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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Journal of Islamic Pharmacy JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Keperawatan Priority JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Indah Sains dan Klinis Mejuajua JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Pengmas Kestra (JPK) Jurnal Indah Sains dan Klinis Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Suprianto Suprianto
Institut Kesehatan Medistra Lubuk Pakam
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Aktivitas Antiinflamasi Ekstrak Metanol Herba Puguntano (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi λ-Karagenan Asfianti, Vivi; Sagala, Vanny Yosepha; Febriady, Andy; Suprianto; Syarifuddin, Shofian
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.02

Abstract

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical exposure, or microbial agents. When excessive, this response may worsen tissue damage and require treatment. Interest in medicinal plants as alternative anti-inflammatory agents remains high because conventional nonsteroidal anti-inflammatory drugs, although effective, may cause adverse effects. Puguntano herb (Picria fel-terrae Lour.) contains flavonoids, saponins, tannins, glycosides, and steroids or triterpenoids that may contribute to anti-inflammatory activity. Objective: This study aimed to evaluate the anti-inflammatory effect of the methanolic extract of puguntano herb in male white rats with λ-carrageenan-induced paw edema and to identify the most effective tested dose. Methods: An experimental design was used in twenty-five healthy male rats divided into five groups. The negative control received 0.5% Na-CMC, the positive control received sodium diclofenac 2.25 mg/kg body weight, and the treatment groups received extract doses of 50, 100, and 200 mg/kg body weight. Acute inflammation was induced by intraplantar injection of 1% λ-carrageenan. Paw volume was measured with a digital plethysmometer for 360 minutes. Percentage of inflammation and percentage of inhibition were analyzed using one-way ANOVA followed by Tukey’s test. Results: The methanolic extract showed anti-inflammatory activity at all tested doses. A dose-dependent pattern was observed, with greater edema suppression at higher doses. The 200 mg/kg body weight dose produced the strongest effect and showed activity comparable to sodium diclofenac. Conclusion: The methanolic extract of puguntano herb demonstrated anti-inflammatory potential in this model, with the 200 mg/kg body weight dose as the most effective treatment for further preclinical study
Aktivitas Kombinasi Ekstrak Daun Sirsak (Annona muricata Linn) dan Kulit Buah Naga (Hylocereus polyrhizus) pada Staphylococcus aureus dan Escherichia coli Suprianto; Sri Zuwinda Zusya Pane; Sumardi
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.03

Abstract

Background: Bacterial infections caused by Staphylococcus aureus and Escherichia coli remain clinically relevant due to their ability to cause skin and gastrointestinal infections. The growing concern over antimicrobial resistance has increased interest in plant-derived antibacterial agents. Soursop leaves (Annona muricata L.) and red dragon fruit peel (Hylocereus polyrhizus) contain secondary metabolites that may contribute to bacterial growth inhibition. Objective: This study aimed to evaluate the antibacterial activity of combined ethanolic extracts of A. muricata leaves and H. polyrhizus peel against S. aureus and E. coli, and to determine the most effective extract ratio based on inhibition zone diameter. Methods: This laboratory experimental study used the disc diffusion method on Nutrient Agar medium. The plant materials were extracted by maceration using 70% ethanol. Five extract ratios were tested, namely 0.05:2.95, 0.10:2.90, 0.15:2.85, 0.20:2.80, and 0.25:2.75. Amoxicillin was used as the positive control, while distilled water served as the negative control. Inhibition zones were measured after 24 hours of incubation at 37°C. Results: The extract combinations showed weak antibacterial activity against S. aureus, with mean inhibition zones ranging from 1.08 to 3.18 mm. Against E. coli, four ratios showed weak activity, while the 0.25:2.75 ratio produced moderate inhibition with the highest mean zone of 5.18 mm. The positive control produced a strong inhibition zone of 13.13 mm, whereas the negative control showed no inhibition. Conclusion: The combination of A. muricata leaf and H. polyrhizus peel extracts demonstrated limited antibacterial activity and did not indicate a strong synergistic effect. The 0.25:2.75 ratio showed the best activity against E. coli and may be considered for further optimization using higher concentrations and more specific antibacterial assays.
Co-Authors Abdul Rahim Adek Chan Adinda Seftia Afriadi Afriadi Agus Kristina Ahmad Hafizullah Ritonga Alam Suhada Alam Suhada Alizha Aisyah Ananda Sri Devy Ancel Mus Silaban Andilala Andraini, Galuh Andy Febriadi Anita Anita Anjur Falden Lingga Annas Reza Annas Reza Ardina Ardina Ardina Pakpahan Arinri Misnangin Sritala Ramadani Arinri Misnangin Sritala Ramadani Asfianti, Vivi Atika, Nur Azzahra, Innayah BENNI ISKANDAR Chan, Adek Chandra Pranata Cut Fatimah Cut Fatimah Cyndi Veronica De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dewi Sartika Munthe Dian Zulkarnain Lubis Dikari Harita Dwi Setio Purnomo Effendy De Lux Putra Elvy Oktima Elvy Oktima Endang Subekti Endang Subekti Enny Fitriani Febriady, Andy Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Fitri Mayang Sari Fitriani Nasution Fitriani, Enny Fridelly Mairani Apt Hasrat Masa Harefa Hendri Faisal Herliana Herlina H Herlina Herlina Hermansyah . Hetty Wahyuni Ihsanul Hafiz Indra Ginting Jakub Tarigan Jakub Tarigan Jelly Syahfitri Johannes Johannes Joko Wibowo Kurniawansyah, Kurniawansyah Kusumastuti, Melati Yulia Leny, Leny Lestari, Wita Lidiya Sasmaita Sihotang Lili Nurmaliza Lisa Syafrida Lukmanul Hakim M. Deddy Harfiansyah Maelani, Mia Mandike Ginting Mandike Ginting Marbun, Intan Coni Caroline Maya Annisa Lubis Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Muhammad Gunawan Muhammad Gunawan Nasution, Lely Fitri Handayani Nilsya Febrika Zebua, Nilsya Febrika Nur Aisyah Pitri Nur Asni Arti Nur Asni Arti Nurasyah Nurasyah Nurlela Petra Saragih Nur’Adina Nur’Adina Nur’Adina Peri Aisyah Zubaidi Permata, Yade Metri Pranata, Chandra Putri Addina Rachel Anastasia R Hutabarat Risma Yeni Rotua Sumihar Sitorus Ruseni Ruth Mayana Rumanti Ruth Mayana Rumanti Sagala, Vanny Yosepha Sahrita Sahrita Samran, Samran Saragih, Safitri Sefryantonius Lase Sertin Prilda Sari Sandoro Sertin Prilda Sari Sandoro Shofian Syarifuddin Sindy Andriani Siregar, Riwandi Siregar, Suci Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Nurbaya Sri Handayani Sri Rahayu SRI RAHAYU Sri Zuwinda Zusya Pane Sucihati, Roos Nana Sudiyarti, Nining Suhendra Tawarnate Sumardi Sumardi Sumardi . Syamsul, Darwin Syarifuddin, Shofian Tambubolon, Regina Elianda Vivi Eulis Diana Vivi Eulis Diana Wandani, Elliza Rizki Wilda Rizwani Winata, Hanafis Sastra Zai, Arifin Putra Zebua, Nilsya Febrika Zebua