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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Journal of Islamic Pharmacy JOURNAL OF INFORMATICS AND TELECOMMUNICATION ENGINEERING Jambura Journal of Sports Coaching JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Keperawatan Priority JURNAL PENELITIAN PERAWAT PROFESIONAL Journal of Islamic Law Jurnal Indah Sains dan Klinis Mejuajua JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Mahasiswa Mengabdi (JIMAWAbdi) Journal of Applied Community Engagement (JACE) Jurnal Pengmas Kestra (JPK) Jurnal Indah Sains dan Klinis Pineleng Theological Review Journal of Critical Ecology Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Geosfera Indonesia
Suprianto Suprianto
Institut Kesehatan Medistra Lubuk Pakam
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Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan Zebua, Nilsya Febrika; Peri Aisyah Zubaidi; Sumardi; Suprianto; Shofian Syarifuddin; Risma Yeni
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.06

Abstract

Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin
Hubungan Pengetahuan dan Sikap Kaum Ibu Punge Blang Cut-Jaya Baru pada Preventivasi Demam Berdarah Lukmanul Hakim; Adek Chan; Suprianto; Vivi Eulis Diana
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.04

Abstract

Background: According to the World Health Organization, annually there are around 50.0-100.0 million cases of dengue fever worldwide, with 0.25-0.50 million of them being cases of dengue hemorrhagic fever (DHF) which causes around 24,000 death. Objective: The study was directed at evaluating the knowledge and attitudes of mothers regarding dengue prevention in Punge Blang Cut, Jaya Baru. Method: A cross-sectional design was used in the study conducted in April 2019. Around 176 heads of families in the village were sampled. Data was collected through a questionnaire with the Chi-Square test at a significance of 0.05. Results: The majority of respondents had sufficient knowledge (46.6%), their mothers had a positive attitude towards dengue prevention (73.3%), and 52.3% of respondents took sufficient preventive measures. Conclusion: The majority of mothers have sufficient knowledge and have a positive attitude towards preventing dengue fever. It is recommended to increase public knowledge and awareness regarding the handling and prevention of dengue fever through appropriate medical and traditional methods.
Kuantifikasi Inversi Galaktomanan Kolang-Kaling (Arenga pinnata Merr.) dengan Iodometri Zebua, Nilsya Febrika Zebua; Nilsya Febrika Zebua; Sumardi; Suprianto; Putri Addina
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.03

Abstract

Background: Kolang-Kaling (Arenga pinnata Merr.) belongs to the Arecaceae family as a source of natural polysaccharides in the form of galactomannan which is usually used as an additional ingredient. Objective: The study was aimed at determining whether galactose-mannose from Kolang-Kaling (GKK) could be separated using chromatography and its levels using the iodometry method. Method: Extraction of galactomannan using distilled water as a solvent. Purification by Paper Chromatography using WEB [Water: Ethanol: Butanol] mobile phase; WAB [Water: Acetate: Butanol]; CH3COOH 10.0% and 50.0%; CA 10.0% and 20.0%. Purification by TLC uses a variation of the EA: H mobile phase. Results: The GKK extraction yield was 18,5 g (3.7%). The levels before and after inversion were 85.53% and 90.23% with a galactose-mannose standard of 94.52%. Conclusion: Galactomannan can be obtained from Kolang-Kaling extraction and its levels are determined using the iodometry method
Analisis Vitamin C Daging dan Kulit Buah Semangka Merah dan Kuning (Citrullus vulgaaris Schard) dengan Spektrofotometri UV Lidiya Sasmaita Sihotang; Suprianto; Samran; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i2.06

Abstract

Latar Belakang: Iklim tropis negara Indonesia karena terletak di daerah khatulistiwa yang memberi peluang berbagai tanaman tumbuh dengan subur, termasuk buah-buahan. Umumnya, vitamin C merupakan salah satu kandungan yang terdapat pada buah-buahan, yang berperan sebagai antioksidan. Sekian banyaknya buah-buahan, slah satunya buah semangka (Citrullus vulgaris Schard). Buah semangka juga dimanfaatkan untuk menurunkan tekanan darah bagi penderita hipertensi, karena kandungan air dan kaliumnya yang tinggi sehingga mampu menstabilisasikan tekanan darah. Tujuan: Tujuannya untuk mendeteksi keberadaan dan kuantitas vitamin C pada daging dan kulit buah semangka merah dan kuning. Metode: Metode yang digunakan meliputi uji kualitas dan kuantitas masing-masing dengan pereaksi warna dan spektrofotometri UV. Hasil: Penelitian memberi informasi pada daging dan kulit buah semangka terdapat vitamin C dengan tanda ada perubahan warna maupun pengendapan kuning-merah bata dan coklat. Vitamin C dari daging dan kulit buah semangka merah dan kuning masing-masing adalah 50,688; 42.482; 34.764; dan 42,152 gr/L. Kesimpulan: Daging maupun kulit buah semangka merah dan kuning ditemukan vitamin C.
OPTIMASI FORMULA MATRIKS KITOSAN DENGAN METILSELULOSA PADA PELEPASAN TERKENDALI SEDIAAN GRANUL TEOFILIN Suprianto Suprianto
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.22

Abstract

The in vitro study was carried out on the release of active ingradient theophylline from granules prepared by moist granulation method. The granule matrix was prepared from the mixture of chitosan isolated from SwaIIo shrimp (Metapenaeus monoceros) (in accordance with the Protan Laboratories, Inc standard requirement) and methylceliuiose 1500 cps. The granules were filled into 850 mg capsules containing 200 mg theophylline. The maximum weight of chitosan and methylcellulose for each capsule was determined by factorial design 22.The result showed that, when the amount of chitosan was kept constant, an increase in the amount of methylcellulose will increase the release rate of theophylline from granules. The optimum weight of chitosan and methyIceIIuIose are 609.24 mg and 20.00 mg, respectively for one capsule.
ANALISIS KINETIKA PELEPASAN TEOFILIN DARI GRANUL MATRIKS KITOSAN Suprianto Suprianto
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i1.50

Abstract

Moment the drug dosage form development, it is important to study the drug release or dissolution that is recognized as an element in drug development. Mathematical models could help optimize the design of drugs to produce models of drug release information. Analysis of quantitative values obtained when depicting dissolution drug release profiles more easily when the mathematical concepts used to describe the drug release kinetics model. Model release of drugs known include zero order, first order, Higuchi models, models Hixon Crowell and Peppas Korsmeyer models. The purpose of this review apply mathematical concepts to study the phenomenon of drug release theophylline granules matrix made from chitosan
Assessing Drug-Likeness The Natural Compounds of Polar Extract Curcuma xanthorrhiza Rhizome via Lipinski's Rules with SWISSADME Web Tool Sumardi, Sumardi; Suprianto, Suprianto
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.03

Abstract

Curcuma xanthorrhiza, commonly known as Javanese turmeric, is widely recognized for its medicinal properties, with its polar extract containing various bioactive compounds. This study aims to assess the drug-likeness of natural compounds found in the polar extract of Curcuma xanthorrhiza rhizome using Lipinski's Rule of Five, analyzed through the SWISSADME web tool. The compounds alpha pinene, alpha thujene, beta pinene, and zingiberene were evaluated for their physicochemical properties, including molecular weight, hydrogen bond donors and acceptors, lipophilicity, and solubility. The analysis confirms that these compounds meet the criteria for oral drug-likeness. Additionally, specific parameters such as fractionCsp3, iLOGP, and MLOGP were found to significantly influence the permeability of these compounds, further supporting their potential as orally administered therapeutics. The findings underscore the utility of SWISSADME in preclinical screening of natural products, offering a valuable approach to identify promising candidates for drug development. This study highlights the potential of Curcuma xanthorrhiza polar extract as a source of drug-like compounds, paving the way for further pharmacological and clinical investigations.
ADMET Prediction Compounds of Polar Extract Curcuma rhizoma Sumardi, Sumardi; Suprianto, Suprianto; Siregar, Suci Rahmadani; Zai, Arifin Putra; Tambubolon, Regina Elianda; Mairani, Fridelly
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.01

Abstract

The pharmacokinetic and metabolic profiles of polar extract compounds from Curcuma rhizoma were evaluated using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions. Most compounds exhibited high gastrointestinal (GI) absorption, with the exception of D-glucose, citric acid, and terpenoids such as alpha-pinene and zingiberene, which demonstrated low absorption, highlighting potential challenges for systemic bioavailability. Blood-brain barrier (BBB) permeability was observed in lipophilic compounds like xanthorrhizol, bisdemethoxycurcumin, and terpenoids, suggesting their potential for CNS-targeted therapies, while polar compounds, including D-glucose, citric acid, and most curcuminoids, were non-permeant. D-glucose was the only compound identified as a P-glycoprotein (Pgp) substrate, indicating minimal efflux-related limitations for other compounds. Selective cytochrome P450 (CYP) enzyme inhibition was detected in compounds such as xanthorrhizol, curcuminoids, and zingiberene, suggesting potential metabolic interactions in multi-drug contexts. Promising therapeutic candidates include curcuminoids and xanthorrhizol, while non-BBB-permeant and low-absorbing compounds may require formulation strategies or alternative applications. These findings provide valuable insights into the pharmacological optimization of Curcuma rhizoma compounds, offering a foundation for further research in drug discovery and development.
Dampak Pewarna Ekstrak Etanol Buah Naga Merah (Hylicerius polyhizus) terhadap Lip Balm Minyak Bunga Kenanga (Cananga oil) Meilani, Debi; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.02

Abstract

Background: Red dragon fruit holds promise as a natural dye alternative due to its anthocyanin content. Objective: This study aimed to evaluate the potential of ethanol extract from red dragon fruit as a dye in Lip Balm formulations and investigate how varying the concentration of this extract affects the formula. Method: The study involved extracting the dye from red dragon fruit and incorporating it into a Lip Balm preparation using natural fruit-based dyes. Results: The findings indicated that the red dragon fruit extract yielded favorable results after undergoing various tests, including organoleptic evaluation, homogeneity, melting point, irritation, and user preference. Conclusion: The extract of red dragon fruit can be utilized as a dye in Lip Balm formulations. The resulting colors range from pink to dark red, with higher concentrations of the extract producing more intense colors in the final Lip Balm product containing ylang-ylang flower oil (Cananga oil)
Analisis Parasetamol Tablet dengan Metode Fourier Transform Infra Red (FTIR) Saragih, Safitri; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.05

Abstract

Background: Paracetamol, a widely used analgesic and antipyretic medication, is commonly prescribed in government healthcare facilities. The FTIR method provides rapid measurements by analyzing spectral graphs that reveal the functional groups within the tested compounds. According to the Indonesian Pharmacopoeia, VI Edition 2020, paracetamol content in tablet formulations must range between 90.0% and 110.0%. Objective: This study aimed to evaluate the paracetamol content in tablet preparations and assess their compliance with the 2020 Indonesian Pharmacopoeia standards and the packaging labels. Method: The research was conducted experimentally using FTIR spectroscopy. A solvent mixture of ethanol and distilled water (1:1) was employed, with analyses performed over the wavelength range of 4000–400 cm⁻¹. Results: The paracetamol content was found to be highest in tablet B (100.33 ± 1.003%), followed by tablet A (100.29 ± 1.002%), tablet D (100.24 ± 1.002%), and tablet E (100.14 ± 1.001%), with the lowest levels observed in tablet C (99.69 ± 0.996%). Method validation indicated an RSD value of 0.056%, confirming that the procedure was accurate and reliable. Conclusion: The findings demonstrate that the FTIR method is suitable for the quantitative analysis of paracetamol in tablet formulations. Moreover, the results meet the standards outlined in the 2020 VI Edition of the Indonesian Pharmacopoeia.
Co-Authors Abdul Rahim Abrori, Abrori Adek Chan Adinda Seftia Afriadi Afriadi Agus Kristina Ahmad Hafizullah Ritonga Alam Suhada Alam Suhada Alizha Aisyah Ananda Sri Devy Ancel Mus Silaban Andilala Andraini, Galuh Andy Febriadi Anita Anita Anjur Falden Lingga Annas Reza Annas Reza Ardina Ardina Ardina Pakpahan Arinri Misnangin Sritala Ramadani Arinri Misnangin Sritala Ramadani Atika, Nur Azzahra, Innayah BENNI ISKANDAR Cahyono, Bowo Eko Chan, Adek Chandra Pranata Chusnul Chotimah Cut Fatimah Cut Fatimah Cyndi Veronica Damianus Pongoh De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dewi Sartika Munthe Dharma Wijaya, Indra Dian Zulkarnain Lubis Dikari Harita Dwi Setio Purnomo Edy Dharma Putra Duhe Effendy De Lux Putra Elok Nur Hamdana Elvy Oktima Elvy Oktima Endang Subekti Endang Subekti Enny Fitriani Febriady, Andy Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Fitri Mayang Sari Fitriani Nasution Fitriani, Enny Fridelly Mairani Apt Hasrat Masa Harefa Hendrawan, M. Afif Hendri Faisal Herliana Herlina H Herlina Herlina Hermansyah . Hetty Wahyuni Ihsanul Hafiz Indra Ginting Izudin, Ahmad Jakub Tarigan Jakub Tarigan Jelly Syahfitri Johannes Johannes Joko Wibowo Kurniawansyah, Kurniawansyah Kusjono, Gatot Kusumastuti, Melati Yulia Leny, Leny Lestari, Wita Lidiya Sasmaita Sihotang Lili Nurmaliza Lisa Syafrida Lukmanul Hakim M. Deddy Harfiansyah Maelani, Mia Mandike Ginting Mandike Ginting Marbun, Intan Coni Caroline Maya Annisa Lubis Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Mochamad Alfan Rosid Mohammad Ridwan Muhammad Gunawan Muhammad Gunawan Muhammad Hafizh Fattah Nasution, Lely Fitri Handayani Nilsya Febrika Zebua, Nilsya Febrika Nur Aisyah Pitri Nur Asni Arti Nur Asni Arti Nurasyah Nurasyah Nurkhoiroh Nurkhoiroh Nurlela Petra Saragih Nur’Adina Nur’Adina Nur’Adina Octaviani, Linggar Ayu Peri Aisyah Zubaidi Permata, Yade Metri Pramana Yoga Saputra Pranata, Chandra Prihanto, Yusep Putri Addina Rachel Anastasia R Hutabarat Risma Yeni Rotua Sumihar Sitorus Ruseni Ruth Mayana Rumanti Ruth Mayana Rumanti Sahrita Sahrita Samran, Samran Saragih, Safitri Sefryantonius Lase Sertin Prilda Sari Sandoro Sertin Prilda Sari Sandoro Shofian Syarifuddin Sindy Andriani Siregar, Riwandi Siregar, Suci Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Nurbaya Sri Handayani SRI RAHAYU Sri Rahayu Sriharini Sucihati, Roos Nana Sudiyarti, Nining Suhendra Tawarnate Sukma Aji Sumardi Sumardi Sumardi . Syamsul, Darwin Tambubolon, Regina Elianda Triatmojo, Muhammad Ikbal Nur Dian Ucok Hasian Refeiater Vivi Eulis Diana Vivi Eulis Diana Wafi, Moh. Abduh Wandani, Elliza Rizki Wilda Rizwani Winata, Hanafis Sastra Zai, Arifin Putra Zebua, Nilsya Febrika Zebua