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All Journal Biology, Medicine, & Natural Product Chemistry Journal of Islamic Pharmacy Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Inovasi Farmasi Indonesia Abdimas Galuh : Jurnal Pengabdian Kepada Masyarakat HERBAPHARMA : Journal of Herb Farmacological Borneo Journal Of Pharmascientech Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Mandala Pengabdian Masyarakat Well Being Jurnal EduHealth PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah STIKES Yarsi Mataram Jurnal Lentera International Journal of Science and Environment Journal of Engineering Science and Technology Management Business and Economic Publication Jurnal Ilmiah Multidisiplin Indonesia Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Media Akademik (JMA) Assoeltan: Indonesian Journal of Community Research and Engagement Contemporary Journal of Applied Sciences (CJAS) International Journal of Global Sustainable Research Indonesian Journal of Community Empowerment Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Penelitian Sains dan Kesehatan Avicenna IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia SEARCH: Science Education Research Gotong Royong Jurnal Pengabdian Kepada Masyarakat Al-Amin Interaksi : Jurnal Pengabdian Kepada Masyarakat Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara Jurnal Ilmu Kesehatan J-CEKI Joong-Ki Amaluna: Jurnal Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian HelFin Journal International Journal of Science and Society (IJSS) Jurnal Kajian dan Inovasi Ilmu (JKII) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service
Fendy Prasetyawan
Prodi Pendidikan Profesi Apoteker, Fakultas Ilmu Kesehatan, Universitas Kadiri
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Effect of Most Favored Regions of Estrogen Receptor β (ERβ) Molecules on MolDock Score Using Tamoxifen Ligand Salmasfattah, Novyananda; Permata, Agung; Prasetyawan, Fendy
JIKES : Jurnal Ilmu Kesehatan Vol. 3 No. 1 (2024): Juli-Desember 2024
Publisher : Yayasan Pendidikan Tanggui Baimbaian Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The estrogen receptor β (ERβ) molecule is one of the target proteins in cancer treatment. The type of ERβ molecule in the protein data bank (PDB) determines the value of most favored regions and MolDock score. The purpose of this study was to determine the effect of most favored regions of ERβ molecules on MolDock score using Tamoxifen ligand. There are 37 molecules that have ERβ protein, 7 molecules were selected to be analyzed for the value of most favored regions and MolDock score, based on the r table value, pearson correlation value 0.548 < 0.754 (r table). This is also the same when viewed from the significance value of 0.203 > 0.05. It can be concluded that there is no correlation between the value of most favored regions and MolDock score.
Increasing Awareness Among Teenagers About Preventing Non-Communicable Diseases Through The Use Of Multimedia At Karang Taruna Wates Bandhi Prasetya Nugroho; milda, ratna; Fendy Prasetyawan; Baarik Lana Fadli; Yuneka Saristiana; Isma Oktadiana; Arsiaty Sumule
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3408

Abstract

Non-Communicable Diseases (NCDs) are currently a serious health problem in the world, because these diseases are one of the most common causes of death. Community empowerment in preventing PTM through community components, one of which is youth organizations or youth organizations which have an important role in taking part, is expected to be able to prevent PTM through various more interesting media. The aim of this community service is to provide PTM education through the use of multimedia. The method used is to convey information accompanied by posters, pictures and discussions. After providing education, it is hoped that youth organizations will be able to be more critical about PTM and be able to provide further education to the wider community, especially in the Wates area, by utilizing multimedia. Keywords: Non-communicable diseases, Karang Taruna, Multimedia
Education about worms through animated videos for early childhood Ana Amalia; milda, ratna; Fendy Prasetyawan; Yuneka Saristiana; Isma Oktadiana; Arsiaty Sumule
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3431

Abstract

This worm disease can infect all ages, but those who are most susceptible to infection are children under five and elementary school age (SD) aged 5 to 14 years. To be able to break the chain of worm infections and reduce the number of worm infections in schools, this can be done by providing information or education. Providing education about worms can increase students' knowledge regarding preventing worms. The aim of this activity is to increase the knowledge of students and girls in preventing worms. The method of this service is to provide education using animated video media about worm disease and hand washing demonstrations. After counseling and demonstrations, the results of the education that has been provided will be evaluated using a questionnaire to evaluate students' knowledge of worms and their prevention after 1 week of providing counseling via educational video media. The results of the activity showed an increase in knowledge and psychomotor skills after being given education regarding worms and washing hands. It is hoped that increasing understanding of the dangers of worms can foster awareness and independence in preventing worms in families and communities. Keywords: Worms, education, animated video
Community Education on Hypertension in Batua Dua Village's Simalungun Regency Area Arsiaty Sumule; okta, isma; Maswan Daulay; Salim Efendy; Fendy Prasetyawan; Ratna Mildawati
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3520

Abstract

According to the 2018 Indonesian Basic Health Research Statistics (Riskesdas), 34.11% of Indonesians aged 18 or older have hypertension, with 8.36% of those affected based on diagnosis. According to the American Heart Association, the number of individuals with hypertension rises annually, and the average death rate from the condition increased by almost 21% between 2000 and 2010. Additionally, the death rate significantly increases in at least 46% of individuals with hypertension. The purpose of this service is to educate clients both before and after counseling on lifestyle compliance. The strategy is to distribute information on hypertension, which can raise public awareness by demonstrating positive answers and accuracy in responding to the questions. There was a difference in knowledge between the 20 respondents who participated in the counseling before and after it was provided.
Prediction of Gingerol from Red Ginger Plant (Zingiber officinale var. rubrum) for 5-Hydroxytryptamine Release Stimulant as Antirheumatic Ratno Setyobudi; Fendy Prasetyawan
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.1

Abstract

Rheumatoid arthritis (RA) is a debilitating autoimmune condition characterized by chronic joint inflammation and pain, often managed with conventional treatments that can present serious side effects. This study investigates the potential of gingerol, the primary bioactive compound found in red ginger (Zingiber officinale var. rubrum), as a natural alternative for RA management. Utilizing in silico methodologies such as molecular docking and dynamics simulations, the research predicts that gingerol acts as a stimulant for the release of 5-hydroxytryptamine (serotonin), a crucial neurotransmitter involved in pain regulation and inflammation modulation. The analysis reveals a high probability (0.960) of gingerol's activity in enhancing serotonin release, suggesting its significant role in mitigating inflammatory responses. The interaction mechanism of gingerol with serotonin receptors indicates a pathway for its therapeutic action, reinforcing its potential as a safe and effective herbal medicine for RA treatment. Further research, including in vitro and in vivo validations, is warranted to explore the efficacy of gingerol as a viable anti-rheumatic agent.
Prediction of Augenol in Cinnamon (Cinnamomum burmannii) Boiled as a Carminative to Overcome Floating Stomach Rika Wahyu Pujiastini; Fendy Prasetyawan; Yuneka Saristiana; M. Wahyu Ariawan; Muhammad Nurul Fadel; Emma Jayanti Besan
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.2

Abstract

Flatulence (meteorismus) is a common condition caused by excess gas accumulation in the digestive tract. One alternative traditional treatment to overcome this condition is the use of herbal plants, such as cinnamon (Cinnamomum burmannii). This study aims to predict the potential of eugenol, an active compound in cinnamon, as a carminative agent using an in silico approach. Data were obtained from PubChem and analyzed using PASS Online to predict its pharmacological activity. The results of the analysis showed that eugenol has a probability of activity as a carminative of 0.941 and a probability of inactivity of 0.001, indicating high potential in helping to relieve flatulence. Thus, eugenol in cinnamon has the potential as an alternative natural treatment to overcome digestive disorders, especially bloating.
Pharmacokinetic Prediction Of Apigenin From Celer (Apium Graveolens L.) Using Pkcsm Lusiana Aprillia; Fendy Prasetyawan; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.3

Abstract

Celery (Apium graveolensL.) is a plant that has various pharmacological activities. One of the main bioactive compounds in celery is apigenin. Understanding the pharmacokinetic properties of apigenin is very important in evaluating its effectiveness and safety as a drug candidate. This study aims to predict the pharmacokinetic properties of apigenin using the pkCSM computational approach. The prediction results show that apigenin has good intestinal absorption, but low water solubility. Distribution ability is moderate, with limited penetration into the central nervous system. Apigenin is not a major substrate of CYP2D6 and CYP3A4 enzymes, but can inhibit CYP1A2 and CYP3A4. The elimination rate is moderate. Apigenin is not mutagenic, not hepatotoxic, and does not cause cardiotoxic effects. Apigenin has low toxicity toT. pyriformisand safe in acute doses with an LD50 of 2,432 log mM.
Molecular Docking of Hygrophila auriculata (Schum.) Heine Compounds Targeting PBP2 Protein in Neisseria gonorrhoeae Salmasfattah, Novyananda; Prayogi, Syaiful; Prasetyawan, Fendy
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31740

Abstract

Antibiotic resistance in gonorrhoea cases and patients is detrimental. Amidst the rising cases of gonorrhoea caused by Neisseria gonorrhoeae, Hygrophila auriculata (Schum.) Heine has activity as an antibiotic for the disease. The penicillin-binding protein 2 (PBP2) is a transpeptidase that catalyses the formation of cross-bridges on bacterial cell wall peptidoglycan, which will be the target of this plant. The purpose of molecular docking study is to see the binding affinity, compounds in Hygrophila auriculata (Schum.) Heine and ceftriaxone which is used as a comparison drug, will be targeted at PBP protein. Discovery studio visualizer v21.1.0.20298 was used for PBP2 protein preparation and visualisation. DoG Site Scorer was used to predict ligand binding sites on PBP2 proteins. PyRx 0.8 was used for virtual screening, validating of the docking method, and ligand preparation. Compounds in Hygrophila auriculata (Schum.) Heine as ligands were derived from MPDB 2.0 and the following PubChem codes; apigenin CID 5280443, luteolin CID 5280445, allagic acid CID 5281855, gallic acid CID 370, quercetin CID 5280343, lupeol CID 259846, lupenone CID 92158, betulin CID 72326, stigmasterol CID 5280794, and comparator drug ceftriaxone CID 447043. The binding affinity of ellagic acid -9,8 from Hygrophila auriculata (Schum.) Heine was lower than ceftriaxone -9,4 on the target PBP2 protein. Some of the amino acid residues that appear in protein-ligand docking include: ALA A:310, THR A:500 and 347, LYS A:313, and SER A:362. These amino acid residues owned by the PBP2 protein serve as the bonding bridge. Ellagic acid, the compound has potential as an antibiotic in gonorrhoea. Further testing and studies are needed to strengthen the evidence of the findings in this study
Protective Role of Paederia foetida L. Against Hepatic Inflammatory Response in a Mice Model of Escherichia coli-Induced Sepsis Savitri, Lisa; Freitas, Maria Do Carmo Da Costa; Prasetyawan, Fendy; Saristiana, Yuneka; Mebung, Konradus Klala; Amanda, Cornelia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.363-368

Abstract

Sepsis is a severe medical condition characterized by a systemic immune response to infection, often leading to multi-organ failure and death if not treated effectively. This study aimed to investigate the antiseptic properties of Paederia foetida leaf extract in male mice induced with sepsis using Escherichia coli. A total of 24 mice were divided into six groups: a normal group (no treatment), a negative control group (distilled water), a positive control group (ciprofloxacin), and three treatment groups receiving P. foetida leaf extract at doses of 100, 300, and 500 mg/kg BW. After 15 days of oral administration, liver tissue samples were analyzed for IL-6 expression, a pro-inflammatory cytokine associated with sepsis. The results revealed a significant reduction in IL-6 expression in the treatment groups, particularly at the 500 mg/kg BW dose. This dose showed the most effective anti-inflammatory response, with IL-6 expression levels comparable to those of the positive control group treated with ciprofloxacin. However, the 100 mg/kg BW dose demonstrated minimal effects, similar to the negative control. These findings suggest that P. foetida leaf extract, especially at higher doses, has potential as an anti-inflammatory agent in sepsis management. The bioactive compounds in the extract, including flavonoids, alkaloids, and terpenoids, likely contribute to its efficacy. This study provides preliminary evidence supporting the use of P. foetida as a potential herbal alternative for managing sepsis, but further clinical research is necessary to confirm its therapeutic potential.
Edukasi Peluang Dan Tantangan Terkini Pharmacist Dengan Distruksi di Industri Farmasi Fendy Prasetyawan; Mujtahid Bin Abd Kadir; Nur Fahma Laili; Prayoga Fery Yuniarto; Datin An Nisa Sukmawati; Arifani Siswidiasari; Neni Probosiwi; Tsamrotul Ilmi; Elsa Mahardika Putri; Yuneka Saristiana; Okky Intan Mawarni; Winartiana; Nimas Ayu Rahardini; Anis Akhwan Dhafin
Khidmah Nusantara Vol. 1 No. 1 (2024): Agustus 2024
Publisher : CV.RIZANIA MEDIA PRATAMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69533/ghy9th25

Abstract

Tingkat pengangguran yang meningkat setiap tahunnya membuat masyarakat mencari sumber informasi dengan tujuan memperoleh dan mendapatkan lapangan pekerjaan, yang dapat dicapai dengan menempuh pendidikan perguruan tinggi. Jurusan farmasi merupakan jurusan yang banyak diminati karena memiliki prospek yang biak kedepannya dan salah satu jurusan populer. Seorang farmasis dapat bekerja disektor industri, indonesia memiliki sebanyak 230 industri farmasi. Dengan jumlah industri yang banyak sehingga industri farmasi membutuhkan banyak tenaga kerja, terutama tenaga farmasi yang profesional. Selain peluang kerja di indsutri farmasi namun di era industri 4.0 ini tantangan yang dihadapi semakin besar, sehingga farmasis harus meningkatkan pengetahuan untuk mengimbangi teknologi yang terus maju. Oleh karena itu diperukan pengetahuan untuk meningkat wawasan terkait indutri farmasi.Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk mendorong mahasiswa farmasi agar dapat bekerja di industri farmasi dan memberikan gambaran tentang industri farmasi. Kegiatan pengabdian ini dilakukan di gedung AULA FIK Universitas Kadiri hari sabtu, 20 April 2024. Hasil kegiatan menunjukkan bahwa peserta antusias mengikuti acara, terlihat dari keikutsertaan mereka dalam mengikuti acara dari awal hingga akhir dan mengajukan pertanyaan selama sesi kuliah pakar berlangsung.Oleh karena itu, kegiatan pengabdian masyarakat ini dinilai berpotensi membantu menginspirasi, mendorong dan informasi bagi mahasiswa farmasi untuk berkarir di industri farmasi.
Co-Authors Abd Rofiq Abd Rofiq Abd Rofiq Abd Rofiq Achmad Wahdi Adiyansyah Lukman Hakim Adiyansyah Lukman Hakim Adiyansyah Lukman Hakim Akhmal Muslikh, Faisal Alshol, Mohammad Firdaus Althaf Rajahala B Sinun Althaf Rajahala B Sinun Alves, Silvina Sandra X. Amanda, Cornelia Ana Amalia Anak Agung Indah Krisnadewi Anis Akhwan Dafin Anis Akhwan Dhafin Anis Akhwan Dhafin Anis Akwan Dhafin Anita Dwi Setyarini Anita Dwi Setyarini Arifani Siswidiasari Arikha Ayu Susilowati Arista Wahyu Ningsih Arsiaty Sumule Ary Kristijono Ary Kristijono Asih Widiyastuti Asrizal Azis Astutik, Widhi Ayu Angger Putri M. Soleh Azis, Asrizal Baarik Lana Fadli Bandhi Prasetya Nugroho Bandhi Prasetya Nugroho Bandhi Prasetyo Nugroho Besan, Emma Jayanti Burhan Ma'arif Burhan Ma’arif Candra Arifin Chandra Arifin Chandra Arifin Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Datin An Nisa Sukmawati Deo Rudita Febrian Waly Deo Rudita Febrian Waly Dewi Retno Puspitosari Dian Permatasari, Yunita Dyah Aryantini, Dyah Edda, Ilda Rambu Eka Hayati Rhomah Eka Nur Fatmawati Eko Hidayaturrohman Khumaeni Elfred Rinaldo Kasimo, Elfred Rinaldo Elsa Mahardika Dhafin Elsa Mahardika Putri Elsa Mahardika Putri Elsa Mahardika Putri Ema Jayanti Besan Ema Tri Wulan Emma Jayanti Besan Erawati, Dyah Anisa Indri Evi Nurul Hidayati Faisal Akhmal Faisal Akhmal Muslihk Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fita Sari Fita Sari, Fita Fitrani Khansa Fitria Apriliyani Fitriani, Evi Tunjung Freitas, Maria Do Carmo Da Costa Gempita Hutami Dameria Gunawan Pamudji Widodo Hamzah, Hasyrul Hasriyani Hasriyani Hasriyani Hasriyani Hasriyani, Hasriyani Herman Hilmi, Mochammad Hanif Ibrahim Fadlannul Haq Ibrahim Irsyadul Ibad Ibrahim Iskandar Alfaris Ika Purwidyaningrum Ilhawa Zahra Ilhawa Zahra Imran, Arlan K Indrayanti, Dian Iramadona, Putri Ayu Isma Oktadiana Isma Oktadiana Ivan Junius Mesak Juan Vega Mahardhika Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Karingga, Devangga Darma Kholis, Muhammad Akbar Nur Kurniawati, Evi Laili, Nur Fahma Leny Witaning Kusumati Lilik Koernia Wahidah Lily Aina Lusiana Aprillia M. Wahyu Ariawan Maharani Dwi Pratiwi Marhenta, Yogi Bhakti maswan daulay Mebung, Konradus Klala Megasari, Elly Meri, Meri milda, ratna Mildawati, Ratna Mildwati, Ratna Muhammad Alviyan Shutiawan Muhammad Alviyan Shutiawan Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Muslihk, Faisal Akhmal Muslikh, Faisal Nanda Ardianto Nanda Ardianto Nanda Ardianto Neni Probosiwi Nimas Ayu Rahardini Nina Nur Jannah Nisa Azzahra Dentika Novyananda Salmasfattah Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Nura Ali Dahbul Octavian Ashido Nababan Octavian Ashido Nababan Okky Intan Mawarni Okky Intan Mawarni okta, isma Oktadiana, Isma Permata, Agung Prayoga Feri Yuniarto Prayoga Fery Yuniarto Prayogi, Syaiful Purnomo Puspitosari, Dewi Retno Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratno Setyobudi Restyana, Anggi Rhomah, Eka Hayati Rika Wahyu Pujiastini Rochmad Krissanjaya Rofiq, Abd Rohmah, Eka Hayati Rosa Juwita Hesturini Salim Efendy Salmasfattah, Novyananda Salmasfattah, Novynanda savitri, Lisa Setyawan, Ferdinta Daniasta Shinta Mayasari Shinta Mayasari Siti Nur Maulita Sugeng Rianto Sugeng, Santoso Susilo Margining Raharjo Syendriva Zeptyan Zenmas Syntia Tanu Juwita Tri Wulan, Ema Tsamrotul Ilmi Wahab, Charliandari Saputra Wahyu Ariawan Widhi Astutik Winartiana Winartiana, Winartiana Wisnu Haryo Widyoko Wulan, Ema Tri Yanti, Novirma Yogi Bhakti Marhenta Yosep Mansen Sado Yosep Mosse Yuneka Sarisitiana Yuneka Saristiana Yunita Dian Permatasari Yunita Dian Permatasari