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Aktivitas Antidiabetes Kulit Batang Arcangelisia flava dari Sulawesi Tenggara, Indonesia Secara In Vivo Terintegrasi dengan Analisis Farmakologi Jaringan A Sida, Nurramadhani; Rifa’atul mahmudah; Hasnawati; Henny Kasmawati; Nurull Hikmah
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49750

Abstract

The Arcangelisia flava plant has previously been reported to reduce blood glucose levels in experimental animals. However, there have been no reports on the antidiabetic activity of its stem bark. This study aimed to evaluate the antidiabetic activity of A. flava extracts and fractions, identify their bioactive compounds, and explore the mechanistic pathways involved using the network pharmacology approach. The chemical constituents of the n-hexane fraction were analyzed using gas chromatography mass spectrometry (GC-MS). The in vivo antidiabetic test was conducted on Mus musculus induced with streptozotocin/niacinamide. Blood glucose levels were measured using the oral glucose tolerance test (OGTT) The antioxidant activity of the extracts and fractions was determined using the ABTS assay. The result showed that the GC-MS analysis of the n-hexane fraction identified 18 compounds belonging to seven chemical groups, namely aromatic hydrocarbons, ketones and alcohols, phenolic aldehydes, sulfur compounds, terpenes, fatty acid derivatives, and alkaloids. The highest percentage of blood glucose reduction was observed in the group treated with ethanolic extract 500 mg/kg BW (50.25%), followed by glibenclamide (43.53%), ethyl acetate fraction 125 mg/kg BW (42.82%), ethanolic extract 250 mg/kg BW (41.88%), n-hexane fraction 125 mg/kg BW (34.96%), butanol fraction 125 mg/kg BW (34.28%), and ethanolic extract 125 mg/kg BW (34.14%), respectively. The ABTS assay produced IC₅₀ values for vitamin C, ethanolic extract, n-hexane fraction, ethyl acetate fraction, and butanol fraction of 8.00, 49.80, 110.25, 10.20, and 18.44 µg/mL, respectively. Network pharmacology analysis of compound 7 and compound 17 from the n-hexane fraction revealed antidiabetic potential through inhibition of the AGE–RAGE signaling pathway in diabetic complications. The key target proteins involved included MAPK1, MMP2, MAPK14, MAPK3, PIK3CA, and TGFBR1. In conclusion, the extracts and fractions of Arcangelisia flava exhibit strong potential as antidiabetic and antioxidant agents. The n-hexane fraction, in particular, is presumed to exert its antidiabetic activity through inhibition of the AGE–RAGE signaling pathway, which plays a critical role in diabetic complications.
Evaluation of Drug Management and Improvement Strategies Nurbaida Nurbaida; Wahyuni Wahyuni; Henny Kasmawati; Suryani Suryani; Ruslin Ruslin; Adryan Fristiohady
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1957

Abstract

The management of pharmaceutical supplies in hospitals involves nine interrelated cycles, ranging from planning to disposal. Objective: This study aimed to evaluate drug management practices at RSUD dr. H. L. M. Baharuddin in Muna Regency based on interviews with two key informants, namely the Head of the Pharmacy Installation and the Head of the Pharmacy Warehouse, and to assess compliance with Ministry of Health Regulation No. 72 of 2016. A descriptive design combined with the Hanlon method was employed, using criteria of problem magnitude, seriousness, effectiveness of intervention, and feasibility (PEARL factors). Result: The evaluation showed that most management cycles were adequately implemented; however, significant issues were identified in the storage stage. Key problems included the distance between multiple warehouses, complicating distribution and stock monitoring; the absence of CCTV; and inadequate physical security, such as lack of fencing. Hanlon analysis identified storage issues as the highest priority due to their impact on medication safety, security, and supply continuity. The frequency of incidents, risk of loss, and limited monitoring highlight the need for immediate intervention. Recommended improvements include optimizing storage layout, installing CCTV, strengthening access control, and enhancing physical security in line with national regulations. Although most cycles meet standards, storage management requires immediate improvement.
Co-Authors ,, Suryani A Sida, Nurramadhani A.A. Ketut Agung Cahyawan W Abd Rafid Achmad Fuad Hafid Aiyi Asnawi Aiyi Asnawi Alfad Fadri Alfian Alfian Alika Rizkiana Iskandar Anjani, Ratna Anwar, Irvan Arfan Arfan Ariani, Eno Retno Armadani, Fery Indradewi Aspadiah, Vica Asriullah Jabar Asriullah Jabbar Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aswani, Aswani Aty Widyawaruyanti Azis, Nurul Ella Kholifatul Damu, Rusliati Desi Sartina Dian Munasari Solo Dias Tama Eka Pebriana Eka, Bau Mirna Ayu Elsa Darmayanti Fauziah, Nining Fery Indradewi Fery Indradewi Armadany Fery Indradewi Armadany Fifi Nirmala Firawati Fitrawan, La Ode Muhammad Fitri Rahmadani Saputri Fitriyanti J. Sami Fitriyanti Jumaetri Sami Fristiohady, Adryan Ghais S. Daud Ghina Salsabila Awandhaputri Halik Hasnawati Hasnawati Hasnawati Hasnawati Hasnawati Hasniar, Wa Ode Hikmah, Nurull Hutamy Viranda Rahman Indalifiany, Astrid Indrayanti, Wa Ode Dian Intan Permata Putri Irnawati Irnawati Jamil, Siti Amaliah Jamsir, Asmaidah Jannah, Sitti Raodah Nurul Khoirul Ummah La Ode Aman La Ode Muh. Fitrawan La Ode Muhammad Diman La Ode Muhammad Fitrawan Linggi Allo, Lisa Talita Loly Subhiaty Idrus Loly Subhiaty Idrus Loly Subhiyati Idrus Madjid, Waode Istiqamah Malaka, Muhammad Hajrul Malina, Rachma Mallarangeng, Andi Nafisah Tendri Adjeng Mardiani, Siti Marwati Marwati Marwati Marwati Mega Fatimah Rosana Mesi Leorita, Mesi Muh Aidil Adha Muh. Arba Muh. Ilyas Y Mulya, Elzah Munarsi Munarsi Mutmainna, Mutmainna Nasrudin Nasrudin Nina Salamah Ningsih, Warda Ayu Nita Trinovitasari Nur Filzanah Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Kharisma Amin Nur Rayani Nur Syam Hidayah Rahma Ismail Nuralifah Nuralifah Nuralifah Nuralifah, Nuralifah Nurbaida Nurbaida NURFAUSIAH Nurramadhani A. Sida Nursamsiar Nursamsiar Nursamsiar Nursamsiar Nurull Hikmah Nurull Hikmah Nurull Hikmah Parawansah Parawansah Pratiwi, Dinda Puriandani, Ketut Ayu Putri, Egi Alisa Rahimah Nurfadilah Dahlan RAHMAT MULIADI, RAHMAT Rahmayani, Nur Rayani, Nur Ridho Fajriyah Jamri Rifa'atul Mahmudah Rifa’atul Mahmudah Rifa’atul Mahmudah Rimala Sanipurnama Kindkasman Rini Hamsidi Riskayanti Mandasari Ruben, Sony Ruslin Ruslin Ruslin , Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin, R Ruslin, Ruslin Rusman, Arman SABARUDIN Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin, S Sarmita, Sarmita Septiyana, Wanda Sherly Intan Ardani Sida, Nurramadhani A. Siti Ruhima Sitti Raodah Nurul Jannah Soleman, Imelda Sarda Sudiman, Aswan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan, Sunandar Sundar Ihsan Sundar Ihsan Suprianti, Rani Suriani Suriani Suryani Suryani Suryani, S Syamsiar, Syamsiar Syamsu Nur Tissa Filiany Mangari Tri Handayani Tridamayanti Fataraing Trihafsari, Hanin Trinovitasari, Nita W Wahyuni, W Wa Ode Dian Indrayanti Wa Ode Mirawanti Wa ode Reskianings Wa Ode Sitti Zubaydah Wahyuni Wahyuni Wanda Hamidah Wandarsih Juniarti Akbar Wardana, Gede Yogi Prana Widari, Niluh Putri Sri Wiwied Ekasari Yamin Yamin , Yamin Yamin Yamin, Y Zubaydah, Wa Ode Sitti