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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Mathematical and Fundamental Sciences Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Mandala Education (JIME) Jurnal Farmasi Indonesia JISIP: Jurnal Ilmu Sosial dan Pendidikan JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia ADI Journal on Recent Innovation (AJRI) Health Information : Jurnal Penelitian Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Katalisator Majalah Cendekia Mengabdi Journal of Pharmaceutical and Sciences. Journal of Health Management and Pharmacy Exploration (JOHMPE) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharma Bhakta International Journal of Contemporary Sciences (IJCS)
Gunawan Pamudji Widodo
Universitas Setia Budi
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Pengaruh Pemberian Ekstrak Etanol Herba Anting-Anting (Acalypha indica) terhadap Ekspresi GLUT 2 pada Pankreas Tikus Diabetes Toding, Ficanata Adhiguna; Islamiati , Utami; Wulandari, Ayu; Nugroho , Agung Endro; Widodo, Gunawan Pamudji; Patala , Recky
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.597

Abstract

Background: Anting-anting herb (Acalypha indica L.) has been traditionally known for its antidiabetic properties. Its mechanism of action is presumed to involve the regeneration of damaged pancreatic β-cells; however, its effect on the expression of GLUT-2, a key glucose transporter in insulin secretion, remains to be further investigated. Objective: This study aimed to analyze the effect of ethanol extract of Anting-anting herb on GLUT-2 protein expression in pancreatic β-cells of Streptozotocin–Nicotinamide–induced diabetic rats. Methods: This laboratory experimental study used 25 male rats (Rattus norvegicus), randomly assigned into five groups: normal control, negative control (diabetes + 1% CMC), positive control (diabetes + glibenclamide 0.45 mg/kg BW), treatment 1 (diabetes + extract 100 mg/kg BW), and treatment 2 (diabetes + extract 200 mg/kg BW). Diabetes was induced intraperitoneally with Streptozotocin (50 mg/kg BW) and Nicotinamide (110 mg/kg BW). The treatments were administered orally for 14 days. GLUT-2 expression in pancreatic tissue was quantitatively analyzed using immunohistochemistry, and protein density was measured with ImageJ software. Data were analyzed using one-way ANOVA. Results: Phytochemical analysis revealed that the extract contained flavonoids, tannins, saponins, and steroids. The group treated with 200 mg/kg BW extract showed a significant increase in GLUT-2 protein density (11,608,400 molecules/µm²) compared with the negative control group (5,074,533 molecules/µm²) (p < 0.05). This value was even higher than that of the positive control (glibenclamide), which showed a density of 10,626,864 molecules/µm². Conclusion: Administration of ethanol extract of Anting-anting herb at a dose of 200 mg/kg BW significantly increased GLUT-2 expression in pancreatic β-cells of diabetic rats. This enhancement is strongly presumed to contribute to the antidiabetic mechanism of Anting-anting herb.
Evaluation of the drug management system at the pharmaceutical supplies installation of the Tegal City Health service in 2019 Wibawa, Anggun Setya; Widodo, Gunawan Pamudji; Iswandi, Iswandi
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2096

Abstract

Drug management involves a series of interconnected activities, including planning, procurement, receipt, storage, distribution, control, recording, reporting, disposal, monitoring, and evaluation. This study aimed to evaluate the drug management system, identify challenges and solutions, and assess its compliance with the 2010 Ministry of Health standards at the Pharmaceutical Supply Installation of the Tegal City Health Office. A descriptive design was used, with retrospective data collected from 2019 documents. Primary data were obtained through direct observation and in-depth interviews to identify obstacles, while secondary data were sourced from drug management records based on ten indicators and compared with the 2010 standards. The results revealed several discrepancies: in the planning stage, drug conformity with the Fornas Level I reached 92.54% and planning accuracy was 184.22%; in procurement, drug availability was 92.04%, generic drugs 88.97%, and budget allocation 98.14%. Storage met standards, with 0% expired or damaged drugs. In distribution, the proportion of drugs in the safe category was 46.27% and average stock-out duration was 27.40%, while distribution accuracy reached 100%. Key challenges include the presence of non-Fornas drugs, disruptions in the e-logistics reporting system, and procurement delays due to an underdeveloped e-catalogue system. Recommended solutions include regular training for drug management staff, improved coordination with the TPOT team based on clinical and pharmacoeconomic considerations, and the addition of pharmacist personnel.
Uji Kualitas Hidup Pasien Post Vaksinasi Covid-19 Dengan Pendekatan SF 36 Dan SF 12 endey, joverly; Widodo, Gunawan Pamudji; Dewi, Lucia Vita Inandha
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.482

Abstract

Pesantnya penyebaran COVID-19 dan bahaya yang akan muncul jika tidak segera ditangani maka salah satu cara yang sangat mungkin untuk mencegah penyebaran virus ini adalah dengan mengembangkan vaksin. Namun, vaksinasi COVID-19 menimbulkan beberapa efek samping jangka panjang dan jangka pendek. Penelitian ini bertujuan untuk mengetahui gambaran sosiodemografi pada pasien pasca vaksinasi COVID-19, gambaran kualitas hidup dengan pendekatan SF 36 dan SF-12, serta membandingkan keduanya. Penelitian ini merupakan desain penelitian deskriptif non eksperimental dengan rancangan cross-sectional. Penelitian ini dilakukan di Puskesmas Kecamatan Banjarsari, Kota Surakarta. Penelitian dekstriptif menggambarkan kualitas hidup masyarakat pasca vaksinasi COVID-19 yang terjadi di Puskesmas Kecamatan Banjarsari, Kota Surakarta. Karakteristik responden penelitian didominasi pasien laki-laki sejumlah 46 pasien (51,69%) dengan kategori umur 17-24 tahun (Remaja Akhir) 42 pasien (47,19%), pendidikan terakhir SMA 47 pasien (52,81 %), status pernikahan belum menikah 51 pasien (57,30%), status pekerjaan pegawai swasta 30 pasien (33,71%), tingkat penghasilan lainnya di luar rentang UMR (1,9 juta) – 3,5 juta sebanyak 40 pasien (44,94% ) dengan mendapatkan vaksin booster pada bulan Februari 2023 77 pasien (86,52%). Kualitas hidup pasien pasca vaksinasi booster COVID-19 dengan kuesioner SF-36 diperoleh hasil kategori baik sebanyak 62 pasien (69,66%). Kualitas hidup pasien pasca vaksinasi booster COVID-19 dengan kuesioner SF-12 diperoleh hasil kategori baik sebanyak 67 pasien (72,28%). Tidak ada perbedaan hasil antara Kuesioner SF-36 dan SF-12 karena hasil dari pengukuran kualitas hidup pasien pasca vaksinasi booster COVID-19 masuk kategori baik dengan nilai Mann Whitney sig. 0,671 > 0,05.
FORMULATION ANTIAGING CREAM MELASTOMA MALABATCHRICUM EXTRACT WITH POLYOXYETHYLENE MONOSTEARATE AND STEARIC ACID Mukti, Yusuf Anggoro; Gunawan Pamudji Widodo; Teuku Nanda Saifullah Sulaiman
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3045

Abstract

Karamunting fruit (Melastoma malabathricum L.) contains flavonoids, triterpenoids and tannins. The purpose of this study was to make anti-aging cream preparations using caramunting fruit extract with a combination of PEG 40 stearic acid and stearic acid to obtain optimum physical quality. Extract with 96% ethanol filter in the form of extracts used for cream preparations using a base of PEG 40 stearic and stearic acid, so that 8 formulas were obtained, then optimized based on the physical quality parameters of viscosity, spreadability, adhesion and pH, then optimization of the formula to determine the formula optimum using the Simplex Lattice Design method. The conclusion obtained based on this research is the optimum combination of PEG 40 stearic and stearic acid in the cream of caramunting fruit extract using the Simplex Lattice Design method, namely PEG 40 Stearate 4.76% and stearic acid 15.74%. The physical quality stability did not change during one month of storage and the cream did not cause irritation. Formula I had a better and almost equal effect on the collagen test while formula V had a better effect on the elasticity test and the moisture test.
Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Fitrianingsih, Sri; Widodo, Gunawan Pamudji; Marlina, Dian
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

Abstract

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).
Improvement Strategy for Procurement Using the Hanlon Method at the Public Health Centers in Kediri Prasetyawan, Fendy; Widodo, Gunawan Pamudji; Purwidyaningrum, Ika
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7254

Abstract

Public Health Center (PHC) was a health center that needed and demanded by the community, accordingly availability and quality of medicines at PHC should met the needs. Purpose of this study were to determine the level of conformity and specify selection and procurement strategies for pharmaceutical service standards in Kediri's PHC based on priority scale of problem using Hanlon analysis. Design of this study was a non-experimental study, with data were analyzed quantitative and qualitative, collected using questionnaire instrument by conducting interviews, while results of this study was data in the form of counting results from respondent’s answers. The research results indicate that the procurement compliance level at the Public Health Centers in Kediri City has one problematic indicator, namely the percentage of procurement compliance with the actual usage for each drug item. Meanwhile, three indicators that are in compliance include the frequency of procurement for each drug item, the frequency of invoice errors, and the frequency of delayed payments by Puskesmas in relation to the established timelines.
Evaluation of Drug Management at the Pharmacy Installation of "X" Regency Health Office Indonesian in 2021 Naha Ndjurumbaha, Echa Malinda; Gunawan Pamudji Widodo; Ismi Rahmawati
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 5 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i5.357

Abstract

Improving public health status can be influenced by the drug management process, one of the components of which is the availability of good drugs. This study aimed to find out the overall process description of drug management, which includes the planning, procurement, storage, and distribution stages, as well as to know the evaluation of drug management related to compliance with the indicators of the Ministry of Health of the Republic of Indonesia & JICA 2010. This study used a type of research descriptive data collection with retrospective and concurrent. Data analysis was carried out by explaining the drug management process at the "X" Regency Health Office, measuring the value of each drug management indicator, and then making a problem-solving based on the Hanlon method. The results of the evaluation of drug management at the Pharmacy Installation of the "X" Regency Health Office were the suitability of the available drug items with the Fornas of 54%; percentage of fund allocation procurement drugs by 93%; percentage suitability of drug planning and procurement by 73%; the percentage of drug planning accuracy is 84%; percentage and value of expired drugs by 8% worth Rp. 39,888,756; The accuracy of drug distribution is 94%; drug availability12-18 months of 94%; and the percentage of drug blanks is 2%. Some indicators are not up to standard, so improvements are made using the Hanlon method.
Effectiveness of Extract and Fraction of Robusta Coffee Beans (Coffea Canephora) Against Streptozotosin-Nicotinamide Induced Blood Glucose Levels of Male White Mice Oklyan, Risny; Wijayanti, Tri; Widodo, Gunawan Pamudji
Journal of Health Management and Pharmacy Exploration Vol. 4 No. 1 (2026): February 2026
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v4i1.640

Abstract

Robusta coffee bean have compounds flavonoids, alkaloids, saponins and tannins. This compound has the benefit of being an antihyperglycemic which plays a role in inhibiting absorption glucose, preventing the formation of AGEs chains, and increasing the activity of antioxidant enzymes. This research aims to determine the effectiveness of the robusta coffee bean fraction which is effective in reducing blood glucose levels in STZ-NA induced mice. Research conducted is experimental research. Using 30 mice aged 2-3 months with a body weight of 18-25 g and grouped into 6 groups, that is group I negative streptozotocin 5.6 mg/kg weight and nicotinamide 15.4 mg/kg weight, group II positive control was given glibenclamide 0.65 mg/kg weight, Group III was given robusta coffee bean extract 400 mg/kg weight Group IV was given the n-hexane fraction of 42 mg/kg weight, group V was given the ethyl acetate fraction of 38 mg/kg weight, group VI was given the water fraction of 216 mg/kg weight. The data has been analyzed and after 21 days of observation it was found that the ethyl acetate fraction and robusta coffee bean extract decreased blood glucose levels the same as the decrease in blood glucose levels in the positive group test.
REVIEW OF PHARMACOLOGY ACTIVITY JOURNAL CLABET SEEDS (Trigonella foenum graceum L) Sukoharjanti, Bintari Tri; Widodo, Gunawan Pamudji; Purwidyaningrum, Ika Ika
Majalah Farmaseutik Vol 22, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i1.116310

Abstract

Biji klabet nama latin Trigonella foenum graecum L. Tanaman yang telah banyak diteliti mengenai manfaat dalam bagian tumbuhannya, terutama bagian biji. Tinjauan ini bertujuan memberikan informasi data ilmiah berbagai aktivitas farmakologi. Metode yang digunakan adalah literature review untuk mengetahui aktivitas farmakologi biji klabet dengan menggunakan tinjauan pustaka (literature review) Kriteria inklusi-eksklusi, search engine dan kata kunci juga ditetapkan sehingga diperoleh hasil studi yang relevan. Pada tinjauan ini data primer dikumpulkan dengan secara online, berupa jurnal nasional maupun jurnal internasional.Hasil kajian yang didapatkan dari beberapa jurnal dan sumber lainnya dapat diungkap potensi biji klabet memiliki kandungan senyawa kimia yang terdapat didalam biji klabet antara lain kuersetin (flavonoid), 4-dihidroksiisoleusin (asam amino), trigonillin (alkaloid), diosgenin (saponin). Biji klabet bisa dimanfaatkan sebagai obat herbal, juga memiliki aktivitas sebagai antidiabetes, antioksidan, antiinflamasi, antikanker, dan antibakteri. Kata kunci: Trigonella foenum graecum L, Aktivitas Farmakologi, Review
Co-Authors Abdul Mahmud Yumassik abdul rofiq Achmad Fudholi Achmad Fudholi Ade Sukma Hamdani Adrianto, Madyo Agnes Christina Budiwati Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Andayani, Tri Murti Aneng Ardiya Sukmawanti Anggun Setya Wibawa, Anggun Setya Arief Nurrochmad arikha ayu susilowati Arisma Nuri Pebryana Aslam, Astri Asri Laksmi Riani Asri Laksmi Riani Astri Aslam Aswandi Aswandi Ayu Wulandari Ayudia Cipta Khairani BETA K. PRAMUDYAWARDHANI Chairun Wiedyaningsih Chandra Arifin Clara Ritawany Sinaga Dan Mona Aprilia Daniel Maharai Daniel Maharai Dedent Eka Bimmaharyanto.s Dewi, Lucia VIta Inandha Dian Marlina Dini Okyaviani Dwi Ningsih Eko Yudha Prasetyo Elin Yulinah Sukandar Elina Endang Sulistyowati Endang Diyah Endang Diyah Endang Dyah Ikasari endey, joverly Ercis Ercis Ercis, Ercis Fauziyyah Al Hasanah Fendy Prasetyawan FEOLISTIN MIENCE POBAS Ferdinan Jalung Ferdinan Jalung Fitrianingsih, Sri Fridly Manawan Gunawan Firmansyah Gusti Ayu Rai Saputri Handayani, Sri Rejeki Handi Mukti Fahrizal Handi Mukti Fahrizal Haris Maspekeh Hartih, Nur Aeni Hartono Hartono Hasbrianti, Armayanti Rindiarko Hastuti, Nita Hasty Martha Wijaya Hierowat, Rina Humaidah, Daffa I Ketut Adnyana Ika Purwidyaningrum INDRAWATI FITRIANA Irmatika Hendriyani Islamiati , Utami Ismi Rahmawati Isna Nur Khasanah Iswandi Iswandi Iswandi Iswandi Ittiqo, Dzun Haryadi Iwan Yuwindry Jason Merari Peranginangin Junagsti Bermalam Kartini Nur Wulandari Latief, Aprilianti A. Lestari, Rizkia Putri Madyo Adrianto Madyo Adrianto Mamik Ponco Rahayu MARIA E.D.O. HUREK MAKING MARIA YANGSYE LENGGU Marlina, Dian Milda Rianty Lakoan Milda Rianty Lakoan Muhamad Aulia Putra Tawakal Muhammad Syukri Mukti, Yusuf Anggoro Naha Ndjurumbaha, Echa Malinda Noval Noval Noval Noval Nugroho , Agung Endro Nugroho Wisnu Putro Nur Aeni Hartih Nuraini Harmastuti NURAINI HARMASTUTI Nuraini Harmastuti Oetari Oetari Oetari Oetari Pare, Nurdiana Tandi Poppy Dwi Citra Jaluri Purwidyaningrum, Ika Ika Puspitasari, Ismi R, Herowati R., Wirdah Wati R.A. Oetari R.A. Oetari R.A. Oetari, R.A. Rahmadani . Rahmawati, Ismi Ranowijaya Ranowijaya Recky Patala Rika Arfiana Safitri Risny Oklyan Rosa Juwita Hesturini Ruly Anggrayni Safwan Safwan, Safwan Santi Dwi Astuti Satibi Satibi . Satibi Satibi Satibi Satibi Satibi Satibi Siswanto, Didik Sri Fitrianingsih Srini, Dwi Sukoharjanti, Bintari Tri Sukrasno Sukrasno Suryono Suryono Teodhora, Teodhora Teuku Nanda Saifullah Sulaiman Theedens, Maria Theodora Toding, Ficanata Adhiguna Tri Murti Andayani Tri Murti Andayani Tri Wijayanti Tri Wijayanti Valiandri Puspadina Wahdah, Rismaul Wahid, Abdul Rahman Widayatul Khairi Widia Wati Widyasti, Jena Hayu Windi Astuti Wirdah Wati R. Yeli Trimayanti Yul Mariyah Yuwindry, Iwan Zamzani, Irfan