Article Per Year (5 Year)
p-Index From 2021 - 2026
6.281
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Universitas Batanghari Jambi As-syifaa Jurnal Farmasi Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Medika Malahayati Poltekita : Jurnal Ilmu Kesehatan UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Global Health research Jurnal Promotif Preventif Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Wal'afiat Hospital Journal Jurnal Ilmiah Kesehatan (JIKA) Journal of Aafiyah Health Research (JAHR) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Formosa Journal of Science and Technology (FJST) YASIN: Jurnal Pendidikan dan Sosial Budaya Jurnal Abdi Kesehatan dan Kedokteran jpki Innovative: Journal Of Social Science Research WAL'AFIAT HOSPITAL JOURNAL JOURNAL OF Qualitative Health Research & Case Studies Reports
Rachmat Faisal Syamsu, Rachmat Faisal
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 53 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 53 Documents
Search

 2   3   4   5   6 
Systematic Review: The Effectiveness of Resveratrol in Inhibiting Colorectal Cancer Cell Proliferation Rifai B, Muh.; Syamsu, Rachmat Faisal; Palloge, Salahuddin Andi
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2715

Abstract

Colorectal cancer is one of the leading causes of cancer-related morbidity and mortality worldwide, with increasing incidence particularly in developing countries. Conventional treatments face challenges such as resistance and toxicity. Resveratrol, a natural polyphenol found in grapes, peanuts, and berries, has been reported to exert antioxidant, anti-inflammatory, and anticancer effects. To systematically evaluate the effects of resveratrol on parameters related to colorectal cancer in experimental animal models. Method: A qualitative systematic review was conducted by searching PubMed, Scopus, Sinta, and Google Scholar for studies published between 2020 and 2025. Inclusion criteria were in vivo studies using animal models of colorectal cancer, with resveratrol as the sole intervention, and reporting at least one parameter such as apoptosis, cell proliferation, oxidative stress, or inflammatory markers. Studies in vitro, in humans, or with combined interventions were excluded. A total of 512 articles were initially identified. After screening and applying eligibility criteria, seven studies were included. The findings consistently demonstrated that resveratrol suppressed tumor initiation and progression via multiple mechanisms: inhibition of Wnt/β-catenin signaling, induction of apoptosis and autophagy through FOXQ1 inhibition, reduction of oxidative stress and DNA damage, suppression of NF-κB signaling, and inhibition of epithelial mesenchymal transition and angiogenesis. Furthermore, resveratrol reduced tumor burden, metastasis, and inflammation in various colorectal cancer models. Resveratrol exhibits significant chemopreventive and therapeutic potential against colorectal cancer through pleiotropic mechanisms targeting proliferation, apoptosis, oxidative stress, and inflammation. These findings support resveratrol as a promising candidate for adjunctive therapy, although further clinical studies are required to confirm efficacy and safety in humans.
Virgin Coconut Oil and Extra Virgin Olive Oil on Total Cholesterol and Triglyceride Levels in Hyperglycemic Obese White Rats Hakim, Dwi Ashariyanti; Bamahry, Aryanti R.; Namirah, Hanna Aulia; Royani, Ida; Syamsu, Rachmat Faisal
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1373

Abstract

The increasing prevalence of obesity and metabolic disorders highlights the need for effective dietary interventions to improve lipid profiles and reduce cardiovascular risk. This study compares the effects of Virgin Coconut Oil (VCO) and Extra Virgin Olive Oil (EVOO) on lipid profiles, specifically total cholesterol and triglyceride levels, in hyperglycemic obese Wistar rats. Obesity and hyperglycemia are major risk factors for cardiovascular diseases and type 2 diabetes. A total of 24 male rats were divided into three groups: a negative control, a VCO group, and an EVOO group. Rats were placed on a high-fat diet for 14 days and administered 2 mL/kg body weight of either VCO or EVOO via oral gavage. Blood samples were collected at baseline, Day 7, and Day 14 for lipid profile analysis. Results revealed that both VCO and EVOO significantly reduced total cholesterol and triglyceride levels compared to the control group. Notably, EVOO resulted in a more substantial reduction in both total cholesterol (to 130,83 ± 24,807 mg/dL) and triglycerides (to 108,17 ± 17,612 mg/dL) by Day 14, surpassing the effects of VCO. These findings suggest that both oils are effective in improving lipid profiles in hyperglycemic obese rats, with EVOO demonstrating superior efficacy. This study provides valuable insights into the potential of VCO and EVOO as dietary interventions for managing obesity-related metabolic disorders, emphasizing EVOO’s greater effectiveness in lipid management.
Analisa Kandungan Antioksidan Polifenol Pada Buah Tin (Ficus Carica) Dan Buah Anggur Merah (Vitis Vinifera) Dengan Metode 2,2-Diphenyl-1- Picrylhydrazyl (DPPH): Analysis of Antioxidant Content of Polyphenols in Figs (Ficus Carica) and Red Grapes (Vitis Vinifera) Using the 2,2-Diphenyl-1- Picrylhydrazyl (DPPH) Method Syamsu, Rachmat Faisal; Listin, Nurhalisa; Putra, Fadil Mula; Muchsin, Achmad Harun; Mulyadi, Farah Ekawati
Jurnal Abdi Keperawatan dan Kedokteran Vol 5 No 1 (2026): Jurnal Abdi Kesehatan dan Kedokteran
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/jakk.v5i1.159

Abstract

Antioxidants play an important role in counteracting free radicals that can damage body cells. Indonesia has a wide variety of natural antioxidant sources, including fig fruit (Ficus carica) and red grapes (Vitis vinifera), which are rich in polyphenol and flavonoid compounds. To determine the antioxidant activity of these fruits, the DPPH method is used because it is simple, rapid, and accurate in measuring the ability of compounds to scavenge free radicals. This study aimed to determine the extraction method for fig fruit (Ficus carica) and red grapes (Vitis vinifera), as well as to analyze the polyphenol antioxidant content of both fruits using the DPPH method. This research was an experimental laboratory study. The results showed that the extraction of fig fruit (Ficus carica) and red grapes (Vitis vinifera) was carried out using the maceration method. This method was chosen because it is simple, easy to perform, requires readily available equipment, and is effective in maintaining the stability of heat-sensitive active compounds, making it suitable for extracting polyphenol compounds. Based on the results of the antioxidant activity test using the DPPH method, the fig fruit extract of the Iraqi variety showed an IC₅₀ value classified as very strong antioxidant activity, while the red grape extract of the Red Globe variety showed an IC₅₀ value classified as strong according to the Blois classification. These results indicate that both fruits contain polyphenol compounds with antioxidant potential, with higher antioxidant activity observed in fig fruit compared to red grapes.
Co-Authors 'Aisy S.Day, Siti Rahadatul Abdillah, Andi Rachmat Abdullah, A. Adila Permata Abdullah, Rezky Putri Indrawati Adriana, Delvi Ahmad Ahmad Ahyar, Farah Firjatillah Akbar, Muhammad Alief Alfaruq, Zulfi Zain Alhumaerah, Musdalifah Alie, Nuzul Shafira Alimun, Sity Rahmatia Amaliyah B, Ilma Khaerina Amrizal Muchtar Ancha, Annisa Andry Pratama, Andry Anggita, Dwi Aqillah Rahis, Fadiah Dewi Arfah, Arni Isnaini Arifin, Arina Fathiyyah Astri Wahyuni Azis, Arung Anugrah Al Bamahry, Aryanti R. Bazith, Akhmad Bima, Irmayanti Haidir Bima, Irmayanti Johar Bonita, Nita Burhanuddin Bahar Dahlia Dahlia Darariani Iskandar Dewi, Anna Sari Domu, Anugrah Julistiar Aksan Efendy, Rizki Amalia Evi Sulastri Fattah, Nurfachanti febriyanti febriyanti Gani, Azis Beru Gayatri, Sri Wahyuni Hadi, Santriani Hakim, Dwi Ashariyanti Hamsah, M. Hasbi, Berry Erida Hazminafni, Nur Zahra Noor Khaerani Hikmah, Annisa Duratul Ida Royani Ikram, Dzul Ilda, Khusnul Indarwati Abdullah, Rezky Putri Indarwati, Rezky Putri Irna Diyana Kartika Jam’an Laoh, Abulkahiril Jannah, Reza Miftahul Jaya, Muh. Alim Jaya, Muhammad Alim Juliani, Sri Julyani, Sry Kamaluddin, Irna Diyana Kartika Karim, Abdul Mubdi Ardiansar Arifuddin Karim, Marzelina Kartika, Andy Visi Khalid, Nur Fadhillah Laddo, Nirwana Latief, Shofiyah Lausiri, Satharia Listin, Nurhalisa Makmun, Armanto Mamile, Rahmawati Mangarengi, Yusriani Mappaware, Nasrudin Andi Maulidiah, Nurul Farah Mayo, Abbas Ali Mochammad Erwin Rachman, Mochammad Erwin Mochtar, Shulhana Mokhtar, Shulhana Mubarok, Rizqi Muchsin, Achmad Harun Mukhtar, Shulhana Mulyadi, Farah Ekawati Musa, Inna Mutmainnah Muthalib, Iqra Muhamad Zulmadhani Z. N, Hermiaty N. Hamzah, Pratiwi Namirah, Hanna Aulia Nasruddin, Hermiaty Nawawi, Nurafni Maharani Noor, Raehana Norman, Fadhilah Nulanda, Mona Nurdin, Abbas Zavey Nurhikma, Nurhikma Nurmadilla, Nesyana Ode Arli, Rosmelidian Safari Oktaviani, Mentari Dwi Palloge, Salahuddin Andi Palo, Nurul Aisyah Pramono, Sigit Dwi Purnamasari, Reeny Putra, Fadil Mula Putri, Riski Astriani Rachman, Moch. Erwin Rachmat, Rizqah Aulyna Rafiqah, Rafiqah Rahman, Dinda Briliani Rahman, Dinda Briliany Rahman, Mochammad Erwin Rasfayanah, Rasfayanah Rifai B, Muh. Rizki Salsabilah R, Andi Fatihah Safitri, Asrini Saifullah, Yayan Yustika Sakti, Muhammad Reyhan Salam, Annisa Salsabilah Salmalia, Raisya Zahra Salsabila, Lu’lu Luqyana Amirah Saputra, Adrian Shamad, Muhammad Ishaq Sholehah, Mar'atun Siska Nuryanti, Siska Sodiqah, Yani Sri Wahyu Surdam, Zulfiyah Suryo, Ersya Putri Alifya Syamsu Rijal Tebi, Tebi Thahir, Ilyas Thahira, Yugni Maula Utami, Dian Fahmi Utami, Nurfika Wardayani Wardayani, Wardayani Wello, Eny Arlini Yusuf, Andini Zulfahmidah, Zulfahmidah Zulfitriani Murfat