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Rimbawan ,
Department Of Community Nutrition, Faculty Of Human Ecology, Bogor Agricultural University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Phytochemical evaluation and antidiabetic potential (In silico) of corn silk (Zea mays L.) and jasmine (Jasminum sambac) Bohari, Bohari; Rimbawan, Rimbawan; Nasution, Zuraidah; Handharyani, Ekowati
AcTion: Aceh Nutrition Journal Vol 10, No 4 (2025): December
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i4.2931

Abstract

Diabetes mellitus is a significant global health challenge, necessitating the exploration of novel therapeutics from natural sources for its treatment. This study aimed to identify the bioactive compounds in a combinatorial methanolic extract of corn silk (Zea mays L.) and jasmine flowers (Jasminum sambac) and predict their antidiabetic potential. The extract was analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). The identified compounds were evaluated in silico via molecular docking simulations against key antidiabetic protein targets: Glucagon-Like Peptide 1 (GLP-1), Insulin-like Growth Factor 1 (IGF-1), Glucose Transporter 4 (GLUT4), alpha-glucosidase, and superoxide dismutase (SOD). The analysis focused on the binding energy (ΔG). A total of 44 metabolites were identified in this study. Molecular docking results indicated that rothindin exhibited the highest binding affinity for GLUT4, with a binding energy of -9.9 kcal/mol. Rothindin and Chlorogenic Acid also showed significant potential as modulators of GLUT4 and α-glucosidase, respectively. In conclusion, the combined extract contains bioactive compounds, particularly roxindin and chlorogenic acid, which demonstrate significant in silico potential as antidiabetic agents.
Effects of Tele-Exercise on Body Composition, Lipid Profile, Mental Health, and SIRT1 Gene Expression in Obese Office Employees in Indonesia Kuswari, Mury; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Dewi, Mira; Gifari, Nazhif; Pamungkas, Rian Adi; Seprianto, Seprianto; Himarwan, Aditya; Putra, Felicia Kartawidjaja; Dijaya, Rendy; Subali, Dionysius
Media Gizi Indonesia Vol. 21 No. 1 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i1.75-89

Abstract

Tele-exercise delivers remote physical activity programs via digital platforms, enhancing accessibility and adherence, making it a promising strategy to address obesity among workers. This study aimed to evaluate the effects of tele-exercise programs on body fat percentage, lipid profile, mental health measures and Sirtuin 1 (SIRT1) gene expression measured via venipuncture & RT-PCR in obese office employees. A total of 33 overweight or obese employees (male/female, 18-45 years old, Body Mass Index (BMI) 23-30 kg/m2) were randomly assigned to the strength (SE) group, strength-cardio (SC) group, and control (CT) group. The strength exercise protocol included core training, circuit training, High Intensity Interval Training (HIIT) and Tabata training; cardio exercise includes low-high impact aerobic exercises. Each group was given nutrition education, whereas the two intervention groups participated in tele-exercise three times/week for twelve weeks. Tele-exercise was delivered via ZOOM application. Mental health indicators were measured using the Depression Anxiety Stress Scale (DASS-42) questionnaire. Compliance levels between intervention groups did not differ significantly (p>0.05). There was a significant reduction in bodyweight in the SC group (p=0.046). Blood High Density Lipoprotein (HDL) levels increased only in the SC group (0.50 mg/dL), but decreased in the SE group and CT group. SIRT1 gene expression increased in SE and CT groups (2.39- and 5.33-fold, respectively), whereas a significant decrease was observed in the SC group (p=0.043). Only the SE group showed a significant reduction in stress level (p=0.03), with a decrease of 30.9%. Strength exercise intervention improves total cholesterol level by -19.09 mg/dL. 
Metabolite Profiling Differences of Single and Physical Mixture of Moringa Leaves (Moringa oleifera) and Red Galangal (Alpinia purpurata (Vieill) K. Schum) Simbolon, Martina; Rimbawan, Rimbawan; Roosita, Kartin; Artika, I Made
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.962

Abstract

econdary metabolites are bioactive plant constituents that contribute to antioxidant, anti-inflammatory, and anti-microbial activities, making them valuable for functional food and nutraceuticals applications. This study aimed to characterize the secondary metabolites present in powdered Moringa oleifera leaves, red galangal (Alpinia purpurata (Vieill) K. Schum) rhizomes, and their combination. The 85:15 ratio used in the mixed powder was selected based on preliminary material composition considerations. Metabolite identification was conducted using Ultra High Performance Liquid Chromatography Tandem High Resolution Mass Spectrometry (UHPLC-HRMS). Data processing and compound annotation were performed using ChemSpider and mzCloud. A total of 21 metabolites were identified in moringa leaf powder, 16 compounds in red galangal rhizome, and 17 compounds in the combined preparation. Flavonoid were the dominant class in moringa leaves with quercitrin, 4-aminobenzoid acids, and pheophorbide A as the most abundant constituents. In contrast, phenolic compounds, particularly benzoic derivatives were predominant in red galangal, where menadiol, abietin, and sweroside were the major metabolites. The combined formulation retained key constituents from both plants, including cinnamaldehyde, 4-aminobenzoic acid, and pheophorbide A, and additionally showed an increased level of nictoflorin. These findings provide preliminary compositional evidence demostrating the distinct and complementary phytochemical profiles of moringa leaves and red galangal rhizomes. This information may guide future studies into potential functional food or nutraceutical formulations for further validation through bioactivity, bioavailability, and interaction studies.
Compliance Level to Food Labelling Regulation for Micro and Small-sized Enterprises Products: A Descriptive Study in Wonosobo District, Indonesia Rimbawan, Rimbawan; Mauludyani, Anna Vipta Resti; Rusyda, Akifa Laila
Jurnal Mutu Pangan : Indonesian Journal of Food Quality Vol. 10 No. 1 (2023): Jurnal Mutu Pangan
Publisher : Department of Food Science and Technology (ITP), Faculty of Agricultural Technology, Bogor Agricultural University (IPB) in collaboration with the Indonesian Food and Beverage Association (GAPMMI), the National Agency of Drug and Food Control, and th

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jmpi.2023.10.1.33

Abstract

Food labelling is an effective tool in protecting consumer health with respect to safety and nutrition. Complying with labelling regulations is essential in preventing product recalls. Thus, the objective of this study was to determine the extent of adherence to food labelling regulations by micro and small-sized enterprises (MSEs) in Wonosobo District, in accordance to the existing guidelines. Primary data were collected through a market survey approach, with analysis conducted through purposive sampling in shops, stalls, home industries, markets, and supermarkets. Content analysis was employed to evaluate four categories of processed food: flour/starch-based products, water-based flavored drinks, processed fruit products, and processed grain, nut, and tuber products, totaling 92 products. The compliance level with labelling regulations was evaluated based on the principal display panel, labelling formats, general labelling requirements, and prohibited statements on the label. The results revealed that the compliance level of labelling flour/starch-based products was good, with an average of 75%. In contrast, the average compliance level for water-based flavored drink products was 58%, while the average compliance levels for processed fruit products and processed grain, nut, and tuber products were 54 and 59%, respectively, indicating a lower level of compliance compared to flour/starch-based products.
Bioactive Compounds, Antioxidant Capacity and HMG-CoA Reductase Inhibitory Potential of Red Fruit Oil (Pandanus conoideus Lam.): An In Silico and In Vitro Study Tande, Ribka; Rimbawan, Rimbawan; Palupi, Eny; Kurniasih, Rini; Haerati, Nur
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111565

Abstract

Cardiovascular disease, the leading cause of death worldwide, can result from dyslipidemia's ability to promote atherosclerosis. Therefore, it is important to address this issue by utilizing local food sources, such as red fruit oil, an endemic fruit from Papua, Indonesia. Red fruit oil contains some bioactive compounds, making it a promising candidate for use in functional foods. This study aimed to assess the bioactive components of red fruit oil, its antioxidant capacity, and its inhibitory potential against 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase enzyme, both in silico and in vitro. The results showed that red fruit oil contained total phenolics of 627.42 ± 61.78 mg GAE/g, flavonoids of 128.06 ± 8.94 mg QE/g, and an antioxidant capacity of 2316.15 ± 135.63 μmol TE/g. Based on the outcomes of in silico investigations, the suspected compounds capable of inhibiting HMG-CoA reductase were isochamaejasm, 6-acetylpicropolin, (−)-pinellic acid, and 2-monolinolein, with binding energies of −8.3620, −7.9660, −7.6980, and −7.6970 kcal/mol, respectively. The in vitro results showed that the inhibitory activity of red fruit oil was 48.36 ± 2.46, which was not significantly different from that of lovastatin 50.82 ± 2.46 (p = 0.288). The findings of this study suggest that red fruit oil may be able to manage dyslipidemia by inhibiting HMG-CoA reductase.
Co-Authors Adi Teruna Efendi Adi Teruna Effendi Adi Teruna Effendi Adi Winarto Agustino Agustino Ahmad Sulaeman Ainia Herminiati Ainia Herminiati Ainia Herminiati Ali Khomsan Angga Rizqiawan Anna Vipta Resti Mauludyani Aprinia Dian Nurhayati Ascobat, Purwantyastuti Asep Rusyana Aslis Wirda Hayati Astuti Lamid Aya Yuriestia Arifin, Aya Yuriestia Azizi, Elsa Carla Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto Betty Yosephin Simanjuntak Bibi Ahmad Chahyanto Bohari Bohari Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Cassandra Permata Nusa Cesilia M Dwiriani Clara M. Kusharto Clara Meliyanti Kusharto Dadan Rohdiana Dadang Sukandar Damayanti, Rinda Daus, Firdaus Firdaus Deddy Muchtadi Deddy Muchtadi Deni Elnovriza DEWI APRI ASTUTI Dewi Kusumawati Dewi Kusumawati Diah M. Utari Diah M. Utari Diffah Hanim Dijaya, Rendy Dionysius Subali Dodik Briawan Drajat Martianto Egayanti, Yusra Ekowati Handharyani Elisa Diana Julianti Emma S Wirakusumah Ennita Fahriza Eny Palupi Eva Susanti Evi Damayanthi Evy Damayanthi Faisal Anwar Fajriaty, Deannisa Febrina Sulistiawati Fifi Retiaty Firdaus Firdaus Firdaus Firdaus Fitrah Ernawati Fitrah Ernawati Fivi Melva Diana, Fivi Melva Gifari, Nazhif Hadi Riyadi Haerati, Nur Hardiansyah, Angga Hardinsyah Harianti, Rini Harianti, Rini Hidayat Syarief Hidayat Syarief Himarwan, Aditya I Gusti Bagus Wiksuana I MADE ARTIKA I.Wayan T.Wibawan, I.Wayan Ika Heri Kustanti Ikeu Ekayanti Ikeu Tanziha Ikue Ekayanti Ilmi Dewi Astuti Ilmi, Ibnu Malkan Bakhrul Indhira Shagti Iswahyudi Iswahyudi ITA DJUWITA Katrin Roosita Khaerul Fadly Khairina, Dini Nur Kharisma Tamimi Kresandra, Anastasha Laeli Nur Hasanah Latifah Darusman Latifah K Darusman Latifah K. Darusman Leily Amalia Leily Amalia Furqon Lidwina Lidwina Lilik Kustiyah Linar Zalinar Udin Lubis, Anwar M. Muslim MADE ASTAWAN MARIA BINTANG Mauludiya, Putri Nur Mira Dewi Mohamad Rafi Muhamad Rizal Martua Damanik Muhammad Aries Muhilal ., Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Mukhlidah Hanun Siregar Mulya Agustina Mury Kuswari Muti'ah Mustaqimatusy Syahadah Nasir, Syifa Qolbiyah Nasution, Zuraidah Naufal Muharam Nurdin Ni Ketut Sutiari Ni'ma Hilyatin Noviana, Astrid Novitasari, Putri Nunung Nurjanah Nur Indrawaty Lipoeto Nurhidayati, Nuzuliyati Nuri Andarwulan Pertiwi, Fenti Dewi Picauly, Intje Pipih Suptijah Purwantyastuti Ascobat Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Puspo Edi Giriwono Putra, Felicia Kartawidjaja Putri Puncak Anjani Rahman, Dewi Rahmayani Rakhmawati FKR Ratu Diah Koerniawati Reisi Nurdiani, Reisi Resita Nurbayani Restu Pertiwi Rian Adi Pamungkas Riana, Nidya Ulfah Rini Kurniasih, Rini Rizal M Damanik, Rizal M Roosita, Kartin Rosyanne Kushargina Rusyda, Akifa Laila Safitri, Debby Endayani Sari, Eny Kurnia Seprianto, Seprianto Simbolon, Martina Siti Madanijah Sri Anna Marliyati Sri Hartati R. Suradijono Sri Nur Amalia Sri Purwaningsih Sri Sumarmi Sri Wahyu Angga Dewi Subangkit, Mawar Sudjana Sibarani Suryana, Suryana Susi Desminarti Susi Nurohmi Susilawati, Esih Sutrisna, Aang SYAHRIAL SYAHRIAL Syartiwidya, Syartiwidya Tande, Ribka TATI NURHAYATI Tresnanda, Muhammad Nawaf Trini Suryowati, Trini Tunggul Waloya Umam, Hafizul V Prihananto Vetnizah Juniantito Warisanti, Dira Wiwin Winarsih Yunianto, Andi Eka Zakiudin Munasir Zakiudin Munasir