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Journal : Narra J

Ivermectin and dexamethasone combination induces apoptosis in SUP-B15 cell line Siregar, Olga R.; Wahyuni, Arlinda S.; Pasaribu, Ayodhia P.; Edianto, Deri; Ugrasena, I DG.; Amelia, Rina; Lubis, Inke ND.; Rusda, Muhammad
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1975

Abstract

The development of glucocorticoid resistance has complicated the management of acute lymphoblastic leukemia (ALL), leading to increased mortality rates. Ivermectin, a low-cost and well-established anthelmintic, exhibits anticancer potential and may enhance glucocorticoid toxicity in ALL, offering a possible strategy to overcome resistance. The aim of this study was to evaluate the apoptotic effect of combining ivermectin with dexamethasone in ALL. ALL SUP-B15 cells were cultured under standard conditions before treatment with dexamethasone (200 nM) alone or combined with ivermectin (5, 10, and 20 µM), with an untreated group serving as the control.  Cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay by measuring cell viability and inhibition. Apoptosis was evaluated through BAX, BCL-2, and CASP3 gene expression analysis using reverse transcription-polymerase chain reaction (RT-PCR). The findings revealed that the combination of ivermectin and dexamethasone was superior in the repression of ALL cell viability compared to control (p<0.001). The combination of dexamethasone 200 nM + ivermectin 20 μM demonstrated the most significant cell inhibition of 38.16±0.04% (p<0.001) and produced the lowest cell viability of 61.84±0.05% (p<0.001). Moreover, the combination of dexamethasone 200 nM + ivermectin 20 μM demonstrated superior upregulations of BAX (p<0.001) and CASP3 (p<0.001). In conclusion, the addition of ivermectin (5 µM) to dexamethasone regimen (200 nM) increases its cytotoxic and apoptotic activities against SUP-B15 cell line as observed by the CASP3 and BAX upregulation. Studies to confirm the enhanced anticancer activity by this combination by observing the protein levels and animal studies are warranted.
Co-Authors AA, Rizka Abdul Latif Adawiyah, Varihatul Al Hafiz, OK Muhammad Alifa, Cut Safira Alnaz, Ahmad Razi Maulana Alona, Ivana Andika Pradana Anggraini, Dwi Rita Annisa, Dinda Aprianti Lubis, Nenni Dwi Ariga, Hijrah Purnama Sari Ariga, Selviana Arlinda Sari Wahyuni Athika Adnani Attamimi, Fandy Faidhul Aulia, Devina Ayodhia P. Pasaribu, Ayodhia P. Bayani, Sri Bisono, Luwih C, Teguh Chusnul Chotimah Cut Putri Hazlianda Dagau, Lelie Dalimunthe, Almira Dalimunthe, Muhammad Bayhaqi Daulay, Majidah Andilaila Deri Edianto Destanul Aulia, Destanul Dewi Susanti Atmaja Dian Putri Oktavia, Dian Putri Dina Arwina Dalimunthe, Dina Arwina Dinda Sani Pratiwi Doni Prabowo Dwi Aprianti Lubis, Nenni Dwi Hanto EM, Samuel Fachry Abda El Rahman Fadillah Tarigan, Muhammad Fahira Mulya Suhady Fajar, Fajar Amanah Ariga Fathia Meirina, Fathia Fauzi, Muhammad Rado Fithri Hervianti Fujiati, Isti Ilmiati Ginting, Daniel Suranta Gunawan, Prayogo Aldi Hamdani, Rifqi Hamdi, Tasrif Hanafie, Achsanuddin Handayani, Bejo Utomo Harahap, Dhiny Yolanda Harahap, Juliandi Haslinda Hendri Wijaya, Hendri Husnul Khatimah Hutagalung, Sunna Vyatra Ihsan, Mhd Imal, Khasanul Irina, Rr. Sinta Irma Sepala Sari Siregar Isna Wati Isna Wati  Jefri, Budi Jelita Siregar Juliandi Harahap Jusuf, Nelva Karmila Karim, Tengku Abdul Keumala Sari, Dina Kholilah, Ma’rifahtul Koswara, Jocelyn Lambok Siahaan Lita Sri Andayani Lubis, Andriamuri Primaputra Lubis, Inke ND. Lubis, Mahrani Lubis, Nenni Dwi Aprianti M. Ilham Magdalena Sinaga, Bintang Yinke Maspuroh, Uah Mayasri, Fadhliani Mayasri, Fadhliani Putri Moh. Anshori Aris Widya Muhammad Ichwan Muhammad Ihsan Muhammad Ramadhan Muhammad Rizal Mula Tarigan Mustafa Mahmud Amin Nainggolan, Zefanya Grace Winneke Nasutiah Nasutiah Nasution, Abdul Hakim Nasution, Afrida Aryani Nasution, Bayu Rusfandi Nasution, Rizki Fauzan Ghali Nisa Purnamasari Nurhidayah, Dea Olga R. Siregar, Olga R. Pandia, Pandiaman Pane, Nikmah Kemalasari Pangestu, Raden Ali Panggabean, Mathilda Parluhutan Siagian Pasaribu, Ayodhia Pitaloka Pertin Sianturi Pradana, Hasta Dwi Putri Chairani Eyanoer, Putri Chairani Qadri Fauzi Tanjung Raihanah Raihanah Reni Asmara Ariga Ribawanto, Muhammad Rafif Rini Savitri Daulay, Rini Savitri Rini Yayuk Priyati, Rini Yayuk Robby Awaluddin Perangin-Angin Rohama, Rohama Rusda, Muhammad Rusdiana Rusdiana Ruslaini, Ruslaini Rusmalawaty, Rusmalawaty Saktioto Saktioto Salbiah, Siti Saragih, Rina Amalia Caromina Satria, Fauzi Budi Selvi Nafianti Silaen, Ester Lantika Sinaga, Janry Lewis Hasan Sarma SITI FATIMAH Sri Budi Astuti, Sri Budi Syamsidah Lubis, Syamsidah Syamsudhuha Syamsudhuha Syifha, Nor Tarigan, Amira Permatasari Tazkiyah, Aulia Tengku Emrinaldi Triyadi, Slamet Ugrasena, I DG. Ulfah, Indar Fauziah Veralia W, Steven Wahyuni, Arlinda S. Wahyuni, Arlinda Sari wicaksono, desmiko haryo Widjaja, Sry Suryani Widowati Hermajiwandini, Chandra Murti Dewi Wijaya, Dadik Wahyu Wisman Dalimunthe, Wisman Y, Devi Yessica Amelia Yetty Machrina Yinke Magdalena Sinaga, Bintang Yosi Mardoni Yunanda, Yuki Yuniar, Nabila Yunita Sari Pane Zainul Abidin Zulkarnain Zulkarnain