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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Syiah Kuala Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Damianus Journal of Medicine Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Obstetri dan Ginekologi Majalah Kedokteran Sriwijaya Jurnal Keperawatan Sriwijaya Biomedical Journal of Indonesia Paediatrica Indonesiana JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan IJEMS (Indonesian Journal of Environmental Management and Sustainability) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Jurnal Integrasi Kesehatan dan Sains Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Majalah Kesehatan Indonesia Cendekia Medika : Jurnal Stikes Al-Ma`arif Baturaja CRJIM (Clinical and Research Journal in Internal Medicine) Journal of Community Development Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Journal of Anesthesiology and Clinical Research Lentera Perawat Majalah Anestesia & Critical Care (MACC) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Neurona Multidisciplinary Indonesian Center Journal Stetoskop : The Journal Of Health Science Journal of Multidisciplinary Academic and Practice Studies Poltekita: Jurnal Pengabdian Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Jurnal Kesehatan
Legiran Legiran
Department Of Biomedical Science, Medical Faculty Of Sriwijaya Universiy, South Sumatera, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Analysis of compliance with Antiretroviral (ARV) drinking of HIV patients in Regional General Hospitals Central Bangka District Kurrohman, Taufik; Sunarsih, Elvi; Sitorus, Rico Januar; Legiran, Legiran; Yunindyawati, Yunindyawati
Journal of Multidisciplinary Academic and Practice Studies Vol. 2 No. 4 (2024): November
Publisher : Goodwood Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jomaps.v2i4.2157

Abstract

Purpose: This study aimed to analyze the knowledge, attitudes, and compliance with antiretroviral (ARV) antidotes among HIV patients at the Central Bangka Regional General Hospital. Research Methodology: This study used a qualitative method with a phenomenological approach. The technique for selecting respondents was a non-probability sampling technique, purposive sampling. Nine informants participated in 9 people. Data were collected using an in-depth interview guide. Results: Findings from the research show that several informants had insufficient knowledge about compliance in taking ARV antidotes. Even though the informants' attitude towards compliance with antiretroviral (ARV) antiretrovirals was relatively good, several key informants stated that they had stopped taking antiretroviral (ARV) antidotes for several months because they felt healthy. However, several months later, they experienced adverse effects that resulted in declining health. Conclusions: The study concludes that Inadequate knowledge and misconceptions about ARV therapy remain significant obstacles to sustained adherence. Strengthening education, family involvement, and consistent supervision are essential for enhancing compliance and improving health outcomes for people living with HIV. Limitations: The study was limited to a small number of participants from a single hospital, which restricts broader generalization. Contribution: This research provides practical insights for healthcare providers and policymakers to design targeted interventions, improve supervision, and foster cross-program collaboration to ensure consistent ARV adherence among patients with HIV, ultimately supporting public health goals in HIV management.
Korelasi Kadar Serum Albumin terhadap Massa, Kekuatan Otot dan Performa Fisik pada Usia Lanjut di Poliklinik Geriatri Rsmh Palembang Riviati, Nur; Legiran; Saleh, Irsan; Indrajaya, Taufik; Dharma, Surya; Reagen, Muhammad; Yuniarti, Fifi; Rasidi, Syafran; Lubis, Fadhyl Zuhry; Indra, Bima
Bahasa Indonesia Vol 22 No 1 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i1.4233

Abstract

Introduction: Sarcopenia is a common problem found in the elderly. It is characterized by loss of muscle mass, muscle strength, and/or low physical performance. Currently, there’s little research on the association between serum albumin and muscle mass, muscle strength, and physical performance in the elderly, especially in Indonesia. This study aimed to find the correlation between serum albumin and muscle mass, muscle strength, and physical performance in the elderly. Method: A cross-sectional study was conducted from July 2022 to December 2022 towards elderly patients (>60 years) from the geriatric polyclinic at RSUP Moh. Hoesin Palembang. Serum albumin was examined for its correlation with muscle mass, muscle strength, and physical performance using Spearman’s test. Result: 41 elderly patients were included in this study (mean age 70.75 ± 7 years, 56.1% women). Correlation analysis showed that there’s a significant positive correlation between serum albumin with muscle strength (r=0.354, p=0.012) and a negative correlation with physical performance (r=-0.5, p <0.001). In comparison, there was no significant correlation between serum albumin and muscle mass (r=- 0.05, p=0.367). Conclusion: Muscle strength and physical performance have a significant correlation with serum albumin in the elderly. Therefore, even in the normal range, lower serum albumin is closely related to sarcopenia in the elderly. Key Words: albumin, muscle mass, muscle strength, physical performance, sarcopenia.
Improvement IL -10 and Reactive Oxygen Species (ROS) in HIV patients : Narrative Review Franajayakk, Indra; Legiran; Salim, Eddy Mart; Hafy, Zen
Jurnal Kesehatan - STIKes Prima Nusantara Vol 16 No 1 (2025): Jurnal Kesehatan Volume 16 Nomor 1 Tahun 2025
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v16i1.1234

Abstract

Background: Infection Human Immunodeficiency Virus (HIV) is still become problem scary health​ for world community . This virus infection causes a bunch symptom disease characterized by with weakening system immunity body . A collection of symptoms This known with designation Acquired Immune Deficiency Syndrome (AIDS). Consequence the decline system immunity , HIV sufferers will prone to For caught various disease infections that can have fatal consequences. Objective: For know How improvement IL-10 and Reactive Oxygen Species (ROS) levels in HIV patients . Research methods: This use Narrative Review design . Articles searched from Google Scholar, PubMed, Science Direct, and EMBASE/ Elviser with use relevant keywords , then chosen based on criteria that have been set , and objectives study . Results: Increased levels of IL-10 and Reactive Oxygen Species (ROS) in patients results in a decrease in the immune system, this is characterized by increased virus replication, deactivation macrophages and depletion of the number of lymphocytes, so that the progression of the infection towards AIDS can occur. Conclusion: HIV infection causes the occurrence dysfunction mitochondria and enhancement production Reactive Oxygen Species (ROS) in cells CD4 + T lymphocytes. Various viral proteins, such as the envelope proteins Gp120, Tat, Nef and Vpr , are able to increase ROS production through various different pathways. The increase in ROS that occurs can increase mRNA expression through activation Nuclear Factor Kappa B ( NFκB ), increased IL-10 mRNA expression ultimately will increase IL-10 levels
Correlation Between Serum Soluble PD-1, CD8+ , CD4+ T Lymphocyte Counts and Liver Stiffness in Antiviral-Naïve Chronic Hepatitis B Patients Aliana, Rizki; Yuristo, Eddy; Legiran, Legiran; Suprianto, Imam; Busro, Vidi Orba; Astoni, Muhamad Ayus; Sya'roni, Anjab Akmal; Suyata, Suyata; Zaky, Samy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202610-18

Abstract

Background: Chronic hepatitis B (CHB) disease is a major global health problem with a high burden in Asia, including Indonesia. Liver stiffness measurement by transient elastography is a non-invasive key tool to assess fibrosis severity. The immune response in CHB involves T cell exhaustion marked by elevated soluble PD-1 (sPD-1) and changes in T lymphocyte subsets, which may influence fibrosis progression. This study aimed to assess the correlation between serum sPD-1, CD4+, and CD8+ T lymphocyte counts and liver stiffness in antiviral-naïve CHB patients.Methods: A cross-sectional study was conducted among 60 untreated CHB patients at Mohammad Hoesin Hospital, Palembang, Indonesia. The sPD-1 was measured by ELISA, while CD4+ and CD8+ T cell counts were determined via flow cytometry. Liver stiffness was assessed by transient elastography. Spearman correlation and multivariate linear regression were used to analyze associations between immune markers and liver stiffness.Results: Serum sPD-1 showed a significant positive correlation with liver stiffness (r = 0.481, p 0.001), while CD8+ T lymphocyte count was negatively correlated (r = –0.553, p 0.001). CD4+ T lymphocyte count showed no significant bivariate correlation (r = –0.189, p = 0.149). In the multivariate analysis, sPD-1 (β = 0.050, p 0.001), CD4+ T cells (β = –0.018, p = 0.001), and AST (β = 0.061, p = 0.005) were independent predictors of liver stiffness.Conclusion: Serum sPD-1 and CD4+ T-lymphocyte count are independently associated with liver stiffness in antiviral-naïve CHB patients. These findings suggested the involvement of immune exhaustion and liver injury in HBV-related fibrosis.
Adjuvant Resveratrol Reduces Albuminuria and Serum Transforming Growth Factor-β Without Improving Glomerular Filtration Rate in Diabetic Kidney Disease: A 12-Week Randomized Controlled Trial Eva Julita; Zulkhair Ali; Yulianto Kusnadi; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1627

Abstract

Background: Diabetic kidney disease (DKD) progresses through inflammation and fibrosis, with transforming growth factor-β (TGF-β) as the principal profibrotic mediator and albuminuria as a clinical surrogate of glomerular injury. Methods: We conducted a 12-week, double-blind, placebo-controlled randomized trial at Dr. Mohammad Hoesin General Hospital, Palembang, between October 2025 and January 2026 to evaluate adjuvant resveratrol on serum TGF-β, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR). Results: Of 61 randomized adults with DKD on standard care, 54 were analyzed (resveratrol n=27 received 25 mg twice daily, derived from Polygonum cuspidatum in 95% lecithin; placebo n=27). Within the resveratrol group, serum TGF-β fell from 123.7 to 77.1 pg/mL (p=0.008) and UACR from 94.1 to 89.8 mg/g (p=0.017); within placebo, UACR rose from 81.9 to 112 mg/g (p=0.029) while TGF-β change was non-significant (p=0.428). Between-group ΔUACR was significant (p<0.001), whereas ΔTGF-β (p=0.303) and ΔeGFR (p=0.567) were not. Multivariable linear regression identified resveratrol as an independent predictor of UACR reduction (B=−394.12 mg/g; 95% CI −659.53 to −128.71; p=0.004; adjusted R²=0.129). Baseline TGF-β was the dominant predictor of ΔTGF-β (B=−0.81; p<0.001; adjusted R²=0.701), and baseline LFG stage predicted ΔeGFR (B=−4.76; p=0.021). Mild bloating was reported in 14.8% of resveratrol versus 11.1% of placebo recipients; no serious adverse events occurred. Conclusion: Adjuvant low-dose resveratrol reduces albuminuria and serum TGF-β over 12 weeks in DKD without short-term improvement in eGFR, supporting an antifibrotic biomarker signal that warrants longer trials.
Adjuvant Resveratrol Reduces Albuminuria and Serum Transforming Growth Factor-β Without Improving Glomerular Filtration Rate in Diabetic Kidney Disease: A 12-Week Randomized Controlled Trial Eva Julita; Zulkhair Ali; Yulianto Kusnadi; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1627

Abstract

Background: Diabetic kidney disease (DKD) progresses through inflammation and fibrosis, with transforming growth factor-β (TGF-β) as the principal profibrotic mediator and albuminuria as a clinical surrogate of glomerular injury. Methods: We conducted a 12-week, double-blind, placebo-controlled randomized trial at Dr. Mohammad Hoesin General Hospital, Palembang, between October 2025 and January 2026 to evaluate adjuvant resveratrol on serum TGF-β, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR). Results: Of 61 randomized adults with DKD on standard care, 54 were analyzed (resveratrol n=27 received 25 mg twice daily, derived from Polygonum cuspidatum in 95% lecithin; placebo n=27). Within the resveratrol group, serum TGF-β fell from 123.7 to 77.1 pg/mL (p=0.008) and UACR from 94.1 to 89.8 mg/g (p=0.017); within placebo, UACR rose from 81.9 to 112 mg/g (p=0.029) while TGF-β change was non-significant (p=0.428). Between-group ΔUACR was significant (p<0.001), whereas ΔTGF-β (p=0.303) and ΔeGFR (p=0.567) were not. Multivariable linear regression identified resveratrol as an independent predictor of UACR reduction (B=−394.12 mg/g; 95% CI −659.53 to −128.71; p=0.004; adjusted R²=0.129). Baseline TGF-β was the dominant predictor of ΔTGF-β (B=−0.81; p<0.001; adjusted R²=0.701), and baseline LFG stage predicted ΔeGFR (B=−4.76; p=0.021). Mild bloating was reported in 14.8% of resveratrol versus 11.1% of placebo recipients; no serious adverse events occurred. Conclusion: Adjuvant low-dose resveratrol reduces albuminuria and serum TGF-β over 12 weeks in DKD without short-term improvement in eGFR, supporting an antifibrotic biomarker signal that warrants longer trials.
Hubungan Morfologi Oosit dengan Angka Fertilisasi dan Kualitas Embryo Pada Program Fertilisasi In VitrO Gita Angella; Legiran Legiran; Yusuf Effendi
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56144

Abstract

Infertilitas masih menjadi masalah kesehatan reproduksi yang signifikan, dan keberhasilan program in vitro fertilization (IVF) dipengaruhi oleh kualitas gamet, khususnya morfologi oosit. Penelitian ini bertujuan menganalisis hubungan morfologi oosit dengan angka fertilisasi serta kualitas embrio pada tahap pembelahan hari ke-3 dan blastokista hari ke-5. Penelitian ini merupakan penelitian analitik observasional dengan desain analitik komparatif menggunakan data sekunder pasien IVF di Blastula IVF Center Siloam Sriwijaya Palembang periode Maret 2021–Desember 2024. Sampel terdiri dari 213 pasien yang dipilih dengan teknik consecutive sampling. Variabel bebas meliputi parameter morfologi oosit (sitoplasma, polar bodi, ruang perivitelline , zona pelusida, dan bentuk oosit), sedangkan variabel terikat adalah angka fertilisasi dan kualitas embrio. Analisis data dilakukan menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa morfologi dengan ruang perivitelline dan zona pelusida berhubungan signifikan dengan angka fertilisasi (p < 0,05). Pada kualitas embrio hari ke-3, ruang perivitelline dan bentuk oosit menunjukkan hubungan bermakna, sedangkan pada tahap blastokista hari ke-5 tidak ditemukan hubungan signifikan antara morfologi oosit dan kualitas embrio. Kesimpulannya, pengaruh morfologi oosit lebih dominan pada tahap awal perkembangan embrio dibandingkan tahap blastokista.
Edukasi Postur Ergonomis dan Pencegahan Nyeri Muskuloskeletal di SMA IT Izzudin Palembang Indri Seta Septadina; Wardiansah Wardiansah; Tri Suciati; Sima Asmara Dewa Marya Mahardika Putri; Msy Rulan Adnindya; Legiran Legiran; Muhammad Ramadhan Odiesta
Journal of Community Development Vol. 6 No. 1 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i1.1750

Abstract

Santri merupakan kelompok yang berisiko tinggi mengalami keluhan muskuloskeletal akibat kebiasaan duduk statis dan postur tubuh yang tidak ergonomis selama belajar dan menghafal Al-Qur’an. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri mengenai postur duduk yang sehat dan pencegahan nyeri muskuloskeletal melalui edukasi ergonomis. Metode pelaksanaan meliputi penyuluhan interaktif ​menggunakan media booklet, video pendek, serta peragaan langsung teknik duduk ergonomis dan peregangan ringan bersama santri dan guru. Program ini diikuti oleh 82 peserta dari SMA IT Izzudin Palembang. Hasil evaluasi menunjukkan peningkatan pengetahuan yang signifikan, terutama pada aspek pemahaman tentang dampak keluhan muskuloskeletal (97,6%) dan gerakan peregangan (93,9%). Kegiatan ini efektif dalam meningkatkan kesadaran dan pemahaman santri mengenai pentingnya postur ergonomis, serta diharapkan menjadi langkah awal untuk penerapan perilaku duduk sehat di lingkungan pesantren.​
Co-Authors Abdul, Zabidah Achmad Ridwan, Achmad Ade Dian Anggraini Ade Permana Adinda Adinda Adinda Adnindya, Rulan Afriani Ahmat Umar Aliana, Rizki Alibasyah A. Chakra Andrina, Hana Angella, Gita Ansyori Hatta Ariani Susanti Arwan Bin Laeto Asri Maharani Astuti, Syurmi Aswin Nugraha Ayeshah A Rosdah Baehaqi Bella Ria Astuti Benny Kusuma Bermansyah Bernhard Arianto Purba Bunga Anggreini Sari Busro, Vidi Orba Chandra, Novy Rosalia Christin, Theresia Danny Amos Tarigan Desi Arlindia Dian Wahyuni Diana Dewi Sartika, Diana Dewi Diana Polania Dini Rizkie Wijayanti Dini Rizkie Wijayanti Dwi Ariska Eddy Mart Salim Eddy Mart Salim, Eddy Mart Edi Susanto Effendi, Kms. Yusuf Efman EU Manawan Efrieni Yusuf Eka Febri Zulissetiana Elvi Sunarsih Erial Bahar Eva Julita Evi Lusiana Febrianto, Yohanes Ferawaty Ferawaty, Ferawaty Ferry Yusrizal Fitri Nurjanah Fitri Nurjanah Fitriani Fitriani Franajayakk, Indra Fredi Heru Irwanto Fredy Ferdinand Carol Furqan Indah Gama Satria Gama Satria Ghanie Abla Gita Angella Hafid Komar Handayani, Sri Harun, Yusril Hasbi, Alfian Henry Sugiharto Indah, Furqan INDRA FRANA JAYA KK Indra, Bima Indrajaya, Taufik Indri Seta Septadina Irfannuddin Irfannuddin Irsan Saleh Irsan Saleh, Muhammad Islamia, Medina Putri Joneri, Alrahman KAMILA, YURI Kartika, Juspeni Kemas Muhammad Dahlan Kesty, Cindy Kgs. M. Rosyidi Kms Yusuf Effendi Kms. Yusuf Effendi Kurniawan, Didy Layal, Kamalia Lubis, Fadhyl Zuhry M. Afif Heldian Putra M. Zalili Azis Malahayati, Putri Martinova, Vera Mediarty Mega Sary Mega Sary Meirisa Rahma Pratiwi Mgs. Irsan Saleh Mgs.Muhammad Irsan Saleh Misnaniarti Misnaniarti Muhamad Ayus Astoni Muhammad Arma Muhammad David Riandy Muhammad Hasnawi Haddani Muhammad Ikhsan Kartawinata Muhammad Irsan Saleh Muhammad Ramadhan Odiesta Muhammad Reagan MUSTIKA FATIMAH Mutiara Budi Azhar Nadia Maharni Nadya Aviodita Nedya Bellinawati Nopriyati Nova Kurniati Novy Rosalia Chandra Nur Qodir Nur Qodir Nur Riviati, Nur Nurjanah, Fitri Odiesta, Muhammad Ramadhan Okta Emilia Patiyus Agustiansyah Patresia, Retta Pirma I.R.M Precelia Fransiska Puspa Zuleika, Puspa Putri Mirani Qodir, Nur Radema Pranata Rasidi, Syafran Reagen, Muhammad Ria Nova Rico Januar Sitorus Ridho Surya Putra Rika Purnama Sari Rini Nindela, Rini Rizal Sanif Rizal Zainal Rizma Adlia Syakurah Rose Mafiana Safyudin Saleh, Muhammad Irsan Salni Salni Sari, Sagita Darma Sary, Mega Sepiwiryanti, Wika Shafira Irmayati Sima Asmara Dewa Marya Mahardika Putri Sima Asmara Dewa Marya Mahardika Putri Siti Nurmaini Siti R. Nanin Siti Rusdiana Puspa Dewi Soenarto Kartowigno Sugiharto, Henry Suly Auline Rusminan Suprianto, Imam Surya Dharma Susila Arita Suyata Suyata Sya'roni, Anjab Akmal Syifa Alkaf Taufik Indrajaya Taufik Kurrohman Theresia Christin Tri Suciati Tri Suciati Tri Suciati Vidro Alif Gunawan Wahyuni, Devi Azri Wardiansah Wardiansah, Wardiansah Wardiansah, Wardiansah Wiria Aryanta Yangtjik Yangtjik Yuli Kurniawati Yulianto kusnadi Yuniarti, Fifi Yunindyawati Yunindyawati Yuniza Yuristo, Eddy Yusni Puspita Yusuf Effendi Yusuf Effendi Yusuf, Khaidir Zakaria Mukalla Zaky, Samy Zen Hafy Zulkhair Ali Zulkifli