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Muhammad Fajar
Halu Oleo University
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Journal : Global Medical and Health Communication

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Effect of Ketapang Leaf Extract on HDL Levels of Rattus norvegicus Induced by High-fat Foods Nurfadly, Nurfadly; Fajar, Muhammad; Thristy, Isra; Yenita, Yenita
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14070

Abstract

High-density lipoprotein (HDL) functions to transport cholesterol from the blood vessel endothelium to the liver and excreted through the digestive tract so that it does not cause dyslipidemia, which is a risk factor for cardiovascular disease. Current treatment for dyslipidemia uses long-term statin drugs, which can cause various side effects, so herbal alternatives such as ketapang leaves (Terminalia catappa L.), which contain flavonoids and have the effect of increasing HDL levels, needed to be evaluated to achieve that reason. This study aims to evaluate whether ketapang leaf extract has an effect on increasing blood HDL levels. This research used experimental animals with a pretest and a posttest with a control group design. It was conducted at the Biochemistry Laboratory and Laboratory Animal Management Unit, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Medan, from September to December 2023. This study used Wistar strain male white rats (Rattus norvegicus) that were induced on a high-fat diet, divided into five groups: negative control, positive control (given simvastatin), treatment 1 (given 21 mg/kgBW ketapang leaf extract), treatment 2 (given 42 mg/kgBW ketapang leaf extract) and treatment 3 (given 84 mg/kgBW ketapang leaf extract). The study results showed a significant difference (p<0.05) in the average HDL levels before and after treatment in the positive control, treatment 2, and therapy three groups. Thus, the study concluded that ketapang leaf extract affected increasing HDL levels of male white rats (Rattus norvegicus).
Effect of Ketapang Leaf Extract on HDL Levels of Rattus norvegicus Induced by High-fat Foods Nurfadly, Nurfadly; Fajar, Muhammad; Thristy, Isra; Yenita, Yenita
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

High-density lipoprotein (HDL) functions to transport cholesterol from the blood vessel endothelium to the liver and excreted through the digestive tract so that it does not cause dyslipidemia, which is a risk factor for cardiovascular disease. Current treatment for dyslipidemia uses long-term statin drugs, which can cause various side effects, so herbal alternatives such as ketapang leaves (Terminalia catappa L.), which contain flavonoids and have the effect of increasing HDL levels, needed to be evaluated to achieve that reason. This study aims to evaluate whether ketapang leaf extract has an effect on increasing blood HDL levels. This research used experimental animals with a pretest and a posttest with a control group design. It was conducted at the Biochemistry Laboratory and Laboratory Animal Management Unit, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Medan, from September to December 2023. This study used Wistar strain male white rats (Rattus norvegicus) that were induced on a high-fat diet, divided into five groups: negative control, positive control (given simvastatin), treatment 1 (given 21 mg/kgBW ketapang leaf extract), treatment 2 (given 42 mg/kgBW ketapang leaf extract) and treatment 3 (given 84 mg/kgBW ketapang leaf extract). The study results showed a significant difference (p<0.05) in the average HDL levels before and after treatment in the positive control, treatment 2, and therapy three groups. Thus, the study concluded that ketapang leaf extract affected increasing HDL levels of male white rats (Rattus norvegicus). DOI: https://doi.org/10.29313/gmhc.v12i3.14070
Co-Authors Abdul Husain, Muhammad Abdul Rachman Abdullah, Ramadhani Aditama, Wahyu Afrianus, Erya Afriyanti, Desi Ahmad Luviadi Ahmad Musadad Ahmad Syafiq Akhiriyanto, Khafid Akmal, Muhammad Luthfi Alamsyah, Vandria alfira, alfira aliyah, faridatul Andi Chairil Ichsan Andrew Andrew, Andrew Andung Dwi Haryanto Angel Angel Anggraini, Nabila Aprida, Dini Ardo, Okilanda Ariffianto, Ony Arizal Eka Putra Armada, Ari Astuti, Putri Widiya Atmaja, Sigit Tri Azzahra, Bela Barkah, Lia Basorudin, Muhammad Bastoni, Bastoni Burhanurobbi, Irsyad Catherine, Ester Sara Clausthaldi, Fadhil Rizki Dian Syahfitri dila, farra Dillena, Kennith G.C. Fahmi Fahmi Fahmi Fahmi Faizah, NM Fajariyanto, Eko Fath, Muhammad Thoriq Al Fauyan, Muchamad Fauziah, Tiara Dilla Fazri AR, M. Rizal Ferdi, Muhammad Fitri Dian Perwitasari Fitri, Anisa Fratama Putra, Gimel Gunawan, Muhammad Isral Hajriani, Meilisa Halomoan, Abdul Hammam, Hammam Hamonangan, Jefri Abner Hardi, Rudi Hardiawanto, Pangestu Pradana Hasibuan, Gina Cynthia Raphita Herfia Rhomadhona Herman Nauwir Hermanzoni, Hermanzoni Hery Fajeriadi Hidayat, Kurnia Hudatwi, Mu'alimah Irawan, Yeyen Gustina Iriana, Nona ISLAMUL HADI Isma, Khilyatul Ismawati Ismawati Isra Thristy IZZAH, NURUL Jannah, Eneng Raudatul Jirana M , Nurul Juli Sardi Juliandra, Galih Juliandri Juliandri Kamil, Muflichan Karo Karo, Panser Kartika, Linda Khairul Anwar Hafizd, Khairul Anwar Khairunnisa, Nanda Khoirun Nasik Kustini, Rini Lubis, Apdi M. Rusydi Alwi M. Shoim Anwar, M. Shoim M. Sholihin M.Rizkal Fajri Manalu, Okto Dewi Sartika Manurung, Wahyudi Mardela, Romi Mardiah Astuti Mariska, Okky Maslachah, Cholilatul Mawansa, Akri Mayang Sari Mochamad Susantok Mu'affan, Muhammad Muhammad Hendra S Ginting Muhammad Muslim Muhammad Nurkholis Kholik Muhlisin, M Mustofa Mustofa Nasution, Dea Amanda Sari Nasution, Juan Akmal Nelvia Iryani Nisa, Nachdiatun Nofirda, Fitri Ayu Noviar, Noviar Nugroho, Anggi Septia Nur Azizah Nur Khaerah, Nur Nur Sakinah Nurfadly, Nurfadly Nurjannah Nurjannah Nurwandi, Rhefky Al Jihad Nuryaman Nuryaman OKTARIA, RINA RINA Pangkung, Andreas Parwati, Tri Ayu Pinindriya, Sinung Tirtha Pranidya, Cici Dwi Prayitno, Hendro Putra, Muhammad Amril Pratama Qawly, Hafiz Iftitah Rachmad, Sri Hartini Rahmadita, Nurmalia Rahmati, Pramita Dwi Ramadhan , Oktaviandi Ramadhan, Puji Sari Ramadhan, Rian Ramadiansyah, Mohamad Luthfi Ramaiyulis, Ramaiyulis Rici, Suchi Avita Rif’iyati, Dian Risma Apdeni Robbani, Hamdan Thufail RR. Ella Evrita Hestiandari Sadiqin, Ikhwan Khairu Safitri, Anggi Said, Awayundu Salvia Salvia Santoso, Ismawardi Septiana, Elyza Setiono, Michael Alvin Shintarahayu, Balqis Shofariyani, Shobah Siahaan, Muhammad Donni Lesmana Sidabutar, Rivaldi Soemaryanto, Arifin Rasyadi Sofiana, Elda Suhaila Husna Samosir Suparintina, Lucie Suri, Puti Andam Suryana, Icha Suryati Suryati Sya'ban, Muhammad Fuad Syahputra Mahmud, Surya Syahputra, Afit Syahputri, Astri Syarifuddin, T. Syubhan Annur, Syubhan Tanjung, Nanda Umroh Umroh Vega, Amelia Vira Noviana, Karisma Wibisono, Okki Navarone Wulandari, Meisy Yenita . Yudha Irhasyuarna Yuliana Sari Yumna, Isna Aulia Zahro, Umi Indasyah Zulkarnain, Akhmad