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Journal : EIGEN MATHEMATICS JOURNAL

Integrative Bioinformatics and Statistical Approaches for Identifying Prognostic Biomarkers and Therapeutic Targets in Breast Cancer Zulhan Widya Baskara; Anuraga, Gangga; Anurogo, Dito; Fitriani, Fenny; Rochmanto, Hani Brilianti; Baskara, Zulhan Widya
Eigen Mathematics Journal Vol 8 No 1 (2025): June
Publisher : University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/emj.v8i1.277

Abstract

Breast cancer is a leading cause of cancer-related mortality worldwide, necessitating the identification of reliable biomarkers for prognosis and targeted therapy. This study employed an integrative bioinformatics and statistical approach to analyze differentially expressed genes (DEGs) in breast cancer using datasets GSE70947 and GSE22820 from the gene expression omnibus (GEO). A protein-protein interaction (PPI) network was constructed to identify hub genes, followed by functional enrichment analysis to determine their biological significance. Survival analysis using the KMplot database revealed that CDC45, KIF2C, CCNB1, KIF4A, CENPE, CHEK1, KIF15, AURKB, NCAPG, and HJURP were significantly associated with poor prognosis. These genes were primarily enriched in cell cycle regulation, mitotic spindle organization, and DNA damage response, highlighting their role in tumor progression. Among them, CCNB1, CHEK1, and AURKB were strongly linked to cell cycle progression and checkpoint regulation, while KIF2C and CENPE played essential roles in mitotic division. High expression levels of these genes correlated with reduced overall survival, suggesting their potential as prognostic biomarkers and therapeutic targets in breast cancer.These discoveries help us better understand how breast cancer develops and point to potential targets for tailored treatments.
Co-Authors Abdul Rahim Abdul Rahman Rahim Adhy Firdaus Agus Gunawan Ainun Jariyah Albertus Ata Maran Albina Bare Telan, Albina Bare Amansyah, Farid Ami Febriza Andari, Soetji Andarmoyo, Sulistyo Anis Fauzi, Anis Arda, Darmi Ardi, Abdullah Aripa, Lusyana Arli Aditya Parikesit Asbath Said Auliah, Rezki Awaliah, Nur Rahmah Bahjah, Dzata Bambang Winardi Bansaleng, Yessikah Feiby Borut, Mohamad Budhy Munawar Rachman Buka, Sisilia Prima Yanuaria Dadang Muhammad Hasyim Dewantara, Muhammad Iqbal Dwi Laksono, Pudjo Dwi Laksono Ekawati, Nur Eko Prastyo Eni Kurniati, Eni Erlinawati, Noor Diah Ernita Sari Fachry Abda El Rahman Farooq Mujahid, Muhammad Umer Farzani, Dwi Andina Fatany, Alief Ihram Fitria, Anni Fitriani, Fenny Gangga Anuraga Gonzales, Samantha Guilin, Xie Habibi Habibi Hani Brilianti Rochmanto Hardin La Ramba Harfika, Meiana Harmanto Harmanto Harris, Oliver Hasibuan, Evis Ritawani Haulussy, Rais Rahman Heni Widyaningsih, Heni Herlambang Prehananto, Herlambang Hermansyah Hermansyah Hidayati, Nanda Hijrah Hijrah Hiola, Siti Fatmah Ibad, M. Nashoihul Ibrahim, Juliani Idris Idris Ikrar, aruna Ikrar, Taruna Ilmi, Ahmad Alfarobi Jauharul Indra, Indra Intes, Amina Iwan Harsono Jia Yi Wang (王 家儀) , Jia Yi Wang Joko Sangaji Judijanto, Loso Junaedi, J Juwariyah, Siti K, Fitriani. Kao, Tzu-Jen Karimah, Annisa Ayu Kasmiati Kasmiati Kerwanto Khairunnisa Khairunnisa Krit, Pong Kurniawati Kurniawati Latif, Sarifudin Andi Lek, Siri Leli, Leli lidia fitri, lidia Mahendika, Devin Mappanyompa, Fatimah Mardikawati, Budi MAURITZ PANDAPOTAN MARPAUNG Mohamad Firdaus Mudrika Mudrika Muhammad Azhar Irwansyah Muhammad Hanif Muhtadi, Muhamad Ammar Mulyadi, Amelia Astrid Muntasir, Muntasir Musiana, Musiana Muslimin Muslimin Nabila Diyana Putri Nelly Nelly ningrum, dedah - Nunung Suryana Jamin Nur Faidah, Nur Nur Hasanah Nuralfin Anripa Nurkhalika, Rachmi Nurmila, Nurmila Nursiah, Andi Nursinah, A. Pannyiwi, Rahmat Parikesit, Arli A Puspita, Kori R. Rusli Rachman , Budhy Munawar Rahagia, Rasi Rahmat, Rezqiqah Aulia Reyes, Maria Clara Rieuwpassa, Sarmalina Rina Inda Sari Rini Nuraini, Rini Rini Susanti Rosdiana Rosdiana Saad, Rahmiyani Sahabuddin, Rosdiana Sakriawati, Sakriawati Salsabila, Anindya Samsani, Samsani Santos, Luis Saprudin, Udin Sardi Anto Sasmita, Niken Sasadhara Sembiring, Rinawati Sipahutar, Pongki Siti Aisyah Smith, James Sobihah, Hani Solehudin, Solehudin Sompa, Andi Weri Srifitayani, Nur Rahma Suarni, Agusdiwana Suat, Hatty Suat, Rahmawati Sulaeman Sulaeman SULASMI ANGGO Sulfiani, Sulfiani Sumarauw, Jeane L.I. Sumerli A, Chevi Herli Syahrir, Andi Karlina Syarif, Abdillah Syarif, Ubed Abdilah Tyas Putri Utami Ulfah Mahardika Pramono Putri Utami, Dia Rejeki Verawati Verawati Wahidin Wahidin Wilanda, Alifah Ximenis, Virgolie Diknas Yakobus, I Ketut Yamtana Yamtana, Yamtana Yanik, Carri Noer Fida Yermi, Yermi Yusraa, Yusraa Zani, Benny Novico Zohriah, Anis Zulham, Zulham Zulhan Widya Baskara Zumratul Rabbani, Khadijah