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Journal : Pharmaceutical Reports

In Vitro Anti-Inflammatory Potential of Buton Forest Honey through Nitric Oxide Inhibition in RAW 264.7 Macrophage Cells Hariana Hariana; Wahyuni Wahyuni; Suryani Suryani; Ari Sartinah; Maulidyah Maulidyah; Agung Wibawa Mahatva Yodha; La Ode Muhammad Julian Purnama; Adryan Fristiohady
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.396

Abstract

Inflammation is a physiological defense response to injury, infection, or stress, mediated by various signaling molecules, including nitric oxide (NO). However, excessive NO production can contribute to tissue damage and the progression of inflammatory conditions. Honey, a natural product derived from floral nectar by bees, contains diverse bioactive compounds with potential pharmacological properties, including anti-inflammatory activity. Buton Regency, located in Southeast Sulawesi, is a major producer of forest honey, making it a promising source of bioactive honey with therapeutic potential. This study aimed to evaluate the in vitro anti-inflammatory activity of Buton forest honey by assessing its ability to inhibit NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results demonstrated that Buton forest honey significantly suppressed NO production in a concentration-dependent manner. At concentrations of 500, 250, 125, 62.5, 31.25, 15.63, 7.81, and 3.91 mg/L, the percentages of inhibition were 94.69 ± 2.94%, 74.03 ± 2.43%, 67.40 ± 2.34%, 62.72 ± 3.09%, 51.80 ± 4.73%, 44.40 ± 4.73%, 19.06 ± 1.79%, and 12.82 ± 0.68%, respectively. Statistical analysis using one-way ANOVA followed by post hoc testing revealed significant differences among the tested concentrations (p 0.05). In conclusion, Buton forest honey exhibits significant anti-inflammatory activity by inhibiting NO production in macrophage cells, suggesting its potential as a natural source for the development of anti-inflammatory agents.
Co-Authors Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Ari Sartinah Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Aulya, Muhammad Sultanul Austin Tee, Selfyana Azdar Setiawan, Muh. Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Balaka, Kemal Idris Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dharmawati, Tuti Dhea, Alisha Dian Munasari Elfahmi Elfahmi, Elfahmi Eny Nurhikma Esti Badia Esti Badia Fadhliyah Malik Fajri Fitra Amalia Fauziah, Yulianti Firasmi Sangadji Firda yanti, Firda Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Frangky Sangande Fristiohady, Adryan Fusvita, Angriani Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Hariana Hariana Hariana Hariana, Hariana Harnita, Wa Ode Haruna, Lidya Agriningsih Hasidu, La Ode Abdul Fajar Haslianti Haslianti, Haslianti I Sahidin I W. Sutapa I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Idris, Sri Aprilianti Ilyas Y, Muhammad Imran Indra Ardiansyah Irnawati Irnawati Irnawati Irvan Anwar Jafriati Jumadil Jung, Jeoun Junli Hong Karmilah Karmilah Karmilah Karmilah, Karmilah Kasnia Kaatu La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Lisa Wulansari Siregar Loly Subhiaty Idrus Loly Subhiaty Idrus Maharani Maharani Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Maulidyah Maulidyah Mega Fatimah Rosana Melati Octapian Simanjuntak Muamar Abdillah Muh. Arnas Muh. Azdar Setiawan Muhammad Azhar Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Munasari, Dian Murtafia Murtafia Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah, Musdalipah NASRUDIN Nirwati Rusli Nohong Nur Af’idah Anas Nur Illiyyin Akib Nur Saadah Daud Nur Saadah Daud Nur Syifa Rahmatika Nur Syifa Rahmatika Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Pascayantri, Asniar Pryangan, Wulandari Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian RAHMAT MULIADI, RAHMAT Ramadhan Tosepu Randa Wulaisfan Raodatul Jannah Reymon Reymon Rina Andryani Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin Selfyana Austin Tee Sernita Sernita Setiawan, Muh. Azdar Setiawan, Muhammad Azdar Sitti Raodah Nurul Jannah Solo, Dian Munasari Sri Aprilianti Idris Sukrasno Sukrasno SURYANI Suryani Suryani Susanti Susanti Syaikhul Aziz Syamsu Alam Syarul Nataqain Baharum Tantrakarnapa, Kraichat Tee, Selfyana Austin Thamrin Azis Umar, Ani WAHYUNI Wahyuni Wahyuni wahyuni wahyuni Wenty, Darmayanita Yulianti Fauziah Zeptiano, Zeptiano