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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kebidanan Dan Kesehatan Tradisional Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Universa Medicina AcTion: Aceh Nutrition Journal Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health JKM (Jurnal Kebidanan Malahayati) Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Jurnal Kebidanan Harapan Ibu Pekalongan Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Nusantara Science and Technology Proceedings Plexus Medical Journal Indonesian Basic and Experimental Health Sciences Folia Medica Indonesiana
Uki Retno Budihastuti
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sebelas Maret, Surakarta/ Dr. Moewardi Hospital, Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
Education on Assisted Reproductive Technology Program with Low Cost Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Wijayanti, Agung Sari
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 1 (2023): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i1.64796

Abstract

Background: Assisted reproductive technology (ART) programs have proven to be a solution to help infertility couples to conceive. However, most couples face a financial crisis related to the relatively expensive cost of ART treatment. This service aims to educate about ART's meaning, direction, and procedures. Thus, couples want children to be able to understand the ART program at an affordable cost (low-cost) and undergo the ART program without any concerns about costs.Method: Seminar participants be given socialization in person and online through zoom software by the service provider. It is in two stages, in-person and online, so participants who cannot attend in person can follow this service program. In addition, participants are given a pre-test and post-test questions to assess their understanding of the ART program at an affordable cost.Result: The pre-test and post-test results were analyzed using Wilcoxon, which showed that after providing education about the ART program, the post-test results were significantly better than the pre-test results. Down value: 5.5%, fixed value: 15.2%, value rise: 79.3% with significance p<0.001.Conclusion: There are significant differences in the pre-test and post-test scores, which means that the participants understood the explanation the servicer gave.
Efforts to Increase Understanding of COVID-19 Screening in Assisted Reproductive Technology Services Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 2 (2023): August
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i2.74618

Abstract

Background: The assisted reproductive technology (ART) program for examining infertile couples requires face-to-face with a doctor. This face-to-face examination for the ART program has a risk for the transmission of COVID-19 to all medical personnel and infertile couples who want to undergo the ART program. This study aims to understand pre- and post-test education about COVID-19 screening on ART services.Methods: A total of 50 infertile couples in the ART program are given education online. The use of online methods using the Zoom application due to the COVID-19 pandemic. Evaluation of the level of understanding using pre and post-test providing education. Data analysis was carried out using the SPSS 23 application.Results: Analysis of the level of understanding of pre-test and post-test education using the Wilcoxon test. Pre-test results were 69.90±12.05, post-test 73.00±10.83 with significance values p<0.001. Chi-Square test analysis results obtained p<0.001 and OR = 15.68.Conclusion: There was a significant increase in understanding of COVID-19 screening in the post-test education ART service via the Zoom application compared to pre-test education.
Co-Authors -, Kartika ., Darto Abdurahman Laqif Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Adhimukti, Fahmi Agustina, Devita Alfi Marita Tristiarti Alfi Marita Tristiarti Alfi Marita Tristiarti Ali Djamhuri Alifa, Rosita Ambar Mudigdo Amir, Nikmah Ayu Ramadhani Angelia Ratnasari, Affi Anggraeni, Asih Anik Lestari Anik Lestari Annang Giri Moelyo Argyo Demartoto, Argyo Arianty, Meike Arifiana, Ratna Arifin, Ayu Kusuma Puspasari Aris Sudiyanto Armadhani, Riska Asih Anggraeni Astuti, Susiana Yuni Bachnas, Muhammad Adrianes Bachtiar, Harrys Bambang Purwanto Besar, Dwi Sakti Berlian Bhisma Murti Brahmana, Ivanna Beru Brian Wasita Cahyono Hadi Chintya, Shally Ayu Cut Sheira Elnita Damalita, Annisa Fitriana Damayanti, Siti Darto Darto Darto Darto - Darto Darto Debree Septiawan Dewanto Suryoningrat Dewi, Rizqa Kartika Dewi, Yulia Lanti Ratna Dewi, Yulia Lanti Ratna Dian Asih Ning Utami Dian Kusumawardani Dian Kusumawardani Dian Rahmawati Diani Octaviyanti Handajani Didik Gunawan Tamtomo Didik Tamtomo, Didik Dwi Apriyanti Eka Tri Wulandari, Eka Tri Endang Sutisna Endang Sutisna Sulaeman Eriana Melinawati Eric Edwin Yuliantara Erin Rizkiana Ermawati, Dwi Hesti Ertiana, Dwi Eti Poncorini Pamungkasari Fahsan, Fatmiyanti Farras Wahdan, Arib Fatmawati, Zeny Fauzia, Raina Lola Fazrina, Gina Firdausia, Shalsabilla Tiara Fitria Wulandari Frafitasari, Dika Yanuar Habibatullah, Afifa Intifadha Hadi, Cahyono Hadianti, Ayunita Dwi Hafi Nurinasari Hafiizha, Attahira Amalia Hafiizha, Atthahira Amalia Handriani, Winei Haniah, Alfi Zamilul Hanifah, Rofi'atul Hanifah, Rofi’atul Harsono Salimo Harsono Salimo Hastuti, Tri Ari Hermawan Udiyanto Heru Priyanto Heru Priyanto Hidayah, Fristyaningrum Ida Nurwati Ilmiyah, Desy Eka Indradewa, Rhian Jannah, Ahadyah Miftahul Jannah, Ahadyah Miftahul Jatiningtyas, Abida Zuhra Jayanti, Saktryana Endang Ragil Juhrotun Nisa, Juhrotun Ksatriya, Yudhistya Ngudi Insan Kunaryanti, Kunaryanti Kunaryanti, Kunaryanti Kusnandar Kusnandar Laqif, Abdurahman Laqif, Abdurrahman Lunardhi Susanto Lutfiana Puspita Sari Maghfiroh, Ainul Mahendra Wijaya Mahendra Wijaya Marbun, Yohan Pamuji Marliana, Wiwit Martaningrum, Herlina Ika Metanolia Sukmawati Mufidah, Amatullah Muhammad Adrianes Bachnas Mulyoto Pangestu MULYOTO PANGESTU Murdikawati, Dayang Fitri Murdikawati, Dayang Fitri Mushthafa, Mufti Mutiara, Bunga Ngudi Insan Ksyatria, Yudhistira Ningrum, Sintia Ayu Ningsih, Hepti Widia Nugrahani, Rosi Rizqi Nurul Qomariah Nurul Wahidah Nutria Widya Purna Anggraini Nuur, Aliffudin Octavia, Dhamayanti Eka Ode, Diana Oktaviani, Anisa Sevi Pamungakasari, Eti Poncorini Pawito -, Pawito Pertiwi, Mumpuni Intan Poncorini, Eti Prasetya, Hanung Prastyoningsih, Aris Prisasanti, Dympna Prameilita Puspita, Ita Fijanah Putriarsih, Ryanawati Qadrijati, Isna Qomariah, Nur Laili Quinita M. J. Noronha Rahardjo, Setyo Sri Rahayu, Baiq Zulvita Rahayu, Putu Sri Rahmadani, Latifah Nur Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratih Sakti Prastiwi Ratih Sakti Prastiwi, Ratih Sakti Ratna Dewi Permatasari Ratnasari, Affi Angelia Regita, Immanuela Maria Reso, Mulya Cunda Ratu Reso, Mulya Cunda Ratu Retno, Yulia Lanti Ria, Matilda Bupu Riawati, Meida Siwi Risang Bhaskoro Rita Adriani Benya Adriani Rita Cempaka Rizkiani, Inne Rofi’atul Hanifah Saputra, Ricky Bernadi Sari, Arum Dessy Rahma Sari, Lutfiana Puspita Sari, Prafista Wulan Satria, Yohanes Aditya Adhi Selvia Febrianti Septiana, Yesika Cahya Simarmata, Imelda Dearni Simarmata, Imelda Dearni SITI KHOLIFAH Siti Maesaroh Siti Munawaroh Siti Nur Hidayati Soetrisno Soetrisno Soetrisno Soetrisno Sri Lestariningsih Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Widarti, Sri Sringatin, Sringatin Suci Arsita Sari Sulistyoningrum, Indah SUMIYATI SUMIYATI Sunarta, Elfania Arumma Suparno, Amalia Ulfah Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Tanti Arianti Teguh Prakosa, Teguh Teha, Zadia Dara Cynintya Tri Nugraha Susilawati Verasita, Prissy Vitri Widyaningsih Wardana, Aisyah Puspa Wardhani, Anindyah Tri Lhaksmi Kusuma Wasyanto, Trisulo Wesliaprilius, Todung Antony Wijayanti, Agung Sari Wisnu Prabowo WISNU PRABOWO Wulandari, Rizqi Amalia Wulandari, Umianita Risca yulia lanti retno dewi Yulyanti, Yulyanti