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FORMULASI SHEET MASK EKSTRAK ETANOL KULIT PISANG AMBON (Musa paradisiaca L.) SEBAGAI MOISTURIZING Adek Chan; Afriadi Afriadi; Hanafis Sastra Winata; Suprianto Suprianto; Sahrita Sahrita
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.424

Abstract

Ambon banana peel contains flavonoid chemical compounds that can moisturize facial skin. Flavonoids are powerful antioxidants. A sheet mask formulation of Ambon banana peel extract that can be used more practically and is able to moisturize facial skin. This study aims to formulate a mask sheet preparation containing ethanol extract of Ambon banana peel as well as better skin maintenance for four weeks of treatment and measuring the moisture content of the skin. The research method used is an experimental method, namely the extract is obtained using the maceration method, then formulated into a sheet mask preparation, consisting of glycerin, butylene glycol, sodium polyacrylate, nipagin, PEG-40 Hydrogenated Castrol oil, aquadest, perfume, and banana peel ethanol extract. Ambon with concentrations of F1 (1%), F2 (3%), F3 (5%), F4 (7%), F5 (9%), respectively. As blank (F0) sheet mask preparation without the addition of extract. The preparation is evaluated including homogeneity test, pH test, stability test, irritation test, Moisture effectiveness test using Moisture Checker and preference test. The treatment is carried out for 4 weeks by applying the mask twice a week. Data obtained from the analysis using the SPSS program. The results showed that the ethanol extract of Ambon banana peel can be formulated in a homogeneous sheet mask preparation, does not change color and remains stable in 4 weeks of storage with a pH of 4.6 - 6.6. Conclusion The ethanol extract of Ambon banana peel can be formulated into sheet masks with concentrations of 1%, 3%, 5%, 7% and 9% with a positive control ratio.
Assessing Drug-Likeness The Natural Compounds of Polar Extract Curcuma xanthorrhiza Rhizome via Lipinski's Rules with SWISSADME Web Tool Sumardi, Sumardi; Suprianto, Suprianto
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.03

Abstract

Curcuma xanthorrhiza, commonly known as Javanese turmeric, is widely recognized for its medicinal properties, with its polar extract containing various bioactive compounds. This study aims to assess the drug-likeness of natural compounds found in the polar extract of Curcuma xanthorrhiza rhizome using Lipinski's Rule of Five, analyzed through the SWISSADME web tool. The compounds alpha pinene, alpha thujene, beta pinene, and zingiberene were evaluated for their physicochemical properties, including molecular weight, hydrogen bond donors and acceptors, lipophilicity, and solubility. The analysis confirms that these compounds meet the criteria for oral drug-likeness. Additionally, specific parameters such as fractionCsp3, iLOGP, and MLOGP were found to significantly influence the permeability of these compounds, further supporting their potential as orally administered therapeutics. The findings underscore the utility of SWISSADME in preclinical screening of natural products, offering a valuable approach to identify promising candidates for drug development. This study highlights the potential of Curcuma xanthorrhiza polar extract as a source of drug-like compounds, paving the way for further pharmacological and clinical investigations.
ADMET Prediction Compounds of Polar Extract Curcuma rhizoma Sumardi, Sumardi; Suprianto, Suprianto; Siregar, Suci Rahmadani; Zai, Arifin Putra; Tambubolon, Regina Elianda; Mairani, Fridelly
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.01

Abstract

The pharmacokinetic and metabolic profiles of polar extract compounds from Curcuma rhizoma were evaluated using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions. Most compounds exhibited high gastrointestinal (GI) absorption, with the exception of D-glucose, citric acid, and terpenoids such as alpha-pinene and zingiberene, which demonstrated low absorption, highlighting potential challenges for systemic bioavailability. Blood-brain barrier (BBB) permeability was observed in lipophilic compounds like xanthorrhizol, bisdemethoxycurcumin, and terpenoids, suggesting their potential for CNS-targeted therapies, while polar compounds, including D-glucose, citric acid, and most curcuminoids, were non-permeant. D-glucose was the only compound identified as a P-glycoprotein (Pgp) substrate, indicating minimal efflux-related limitations for other compounds. Selective cytochrome P450 (CYP) enzyme inhibition was detected in compounds such as xanthorrhizol, curcuminoids, and zingiberene, suggesting potential metabolic interactions in multi-drug contexts. Promising therapeutic candidates include curcuminoids and xanthorrhizol, while non-BBB-permeant and low-absorbing compounds may require formulation strategies or alternative applications. These findings provide valuable insights into the pharmacological optimization of Curcuma rhizoma compounds, offering a foundation for further research in drug discovery and development.
Dampak Pewarna Ekstrak Etanol Buah Naga Merah (Hylicerius polyhizus) terhadap Lip Balm Minyak Bunga Kenanga (Cananga oil) Meilani, Debi; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.02

Abstract

Background: Red dragon fruit holds promise as a natural dye alternative due to its anthocyanin content. Objective: This study aimed to evaluate the potential of ethanol extract from red dragon fruit as a dye in Lip Balm formulations and investigate how varying the concentration of this extract affects the formula. Method: The study involved extracting the dye from red dragon fruit and incorporating it into a Lip Balm preparation using natural fruit-based dyes. Results: The findings indicated that the red dragon fruit extract yielded favorable results after undergoing various tests, including organoleptic evaluation, homogeneity, melting point, irritation, and user preference. Conclusion: The extract of red dragon fruit can be utilized as a dye in Lip Balm formulations. The resulting colors range from pink to dark red, with higher concentrations of the extract producing more intense colors in the final Lip Balm product containing ylang-ylang flower oil (Cananga oil)
Analisis Parasetamol Tablet dengan Metode Fourier Transform Infra Red (FTIR) Saragih, Safitri; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.05

Abstract

Background: Paracetamol, a widely used analgesic and antipyretic medication, is commonly prescribed in government healthcare facilities. The FTIR method provides rapid measurements by analyzing spectral graphs that reveal the functional groups within the tested compounds. According to the Indonesian Pharmacopoeia, VI Edition 2020, paracetamol content in tablet formulations must range between 90.0% and 110.0%. Objective: This study aimed to evaluate the paracetamol content in tablet preparations and assess their compliance with the 2020 Indonesian Pharmacopoeia standards and the packaging labels. Method: The research was conducted experimentally using FTIR spectroscopy. A solvent mixture of ethanol and distilled water (1:1) was employed, with analyses performed over the wavelength range of 4000–400 cm⁻¹. Results: The paracetamol content was found to be highest in tablet B (100.33 ± 1.003%), followed by tablet A (100.29 ± 1.002%), tablet D (100.24 ± 1.002%), and tablet E (100.14 ± 1.001%), with the lowest levels observed in tablet C (99.69 ± 0.996%). Method validation indicated an RSD value of 0.056%, confirming that the procedure was accurate and reliable. Conclusion: The findings demonstrate that the FTIR method is suitable for the quantitative analysis of paracetamol in tablet formulations. Moreover, the results meet the standards outlined in the 2020 VI Edition of the Indonesian Pharmacopoeia.
Penerapan Sanitasi dan Higienis dalam Pembuatan Jamu Gendong di Kota Tebing Tinggi Suprianto, Suprianto; De Lux Putra, Effendy; Nurbaya, Siti; Samran, Samran; Sumardi, Sumardi; Nasution, Derlina; Lestari, Wita
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 4 No. 3 (2025): April 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v4i3.220

Abstract

Jamu Gendong is a traditional drink that has the potential to be contaminated with worms, parasites, bacteria, fungi, viruses and rickettsia. Sources of contaminants include materials, equipment, facilities, personnel, animals and production environments, so their efficacy is questionable. The activity was carried out in the form of providing information on the implementation of sanitation and hygienic production to 38 Jamu Gendong traders in Tebing Tinggi City, Deli Serdang, North Sumatra. The material was delivered using illustrated power point media to facilitate the delivery of increased understanding of sanitation and hygiene, including objectives, benefits, programs, fixed procedures, disinfectant and washing materials as well as documentation in accordance with RI POM Regulation Number 31, 2022. Activities were carried out on April 29, 2024 and received positive responses from all participants. Activities are expected to be sustainable so that the Jamu Gendong produced is of higher quality.
Korelasi Konsumsi Sidaguri dengan Kadar Asan Urat Darah Suprianto, Suprianto; Adek Chan; Joko Wibowo; Samran; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.02

Abstract

Background: Hyperuricemia as an indicator of increased blood uric acid. The prevalence rate in Indonesia is not recorded with certainty. However, the prevalence of gout reached 655,745 people out of 238,452,952 people in Indonesia, ranking first in Southeast Asia. Sidaguri flavonoids have inhibitory power against Xanthine Oxidase so that they can reduce uric acid. Objective: The study was aimed at detecting the effect and correlation of Sidaguri capsule consumption (Sida rhombifolia L) on reducing uric acid in patients. Method: The study was conducted Pretest and Posttest on 22 patients with hyperuricemia with the Easy Touch GCU Instrument. Results: The results showed that the average uric acid level before the intervention was 8.37 mg/dL and after the intervention was 6.57 mg/dL. Conclusion: Sidaguri capsules have an effect on reducing uric acid levels in patients
EFEKTIVITAS PENERAPAN MODEL PBL UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH SISWA PADA MATERI TERMODINAMIKA KELAS XI B1 SMAN 2 PAMEKASAN Mulyadi, Syifaul Aini; Musyarrofah, Wilda; Ibana, Lukluk Ibana; Suprianto, Suprianto; Indrasari, Hairuni; Rahman, Khalifatur
PeTeKa (Jurnal Penelitian Tindakan Kelas dan Pengembangan Pembelajaran) Vol 8, No 3 (2025): PeTeKa (Jurnal Penelitian Tindakan Kelas dan Pengembangan Pembelajaran)
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/ptk.v8i3.1171-1191

Abstract

Termodinamika merupakan materi yang sulit dipahami oleh banyak siswa karena konsepnya yang abstrak dan kompleks. Metode pengajaran tradisional dianggap masih kurang mengembangkan kemampuan pemecahan masalah siswa. Penerapan model Problem Based Learning (PBL) menawarkan pendekatan berbasis masalah kontekstual dalam dunia nyata, menjadikannya pilihan yang meningkatkan keterlibatan siswa dan kemampuan pemecahan masalah. Penelitian ini bertujuan untuk mengetahui dan mengevaluasi efektivitas model PBL dalam meningkatkan kemampuan pemecahan masalah siswa dalam pembelajaran materi termodinamika kelas XI B1 di SMAN 2 Pamekasan. Setiap siklus yang digunakan sebagai Penelitian Tindakan Kelas (PTK), mencakup tahapan untuk mempersiapkan, melaksanakan, mengamati, dan merefleksi. Data dikumpulkan melalui observasi, wawancara, tes kemampuan pemecahan masalah dan dokumentasi yang selanjutnya dianalisis secara deskriptif dan kuantitatif. Kemampuan pemecahan masalah siswa meningkat secara signifikan dari 48,40% pada Pra Siklus menjadi 76,30% pada Siklus I dan selanjutnya menjadi 91,32% pada Siklus II. Temuan ini menunjukkan bahwa paradigma PBL berhasil meningkatkan kemampuan pemecahan masalah siswa untuk menyelesaikan kesulitan terkait termodinamika.
The Relationship of Legal Subjects in Making Agreements Without Conducting Face-to-Face Meetings Based on the Artificial Intelligence (AI) Ecosystem: Business Law Implementation S, Ahmad Suryadi; Suprianto, Suprianto; Saswan, Munadi Agri; Rahmi, Siti
Journal of Social Science and Economics (JOSSE) Volume 2, Issue 2, August 2025
Publisher : Asha Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70188/1vzv2j67

Abstract

The development of Artificial Intelligence (AI)-based technology has presented new challenges in treaty law, especially regarding the validity of legal relations that occur without face-to-face meetings. This study uses a normative-empirical method to analyze the application of treaty law in the context of the AI ecosystem. The purpose of this study is to understand the relationship between the legal terms of agreements based on Article 1320 of the Civil Code and the practice of agreements made through AI-based digital media. The data sources came from a literature study of laws and regulations, jurisprudence, and online treaty practices. Data collection techniques are carried out through literature studies and participatory observation of the implementation of AI in community legal interactions. The data analysis technique uses the law enforcement approach and the concept of recht vacuum to assess whether there is a legal vacuum. The results of the study show that agreements made through AI are still declared valid and binding as long as they meet the legal elements of the agreement according to the Civil Code, except for certain types of agreements that legally require face-to-face meetings such as land buying and selling, notary deeds, and grants, in accordance with the provisions of Law Number 1 of 2024 concerning Information and Electronic Transactions
Sosialisasi dan Implementasi Ekonomi Kreatif dan Digitalisasi UMKM Desa Karangharja Melalui Integrasi QRIS, Geotagging Google Map Kios, dan Banner Promosi Dalam Program KKN Universitas Pelita Bangsa Tahun 2025 Syukur, Hendrodinus Widono; Ardani, Ardani; Suprianto, Joko; Fauzi, Rafli; Alfani, Andri; Ningsih, Risma; Latif, Abdul
JGEN : Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 4 (2025): JGEN : Jurnal Pengabdian Kepada Masyarakat, Agustus 2025
Publisher : Lumbung Pare Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60126/jgen.v3i4.1202

Abstract

Program Pengabdian kepada Masyarakat ini bertujuan untuk mempercepat digitalisasi UMKM di Desa Karangharja melalui integrasi sistem pembayaran nontunai QRIS, pendaftaran lokasi digital menggunakan Google Maps Geotagging, serta penguatan promosi melalui media banner. Kegiatan dilaksanakan dalam tiga tahap, yaitu pra-intervensi (asesmen dan pemetaan UMKM), intervensi (pelatihan, pendampingan, dan implementasi), dan pasca-intervensi (monitoring dan evaluasi). Sebanyak 15 UMKM dipilih sebagai peserta dengan kriteria operasional aktif, belum sepenuhnya mengadopsi pembayaran digital, dan bersedia mengikuti seluruh rangkaian program. Hasil kegiatan menunjukkan 80% UMKM berhasil memahami dan mengimplementasikan QRIS, 53% memiliki titik lokasi terverifikasi di Google Maps, dan 33% mendapatkan media banner promosi yang dapat direplikasi. Peningkatan ini menunjukkan adanya perbaikan signifikan pada literasi digital dan visibilitas online UMKM, sekaligus membentuk model intervensi yang dapat direplikasi untuk desa lain. Program ini menegaskan bahwa kolaborasi antara universitas, pemerintah desa, pelaku UMKM, dan sponsor mampu menciptakan dampak berkelanjutan terhadap penguatan ekonomi kreatif desa.
Co-Authors Abdul Latif Abdul Rahim Adek Chan Afriadi Afriadi Agustine, Nita Claudia Ahmad Hafizullah Ritonga Akhsal, Muhammad Alam Suhada Alam Suhada Alamsyah, Sayyidul Aulia Alfani, Andri Alizha Aisyah Ananda Sri Devy Ancel Mus Silaban Andilala Andraini, Galuh Anita Anita Anjur Falden Lingga Annas Reza Annas Reza Ardani Ardani Ardina Ardina Ardina Pakpahan Arie Wardhono Arinri Misnangin Sritala Ramadani Arinri Misnangin Sritala Ramadani As-Sidqi, Miftakhul Hidayatullah Atika, Nur Ayomi, Siti Azmi, Muhammad Farhan Bambang Purnomo Yanuarso BENNI ISKANDAR Bunga Nur Julianingtyas, Bunga Nur Cahyono, Bowo Eko Chan, Adek Cinde Ririh Windayu Cut Fatimah Cut Fatimah Cyndi Veronica DARMANSYAH . Darmawan, Sukma Adi De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dewi Sartika Munthe Dian Zulkarnain Lubis Dikari Harita Dwi Fita Heriyawati Dwi Setio Purnomo Effendy De Lux Putra Eko Sutrisno, Eko Elliza Rizki Wandani Elvy Oktima Elvy Oktima Endang Subekti Endang Subekti Enny Fitriani Fadilah, Ilham risqi Fahad Fahad Fartimah, Siti Fauzi, Rafli Febriady, Andy Ferdiansah, Muhammad Vicky Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Firnanda, Basyid Fitri Mayang Sari Fitriani Nasution Fitriani, Enny Gatot Kusjono Haerul Pathoni, Haerul Hakim, Syamsul Hamdani Hamdani Hanafi, Mohammad Iqbal Handrito , Radityo Putro Hapsari Peni Harianto, Bambang Bagus Harman, Anita Hasrat Masa Harefa Hendri Faisal Herliana Herlina H Herlina Herlina Hermansyah . Hetty Wahyuni Hunowu, Adam Husnul Khatimah I Gusti Putu Asto Buditjahjanto I Kadek Suardika I Made Budiarsa I.G.P Asto Buditjahjanto Ibana, Lukluk Ibana Ihsanul Hafiz Indra Ginting Indrasari, Hairuni Jainuddin, Jainuddin Jakub Tarigan Jakub Tarigan Jamaluddin Jelly Syahfitri Johannes Johannes Joko Wibowo Kantari, Losa Ade Kartika, Unit Three Kurniawansyah Kurniawansyah Kusjono, Gatot Kusmini Suprihatin Kusumastuti, Melati Yulia Leny, Leny Lestari, Wita Lidiya Sasmaita Sihotang Lili Nurmaliza Lilik Anifah Loetfia Dwi Rahariyani Lukman Hakim Lukmanul Hakim Luly Triningsih Mairani, Fridelly Mandike Ginting Mandike Ginting MARIFANI FITRI ARISA Maulana Muhammad Jogo Samudro Maya Annisa Lubis Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Merita Indrawati, Elsanda Mia Maelani Moch. Bahrudin Mohammad Hidayaturrahman Mubarak, Abdulah Mudakir, Kharis Muh. Hasbi Muhammad Deddy Harfiansyah Muhammad Deddy Harfiansyah Muhammad Gunawan Muhammad Gunawan MUHAMMAD HASBI Muiz, Ahmad Habibul Mulyadi, Syifaul Aini Musyarrofah, Wilda Muzakki, Naufal Nasir Nasir Nasrullah, Muh. Nasution, Lely Fitri Handayani Nicko, Abed Nilsya Febrika Zebua, Nilsya Febrika Ningsih, Risma Nining Sudiyarti Novia Susanti Novitasari, Intan Sekar Nur Aini, Intan Nur Aisyah Pitri Nur Asni Arti Nur Asni Arti Nurasyah Nurasyah Nurhayati Nurhayati Nurlela Petra Saragih Nurul Ratnawati, Nurul Nur’Adina Nur’Adina Nur’Adina Pangga, Dwi Panjaitan, John David Willy Peri Aisyah Zubaidi Permata, Yade Metri Pranata, Chandra Prihanto, Yusep Putri Addina Rachel Anastasia R Hutabarat Rahman, Khalifatur Ramli Ramli Rehanun Resaldi A, Devano Ilham Riesha, Riezky Army Rifa'i, Anggi Muhammad Rifqi Firmansyah, Rifqi Rillia Aisyah Haris Rini Agustina Riska Riska Risma Niswaty Risma Yeni Roos Nana Sucihati Rosary, A. Osfira Rotua Sumihar Sitorus Ruseni Ruth Mayana Rumanti Ruth Mayana Rumanti S, Ahmad Suryadi Sahrita Sahrita Said , Amal Samran, Samran Saputra, Zanuar Faudino Saragih, Safitri Sasilatha, T. Saswan, Munadi Agri Sefryantonius Lase Septian, Afan Maulana Sertin Prilda Sari Sandoro Sertin Prilda Sari Sandoro Setiawan, Bhayu Aji Shofian Syarifuddin Sindy Andriani Siregar, Dwiki Rifhardi Siregar, Riwandi Siregar, Suci Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Nurbaya Siti Rahmi, Siti Sri Handayani SRI RAHAYU Sri Rahayu Sudirman Sugiantiningsih, Anak Agung Putu Suhendra Tawarnate Sumardi Sumardi Sumardi . Sutji Rochaminah Syamruddin Syamruddin Syamsul, Darwin Syukur, Hendrodinus Widono Tambubolon, Regina Elianda Ubaid, Ahmad Hasan Ucok Hasian Refeiater Umniyah, Inas Alfiyatul Unit Three Kartini Vivi Eulis Diana Vivi Eulis Diana Wilda Rizwani Winarsih, Rini Winarsih Winata, Hanafis Sastra Yudairawan, Listyo Zai, Arifin Putra Zebua, Nilsya Febrika Zebua Zuhrie, Muhamad Syariffuddien Zulkia, Andipta Ahmad