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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Journal of Islamic Pharmacy JOURNAL OF INFORMATICS AND TELECOMMUNICATION ENGINEERING Jambura Journal of Sports Coaching JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Keperawatan Priority JURNAL PENELITIAN PERAWAT PROFESIONAL Journal of Islamic Law Jurnal Indah Sains dan Klinis Mejuajua JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Mahasiswa Mengabdi (JIMAWAbdi) Journal of Applied Community Engagement (JACE) Jurnal Pengmas Kestra (JPK) Jurnal Indah Sains dan Klinis Pineleng Theological Review Journal of Critical Ecology Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Geosfera Indonesia
Suprianto Suprianto
Institut Kesehatan Medistra Lubuk Pakam
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Penerapan Sanitasi dan Higienis dalam Pembuatan Jamu Gendong di Kota Tebing Tinggi Suprianto, Suprianto; De Lux Putra, Effendy; Nurbaya, Siti; Samran, Samran; Sumardi, Sumardi; Nasution, Derlina; Lestari, Wita
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 4 No. 3 (2025): April 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v4i3.220

Abstract

Jamu Gendong is a traditional drink that has the potential to be contaminated with worms, parasites, bacteria, fungi, viruses and rickettsia. Sources of contaminants include materials, equipment, facilities, personnel, animals and production environments, so their efficacy is questionable. The activity was carried out in the form of providing information on the implementation of sanitation and hygienic production to 38 Jamu Gendong traders in Tebing Tinggi City, Deli Serdang, North Sumatra. The material was delivered using illustrated power point media to facilitate the delivery of increased understanding of sanitation and hygiene, including objectives, benefits, programs, fixed procedures, disinfectant and washing materials as well as documentation in accordance with RI POM Regulation Number 31, 2022. Activities were carried out on April 29, 2024 and received positive responses from all participants. Activities are expected to be sustainable so that the Jamu Gendong produced is of higher quality.
Korelasi Konsumsi Sidaguri dengan Kadar Asan Urat Darah Suprianto, Suprianto; Adek Chan; Joko Wibowo; Samran; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.02

Abstract

Background: Hyperuricemia as an indicator of increased blood uric acid. The prevalence rate in Indonesia is not recorded with certainty. However, the prevalence of gout reached 655,745 people out of 238,452,952 people in Indonesia, ranking first in Southeast Asia. Sidaguri flavonoids have inhibitory power against Xanthine Oxidase so that they can reduce uric acid. Objective: The study was aimed at detecting the effect and correlation of Sidaguri capsule consumption (Sida rhombifolia L) on reducing uric acid in patients. Method: The study was conducted Pretest and Posttest on 22 patients with hyperuricemia with the Easy Touch GCU Instrument. Results: The results showed that the average uric acid level before the intervention was 8.37 mg/dL and after the intervention was 6.57 mg/dL. Conclusion: Sidaguri capsules have an effect on reducing uric acid levels in patients
Validasi Metode Penetapan Kadar Monosodium Glutamat pada Mie Ayam dengan Spektrofotometri UV–Vis Setelah Derivatisasi Ninhidrin Suprianto; Effendy De Lux Putra; Samran; Siti Nurbaya; Cyndi Veronica; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.05

Abstract

Pendahuluan: Mie Ayam merupakan aneka olahan mie yang dijajakan, disajikan dan dinikmati dengan cita rasa yang sangat lezat; dijajakan dari mulai gerobak jalan, di pinggir jalan maupun tempat lesehan. Mie Ayam diolah dengan penambahan berbagai bahan tambahan pangan agar diperoleh makanan yang dapat membangkitkan selera konsumen. Mie Ayam yang disajikan harus diproses dengan benar sehingga konsumen aman setelah konsumsi makanan tersebut. Monosodium glutamate (MSG) merupakan bahan tambahan pangan yang biasa ditambahkan pada makanan untuk meningkatkan cita rasa makanan, terutama rasa lezat makanan. MSG ditambahkan pada produk pangan tidak lebih dari 10g/kg Bahan Pangan agar konsumen terjamin kesehatannya. MSG dapat diderivatisasi dengan ninhidrin sehingga penetapan kadar dapat dilakukan dengan spektrofotometri visibel. Tujuan: Menentukan kadar MSG pada Mie Ayam secara spektrofotometri UV. Metode: Penetapan kadar MSG dilakukan secara spektrofotometri UV setelah dilakukan derivatisasi dengan Ninhidrin. Hasil: Kadar MSG pada Mie diperoleh pada rentang 1,9441- 2,4726 g/kg bahan pangan dan di bawah batas maksimum 10 g /kg bahan pangan menurut EPSA. Kesimpulan: Kadar MSG pada Mie Ayam pada rentang tertentu dan masih di bawah batas maksimum.
Controlled release kinetics of furosemide from chitosan matrix tablets with hydroxypropyl methylcellulose phthalate coated Samran, Samran; Suprianto, Suprianto; Sumardi, Sumardi; Ritonga, Ahmad Hafizullah; Kusumastuti, Melati Yulia
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28097

Abstract

Sustained-release dosage forms were critical in drug delivery, ensuring controlled and prolonged release for optimal therapeutic outcomes. Chitosan (CH) has become pivotal in sustained-release tablet formulation due to its biocompatibility and mucoadhesive properties. This study aims to explore the release kinetics of furosemide (FS) from CH matrix tablets in a concurrent medium. The formulation involves a core tablet and coated tablet, with CH matrix as a binder and Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) as a film-coated for the core tablet, and both are made using the wet granulation method. Assessment parameters include tablet hardness, disintegration, and FS release profiles across various media, analyzed using spectrophotometric methods to comprehend drug release kinetics with multiple models such as zero-order, first-order, Higuchi, and Korsmeyer-Peppas employed. In the press-coated tablet comprising core tablet CH as matrix uncoated with 20 mg CH per tablet core, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h, which displayed first-order release kinetics within 2-6 h and 6-16 h in concurrent media of pH 5.8 and 7.4. Notably, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h. Press-coated tablets incorporating CH matrix with HPCMP coated (CH-HPCMP), also containing 20 mg CH per tablet, exhibited diverse drug release kinetics. These tablets showed Korsmeyer-Peppas, zero-order, and first-order kinetics in pH 1.2, 5.8, and 7.4, respectively. The study suggests that a Press-coated tablet incorporating CH-HPMCP is suitable as the candidate for sustained-release formulations. The observed versatility in release kinetics across varying pH environments underscores the potential adaptability of these formulations in addressing diverse therapeutic needs.
Correlation of Education Level with Mother's Knowledge About the Nutritional Status of Stunted Toddlers Sitorus, Rotua Sumihar; Suprianto, Suprianto
Jurnal Keperawatan Priority Vol. 7 No. 1 (2024)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v7i1.4472

Abstract

Chronic malnutrition due to prolonged malnutrition resulting in stunted growth and development. Educated and knowledgeable mothers have a big influence on the pattern of regulating balanced food needs for the growth and development of toddlers. The research was directed at determining the correlation between educated and knowledgeable mothers on the nutritional status of stunted toddlers in the Namorambe Community Health Center work area. Quantitative descriptive research was conducted cross-sectionally. The population was 32 mothers who had stunted toddlers (0-59 months) and the total was the sample. Univariate and bivariate analyzes were carried out to describe the frequency distribution of respondents' characteristics and determine the correlation between educated and knowledgeable mothers regarding the nutritional status of stunted toddlers. The results showed that mothers ranged from 20-30 years old and had upper secondary education as many as 25 (78.1%) and 21 (65.6%); toddler age 37-60 months, male gender, stunted toddler, and poor maternal knowledge were 16 (50%), 17 (53.1%), 22 (68.8%) and 23 (71.9%); and as many as 21 (65.6%) and 12 (37.5%) respondents had high school education and poor knowledge; as well as the Chi-square analysis results of p-value = 0.038, respectively. In the research, there was a correlation between educated and knowledgeable mothers on the nutritional status of stunted toddlers in the Namorambe Community Health Center work area.
FORMULASI SHEET MASK EKSTRAK ETANOL KULIT PISANG AMBON (Musa paradisiaca L.) SEBAGAI MOISTURIZING Adek Chan; Afriadi Afriadi; Hanafis Sastra Winata; Suprianto Suprianto; Sahrita Sahrita
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.424

Abstract

Ambon banana peel contains flavonoid chemical compounds that can moisturize facial skin. Flavonoids are powerful antioxidants. A sheet mask formulation of Ambon banana peel extract that can be used more practically and is able to moisturize facial skin. This study aims to formulate a mask sheet preparation containing ethanol extract of Ambon banana peel as well as better skin maintenance for four weeks of treatment and measuring the moisture content of the skin. The research method used is an experimental method, namely the extract is obtained using the maceration method, then formulated into a sheet mask preparation, consisting of glycerin, butylene glycol, sodium polyacrylate, nipagin, PEG-40 Hydrogenated Castrol oil, aquadest, perfume, and banana peel ethanol extract. Ambon with concentrations of F1 (1%), F2 (3%), F3 (5%), F4 (7%), F5 (9%), respectively. As blank (F0) sheet mask preparation without the addition of extract. The preparation is evaluated including homogeneity test, pH test, stability test, irritation test, Moisture effectiveness test using Moisture Checker and preference test. The treatment is carried out for 4 weeks by applying the mask twice a week. Data obtained from the analysis using the SPSS program. The results showed that the ethanol extract of Ambon banana peel can be formulated in a homogeneous sheet mask preparation, does not change color and remains stable in 4 weeks of storage with a pH of 4.6 - 6.6. Conclusion The ethanol extract of Ambon banana peel can be formulated into sheet masks with concentrations of 1%, 3%, 5%, 7% and 9% with a positive control ratio.
Skrining Fitokimia, Profil Kromatografi Lapis Tipis dan Karakterisasi FTIR Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) Adinda Seftia; Suprianto; Effendy De Lux Putra; Samran; Siti Nurbaya
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.02

Abstract

Background: Rambutan (Nephelium lappaceum L.) leaves have potential as a source of bioactive secondary metabolites, yet baseline data on their preliminary chemical profile and functional-group features are still limited. Objective: This study aimed to (i) screen the phytochemical constituents of rambutan leaf ethanol extract, (ii) verify major metabolite classes using thin-layer chromatography (TLC), and (iii) characterize dominant functional groups by Fourier Transform Infrared (FTIR) spectroscopy. Method: Dried rambutan leaves collected from Langkat Regency and Binjai City were extracted by maceration with 96% ethanol (1:10; 3×24 h), followed by remaceration (1×24 h). The filtrate was concentrated at 58 °C. Qualitative tests were conducted for alkaloids, flavonoids, tannins, saponins, and steroids. TLC analysis employed silica gel 60 F254 plates with class-specific mobile phases, while FTIR spectra were recorded in the range of 4000–600 cm⁻¹. Results: The extract yield was 25.7%. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, saponins, and steroids, with TLC Rf values of 0.70 and 0.46 (alkaloids), 0.80 (flavonoids), 0.70 (tannins), and 0.50 (steroids). FTIR bands at 3365 cm⁻¹ (O–H), 3010 cm⁻¹ (aromatic C–H), 1629 cm⁻¹ (C=C), and 1048 cm⁻¹ (C–O) indicated oxygenated secondary metabolites, particularly phenolic-related compounds. Conclusion: The integrated phytochemical screening, TLC, and FTIR approach provides a concise chemical baseline for rambutan leaf ethanol extract, supporting its potential use in further standardization and marker-based studies.
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Kumis Kucing (Orthosiphon aristatus) dan Daun Mangga Madu (Mangifera indica L.) terhadap Propionibacterium acnes Agus Kristina; Suprianto; Debi Meilani; Andy Febriadi; Shofian Syarifuddin
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.03

Abstract

Background: Acne is strongly linked to the overgrowth of Propionibacterium acnes. Because long-term use of conventional antibacterials may contribute to resistance and irritation, plant-derived extracts are being explored as alternative or complementary options. Kumis Kucing (Orthosiphon aristatus) and Mangga Madu (Mangifera indica L.) leaves are known to contain secondary metabolites that may help suppress bacterial growth. Objective: This study aimed to evaluate the antibacterial effect of combined ethanol extracts of O. aristatus and M. indica leaves against C. acnes and to determine which formulation ratio produced the best inhibition. Method: Each plant material was extracted separately using ethanol, then blended into five different combination formulas (F1–F5). Antibacterial activity was assessed in vitro using the disc diffusion technique with a standardized inoculum (0.5 McFarland). The diameter of the clear zone around each disc was measured and used to categorize antibacterial strength. Results: Qualitative phytochemical screening confirmed that both extracts contained key metabolite groups, including alkaloids, tannins/phenolics, flavonoids, and saponins. The negative control showed no clear zone, while clindamycin (positive control) produced a strong inhibition zone of 19.2 mm. All combined formulas inhibited C. acnes, with inhibition zones between 8.6 mm and 11.5 mm. Formula 3 generated the widest zone (11.5 mm; strong category), whereas Formula 2 showed the smallest inhibition (8.6 mm; weak category). Conclusion: The ethanol extracts of O. aristatus and M. indica leaves, when combined, were able to inhibit C. acnes. The level of inhibition varied with the mixing ratio, and Formula 3 demonstrated the most promising antibacterial activity among the tested formulations
Penetapan Kadar Total Fenol dan Total Flavonoid pada Lotion Berbahan Ekstrak Daun Sisrsak (Annona muricata) dan Kulit Buah Naga Merah (Hylocereus polyrhizus) Menggunakan Spektrofotometri UV–VIS Siregar, Suci Rahmadani; Suprianto; Chandra Pranata; Marbun, Intan Coni Caroline
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.04

Abstract

Background: Phenolic and flavonoid compounds from soursop (Annona muricata) leaves and red dragon fruit (Hylocereus polyrhizus) peel have potential applications in lotion formulations; therefore, their quantification is important for quality evaluation. Objective: To determine total phenolic content (TPC) and total flavonoid content (TFC) in lotion formulations containing combined plant extracts and to assess the analytical method performance. Method; Four formulations were prepared: F0 (without extract), F1 (0.5% + 0.5%), F2 (1.0% + 1.0%), and F3 (1.5% + 1.5%). TPC was measured using the Folin–Ciocalteu method (mg GAE/g) and TFC using the AlCl₃ colorimetric method (mg QE/g). Method validation included repeatability (%RSD, n = 6) and spike-recovery accuracy at 80–120%. Results: The method showed good precision (%RSD 1.08% for TPC and 1.21% for TFC) and acceptable accuracy with recoveries of 98–102%. F0 showed non-detectable values, while increasing extract concentration resulted in higher TPC (3.82 ± 0.14 to 9.71 ± 0.33 mg GAE/g) and TFC (0.86 ± 0.05 to 2.35 ± 0.10 mg QE/g). Differences among formulations were statistically significant (p < 0.05). Conclusion: The UV–Vis method is suitable for determining TPC and TFC in lotion matrices, and higher levels of combined extracts significantly increase both parameters, supporting their use for quality standardization of herbal lotions.
Formulasi Sediaan Lotion Antioksidan Ekstrak Daun Sirsak (Annona muricata L.) dan Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) sebagai Pelembab Sumardi; Suprianto; Azzahra, Innayah; Lisa Syafrida
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.05

Abstract

Background: A lotion made from ethanol extracts of Sirsak (Annona muricata) leaves and Naga Merah fruit (Hylocereus polyrhizus) peels is a potential antioxidant moisturizer, but its quality, safety, and hydration effect need confirmation. Objective: To formulate five oil-in-water lotions with different extract ratios (total extract 3% w/w) and evaluate physical quality, preliminary safety, and moisturizing performance. Method: The formulations were tested for organoleptic properties, homogeneity, pH, and spreadability. A simple irritation test and a three-day forearm hydration assessment using a skin analyzer were conducted in 25 panelists, followed by one-way analysis of variance. Results: All formulations had pH 6.67–6.96, with minor inhomogeneity observed in one formulation. Acceptable spreadability was achieved by three formulations under specific loads. No irritation occurred. All formulations increased hydration, with significant differences between them (p < 0.001); the two best-performing formulations produced the highest and most stable moisture over three days. Conclusion: The combined-extract oil-in-water lotion at 3% w/w is feasible and preliminarily safe, and the two top formulations are recommended for further development
Co-Authors Abdul Rahim Abrori, Abrori Adek Chan Adinda Seftia Afriadi Afriadi Agus Kristina Ahmad Hafizullah Ritonga Alam Suhada Alam Suhada Alizha Aisyah Ananda Sri Devy Ancel Mus Silaban Andilala Andraini, Galuh Andy Febriadi Anita Anita Anjur Falden Lingga Annas Reza Annas Reza Ardina Ardina Ardina Pakpahan Arinri Misnangin Sritala Ramadani Arinri Misnangin Sritala Ramadani Atika, Nur Azzahra, Innayah BENNI ISKANDAR Cahyono, Bowo Eko Chan, Adek Chandra Pranata Chusnul Chotimah Cut Fatimah Cut Fatimah Cyndi Veronica Damianus Pongoh De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dewi Sartika Munthe Dharma Wijaya, Indra Dian Zulkarnain Lubis Dikari Harita Dwi Setio Purnomo Edy Dharma Putra Duhe Effendy De Lux Putra Elok Nur Hamdana Elvy Oktima Elvy Oktima Endang Subekti Endang Subekti Enny Fitriani Febriady, Andy Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Fitri Mayang Sari Fitriani Nasution Fitriani, Enny Fridelly Mairani Apt Hasrat Masa Harefa Hendrawan, M. Afif Hendri Faisal Herliana Herlina H Herlina Herlina Hermansyah . Hetty Wahyuni Ihsanul Hafiz Indra Ginting Izudin, Ahmad Jakub Tarigan Jakub Tarigan Jelly Syahfitri Johannes Johannes Joko Wibowo Kurniawansyah, Kurniawansyah Kusjono, Gatot Kusumastuti, Melati Yulia Leny, Leny Lestari, Wita Lidiya Sasmaita Sihotang Lili Nurmaliza Lisa Syafrida Lukmanul Hakim M. Deddy Harfiansyah Maelani, Mia Mandike Ginting Mandike Ginting Marbun, Intan Coni Caroline Maya Annisa Lubis Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Mochamad Alfan Rosid Mohammad Ridwan Muhammad Gunawan Muhammad Gunawan Muhammad Hafizh Fattah Nasution, Lely Fitri Handayani Nilsya Febrika Zebua, Nilsya Febrika Nur Aisyah Pitri Nur Asni Arti Nur Asni Arti Nurasyah Nurasyah Nurkhoiroh Nurkhoiroh Nurlela Petra Saragih Nur’Adina Nur’Adina Nur’Adina Octaviani, Linggar Ayu Peri Aisyah Zubaidi Permata, Yade Metri Pramana Yoga Saputra Pranata, Chandra Prihanto, Yusep Putri Addina Rachel Anastasia R Hutabarat Risma Yeni Rotua Sumihar Sitorus Ruseni Ruth Mayana Rumanti Ruth Mayana Rumanti Sahrita Sahrita Samran, Samran Saragih, Safitri Sefryantonius Lase Sertin Prilda Sari Sandoro Sertin Prilda Sari Sandoro Shofian Syarifuddin Sindy Andriani Siregar, Riwandi Siregar, Suci Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Nurbaya Sri Handayani Sri Rahayu SRI RAHAYU Sriharini Sucihati, Roos Nana Sudiyarti, Nining Suhendra Tawarnate Sukma Aji Sumardi Sumardi Sumardi . Syamsul, Darwin Tambubolon, Regina Elianda Triatmojo, Muhammad Ikbal Nur Dian Ucok Hasian Refeiater Vivi Eulis Diana Vivi Eulis Diana Wafi, Moh. Abduh Wandani, Elliza Rizki Wilda Rizwani Winata, Hanafis Sastra Zai, Arifin Putra Zebua, Nilsya Febrika Zebua