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Prediksi Profil Farmakokinetik dan Toksisitas Senyawa Aktif Ekstrak Daun Kratom (Mitragyna speciosa) Secara In Silico Menggunakan pkCSM dan SwissADME anjas, Anjas Wilapangga; Nia marlina Kurnia; Mokhamad Mahroji; Arif Hidayat
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The kratom plant (Mitragyna speciosa) has several beneficial pharmacological effects in humans. The pharmacokinetic profiles of secondary metabolites from kratom leaf extract were examined. The aim of this study was to predict the pharmacokinetic and toxicity profiles of active compounds from kratom leaf extract (Mitragyna speciosa) in silico using pkCSM and SwissADME tools. The five main compounds studied were mitragynine, 7-hydroxymitragynine, paynantheine, speciogynine, and speciociliatine. Pharmacokinetic predictions showed that all compounds had good oral absorption profiles and high blood-brain barrier (BBB) ​​penetration, consistent with their pharmacological effects on the central nervous system. However, mitragynine and 7-hydroxymitragynine were predicted to have strong interactions with cytochrome P450 enzymes, particularly CYP3A4 and CYP2D6, indicating potential serious drug-drug interactions. In terms of toxicity, mitragynine is predicted to have mild hepatotoxicity and low genotoxicity. Meanwhile, 7-hydroxymitragynine exhibits a higher toxicity risk profile due to its potent opioid interactions. Overall, these in silico data provide important insights into the potential risks and benefits of kratom use. These results provide a strong foundation for further experimental and clinical studies to validate these predictions and develop guidelines for safe and responsible use.
The Influence Of Organizational Culture And Leadership Style On Performance Through Motivation As An Intervening Variable At PT Indonesia Chemi-Con: Pengaruh Budaya Organisasi dan Gaya Kepemimpinan terhadap Kinerja melalui Motivasi sebagai Variabel Intervensi di PT Indonesia Chemi-Con Mursalin, Mat; Sri Mulyani; Arif Hidayat
Jurnal Bisnis dan Ekonomi Vol 4 No 2 (2026): Jurnal Bisnis dan Ekonomi
Publisher : OGZ Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61597/jbe-ogzrp.v4i2.195

Abstract

Abstract: This study aims to analyse the influence of organisational culture and leadership style on employee performance mediated by work motivation among employees of PT Indonesia Chemi Con. This study uses a quantitative approach with a survey method. Data was collected by distributing questionnaires to employees of PT Indonesia Chemi Con as research respondents. The data analysis technique used was Structural Equation Modelling (SEM) with a Partial Least Squares (PLS) approach. The results of the study indicate that organisational culture has a positive and significant effect on employee performance. In addition, leadership style also has a positive and significant effect on employee performance. Furthermore, the results of the study prove that organisational culture and leadership style have a positive and significant effect on work motivation. Work motivation is also proven to have a positive and significant effect on employee performance. The test results show that work motivation acts as a mediating variable that strengthens the influence of organizational culture on employee performance. In addition, work motivation has also been proven to mediate the influence of leadership style on employee performance. Thus, it can be concluded that the improvement in employee performance at PT Chemi Con Indonesia is not only directly influenced by organizational culture and leadership style, but also indirectly through increased work motivation Keywords: Organizational Culture, Leadership Style, Work Motivation, Employee Performance
Analysis Of Digital Marketing Implementation In Increasing Brand Awareness And Sales: A Case Study Of Pertiwi Village: Analisis Implementasi Pemasaran Digital dalam Meningkatkan Kesadaran Merek dan Penjualan: Studi Kasus Desa Pertiwi Viko Rachmatullah Putra; Sri Mulyani; Arif Hidayat
Jurnal Bisnis dan Ekonomi Vol 4 No 2 (2026): Jurnal Bisnis dan Ekonomi
Publisher : OGZ Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61597/jbe-ogzrp.v4i2.204

Abstract

Abstrak :The rapid development of digital technology has transformed consumer behavior within the tourism industry, necessitating accommodation service providers to adapt to more modern marketing strategies. Pertiwi Village, a provider of resort, villa, and convention services in Cisarua, Bogor, faces challenges in optimizing extensive market potential through digital platforms. This study aims to analyze the implementation of digital marketing conducted by Pertiwi Village and the extent to which this implementation can increase brand awareness and sales. The research methodology employed is descriptive qualitative with a case study approach. Primary data were obtained through in-depth interviews with the owner, management, digital marketing team, and consumers. Secondary data were gathered through direct observation of the company's digital assets (Instagram, TikTok, WhatsApp) and internal documentation related to sales reports and photographs of Pertiwi Village. Data validity was ensured through source and method triangulation.The results indicate that digital marketing implementation at Pertiwi Village focuses on utilizing Instagram and TikTok as primary channels for building brand awareness through visual content. However, challenges remain regarding content consistency, substance, and variety, as well as the synchronization between digital activities and optimal sales conversion. Furthermore, the TikTok platform has not been optimallyutilized by Pertiwi Village. Evaluation of success indicators shows that while there has been a significant increase in reach and engagement, sales growth strategies are still highly dependent on the responsiveness of the reservation team in handling inquiries via WhatsApp. This study provides recommendations including the renewal of created content, updates to digital marketing strategies, more optimal use of TikTok, as well as strengthening the integration of digital reservation systems and optimizing the use of paid advertising to reach more specific market segments.Research Objectives: :1. To identify the implementation of Digital Marketing (such as platforms, content types, and campaigns) that has been carried out by Pertiwi Village.2. To analyze the extent to which the implementation of Digital Marketing is able to increase Brand Awareness.3. To analyze how the implementation of Digital Marketing at Pertiwi Village contributes to the increase in Sales..Method : This study employs a descriptive qualitative research method with a case study approach. Primary data were obtained through interviews and direct observations at Pertiwi Village, while secondary data were sourced from supporting documents, such as photographs and company archives. Results : 1. The Digital Strategy: Building the Foundation Right now, Pertiwi Village is in the early but crucial stages of its digital journey. They’ve successfully tapped into the power of social media—specifically Instagram and TikTok—to act as their visual storefront. By using WhatsApp Business as their main communication hub, they’ve created a direct line to their customers. However, there’s still a big opportunity to level up. Moving beyond social media by building an official website and joining major travel platforms (OTAs) would take their professionalism and accessibility to the next level.2. Brand Awareness: Creating the "Homie" Identity One of the most impressive findings is how well the brand’s identity resonates with the public. Pertiwi Village has managed to carve out a reputation for being a "home away from home." Their digital content doesn't just look good; it’s honest. Because the peaceful vibe people see on their screens matches the actual experience at the villa, they’ve built a strong sense of trust. The high ratings on Google Maps further prove that their brand isn't just a logo—it’s a promise of quality that people actually recognize.3. Sales Performance: From Likes to Bookings When we look at the bottom line, the digital efforts are clearly paying off. We’ve seen a steady climb in bookings from 2023 through 2025, which tells us that their online presence is doing more than just gaining "likes"—it’s driving revenue. The sales process is very human-centric; it starts with a spark of interest on social media and ends with a conversation on WhatsApp. The takeaway here is that while the content catches the eye, it’s the quick and friendly response from the reservation team that ultimately closes the deal.
Color and Motif Adjustment Strategies of Batik Cap in Overcoming Consumer Ambiguity for Batik MSME Sales Improvement in Jakarta: Strategi Penyesuaian Warna dan Motif Batik Cap dalam Mengatasi Ambiguitas Konsumen untuk Peningkatan Penjualan UMKM Batik di Jakarta Ade; Danang Aziz Akbarona; Arif Hidayat
Jurnal Bisnis dan Ekonomi Vol 4 No 2 (2026): Jurnal Bisnis dan Ekonomi
Publisher : OGZ Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61597/jbe-ogzrp.v4i2.205

Abstract

Abstract Objective: This study aims to examine color and motif adjustment strategies of batik cap in reducing consumer ambiguity to increase batik MSME sales in Jakarta.Methodology: A descriptive qualitative approach was employed with thematic analysis of 8 informants consisting of 2 batik cap MSME practitioners, 5 multigenerational consumers (ages 22–29 and 58–65), and 1 Visual Communication Design academic. Data were collected through in-depth interviews, field observation, and documentation studies.Findings: The research revealed three dimensions of consumer ambiguity: (1) perceptual ambiguity (inability to distinguish batik cap from digital printing), (2) referential ambiguity (emptiness of symbolic meaning of traditional motifs among younger generations), and (3) evaluative ambiguity (collapse of cultural hierarchy due to inconsistent product positioning). Successful MSMEs implemented three integrated strategies: generation- and region-based segmented visual design, cultural bridging through the principle of "adaptation not adoption," and quality signaling through production process transparency. These strategies increased purchase conversion by 35–100%, opened new consumer segments aged 20–45, and built long-term trust with repurchase rates up to 38%.
Co-Authors Abdulloh Fuad Achmad Ludvy ade Adrian Saputra AFRIZAL FIKRI AGUS SETIAWAN Ahmad Bustomi Ahmad Fatwa Ahmad Fauzi Ahmad Hisam Bintoro Ahmad Kalim Nasurullah Ahmad Taufiq Alan Hafiludin Ali Syahputra Nasution Alifian Sandi Nugroho Andi Wahyudi Andriani Sariwardani Anggeta Purnama Ani Nour Azizah Ani Nur Aeni Anindita Septiarini, Anindita Anita Septiani Anjas, Anjas Wilapangga Antika Diah Cahyani April Gunawan Malau Aprizal Fikri Ari Pristiana Dewi Arifianto Adi Wibowo Arini Dwi Swandari Asep Sujana Awam Mukhatam Riziq Ayang Fitrianti Aynin Mashfufah Ayom Widipaminto Bagus Endrawan Bayu Azizi Bayu Hardiono Bayu Rahayudi Benny Syahrir Abdurohman Bunga Henida Putri Claryza Danang Aziz Akbarona Danang Dwi Harmoko Danawan, Agus Dani Anggoro Darmawan, Roslinda jasmine Darodjat DENI SETIAWAN Desnawita Dwi Anggita Desy Novinaty Devy Habibi Muhammad Dewi, Damayanti Kusuma Diah Ragil Kusuma Diah Zakiah Diana Tri Rahayu Didik Sapto Raharjo Dika Apriyanto Dinda Dinda Annisha Kurnianingtyas Dony Yunianto Yunianto Dwi Saktiawan Dyah Retno Sawitri Eka Diah Kartiningrum Elza Fauziah Shihab Ema Nurmawaty Enik Chairul Umah Episiasi Erna Rokhimiya Putri Ervina Aryanti Erwin Erwin ' ' Erwin Setiawan Evita Dwi Lestari Fadhilah Nur S Faqih Maulana Faqih, Nasyiin Fatchur Roehman Feida Noor Laila Isti Ferry Hermawan Ghania Rifqa Danish Ara Guna Yanti Kemala Sari Siregar Gushelmi . H.M. Slamet Yahya Hadi Suwono Haris Perwira Hartono Hartono Hendra Susanto Herlini Puspika Sari Hidayat Gunawan Ian Harum Prasasti Ida Rohmah Susiani IIN KURNIA Ike Prafita Sari Indriana Firdaus Indy Nurshalshabila Ines Febri Fitriyah Irma Mila Karimah Jati Utomo Dwi H Jati Utomo Dwi Hatmoko Jaya Mahar Maligan Jihan Nabilatul Azzah Kania Indah Pratiwi Karmila Utari Karolina Karolina Kholid Mawardi Khotibul Umam Kurnia, Nia Marlina Kusnunnahari Laksono Trisnantoro Larsen Barasa Lia Yuliati Lili Purnamasita Lilis Muhlisoh Lintang Ratri Rahmiaji Lisa Ainun Najihah Lutviatun Nikmah Lya Rizka Herawati M Hermana M Naufal Waliyullah M. Haris Satria Mada Faisal Akbar Maharani Fatimah Azzahra Mahmun Nurudin Makhrisyafrisal, Mohammad Mardliyana Ifadah Margareta, Agatha Lola Margareta Markus Diantoro Martinus Martinus, Martinus Medi Taruk Melinda Noer Mochamad Agung Wibowo Mohammad Basri Mokhamad mahroji Muchammad Soleh Muhamad Badru Zaman Muhammad Nur Amin Muhardjito Muhardjito Munsharif Abdul Chalim Munzil Mursalin, Mat Muslimin Muslimin Musthafa Zahir Mustika Mustika Mustika Nadia Ayu Salsabilla Nadia Shafa Fellisha Nadya Prabaningtias Nanda Amika Putri Nandang Mufti Neni Neni Niken Juliani Nimas Mayang Sabrina Sunyoto Novianto Saputra Noviria Sukawati Nur Millaty Abadiah Nurfadilah Fitria Fatayana Nurrahma, Ashtria Nurul Hidayah Parisya Premiera Rosulindo Parsaoran Siahaan Phurkonni Saleah Pradananta, Hidayat Purnomo Putra Habib Dhitareka Putri Sukmawati Ramadhan Wisnu Wardana Ramdhani Bayu Putra Raras Setyo Retno Refa Muthia Bilqisthi Regina Yovita Aiko Rian Febriansyah Rini Yulianingsih Rio Anggala Riqi Radian Khasani Risanti Vani Fadilla Rosita, Indah Rovi Latif Rusyani Sabrina Salsa Aulia Salbila Octanadanti Salwa Diajeng Marhendra Salwa Naofalia Saptyaji Harnowi Saputra, Ismail Puji Sarah Lutfiah Satria Gunawan Zain Sayyadi, Muhammad Selvi Atesya Kesumawati Selvi Melianty Setiyanto Shinta Permata Sari Siswahyudianto Siti Asmaul Mustaniroh Siti Kholisah Sri Mulyani Sri Rahmawati Sriyanto ST. Ulfawanti Intan Subadra Subakti S Sudarmaji SUGIARTO, LAGA Suhendi Sujatmiko, Yudi Supriyono Koes Handayanto Susilawati Sutedi Sutedi Suwito N.S Syahputra, Arfan Rahardian Syaiful Firmanzah Syamsurijal Syarifuddin Syarifuddin Tata Sutabri Tiara Anindya Jufiantira Tita Miawati Tsabita Yamna Putri R. TUTUT NURITA Uki Kusuma Herdiva Usman Effendi Viko Rachmatullah Putra Viko Rahmatullah Putra Vindhya Tri Widayanti Vivi Nila Sari Yeni Ambar Wati Yosef Budiman Yossi Hendrawan Saraswanta Yova Okta Vendra Yusmar Mahmud Zein Muchamad Masykur ⁠M. Haris Satria