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All Journal Jurnal Gizi dan Pangan Jurnal Teknologi Dan Industri Pangan Jurnal Ilmu-Ilmu Perairan dan Perikanan Indonesia Forum Pasca Sarjana Media Gizi dan Keluarga Jurnal Sain Veteriner JURNAL GIZI INDONESIA Media Kesehatan Masyarakat Indonesia NUTRIRE DIAITA Media Ilmu Keolahragaan Indonesia Indonesian Journal of Human Nutrition agriTECH Journal of Consumer Science Jurnal Media Gizi Indonesia (MGI) Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Jurnal Sains Teh dan Kina GIZI INDONESIA Jurnal Aplikasi Teknologi Pangan AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Argipa (Arsip gizi dan Pangan) Indonesian Journal of Chemistry JOURNAL SPORT AREA Jurnal Aplikasi Teknologi Pangan Amerta Nutrition JUARA : Jurnal Olahraga JURNAL PANGAN YARSI Medical Journal Jurnal Mutu Pangan : Indonesian Journal of Food Quality JURNAL GIZI DAN KESEHATAN Community Development Journal: Jurnal Pengabdian Masyarakat Narra J Jurnal Gizi Masyarakat Indonesia (The Journal of Indonesian Community Nutrition) Tirtayasa Medical Journal Jurnal Ilmu Gizi dan Dietetik Jurnal Pendidikan Indonesia (Japendi) Bulletin of Culinary Art and Hospitality Jurnal Kedokteran Hewan Tirtayasa Medical Journal Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Proceeding Mulawarman International Conference on Tropical Public Health Jurnal Kesehatan Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rimbawan ,
Department Of Community Nutrition, Faculty Of Human Ecology, Bogor Agricultural University, Bogor 16680, Indonesia
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Bioactive Compounds, Antioxidant Capacity and HMG-CoA Reductase Inhibitory Potential of Red Fruit Oil (Pandanus conoideus Lam.): An In Silico and In Vitro Study Tande, Ribka; Rimbawan, Rimbawan; Palupi, Eny; Kurniasih, Rini; Haerati, Nur
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111565

Abstract

Cardiovascular disease, the leading cause of death worldwide, can result from dyslipidemia's ability to promote atherosclerosis. Therefore, it is important to address this issue by utilizing local food sources, such as red fruit oil, an endemic fruit from Papua, Indonesia. Red fruit oil contains some bioactive compounds, making it a promising candidate for use in functional foods. This study aimed to assess the bioactive components of red fruit oil, its antioxidant capacity, and its inhibitory potential against 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase enzyme, both in silico and in vitro. The results showed that red fruit oil contained total phenolics of 627.42 ± 61.78 mg GAE/g, flavonoids of 128.06 ± 8.94 mg QE/g, and an antioxidant capacity of 2316.15 ± 135.63 μmol TE/g. Based on the outcomes of in silico investigations, the suspected compounds capable of inhibiting HMG-CoA reductase were isochamaejasm, 6-acetylpicropolin, (−)-pinellic acid, and 2-monolinolein, with binding energies of −8.3620, −7.9660, −7.6980, and −7.6970 kcal/mol, respectively. The in vitro results showed that the inhibitory activity of red fruit oil was 48.36 ± 2.46, which was not significantly different from that of lovastatin 50.82 ± 2.46 (p = 0.288). The findings of this study suggest that red fruit oil may be able to manage dyslipidemia by inhibiting HMG-CoA reductase.
Analisis Kandungan Fitokimia Kombinasi Teh Putih dan Jahe Bubuk dengan Metode HPLC Kresandra, Anastasha; Setiawan, Budi; Rimbawan, Rimbawan
Jurnal Pendidikan Indonesia Vol. 6 No. 2 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i2.7336

Abstract

Teh putih merupakan salah satu jenis teh yang merupakan jenis teh yang memiliki kadar polifenol tertinggi dibanding teh hijau, teh hitam, dan teh oolong. Polifenol pada teh paling banyak terdapat dalam bentuk katekin. Sekitar 60% dari katekin terdapat dalam bentuk epigallocatechin-3-gallate (EGCG). Tujuan penelitian ini adalah untuk menentukan perlakuan terbaik dalam pengembangan produk teh putih dan jahe bubuk. Penelitian ini menggunakan metode HPLC dalam pengukuran kadar fitokimia yang terdapat pada kombinasi teh putih dan jahe bubuk. Penelitian ini menggunakan desain eksperimental dengan dua kali pengulangan. Senyawa yang difokuskan pada penelitian ini antara lain penetapan kadar katekin, EGCG, asam galat, dan kafein. Teh putih yang digunakan pada penelitian ini berasal dari Pusat Penelitian Teh dan Kina (PPTK) Gambung dan jahe bubuk yang berasal dari Balat Penelitian Tanaman Rempah dan Obat (BALITTRO). Terdapat tiga perlakuan perbandingan rasio teh putih dan jahe, yakni rasio teh putih:jahe pada perlakuan P1 (30:70), P2 (50:50), P3 (70:30). Hasil yang diperoleh menunjukkan rata-rata kadar katekin, EGCG, dan kafein memiliki perbedaan yang signifikan antara ketiga kombinasi teh putih dan jahe dan tidak berbeda signifikan pada rata-rata kadar asam galat. Rata-rata kadar katekin, EGCG, asam galat, dan kafein tertinggi ditemukan pada perlakuan P3 dengan kadar masing-masing senyawa tersebut secara berurutan sebesar 0,645±0,060%, 2,140±0,195%, 0,164±0,049%, 1,861±0,122%. Perlakuan P3 merupakan perlakuan terpilih dalam pengembangan produk teh putih dan jahe dikarenakan memiliki kadar katekin, EGCG, asam galat, dan kafein tertinggi.
Compliance level difference of tele-exercising obese office employee on body weight and body fat Kuswari, Mury; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Dewi, Mira; Gifari, Nazhif
Journal Sport Area Vol 7 No 2 (2022): August
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2022.vol7(2).8917

Abstract

The problem of overnutrition and obesity tend to increase year by. Office employee are susceptible to physical inactivity and obesity. In context of current pandemic, exercising via online media, termed ‘tele-exercise’ may be an effective alternative intervention. However, the effect of compliance and timing of exercise on overall health-related output are still not often discussed. The purpose of the study is to compare the effect of tele-exercise done during working hours vs. after working hours on obese office employee’s weight loss and improvement of body fat percentage, as well as their relation to compliance level. The design of this study is quasi-experimental design, with obese office employee as participants, which then grouped into after work exercise (AW, n = 36, 1-hour duration) and mid-work exercise (DW, n = 21, 30-minute duration). Total sampling was used since the target population were under 100 people. Exercises were done 3 times/week for 12 weeks. Data collected were sample characteristics, bodyweight, and percentage of body fat. Both timing of intervention is effective on reducing body weight significantly (p<0.05). Significant reduction (p<0.05) on percentage of body fat is only occurring in DW group. Compliance level for AW and DW group are 63.75% and 61.23%, respectively, and being insignificant to each other (p>0.05). The contribution of compliance in shorter exercise/DW on body fat loss and weight loss is 23.1% and 20.9%, respectively; while the contribution of compliance in longer exercise/AW is 11.3% on body weight loss. A short, mid-working exercise have the similar or even better effect than 1-hour after-work exercise session on weight loss and body fat loss. We recommend tele-exercising during working hours for at least 30 minutes to achieve significant body weight and body fat loss.
Phytochemical evaluation and antidiabetic potential (In silico) of corn silk (Zea mays L.) and jasmine (Jasminum sambac) Bohari Bohari; Rimbawan Rimbawan; Zuraidah Nasution; Ekowati Handharyani
AcTion: Aceh Nutrition Journal Vol 10, No 4 (2025): December
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i4.2931

Abstract

Diabetes mellitus is a significant global health challenge, necessitating the exploration of novel therapeutics from natural sources for its treatment. This study aimed to identify the bioactive compounds in a combinatorial methanolic extract of corn silk (Zea mays L.) and jasmine flowers (Jasminum sambac) and predict their antidiabetic potential. The extract was analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). The identified compounds were evaluated in silico via molecular docking simulations against key antidiabetic protein targets: Glucagon-Like Peptide 1 (GLP-1), Insulin-like Growth Factor 1 (IGF-1), Glucose Transporter 4 (GLUT4), alpha-glucosidase, and superoxide dismutase (SOD). The analysis focused on the binding energy (ΔG). A total of 44 metabolites were identified in this study. Molecular docking results indicated that rothindin exhibited the highest binding affinity for GLUT4, with a binding energy of -9.9 kcal/mol. Rothindin and Chlorogenic Acid also showed significant potential as modulators of GLUT4 and α-glucosidase, respectively. In conclusion, the combined extract contains bioactive compounds, particularly roxindin and chlorogenic acid, which demonstrate significant in silico potential as antidiabetic agents.
Co-Authors Adi Teruna Efendi Adi Teruna Effendi Adi Teruna Effendi Adi Winarto Agustino Agustino Ahmad Sulaeman Ainia Herminiati Ainia Herminiati Ainia Herminiati Ali Khomsan Angga Rizqiawan Anna Vipta Resti Mauludyani Aprinia Dian Nurhayati Ascobat, Purwantyastuti Asep Rusyana Aslis Wirda Hayati Astuti Lamid Aya Yuriestia Arifin, Aya Yuriestia Azizi, Elsa Carla Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto Betty Yosephin Simanjuntak Bibi Ahmad Chahyanto Bohari Bohari Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Cassandra Permata Nusa Cesilia M Dwiriani Clara M. Kusharto Clara Meliyanti Kusharto Dadan Rohdiana Dadang Sukandar Damayanti, Rinda Daus, Firdaus Firdaus Deddy Muchtadi Deddy Muchtadi Deni Elnovriza DEWI APRI ASTUTI Dewi Kusumawati Dewi Kusumawati Diah M. Utari Diah M. Utari Diffah Hanim Dijaya, Rendy Dionysius Subali Dodik Briawan Drajat Martianto Egayanti, Yusra Ekowati Handharyani Ekowati Handharyani Elisa Diana Julianti Emma S Wirakusumah Ennita Fahriza Eny Palupi Eva Susanti Evi Damayanthi Evy Damayanthi Faisal Anwar Fajriaty, Deannisa Febrina Sulistiawati Fifi Retiaty Firdaus Firdaus Firdaus Firdaus Fitrah Ernawati Fitrah Ernawati Fivi Melva Diana, Fivi Melva Gifari, Nazhif Hadi Riyadi Haerati, Nur Hardiansyah, Angga Hardinsyah Harianti, Rini Harianti, Rini Hidayat Syarief Hidayat Syarief Himarwan, Aditya I Gusti Bagus Wiksuana I.Wayan T.Wibawan, I.Wayan Ika Heri Kustanti Ikeu Ekayanti Ikeu Tanziha Ikue Ekayanti Ilmi Dewi Astuti Ilmi, Ibnu Malkan Bakhrul Indhira Shagti Iswahyudi Iswahyudi ITA DJUWITA Katrin Roosita Khaerul Fadly Kharisma Tamimi Kresandra, Anastasha Laeli Nur Hasanah Latifah Darusman Latifah K Darusman Latifah K. Darusman Leily Amalia Leily Amalia Furqon Lidwina Lidwina Lilik Kustiyah Linar Zalinar Udin Lubis, Anwar M. Muslim MADE ASTAWAN MARIA BINTANG Mauludiya, Putri Nur Mira Dewi Mohamad Rafi Muhamad Rizal Martua Damanik Muhammad Aries Muhilal ., Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Mukhlidah Hanun Siregar Mulya Agustina Mury Kuswari Muti'ah Mustaqimatusy Syahadah Nasir, Syifa Qolbiyah Nasution, Zuraidah Naufal Muharam Nurdin Ni Ketut Sutiari Ni&#039;ma Hilyatin Noviana, Astrid Novitasari, Putri Nunung Nurjanah Nur Indrawaty Lipoeto Nurhidayati, Nuzuliyati Nuri Andarwulan Pertiwi, Fenti Dewi Picauly, Intje Pipih Suptijah Purwantyastuti Ascobat Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Puspo Edi Giriwono Putra, Felicia Kartawidjaja Putri Puncak Anjani Rahman, Dewi Rahmayani Rakhmawati FKR Ratu Diah Koerniawati Reisi Nurdiani, Reisi Resita Nurbayani Restu Pertiwi Rian Adi Pamungkas Riana, Nidya Ulfah Rini Kurniasih, Rini Rizal M Damanik, Rizal M Rosyanne Kushargina Rusyda, Akifa Laila Safitri, Debby Endayani Sari, Eny Kurnia Seprianto Siti Madanijah Sri Anna Marliyati Sri Hartati R. Suradijono Sri Nur Amalia Sri Purwaningsih Sri Sumarmi Sri Wahyu Angga Dewi Subangkit, Mawar Sudjana Sibarani Suryana, Suryana Susi Desminarti Susi Nurohmi Susilawati, Esih Sutrisna, Aang SYAHRIAL SYAHRIAL Syartiwidya, Syartiwidya Tande, Ribka TATI NURHAYATI Tresnanda, Muhammad Nawaf Trini Suryowati, Trini Tunggul Waloya Umam, Hafizul V Prihananto Vetnizah Juniantito Warisanti, Dira Wiwin Winarsih Yunianto, Andi Eka Zakiudin Munasir Zakiudin Munasir Zuraidah Nasution