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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Harmoni Sosial: Jurnal Pendidikan IPS Jurnal Terapan Abdimas Al-Jabar : Jurnal Pendidikan Matematika Jurnal Farmasi Sains dan Komunitas Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Syntax Literate: Jurnal Ilmiah Indonesia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Pharmacoscript Jurnal Ilmiah Cendekia Eksakta Indonesian Journal of Global Health research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Multidisiplin Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kajian Ilmiah Prima Abdika: Jurnal Pengabdian Masyarakat Journal La Lifesci Jurnal Penelitian Inovatif Indo-MathEdu Intellectuals Journal International Journal of Islamic and Complementary Medicine Journal Of Human And Education (JAHE) Jurnal Bakti Untuk Negeri Duta Pharma Journal Jurnal Katalisator Journal of Food and Pharmaceutical Sciences Riemann : Research of Mathematics and Mathematics Education Jurnal Farmasi Galenika Contemporary Education and Community Engagement JI-KES (Jurnal Ilmu Kesehatan) Folia Medica Indonesiana
Kintoko Kintoko
Prodi Magister Pendidikan Matematika, Pascasarjana, FKIP – UNS
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Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Nur Arib, Faisal; Kintoko, Kintoko; Sulistyani, Nanik; Akrom, Akrom
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Nur Arib, Faisal; Kintoko, Kintoko; Sulistyani, Nanik; Akrom, Akrom
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended.
Acute Toxicity Test of Healthy Drink of Anthocyanin Pigmented Polyphenols from Black Rice and Sprouts Soybean Kintoko, Kintoko; Salamah, Nina; Witasari, Hardi Astuti; Maulizah, Rizlah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25784

Abstract

Black rice and sprouted soybean (BRiSS) can be formulated into a healthy drink BRiSS. The safety of this novel combination must be rigorously tested. Therefore, this study was designed to conduct a comprehensive acute toxicity test of the healthy drink flavylium anthocyanins from black rice (Oryza sativa L. indica) pigmented polyphenols from soybean sprouts (Glycine max L.). The black rice was extracted with a 96% ethanol solution in 3% citric acid. The pigmentation process was achieved by adding hydroxyl groups from soybean polyphenols. The active material was mixed with 20% maltodextrin, shaken, poured into a pan, and dried with a cabinet dryer (60° C). The mixture was stirred with 0.3% sodium, 0.1% citric acid, 50% active ingredients, 5% sucrose as a sweetener, 0.05% sodium benzoate, and water, 100 ml. The five groups of male Wistar rats were acclimatized. Group 1 was a control, and groups 2, 3, 4, and 5 were sequentially treated with a healthy drink containing extract doses of 5, 50, 300, and 2000 mg/kg BW. The acute toxicity test results at 30 minutes, 3 to 24 hours, day 3, and day 14 were written on the acute toxicity test clinical symptom observation sheet. All test animals, including both the control and test groups with various dosage variations, did not exhibit changes in skin, fur, eyes, behavior, respiratory systems, and did not experience weight loss, seizures, tremors, lethargy, or diarrhea. The limitation was that the macropathology examination of internal organs (kidneys, liver, heart, brain, stomach, intestines, pancreas) was not performed. Not all animals have mortality in a 5-3000 (mg/kg BW) extract dose.
Acute Toxicity Test of Healthy Drink of Anthocyanin Pigmented Polyphenols from Black Rice and Sprouts Soybean Kintoko, Kintoko; Salamah, Nina; Witasari, Hardi Astuti; Maulizah, Rizlah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25784

Abstract

Black rice and sprouted soybean (BRiSS) can be formulated into a healthy drink BRiSS. The safety of this novel combination must be rigorously tested. Therefore, this study was designed to conduct a comprehensive acute toxicity test of the healthy drink flavylium anthocyanins from black rice (Oryza sativa L. indica) pigmented polyphenols from soybean sprouts (Glycine max L.). The black rice was extracted with a 96% ethanol solution in 3% citric acid. The pigmentation process was achieved by adding hydroxyl groups from soybean polyphenols. The active material was mixed with 20% maltodextrin, shaken, poured into a pan, and dried with a cabinet dryer (60° C). The mixture was stirred with 0.3% sodium, 0.1% citric acid, 50% active ingredients, 5% sucrose as a sweetener, 0.05% sodium benzoate, and water, 100 ml. The five groups of male Wistar rats were acclimatized. Group 1 was a control, and groups 2, 3, 4, and 5 were sequentially treated with a healthy drink containing extract doses of 5, 50, 300, and 2000 mg/kg BW. The acute toxicity test results at 30 minutes, 3 to 24 hours, day 3, and day 14 were written on the acute toxicity test clinical symptom observation sheet. All test animals, including both the control and test groups with various dosage variations, did not exhibit changes in skin, fur, eyes, behavior, respiratory systems, and did not experience weight loss, seizures, tremors, lethargy, or diarrhea. The limitation was that the macropathology examination of internal organs (kidneys, liver, heart, brain, stomach, intestines, pancreas) was not performed. Not all animals have mortality in a 5-3000 (mg/kg BW) extract dose.
Narrative Structures and Methodological Principles in Boyer and Merzbach’s Historiography for Mathematics Education Kintoko, Kintoko; Siswanto, Deny Hadi; Khuzaini, Nanang
Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Vol 10 No 2 (2026)
Publisher : Universitas Mercu Buana Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26486/r6f79y20

Abstract

This study aims to analyze the narrative structure, periodization, and methodological principles in A History of Mathematics by Carl B. Boyer and Uta C. Merzbach (third edition, 2011) as a historiographical model in mathematics education. The research employs a descriptive qualitative approach using the content analysis method. Data were collected through an in-depth reading of all chapters of the book and analyzed based on two main dimensions: internal history (the development of concepts and mathematical rigor) and external history (the social, cultural, and economic influences on the emergence of mathematical ideas). The findings reveal that Boyer and Merzbach construct the historical narrative of mathematics both chronologically and thematically, tracing its evolution from ancient to modern times while emphasizing the continuity of mathematical ideas across civilizations. Merzbach’s approach, which integrates linguistic, social, and economic contexts, demonstrates that the development of mathematics is the result of an interaction between abstract ideas and human practical needs. Furthermore, the principle of “extension without correction” indicates that each new mathematical theory does not negate earlier ones but rather expands and enriches the existing scientific framework. The study concludes that A History of Mathematics possesses significant pedagogical value and is highly relevant as a learning resource for the history of mathematics, as it cultivates a philosophical and historical understanding of mathematics as both a cultural product and an ongoing intellectual process
Eksplorasi Potensi Antidiabetes Gynura procumbens: Analisis Bibliometrik Berbasis Data Scopus Arib, Faisal Nur; Chotimah, Aditya Nurul; Kintoko, Kintoko; Salamah, Nina
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.98143

Abstract

Gynura procumbens (Lour.) Merr., tumbuhan tropis dari famili Asteraceae, telah lama digunakan dalam pengobatan tradisional untuk berbagai penyakit. Studi praklinis menunjukkan potensi G. procumbens sebagai agen antidiabetes, yang relevan dengan tren peningkatan kasus diabetes melitus (DM) secara global. Penelitian ini bertujuan mengevaluasi perkembangan riset praklinis G. procumbens sebagai agen antidiabetes melalui analisis bibliometrik berbasis data Scopus. Sebanyak 23 artikel terpilih (2000–2024) dianalisis menggunakan perangkat lunak VOSviewer. Analisis meliputi pemetaan tren publikasi, jaringan keterkaitan kata kunci (keyword co-occurrence), distribusi negara dan institusi, artikel paling berpengaruh, hubungan referensi bersama (bibliographic coupling), dan kutipan bersama (co-citation). Hasil menunjukkan peningkatan tren publikasi sejak tahun 2000, dengan Malaysia sebagai kontributor utama, khususnya Universiti Sains Malaysia. Tema utama mencakup efek hipoglikemik, mekanisme molekuler, identifikasi senyawa aktif, serta potensi unik dalam meningkatkan fertilitas pada kondisi DM—suatu arah riset yang jarang ditemukan pada agen antidiabetes lain. Perkembangan penelitian bergerak dari studi ekstrak kasar menuju formulasi inovatif seperti nanopartikel. Analisis bibliographic coupling dan co-citation mengungkap keterkaitan antar tema, membentuk empat klaster utama yang saling beririsan. Studi ini mengidentifikasi celah penting, termasuk kurangnya data toksikologi kronis dan profil farmakokinetik. Temuan pada penelitian ini menegaskan G. procumbens sebagai kandidat terapi antidiabetes berbasis bukti ilmiah, dengan peluang pengembangan pada terapi komplikasi reproduksi akibat DM. Temuan ini menyediakan peta tematik yang dapat dimanfaatkan peneliti untuk merancang studi multidisiplin, mempercepat pemahaman mekanisme kerja, dan mendorong pengembangan formulasi G. procumbens yang efektif dan aman untuk aplikasi klinis.
Co-Authors Alfarisyi, Muhammad Iqbal Ananda, Aghnia Nabila Anggraeni, Linda Suci Ari Satia Nugraha Arib, Faisal Nur Aris Setyawan Ariyanti, Lusi Mardika Astuti, Andarweni Atmarani, Rizki Essa aviory, koryna Ayu Shabrina Billy Harnaldo Putra, Dini Fatmi, Botutihe, Lisa Agustina Cahayani, Devita Mika Chotimah, Aditya Nurul Dani Kusuma Desmayanti, Astri Dhian Arista Istikomah Dian Aprilia, Dian Dona, Suzana Dwi Utami Eka Siswanto Syamsul Epi Taufik Faisal Nur Arib Fajar Fajar Farid , Muhammad Ferani Mulianingsih Gunawan Gunawan Gunawan, Adhi Gusriyani, Sri Gustinanda, Rizky Hadi Siswanto, Deny Hardi Astuti Witasari Hari Susanti Harry Ade Saputra Hasana, Siti Nur Hayatus Sa`adah Hutari, Andri Iis Wahyuningsih Ilmia, Nisrien Indahsari, Kharisma Safitri Nur Jana, Padrul Khrisna Agung Cendekiawan Khusnul, Latifah Kusumo, Djati Wulan Lestariningrum, Wahyu Titis M. Yogi Riyantama Isjoni Maghfirah, Yolanda Sajjida Makati, Annisa Camellia Maulizah, Rizlah Mehta, Kunal Meki Pranata Mochammad Saiful, Bachri Muhammad Iqbal Birsyada Muldiyana, Tya Mustofa Ahda Mutti, Annisa Aulia Nanang Khuzaini, Nanang Nanik Sulistyani Nina Salamah Nina Widyaningsih Ningrum, Lailatul Fitria Nining Sugihartini Novitasari, Putri Rachma Nur Arib, Faisal Nurkhasanah Mahfudh Nurlita, Tasya Nuryani, Eva Oktavia, Lisa Pamungkas, Megita Dwi Poerwahyuningrum, Neny Pulhehe, Hasni Rangkuti, Ahmad Faizal Ranti, Imaniar Rejeki, Marsudi Endang Sri Restu Ayu Mumpuni, Restu Ayu Ridho, Anisa Rifka Rifki Febriansah Rohma, Siti Rohmah, Lely Arbiati Nur Rukaya, Benazir Evita Safira, Rizka Santoso, Blegoh Iwan Sapto Yuliani Saputri, Ginanjar Zukhruf Septian Aji Permana Septiana Wijayanti Setianingrum, Ervina Setiyawati, Fitri Indah Shary, Aprilya Kumala Siswanto, Deny Hadi Sri Budiarti, Nur Idha Suhendra Suhendra Sulistyani , Nanik Sunanti, Titis Supomo Supomo Suryaningsih, Andri Susetyawati, MM Endang Susetyawati, MM. Endang Susetyowati, MM Endang Tri Puspita Yuliana Urmatul Waznah Utami, Febri Via Yustitia Wahyu Widyaningsih Wahyuni, Dina Wardhani, Firdha Aprillia Warniasih, Kristina Widyaningrum, Rachmawati Wuryandari, Tutik Wuryandari, Tutik Yanti, Asti Afrida Yuli Nurullaili Efendi, Yuli Nurullaili Yulia Yesti, Yulia Yulianto Yulianto Yuni Suprapto, Yuni