Bina Husada Kendari
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

Published : 36 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 36 Documents
Search

 1   2   3   4 
Metabolite Profiling and Anti-Inflammatory Potential of East Kolaka Forest Honey: Targeting Protein Denaturation through GC-MS/MS Characterization Hariana, Hariana; Wahyuni, Wahyuni; Irnawati, Irnawati; Fitrawan, La Ode Muhammad; Munasari, Dian; Yodha, Agung Wibawa Mahatva; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.860

Abstract

Forest honey is a natural product produced by wild bees that gather nectar from various types of flowers, creating a unique chemical composition influenced by the biodiversity of the surrounding environment. This honey contains bioactive compounds such as phenolics, flavonoids, terpenoids, and volatile substances that contribute to its pharmacological properties, particularly as an anti-inflammatory agent. This study aimed to identify bioactive compounds in forest honey from East Kolaka using Gas Chromatography-Mass Spectrometry (GC-MS) and to evaluate its anti-inflammatory activity through in vitro assays, including red blood cell (RBC) membrane stabilization, protein denaturation inhibition, and nitric oxide (NO) production inhibition. GC-MS analysis revealed several volatile compounds with antioxidant, antimicrobial, and anti-inflammatory properties. The RBC membrane stabilization assay showed increased membrane stability as honey concentration increased, reaching 92.55% at 100 mg/L compared to 97.00% for sodium diclofenac. In the protein denaturation assay, East Kolaka forest honey had an IC?? value of 12.70?±?0.02?mg/L, categorized as moderate, while the NO inhibition assay recorded an IC?? of 2.97?±?1.34?mg/L, indicating strong activity, approaching that of vitamin C (1.07?±?0.39?mg/L). Statistical tests showed significant differences (p < 0.05) in all tested parameters compared to positive controls. These results support the potential of East Kolaka forest honey as a natural anti-inflammatory agent through mechanisms involving membrane stabilization, protein protection, and nitric oxide suppression.
Isolation of Secondary Metabolite Compounds from the Soft Coral Isis sp., Antimicrobial Testing and Molecular Docking Studies Imran; Fajri Fitra Amalia; Sahidin; Agung Wibawa Mahatva Yodha; Nohong; I Wayan Sutapa; Thamrin Azis
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.10830

Abstract

Soft coral Isis sp. is a type of soft coral that contains many chemical compounds with various benefits that have not been widely studied. This study aims to identify and isolate secondary metabolite compounds contained in the ethyl acetate extract fraction of Isis sp. soft coral, determine of antimicrobial activity, and molecular docking study. Compound separation was carried out by maceration followed by fractionation using Liquid Vacuum Chromatography (LVC). The fractions obtained were identified by Liquid Chromatography Tandem-Mass Spectrometry (LC-MS/MS) technique. Four compounds were successfully identified through LC-MS/MS analysis namely Deoxyadenosine (C10H13N5O3), Spinasterol (C29H48O), Pseudoionone (C11H16O) and Isosalsoline (C11H15NO2). Antimicrobial activity test was conducted against Staphylococcus aureus, and Escherichia coli. The results of the antimicrobial activity test showed strong activity against S.aureus bacteria and E. coli bacteria with the same MIC value of 2 µg/mL. Based on molecular docking analysis can be predicted that compounds isolated from soft coral Isis sp., namely pseudoinone compounds have a role as anti-bacterial S. aureus (PDB: 6KVS). This compound also shows a strong ability as an anti- gram positive bacteria than gram negative. Isosalsoline compounds have a role as anti-bacterial E. coli (PDB: 5BNM). This compound also shows a strong ability as an anti-gram negative bacteria rather than gram positive.
Skrining Senyawa Metabolit Sekunder Ekstrak Daun dan Kulit Batang Bruguiera gymnorrhiza dari Laguna Anano Te’i, Buton Tengah Maharani Maharani; La Ode Abdul Fajar Hasidu; Raodatul Jannah; Melati Octapian Simanjuntak; Kasnia Kaatu; Indra Ardiansyah; Sri Aprilianti Idris; Agung Wibawa Mahatva Yodha
Journal of Marine Research Vol 14, No 4 (2025): Journal of Marine Research
Publisher : Departemen Ilmu Kelautan, Fakultas PerikanJurusan Ilmu Kelautan, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmr.v14i4.53760

Abstract

Ekosistem mangrove kaya akan senyawa metabolit sekunder yang memiliki nilai ekologis dan farmakologis. Bruguiera gymnorrhiza merupakan salah satu spesies mangrove dominan yang telah lama dimanfaatkan dalam pengobatan tradisional, namun profil bioaktifnya pada habitat unik masih jarang dikaji. Penelitian ini bertujuan mengetahui komposisi kualitatif dan kuantitatif bioaktif pada daun dan batang B. gymnorrhiza dari Laguna Anano Te’i, Buton Tengah. Sampel diekstraksi dengan metode maserasi menggunakan etanol, kemudian dilakukan skrining fitokimia dan kuantifikasi spektrofotometri. Analisis kualitatif menunjukkan keberadaan alkaloid, flavonoid, steroid, dan fenolik pada kedua bagian tanaman. Secara kuantitatif, daun mengandung fenolik sebesar 465,596 mg GAE/g ekstrak, steroid 275,794 mg CE/g, alkaloid 83,944 mg CE/g, dan flavonoid 6,501 mg QE/g. Kulit batang didominasi oleh steroid sebesar 362,745 mg CE/g, diikuti fenolik 149,807 mg GAE/g, alkaloid 25,889 mg CE/g, dan flavonoid 6,419 mg QE/g. Variasi ini menunjukkan adanya pengaruh lingkungan laguna terhadap biosintesis senyawa metabolit sekunder, dengan daun memiliki potensi lebih besar sebagai antioksidan dan antimikroba. 
Education on the Dangers of Environmental Chemical Exposure and Urine Protein Examination as Risk Factors for Impaired Renal Function Among Students at SDN 6 Kendari Yanti, Firda; Umar, Ani; Jung, Jeoun; Tantrakarnapa, Kraichat; Idris, Sri Aprilianti; Susanti, Susanti; Setiawan, Muhammad Azdar; Aulya, Muhammad Sultanul; Balaka, Kemal Idris; Tosepu, Ramadhan; Dharmawati, Tuti; Fusvita, Angriani; Yodha, Agung Wibawa Mahatva
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 12, No 1 (2026): Maret
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.103358

Abstract

This community service activity aimed to improve primary school students’ knowledge regarding environmental chemical exposure and kidney health while introducing a simple renal screening approach as an educational awareness tool. The program was conducted in 2023 at Sekolah Dasar Negeri 6 Kendari and involved 30 grade 5 and grade 6 students selected using accidental sampling. The activities consisted of interactive, age-appropriate education sessions and preliminary screening using urine protein dipstick testing, together with serum urea and creatinine measurements. Knowledge scores increased from a mean of 3.13 (SD 1.93) before the education sessions to 8.83 (SD 1.02) after the sessions (p < 0.001), indicating substantial short-term improvement in understanding. Most participants had negative urine protein findings, with a small proportion showing low-level positivity, whereas biochemical values were generally within expected ranges. The screening results are presented descriptively to support awareness and should not be interpreted as a clinical diagnosis or as evidence of impaired renal function. Overall, the activity demonstrates the feasibility of integrating school-based health education with simple screening to promote awareness and engagement, providing a practical model for community health promotion while avoiding overstatement of clinical implications.
In Vitro Anti-Inflammatory Potential of Buton Forest Honey through Nitric Oxide Inhibition in RAW 264.7 Macrophage Cells Hariana Hariana; Wahyuni Wahyuni; Suryani Suryani; Ari Sartinah; Maulidyah Maulidyah; Agung Wibawa Mahatva Yodha; La Ode Muhammad Julian Purnama; Adryan Fristiohady
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.396

Abstract

Inflammation is a physiological defense response to injury, infection, or stress, mediated by various signaling molecules, including nitric oxide (NO). However, excessive NO production can contribute to tissue damage and the progression of inflammatory conditions. Honey, a natural product derived from floral nectar by bees, contains diverse bioactive compounds with potential pharmacological properties, including anti-inflammatory activity. Buton Regency, located in Southeast Sulawesi, is a major producer of forest honey, making it a promising source of bioactive honey with therapeutic potential. This study aimed to evaluate the in vitro anti-inflammatory activity of Buton forest honey by assessing its ability to inhibit NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results demonstrated that Buton forest honey significantly suppressed NO production in a concentration-dependent manner. At concentrations of 500, 250, 125, 62.5, 31.25, 15.63, 7.81, and 3.91 mg/L, the percentages of inhibition were 94.69 ± 2.94%, 74.03 ± 2.43%, 67.40 ± 2.34%, 62.72 ± 3.09%, 51.80 ± 4.73%, 44.40 ± 4.73%, 19.06 ± 1.79%, and 12.82 ± 0.68%, respectively. Statistical analysis using one-way ANOVA followed by post hoc testing revealed significant differences among the tested concentrations (p 0.05). In conclusion, Buton forest honey exhibits significant anti-inflammatory activity by inhibiting NO production in macrophage cells, suggesting its potential as a natural source for the development of anti-inflammatory agents.
Identification of Bioactive Constituents in Forest Honey Using GC-MS and Anti-Inflammatory Activity Through Protein Denaturation Hariana, Hariana; Fristiohady, Adryan; Purnama, La Ode Muhammad Julian; Yodha, Agung Wibawa Mahatva; Irnawati, Irnawati; Wahyuni, Wahyuni; Jumriani, Jumriani
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.62972

Abstract

Honey is a natural product rich in bioactive compounds with various pharmacological and anti-inflammatory effects. Bee species and nectar sources influence the composition of bioactive compounds in honey. This study aimed to identify bioactive compounds and evaluate the anti-inflammatory activity of honey from Apis mellifera and Apis dorsata. Compound identification from both honey types was performed using Gas Chromatography-Mass Spectrometry (GC-MS). At the same time, anti-inflammatory activity was assessed through the human red blood cell (HRBC) membrane stabilization method and protein denaturation inhibition assay, with sodium diclofenac as a positive control. GC-MS analysis revealed various bioactive compounds, notably 2-Propenoic acid, 3-(4-methoxyphenyl)-2-ethylhexyl ester, consistently present in both honey types. In the HRBC assay, Apis mellifera honey showed the highest stabilization value of 94.14% at a concentration of 6.25 mg/L honey solution, surpassing sodium diclofenac (87.96%), while Apis dorsata honey reached 85.21%. All samples achieved over 95% stabilization at 100 mg/L. In the protein denaturation assay, Apis dorsata honey exhibited stronger anti-inflammatory potential with an IC₅₀ of 12.85 ± 1.477 mg/L compared to Apis mellifera (25.35 ± 0.024 mg/L). In conclusion, both types of honey possess promising natural anti-inflammatory potential through membrane stabilization and protein protection mechanisms.
Co-Authors Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Ari Sartinah Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Aulya, Muhammad Sultanul Austin Tee, Selfyana Azdar Setiawan, Muh. Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Balaka, Kemal Idris Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dharmawati, Tuti Dhea, Alisha Dian Munasari Elfahmi Elfahmi, Elfahmi Eny Nurhikma Esti Badia Esti Badia Fadhliyah Malik Fajri Fitra Amalia Fauziah, Yulianti Firasmi Sangadji Firda yanti, Firda Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Frangky Sangande Fristiohady, Adryan Fusvita, Angriani Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Hariana Hariana Hariana Hariana, Hariana Harnita, Wa Ode Haruna, Lidya Agriningsih Hasidu, La Ode Abdul Fajar Haslianti Haslianti, Haslianti I Sahidin I W. Sutapa I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Idris, Sri Aprilianti Ilyas Y, Muhammad Imran Indra Ardiansyah Irnawati Irnawati Irnawati Irvan Anwar Jafriati Jumadil Jumriani, Jumriani Jung, Jeoun Junli Hong Karmilah Karmilah Karmilah Karmilah, Karmilah Kasnia Kaatu La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Lisa Wulansari Siregar Loly Subhiaty Idrus Loly Subhiaty Idrus Maharani Maharani Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Maulidyah Maulidyah Mega Fatimah Rosana Melati Octapian Simanjuntak Muamar Abdillah Muh. Arnas Muh. Azdar Setiawan Muhammad Azhar Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Munasari, Dian Murtafia Murtafia Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah, Musdalipah NASRUDIN Nirwati Rusli Nohong Nur Af’idah Anas Nur Illiyyin Akib Nur Saadah Daud Nur Saadah Daud Nur Syifa Rahmatika Nur Syifa Rahmatika Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Pascayantri, Asniar Pryangan, Wulandari Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian RAHMAT MULIADI, RAHMAT Ramadhan Tosepu Randa Wulaisfan Raodatul Jannah Reymon Reymon Rina Andryani Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin Selfyana Austin Tee Sernita Sernita Setiawan, Muh. Azdar Setiawan, Muhammad Azdar Sitti Raodah Nurul Jannah Solo, Dian Munasari Sri Aprilianti Idris Sukrasno Sukrasno SURYANI Suryani Suryani Susanti Susanti Susanti Susanti Syaikhul Aziz Syamsu Alam Syarul Nataqain Baharum Tantrakarnapa, Kraichat Tee, Selfyana Austin Thamrin Azis Umar, Ani WAHYUNI wahyuni wahyuni Wahyuni Wahyuni Wenty, Darmayanita Yulianti Fauziah Zeptiano, Zeptiano