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All Journal Jurnal Gizi dan Pangan Jurnal Kesehatan Andalas Riau Journal of Computer Science Sari Pediatri Paediatrica Indonesiana MUDRA Jurnal Seni Budaya Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Pendas : Jurnah Ilmiah Pendidikan Dasar Indonesian Journal of Obstetrics & Gynecology Science Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Kesehatan Komunitas Indonesia Jurnal Katalisator Jurnal Penyakit Dalam Indonesia RJOCS (Riau Journal of Computer Science) Jurnal Sains, Teknologi dan Kesehatan Jurnal Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan Indonesian Journal of Global Health Research
Efrida Efrida
Bagian Patologi Klinik Dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Interleukin-18 and Procalcitonin Factors as Predictors of Early-Onset Neonatal Sepsis Devi Gusmaiyanto; Efrida Efrida; Hardisman Hardisman; Mayetti Mayetti
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.517

Abstract

Neonatal sepsis is a leading cause of morbidity and mortality worldwide, and one of the most common causes of neonatal death (15%). Early-onset neonatal sepsis (ESNAD) has a higher case-fatality rate than late-onset neonatal sepsis (SNAL). The gold standard for neonatal sepsis diagnosis is bacterial detection through blood culture, but this test has limitations such as being time-consuming and not being available in all health facilities. This study aims to determine the relationship between perinatal risk factors, hematological parameters in infants, procalcitonin, IL-18 with the incidence of SNAD. The population of this study were all babies who had risk factors for SNAD according to the PP Idai UKK Neonatology Clinical Practice Guidelines. The research sample was infants from an accessible population who met the inclusion and exclusion criteria. To fulfill statistical rules and fulfill the requirements for data analysis, in this study a minimum of 30 of each will be taken. The use of umbilical cord blood is a promising diagnostic tool in the diagnosis of SNAD. The IT and CRP ratios are elevated in umbilical cord blood from birth and are good indicators for detecting SNAD in infants at risk of infection. Umbilical blood procalcitonin is elevated in infants born >32 weeks with proven sepsis and low in infants with risk factors but without proven sepsis. Therefore, it is concluded that umbilical blood procalcitonin is a promising biomarker for detecting SNAD. IL-18 serves as a risk variable for neonatal sepsis. IL-18 has good discriminatory ability in the diagnosis of neonatal sepsis.
The Effect of Anesthesia on TGF-β Levels in Lung Tumor Patients Undergoing Bronchoscopy: A Literature Review Johannas; Efrida; Masrul Basyar; Eryati Darwin
Jurnal Kesehatan Komunitas Indonesia Vol 6 No 1: April 2026
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jkki.v6i1.713

Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide, with persistently low survival rates. Bronchoscopy is an essential diagnostic procedure in patients with lung tumors and often requires anesthesia to improve comfort and procedural success. Emerging evidence suggests that anesthetic agents and techniques may influence tumor biology through modulation of immune responses and inflammatory mediators. Transforming Growth Factor-Beta (TGF-β) is a multifunctional cytokine involved in cell proliferation, differentiation, immune regulation, and extracellular matrix remodeling, and plays a critical role in cancer progression. This literature review aims to evaluate current evidence regarding the effects of anesthetic agents and techniques on TGF-β levels and their implications for tumor biology in patients with lung tumors undergoing bronchoscopy. A narrative literature review approach was used to analyze scientific publications exploring the relationship between anesthesia, immune modulation, cytokine alterations, and cancer progression, particularly focusing on inhalational and intravenous anesthetics. Surgical stress and anesthetic exposure can alter immune responses through activation of neuroendocrine pathways, leading to cytokine imbalance and immunosuppression. TGF-β exhibits dual roles in cancer, acting as a tumor suppressor in early stages and a tumor promoter in advanced stages. Inhalational anesthetics may enhance tumor progression, whereas intravenous anesthetics such as propofol may have immunomodulatory effects. Anesthetic techniques may influence tumor-related pathways, including TGF-β; however, evidence remains limited and inconsistent, requiring further well-designed studies.
Hubungan Derajat Aktivitas LES dengan Kejadian Anemia di RS Dr. M. Djamil Alifah Amirah; Afdal Afdal; Dwitya Elvira; Efrida Efrida; Anggia Perdana Harmen; Zurayya Fadila
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1453

Abstract

Latar Belakang: Lupus eritematosus sistemik (LES) merupakan penyakit autoimun yang berhubungan dengan berbagai sistem tubuh dan berhubungan secara signifikan dengan morbiditas dan mortalitas. Anemia pada penderita LES banyak terjadi akibat penyakit kronis. Anemia dapat menggambarkan tingkat keparahan penyakit yang mendasarinya sehingga evaluasi terhadap derajat aktivitas penyakit, salah satu caranya dengan menggunakan MEX-SLEDAI dan status anemia pasien LES diperlukan untuk menentukan rencana pengawasan dan tatalaksana dari pasien tersebut. Objektif: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara derajat aktivitas penyakit dengan kejadian anemia pada pasien LES di RS Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian analitik dengan pendekatan cross-sectional menggunakan data sekunder dari rekam medik pasien LES di RS Dr. M. Djamil Padang dan derajat aktivitas penyakit didapatkan berdasarkan MEX-SLEDAI. Teknik pengambilan sampel dengan consecutive sampling dengan total 69 sampel. Analisis data yang dilakukan menggunakan uji Fisher’s Exact dalam SPSS versi 29. Hasil: Hasil penelitian didapatkan mayoritas pasien LES berjenis kelamin perempuan (98,6%) dengan kelompok usia 18-25 tahun (40,6%), dan mayoritas dengan derajat aktivitas penyakit berat (53,6%). Penelitian ini didapatkan angka kejadian anemia pada derajat aktivitas penyakit ringan-sedang (87,5%) dan derajat aktivitas penyakit berat (89,2%) dengan hasil uji statistik didapatkan nilai p >0,05. Kesimpulan: Penelitian ini menunjukkan bahwa tidak terdapat hubungan yang signifikan antara derajat aktivitas penyakit dengan kejadian anemia pada pasien LES di RS Dr. M. Djamil Padang.
EFFECT OF WEST SUMATRAN DADIAH ON BODY WEIGHT AND GLYCEMIA IN HYPERGLYCEMIC RATS Meri Wulandari; Ety Yerizel; Harnavi Harun; Efrida
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/bbn89q35

Abstract

This study was a laboratory-based experimental study using a post-test control group design to evaluate the effect of curd administration on body weight and blood glucose levels in hyperglycemic rat model. Male Wistar rats (Rattus norvegicus) aged 8–10 weeks with body weights of 250–300g were used and randomly divided into four groups: a negative control group without diabetes induction or treatment, a positive control group with diabetes induction without therapy, and two treatment groups receiving curd at different doses, P1 (1.8750 g/250 g body weight) and P2 (3.750 g/250 g body weight). The mean body weight was 277.67 g in the negative control group and 227.50 g in the positive control group. Treatment groups showed increased body weights of 246.83 g in P1 and 262.50 g in P2. Blood glucose levels were 125.56 mg/dL in the negative control group and increased to 487.00 mg/dL in the positive control group, while curd administration reduced levels to 122.17 mg/dL in P1 and 101.83 mg/dL in P2. These results indicate that curd improves body weight and lowers blood glucose in hyperglycemic rats, with greater effects at higher doses, suggesting its potential as a functional food for metabolic and glycemic control.
PENGARUH PENGGUNAAN MODEL PEMBELAJARAN KOOPERATIF TIPE TALKING CHIPS TERHADAP KETERAMPILAN ARGUMENTASI SISWA KELAS IV SDN 09 KOTO BARU Efrida; Saputra, Riyadi; Hasibuan, Sukriadi
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 03 (2026): Volume 11 No. 03, September 2026 Release
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i03.61706

Abstract

This research was motivated by the low argumentation skills of fourth-grade students at SDN 09 Koto Baru, who tended to be passive and faced difficulties in expressing logically structured opinions. This study aimed to examine and describe the effect of using the Talking Chips cooperative learning model on students' argumentation skills based on Toulmin's argumentation components (Claim, Data, Warrant, and Rebuttal). The research utilized a quantitative approach with an experimental method through a Pre-Experimental Design in the form of a One-Group Pretest-Posttest Design. The research sample consisted of a saturated sample of 23 fourth-grade students. The data collection instrument employed an oral test based on contextual dilemma stories evaluated using an observation sheet of argumentation skills adapted from Toulmin's model with a 1-4 scale. The data were analyzed using the Paired Samples T-Test and Normalized Gain (N-Gain) Score analysis. The results indicated a significant increase in the classical mean score of argumentation skills, rising from 31.39 in the pre-test to 77.65 in the post-test. Based on the hypothesis testing, the obtained was -29.969 with a significance value (2-tailed) of 0.000 < 0.05, thereby rejecting the null hypothesis ( ) and accepting the alternative hypothesis ( ). Furthermore, the classical N-Gain analysis yielded a score of 0.682 (68.2%), which falls into the moderate category and is interpreted as quite effective. In conclusion, the Talking Chips cooperative learning model has a significant effect on improving the argumentation skills of fourth-grade students at SDN 09 Koto Baru in Pancasila Education subject.
Co-Authors A.A. Ketut Agung Cahyawan W Ade Asyari Afdal Afdal Afriwardi Afriwardi Aghnia Jolanda Putri Akmal M. Hanif Al Hafiz Al Hafiz Alifah Amirah Almurdi Almurdi Alya Binti Azmi Amanda, Dela Sasqia Amirah Zatil Izzah Andani E Putra Andani Eka Putra Angela Lovena Anggia Perdana Harmen Anggun Hatika Riska Arnelis Arnelis Arni Amir Asman Manaf Asterina Asterina Atika Indah Sari Bakma, Isphandra Basorudin Besri, Hanifa Zahra Bestari Jaka Budiman Budi Setyastuti Cindi Aulia Ali Desmawati Desmawati Deswita Sari Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar, Desywar Devi Gusmaiyanto Devi Gusmaiyanto Dhea Syapira Dia Rofinda, Zelly Dia Dian Eka Putri Dian Eka Putri, Dian Eka Dian Pertiwi Dian Pertiwi Doan Atrya Dolly Irfandy Dona Mirsa Putri Donaliazarti Donaliazarti Dwi Amelisa Edwina Dwi yulia Dwi Yulia Dwitya Elvira Dwitya Elvira, Dwitya Effy Huriyati Efiariza, Nurul Navela Ega Purnamasari Eka Musmita Sabebegen Eka Nofita Elfira Yusri Elfira Yusri Elisda Yusra Ellyza Nasrul Ellyza Nasrul Elmatris Sy Elvinawaty Elvinawaty Endang Primawaty Harahap Endrinaldi Erni Rouza Erni Rouza, Erni Eryati Darwin Eryati Darwin Eti Yerizel Ety Yerizel Ety Yerizel Eugeny Alia Eva Chundrayetti Fachzi Fitri Fadhilaturrizqie Siregar Fadil Oenzil Fathiyyatul Khaira, Fathiyyatul Febria Prima Utari Fika Tri Anggraini Finny Fitry Yani Fiona Septi Mulya Firdawati Firdawati Fitrina, Dewi Wahyu Franesia - Dwirahmana Gestina Aliska Ghina Zartin Hanifah Maani Hanny Hafiar Harahap, Endang Primawaty Hardisman Harun Harnavi Hasibuan, Sukriadi Hasmiwati Hendra Permana Herman, Deddy Hidayat, Hedo Husni Husni Husni Husni Husni Husnil Kadri Ida Parwati Ida Rahmah Burhan Ihsan, Rafiq Ike Sri Redjeki Ikhsan Marzony Ilhamifithri Ilhamifithri Ilmiawati, Ilmiawati Ima Septia Indah Fitriani Indah Fitriani Indah Sulastuti, Katarina Indra Ihsan Isphandra Bakma Jacky Munilson Jacky Munilson Jamsari Jamsari Johannas Kartika Aulia Sari Kenny Lestari, Rahmi Lillah Lillah M. Daffa Almuzaki Malinda Meinapuri Mamik Widyastuti Masrul Basyar Masrul Basyar Masrul Syafri Mayetti Mayetti Mega Redha Putri Meri Wulandari Mira Purwinanty Mohamad Reza Mulya, Fiona Septi Nanda Oktavia Nanda Oktavia Nanda Oktavia Narlis Narlis Nasution, Irfan Sazali Nayla Raihani Malau Netti Suharti Nirza Warto Novialdi . Nur Afrainin Syah Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nuryanto Nuzulia Irawati Oktavia, Nanda Prihandani, Tuty Prima O Damhuri Puja, Annisa Fitria Putri Yuriandini Yulsam Putri, Andina Ayu Rahmadina, Rahmadina Rahmadina, Rahmadina Rahmatini . Raisa Putri Secioria Ramadhani, Jihan Rara Aulia Alzazira Raveinal Regina Ivanovna Rendi Dwi Prasetyo Reni Asprilia Reni Lenggogeni Reza , Mohamad Rikarni Rikarni Rike Puspasari Rismawati Yaswir Rismawati Yaswir Rismawati Yaswir Rizanda Machmud Rizqy Auliya Lubis Rossy Rosalinda Roza Kurniati Rudy Afriant Russilawati, Russilawati Sabebegen, Eka Musmita Saptino Miro Saputra, Riyadi Sari, Kartika Aulia Selfi Renita Rusjdi Setya Widyawati Silvia Rega Siti Nurhajjah Sofitri Sofitri Sri Vanny Suhirman Suchi Ilmi Herman Sukri Rahman Sunardi Susmiati Susmiati Syarifah Tridani Fitria Syofiati Syofiati Syofiati Syofiati Syofiati Syofiati Syofiati Trisuliandre, Muhammad Rizki Tuty Prihandani Ulti, Zifa Amanda Ulya Uti Fasrini Vanny Syafitri Vika Rahma Velina Wahid , Irza Yan Edward Yanni, Mefri Yessi Yestiani Yhosie Anto Chicamy Yosa, Nelvia Okta Yulia, Dwi Yulistini, Yulistini Yusrawati Yusrawati Yusri Dianne Jurnalis Yustini Alioes Zahira, Aisyah Dhia Zelly Dia Rofinda Zhuhra, Rahma Tsania Zurayya Fadila