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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Journal of Islamic Pharmacy AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat JPM (Jurnal Pemberdayaan Masyarakat) Jurnal Ilmiah Manuntung JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Keperawatan Priority JURNAL PENELITIAN PERAWAT PROFESIONAL Abdi Masyarakat Jurnal Indah Sains dan Klinis Mejuajua Jurnal Ilmiah MADIYA: Masyarakat Mandiri Berkarya Indonesian Journal of Education Methods Development JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Pengmas Kestra (JPK) Jurnal Muara Olahraga Jurnal Pengabdian Inovasi Masyarakat Indonesia Jurnal Informatika Polinema (JIP) Jurnal Indah Sains dan Klinis Jurnal Medika: Medika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Edutik : Jurnal Pendidikan Teknologi Informasi dan Komunikasi Journal of Innovation and Sustainable Services
Suprianto Suprianto
Institut Kesehatan Medistra Lubuk Pakam
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Optimasi Potensi Anti Escherichia coli dan Staphylococcus aureus Kombinasi Ekstrak Etil Asetat Allium cepa dan Allium sativum Suprianto; Dikari Harita; Dwi Setio Purnomo
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.01

Abstract

Background: Natural antibiotics are often used as an alternative therapy. Microbial infections are the main cause of mortality and morbidity in developing countries, including Indonesia. Staphylococcus aureus and Escherichia coli are two microbes that are often used for testing natural antibiotics. Objective: This study aims to optimize the combination of shallot and white onion extracts to potentially inhibit bacterial growth and development. Method: This study used a randomised design method of a combination of onion and garlic extracts tested based on the inhibitory area response. Results: The combination of shallot and white onion ethyl acetate extracts showed activity as an inhibitor of bacterial growth and development. The combination of EBM and EBP provides an inhibitory response against Escherichia coli (X2) and Staphylococcus aureus (X3). Conclusion: Combining EBM and EBP can inhibit the growth and development of Escherichia coli and Staphylococcus aureus. The best combination as an inhibitor of growth and development was Escherichia coli (X2; 14.53 mm) and Staphylococcus aures (X3: 15.7 mm), respectively
Gambaran Pemakaian Bahan Medis Habis Pakai Gudang Depo Farmasi Rindu B RSUP H. Adam Malik Medan Berdasarkan Standar Operasional Prosedur Tahun 2019 Anjur Falden Lingga; Adek Chan; Suprianto
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.02

Abstract

Introduction: Managing consumable medical materials involves coordinating activities to ensure they work well together, aiming for effective and efficient management. This ensures doctors always have an adequate supply of high-quality consumable medical materials to support quality services. Objective: This study aimed to describe the Utilization of Consumable Medical Materials at the Pharmacy Warehouse of Depo Rindu B H. Based on the 2019 Standard Operating Procedures (SOP), Adam Malik Hospital Medan. Methods: The study utilized direct observation and interviews conducted from May to July 2019. Results: Expenditures in January, February, and March 2019 were 25,726, 22,332, and 24,503 units respectively. Distribution is facilitated through online prescribing and delivery. Observations indicated the use of storage systems such as First In First Out (FIFO) and First Expired First Out (FEFO), organised by dosage form, alphabetical order, and category. Conclusion: Procurement at the Depo Rindu B pharmaceutical warehouse at H. Adam Malik Hospital Medan during the 2019 period was by the applicable 2019 SOP
Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan Zebua, Nilsya Febrika; Peri Aisyah Zubaidi; Sumardi; Suprianto; Shofian Syarifuddin; Risma Yeni
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.06

Abstract

Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin
Hubungan Pengetahuan dan Sikap Kaum Ibu Punge Blang Cut-Jaya Baru pada Preventivasi Demam Berdarah Lukmanul Hakim; Adek Chan; Suprianto; Vivi Eulis Diana
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.04

Abstract

Background: According to the World Health Organization, annually there are around 50.0-100.0 million cases of dengue fever worldwide, with 0.25-0.50 million of them being cases of dengue hemorrhagic fever (DHF) which causes around 24,000 death. Objective: The study was directed at evaluating the knowledge and attitudes of mothers regarding dengue prevention in Punge Blang Cut, Jaya Baru. Method: A cross-sectional design was used in the study conducted in April 2019. Around 176 heads of families in the village were sampled. Data was collected through a questionnaire with the Chi-Square test at a significance of 0.05. Results: The majority of respondents had sufficient knowledge (46.6%), their mothers had a positive attitude towards dengue prevention (73.3%), and 52.3% of respondents took sufficient preventive measures. Conclusion: The majority of mothers have sufficient knowledge and have a positive attitude towards preventing dengue fever. It is recommended to increase public knowledge and awareness regarding the handling and prevention of dengue fever through appropriate medical and traditional methods.
Kuantifikasi Inversi Galaktomanan Kolang-Kaling (Arenga pinnata Merr.) dengan Iodometri Zebua, Nilsya Febrika Zebua; Nilsya Febrika Zebua; Sumardi; Suprianto; Putri Addina
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.03

Abstract

Background: Kolang-Kaling (Arenga pinnata Merr.) belongs to the Arecaceae family as a source of natural polysaccharides in the form of galactomannan which is usually used as an additional ingredient. Objective: The study was aimed at determining whether galactose-mannose from Kolang-Kaling (GKK) could be separated using chromatography and its levels using the iodometry method. Method: Extraction of galactomannan using distilled water as a solvent. Purification by Paper Chromatography using WEB [Water: Ethanol: Butanol] mobile phase; WAB [Water: Acetate: Butanol]; CH3COOH 10.0% and 50.0%; CA 10.0% and 20.0%. Purification by TLC uses a variation of the EA: H mobile phase. Results: The GKK extraction yield was 18,5 g (3.7%). The levels before and after inversion were 85.53% and 90.23% with a galactose-mannose standard of 94.52%. Conclusion: Galactomannan can be obtained from Kolang-Kaling extraction and its levels are determined using the iodometry method
Analisis Vitamin C Daging dan Kulit Buah Semangka Merah dan Kuning (Citrullus vulgaaris Schard) dengan Spektrofotometri UV Lidiya Sasmaita Sihotang; Suprianto; Samran; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i2.06

Abstract

Latar Belakang: Iklim tropis negara Indonesia karena terletak di daerah khatulistiwa yang memberi peluang berbagai tanaman tumbuh dengan subur, termasuk buah-buahan. Umumnya, vitamin C merupakan salah satu kandungan yang terdapat pada buah-buahan, yang berperan sebagai antioksidan. Sekian banyaknya buah-buahan, slah satunya buah semangka (Citrullus vulgaris Schard). Buah semangka juga dimanfaatkan untuk menurunkan tekanan darah bagi penderita hipertensi, karena kandungan air dan kaliumnya yang tinggi sehingga mampu menstabilisasikan tekanan darah. Tujuan: Tujuannya untuk mendeteksi keberadaan dan kuantitas vitamin C pada daging dan kulit buah semangka merah dan kuning. Metode: Metode yang digunakan meliputi uji kualitas dan kuantitas masing-masing dengan pereaksi warna dan spektrofotometri UV. Hasil: Penelitian memberi informasi pada daging dan kulit buah semangka terdapat vitamin C dengan tanda ada perubahan warna maupun pengendapan kuning-merah bata dan coklat. Vitamin C dari daging dan kulit buah semangka merah dan kuning masing-masing adalah 50,688; 42.482; 34.764; dan 42,152 gr/L. Kesimpulan: Daging maupun kulit buah semangka merah dan kuning ditemukan vitamin C.
OPTIMASI FORMULA MATRIKS KITOSAN DENGAN METILSELULOSA PADA PELEPASAN TERKENDALI SEDIAAN GRANUL TEOFILIN Suprianto Suprianto
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.22

Abstract

The in vitro study was carried out on the release of active ingradient theophylline from granules prepared by moist granulation method. The granule matrix was prepared from the mixture of chitosan isolated from SwaIIo shrimp (Metapenaeus monoceros) (in accordance with the Protan Laboratories, Inc standard requirement) and methylceliuiose 1500 cps. The granules were filled into 850 mg capsules containing 200 mg theophylline. The maximum weight of chitosan and methylcellulose for each capsule was determined by factorial design 22.The result showed that, when the amount of chitosan was kept constant, an increase in the amount of methylcellulose will increase the release rate of theophylline from granules. The optimum weight of chitosan and methyIceIIuIose are 609.24 mg and 20.00 mg, respectively for one capsule.
ANALISIS KINETIKA PELEPASAN TEOFILIN DARI GRANUL MATRIKS KITOSAN Suprianto Suprianto
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i1.50

Abstract

Moment the drug dosage form development, it is important to study the drug release or dissolution that is recognized as an element in drug development. Mathematical models could help optimize the design of drugs to produce models of drug release information. Analysis of quantitative values obtained when depicting dissolution drug release profiles more easily when the mathematical concepts used to describe the drug release kinetics model. Model release of drugs known include zero order, first order, Higuchi models, models Hixon Crowell and Peppas Korsmeyer models. The purpose of this review apply mathematical concepts to study the phenomenon of drug release theophylline granules matrix made from chitosan
Assessing Drug-Likeness The Natural Compounds of Polar Extract Curcuma xanthorrhiza Rhizome via Lipinski's Rules with SWISSADME Web Tool Sumardi, Sumardi; Suprianto, Suprianto
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.03

Abstract

Curcuma xanthorrhiza, commonly known as Javanese turmeric, is widely recognized for its medicinal properties, with its polar extract containing various bioactive compounds. This study aims to assess the drug-likeness of natural compounds found in the polar extract of Curcuma xanthorrhiza rhizome using Lipinski's Rule of Five, analyzed through the SWISSADME web tool. The compounds alpha pinene, alpha thujene, beta pinene, and zingiberene were evaluated for their physicochemical properties, including molecular weight, hydrogen bond donors and acceptors, lipophilicity, and solubility. The analysis confirms that these compounds meet the criteria for oral drug-likeness. Additionally, specific parameters such as fractionCsp3, iLOGP, and MLOGP were found to significantly influence the permeability of these compounds, further supporting their potential as orally administered therapeutics. The findings underscore the utility of SWISSADME in preclinical screening of natural products, offering a valuable approach to identify promising candidates for drug development. This study highlights the potential of Curcuma xanthorrhiza polar extract as a source of drug-like compounds, paving the way for further pharmacological and clinical investigations.
ADMET Prediction Compounds of Polar Extract Curcuma rhizoma Sumardi, Sumardi; Suprianto, Suprianto; Siregar, Suci Rahmadani; Zai, Arifin Putra; Tambubolon, Regina Elianda; Mairani, Fridelly
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.01

Abstract

The pharmacokinetic and metabolic profiles of polar extract compounds from Curcuma rhizoma were evaluated using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions. Most compounds exhibited high gastrointestinal (GI) absorption, with the exception of D-glucose, citric acid, and terpenoids such as alpha-pinene and zingiberene, which demonstrated low absorption, highlighting potential challenges for systemic bioavailability. Blood-brain barrier (BBB) permeability was observed in lipophilic compounds like xanthorrhizol, bisdemethoxycurcumin, and terpenoids, suggesting their potential for CNS-targeted therapies, while polar compounds, including D-glucose, citric acid, and most curcuminoids, were non-permeant. D-glucose was the only compound identified as a P-glycoprotein (Pgp) substrate, indicating minimal efflux-related limitations for other compounds. Selective cytochrome P450 (CYP) enzyme inhibition was detected in compounds such as xanthorrhizol, curcuminoids, and zingiberene, suggesting potential metabolic interactions in multi-drug contexts. Promising therapeutic candidates include curcuminoids and xanthorrhizol, while non-BBB-permeant and low-absorbing compounds may require formulation strategies or alternative applications. These findings provide valuable insights into the pharmacological optimization of Curcuma rhizoma compounds, offering a foundation for further research in drug discovery and development.
Co-Authors Abdul Rahim Adek Chan Afriadi Afriadi Agustang, Andi Tenri Pada Ahmad Hafizullah Ritonga Ahmad Suryadi, Ahmad Akmal, Muh. Ikramullah Alam Suhada Alam Suhada Alizha Aisyah Ananda Sri Devy Ancel Mus Silaban Andilala Andraini, Galuh Anita Anita Anjur Falden Lingga Annas Reza Annas Reza Ardina Ardina Ardina Pakpahan Ariantini, Nisa Arinri Misnangin Sritala Ramadani Arinri Misnangin Sritala Ramadani Arti, Widi Atika, Nur BENNI ISKANDAR Chan, Adek Cinde Ririh Windayu Cut Fatimah Cut Fatimah Cyndi Veronica De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dewi Sartika Munthe Diah Padmi, Ni Made Dian Zulkarnain Lubis Dikari Harita Dwi Setio Purnomo Effendy De Lux Putra Efriwanda Pratama, Calvine Elvy Oktima Elvy Oktima Endang Subekti Endang Subekti Enny Fitriani Febriady, Andy Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Fitri Mayang Sari Fitriani Nasution Fitriani, Enny G Bula, Yuyun Haryani, Meri Hasrat Masa Harefa Hendri Faisal Herliana Herlina H Herlina Herlina Hermansyah . Herwin Herwin, Herwin Hetty Wahyuni Hindarto Idrus, Muh. Ikhsan Ihsanul Hafiz Ikramullah, Muh Indra Ginting Iskandar, Didik Jakub Tarigan Jakub Tarigan Jelly Syahfitri Johannes Johannes Joko Wibowo Khusna Arif Rakhman, Khusna Arif Kurniawansyah, Kurniawansyah Kusumastuti, Melati Yulia Leny, Leny Lestari, Wita Letisia, Maria Lidiya Sasmaita Sihotang Lili Nurmaliza Lukmanul Hakim Luly Triningsih Luthfi Siraj, Muhammad Maelani, Mia Mairani, Fridelly Mandike Ginting Mandike Ginting Maya Annisa Lubis Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Mochamad Alfan Rosid Muhammad Deddy Harfiansyah Muhammad Deddy Harfiansyah Muhammad Gunawan Muhammad Gunawan Muhammad Luthfi Muhammad Rusdi Nasution, Lely Fitri Handayani Nilsya Febrika Zebua, Nilsya Febrika Ningsih, Chairunnisah Putri Ayu Nur Aisyah Pitri Nur Asni Arti Nur Asni Arti Nurasyah Nurasyah Nurfatimah Sugrah Nurkhoiroh Nurkhoiroh Nurlela Petra Saragih Nurul Fadilah, Nurul Nurwirhanuddin, Nurwirhanuddin Nur’Adina Nur’Adina Nur’Adina Okky Zubairi Abdillah Peri Aisyah Zubaidi Permata, Yade Metri Pinem, Mhd Daud Pradana, Andre Aditya Pranata, Chandra Priyono, Alfanda Wahyu Oktavia Putri Addina Rachel Anastasia R Hutabarat Rahmania, Fitri Ramadhan, Mochammad Hisyam Syah Renyaan, Anastasya Risma Yeni Rotua Sumihar Sitorus Ruseni Ruth Mayana Rumanti Ruth Mayana Rumanti safri Irawan Sahrina, Alfi Sahrita, Sahrita Samran, Samran Saprini Hamdiani Saputra, Sepriadi Saragih, Safitri Sasmayunita Sefryantonius Lase Sertin Prilda Sari Sandoro Sertin Prilda Sari Sandoro Setyadi, Arrohman Shofian Syarifuddin Siga, Adolfus Siktus Sindy Andriani Siregar, Riwandi Siregar, Suci Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Nurbaya Siti Rahmi, Siti Sovayunanto, Riski Sri Handayani SRI RAHAYU Sri Rahayu Stephanie Bija Sucihati, Roos Nana Sudiyarti, Nining Suhendra Tawarnate Suherman Sumardi Sumardi Sumardi . Sundari Suryadi S, Ahmad Syamsul, Darwin Syarifuddin Syarifuddin Tambubolon, Regina Elianda Trisakti, Jhon Citro Umafagur, Dea Andela UMAR ISKANDAR, UMAR Vivi Eulis Diana Vivi Eulis Diana Wahab, Iis Hamsir Ayub Wandani, Elliza Rizki Wilda Rizwani Winata, Hanafis Sastra Y, Hasyrif S Yani, Achmad Yusri Sapsuha Zai, Arifin Putra Zebua, Nilsya Febrika Zebua