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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Sari Pediatri Jurnal Kesehatan Komunitas Journal of Maternal and Child Health JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Katalisator B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Buletin Ilmiah Nagari Membangun Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Andalas obstetrics and gynecology journal Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Health Sciences Research and Development (IJHSRD) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks International Journal of Science and Society (IJSOC) Indonesian Journal of Multidisciplinary Science Jurnal Ilmu Kesehatan Indonesia (JIKSI) Andalas Dental Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy International Journal of Advanced Science Computing and Engineering Jurnal Penyakit Dalam Indonesia Medika: Jurnal Ilmiah Kesehatan Jurnal Riset Ilmiah Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran JIDAN (Jurnal Ilmiah Bidan) Stikes Pelita Ilmu Depok
Andani Eka Putra
Fakultas Farmasi Universitas Andalas
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Journal : Indonesian Journal of Multidisciplinary Science

 1 
The Efficacy of Application of Oral Antibiotic Loaded Polymethyl Methacrylate Against Staphylococcus aureus Rahmadian, Rizki; Edison, Ebill Fuji; Kaharudin, Kaharudin; Irrahmah, Miftah; Putra, Andani Eka
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 9 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i9.543

Abstract

Chronic osteomyelitis is still common in the developing world and presents a continuing therapeutic challenge. Local antibiotic therapy is performed as the first stage treatment algorithm for 4 to 8 weeks. Given the high patient morbidity, mortality, and economic burden caused by osteomyelitis and its treatment, it is important to find another effective and efficient treatment.  Intravenous antibiotics and polymethylmethacrylate (PMMA) combination have shown effectiveness, but the potential of oral antibiotics and PMMA combination is still rare and is debatable. It aimed to compare efficacy among oral antibiotic-loaded PMMA in many concentrations (5%, 10%, 20%) and controls (0%) against Staphylococcus aureus. This experimental study was conducted in the Microbiology Department of Andalas University. The object was S. aureus. We used ten oral antibiotics and compared among its many concentrations (5%, 10%, 20%) and controls (0%).  Data were analyzed by analysis of variance (ANOVA) test. The lowest counts of S. aureus were found in ciprofloxacin 20%, followed by tetracycline 10%, erythromycin 5%, rifampicin 10%, ofloxacin 20%, clindamycin 20%, amoxiclav 20%, cefixime 5%, cotrimoxazole 20%, and chloramphenicol 20% consecutively. All oral antibiotics loaded PMMA in each concentration might reduce the number of colonies up to 90%. A study in 2013 revealed that a combination of several antibiotics and PMMA was proven to be effective. The oral antibiotics loaded PMMA in various concentrations have a significant bactericidal effect on the growth of S. aureus and able to reduce the number of S. aureus.
Co-Authors - Johan Abdiana Abdiana, Abdiana Adang Bachtiar Ade Asyari Afida Razuna Ave Afrizal Agustian, Dede Rahman Aisyah Elliyanti Akmal Djamaan Alioes , Yustini Amelin, Fitrisia Amirah Zatil Izzah Amrin Alkamar Anavelda, Aura Putri Annisa Widi Rizkia Antonius, Puja Agung Arfai, Arfai Arfiandi Arfiandi Ariani, Tutty Arni Amir Arni Amir arniamir, Arni Amir Asri, Ennesta Bari'ah, Puti Asma Basyir, Vaulinne Besri, Hanifa Zahra Bobby Indra Utama Cimi Ilmiawati, Cimi Darfioes Basir Deddy Saputra Dede Agustian Rahman Defni, - Defrin, Defrin Delfican Delfican Delfilaura, Asyifa Delmi Sulastri Densi Selpia Sopianti Densi Selpia Sopianti Desmawati Desmawati Dessy Arisanty Desy Nofita Sari Djanas, Dovy Edison, Ebill Fuji Efrida Efrida Eka Fithra Elfi, Eka Fithra Elizabeth Bahar Elizabeth Bahar Elmatris Sy Eryati Darwin Eti Yerizel Fahma, Siskalil Farashanda, Meysha Farras, Umar Al Fathiyyatul Khaira Fauzul Azhim Febrianti, Ika Kurnia Feby Resicha Fenty Anggraini Finny Fitry Yani Fiona Dewanti Firdawati, Firdawati Fitri Anggraini, Fitri Fitri Nova, Fitri Fitri, Azdiana Fitrina, Dewi Wahyu Gardenia Akhyar Gestina Aliska Hafni Bachtiar Hanif, Monica Mulnia Hanif, Rayhendra Hardisman Hari, Dewi Gulyla Hasmiwati Haviz Yuad Haviz Yuad Helmizar Hermawan, Budi Junio Hidayanti, Rahmi Husna Yetti Husna, Annisa Tamara Husni Husni Ida Parwati Ika Kurnia Febrianti Ilmiawati, Ilmiawati Irrahmah, Miftah Irvan Medison Jamsari Jamsari Kaharudin Kaharudin Kaisar , Kevin Florentino Kosno Suprianto Leona, Denada Florencia Linosefa Linosefa Linosefa Liza Fitria M. Alfian Agustian Mahata, Liganda Endo Malinda Meinapuri Marlina . Megariani Megariani Menkher Manjas Mentari Faisal Putri Mila Permata Sari Muhammad Rayhan Firdaus Muhammad Reza Nelmi Silvia Netti Suharti Netti Suharti, Netti Nia Ayuni Putri Nila Kasuma Novita Ariani Nur Indrawaty Lipoeto Nur, Yuliati Shafan Nurhayati, Nurhayati Oky Masir Prima Indra Putri Rizki Fitriani Putri, Mentari Faisal Rahmadian, Rizki Rahmat Syawqi Rahmi Lestari Rahmi, Wahida Ramadhan, Mario Arya Ranne Balqis RAVEINAL RAVEINAL Rheta Elkhaira Rinang Mariko Rinang Mariko Rita Hamdani Rizanda Machmud Rosfita Rasyid Roslaili Rasyid Roza Sri Yanti Russilawati, Russilawati Rustini Rustini Salmiah Agus Salmiah Agus Saptino Miro Sary, Rizka Yulia Sef Zani Meria silviayolanda, Silvia Yolanda Sinai, Nadiva Kezia Sosmiarti, Sosmiarti Sriyanti, Roza Suharti , Netti Suzana Devi Syahrul, Muhammad Zulfadli Syamel Muhammad Tarigan, Herri Novita Taufiqulhakim, Muhammad Rafi Tresnaningtyas, Sekar Asri Tri Anggraini, Fika Tyas, Syanindhita Wikanthining Utama, Bobby Indra Utami, Refi Amalia Wahyu Zikra Wahyuni, Yosha Putri Wenny Nursa Octarina Wiwik Andriani Yefri Zulfiqar Yessi Widya Putri Yuad, Haviz Yufri Aldi Yufri Aldy Yusri Dianne Jurnalis