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Potensi Antioksidan Dari Ekstrak Etanol Kulit Buah Asam Jawa (Tamarandus Indica L.) sebagai Anti Aging Dalam Sediaan Kosmetik Gel Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai; Andjelie, Tiara; Zulhij, Fizrya
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17992

Abstract

Skin aging can be caused by intrinsic factors which are aging processes that take place naturally and extrinsic factors caused by environmental influences such as sunlight, air, chemicals and the surrounding environment. Prevention of premature aging can be done by giving anti-oxidants, especially herbal skin care products and anti-oxidant cosmetic preparations. plants and spices. One plant that functions as an anti-oxidant is tamarind fruit (Tamarindus indica L.) is a plant with the family Mimosaceae. The method used in this study is a preparation made based on the standard formula of Na-CMC gel base according to Muttiin (2021), a gel standard formula based on Sodium Carboxymethyl cellulose (Na-CMC) based on % w/w. The results of research on the physical characteristics of gel preparations concluded that the gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) has met the physical quality standards of facial gel preparations. Gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) can provide anti-aging effects which can improve skin condition in the first week.
Optimasi Dan Formulasi Minuman Instan Granul Bunga Kecombrang (Etlingera Elatior (Jack) R.M.Sm) Dengan Kombinasi Xylitol, Madu Dan Sukrosa Zulhij, Fizrya; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18034

Abstract

Kecombrang merupakan tumbuhan dari keluarga Zingiberaceae, tumbuh di banyak tempat di Indonesia. Tujuan penelitian ini adalah untuk mengetahui hasil formula optimum granul instan serbuk bunga kecombrang (Etlingera elatior) dengan kombinasi Xylitol, Madu dan Sukrosa dari Simplex Lattice Design, untuk mengetahui hasil sediaan granul instan yang dilihat dari persyaratan sebagai granul instan. Metode yang digunakan adalah eksperimental. Granul instan diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi dan diuji karakteristik fisiknya. Data yang diperoleh kemudian di input kedalam aplikasi dan di dapatkan prediksi formula optimum dari aplikasi, selanjutnya prediksi formula optimum di formulasi lalu dibandingkan antara prediksi software Design Expert® versi 13 dengan menggunakan Uji-t one sample pada software SPSS®. Hasil penelitian menunjukkan granul dengan kombinasi Xylitol, Madu dan Sukrosa pada granul instan serbuk bunga kecombrang (Etlingera elatior) mendapatkan hasil formula yang optimum menggunakan metode simplex lattice design dengan konsentrasi Xylitol (9.6%), Madu (6%) dan Sukrosa (5.4%). Sediaan granul serbuk bunga kecombrang tidak memenuhi persyaratan sebagai granul instan yang dimana pada uji waktu alir mendapatkan hasil t>4-10 gr/detik, kelembaban granul MC>4%.
OPTIMASI DAN FORMULASI GRANUL DAUN SINGKONG (Manihot esculenta Crantz) DENGAN KOMBINASI MANITOL, SUKROSA DAN MADU silalahi, zahra salsabila; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18035

Abstract

Tanaman daun singkong (Manihot esculenta Crantz) merupakan salah satu tumbuhan obat yang digunakan secara turun temurun. Secara farmakologi daun singkong mempunyai aktivitas sebagai antiinflamasi, antibakteri, antioksidan. Pada penelitian ini metode yang digunakan adalah eksperimental. Formula granul diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi di formulasi secara konvensional dan diuji karakteristik fisiknya. Hasil penelitian ini menunjukkan bahwa formula optimum granul yang diperoleh yaitu dengan konsentrasi manitol 14%, sukrosa 5,4% dan madu 2,6%. Hasil uji evaluasi yang diperoleh indeks tap 10%, waktu alir 3.58 detik dan sudut diam 24.42o. Hasil pengujian menggunakan Uji-t one sample pada software SPSS Statistic® didapati bahwa nilai p>0,05 sehingga data dinyatakan tidak berbeda signifikan .Hasil pengujian antibakteri menunjukkan bahwa formula optimum memiliki daya hambat yang kuat.
Formulation And Evaluation Of Hand Sanitizer Gel From Clove Flower Extract (Eugenia aromatica L.) Robiatun, Robiatun Rambe; Pangondian, Aswan; Paramitha, Ratih; Zulmai Rani; Gultom, Evi Depiana
International Journal of Science, Technology & Management Vol. 3 No. 2 (2022): March 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i2.472

Abstract

Clove flower (Eugenia aromatica L.) is a plant from the Myrtaceae family, the compounds contained in clove flowers are flavonoids, tannins, alkaloids, and saponins that can function as antibacterial. In addition, clove flowers also function as analgesic, anti-inflammatory, antimicrobial, antiviral, antifungal, antiseptic, antispasmodic, antiemetic, stimulant, and local anesthetic. The purpose of this study was to determine does clove flower extract (Eugenia aromatica L.) could be used as a hand sanitizer gel preparation. Clove flower simplicia powder was extracted with ethanol 96% by maceration. The extract obtained was then screened for phytochemicals, then formulated in the form of a hand sanitizer gel, by adding clove flower extract to each formula with different concentrations. The clove flower extract concentrations used were 5%, 10%, and 15%. After the hand sanitizer gel preparation was formed, the clove flower extract was then tested for the stability of the gel preparation. The clove flower extract obtained was 116.4 grams of thick extract. The results of phytochemical screening of clove flower extract showed the presence of secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. Based on the evaluation of the hand sanitizer gel preparation, clove extract showed that it was physically stable during storage. Based on the acceptability or liking test conducted on 20 respondents using a questionnaire sheet, the results showed that the respondents really liked the aroma of formula F3.
Phytochemical Screening And Antibacterial Activity Test Of Ethanol Extract Of Jengkol Leaves (Archidendron Pauciflorum Benth.) I.C. Nielsen Against Staphylococcus Epidermidis And Propionibacterium Acnes Munandar Nasution, Haris; Yuniarti, Rafita; Rani, Zulmai; Nursyafira, Arini
International Journal of Science, Technology & Management Vol. 3 No. 3 (2022): May 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i3.509

Abstract

Skin disease was a disease that attacked the surface of the body, and was caused by various agents, one was bacteria. One of the plants that had antibacterial activity was jengkol leaf (Archidendron pauciflorum Benth.) I.C. Nielsen because it contained compounds that had antibacterial properties that had previously been studied by other researchers against Staphylococcus aureus and Escherichia coli bacteria. So that researcher was interested in researching on the antibacterial activity of jengkol leaves (Archidendron pauciflorum Benth.) I.C. Nielsen against Staphylococcus epidermidis and Propionibacterium acnes. Fresh Jengkol leaves were processed into simplicia and extracted using 96% ethanol. Phytochemical screening was carried out on simplicia powder and extracts of jengkol leaves. Ethanol extract jengkol leaves was made in several concentrations, namely 20%, 25%, and 30%, positive control using Tetracycline HCl, and negative control using 1% DMSO. There were several tests carried out on jengkol leaves in addition to phytochemical screening, namely examination of simplicia characteristic including macroscopic examination, microscopic examination, examination of water content, examination of water-soluble extract levels, examination of ethanol-soluble extracts, examination of total ash content, and also an examination of acid-insoluble ash levels and antibacterial activity test of jengkol leaves. The results of phytochemical screening showed that the compound of jengkol leaves (Archidendron pauciflorum Benth.) I.C. Nielsen contained a class of secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. And for the results of the antibacterial activity research also showed that jengkol leaves could be used as antibacterial because it has a strong inhibitory power at a concentration of 20% and the strongest at a concentration of 30% against Staphylococcus epidermidis, namely 15.06 mm and 17.83 mm, while in diameter of growth inhibition zone Propionibacterium acnes was 15.86 mm and 18.1 mm.
The Buas Buas Leaf Utilization of Buas Buas Leaf (Premna pubescens Blume) Ethanol Extract as Liquid Soap With Anti-Bacteria Activity Rafita, Rafita Yuniarti; Munandar Nasution, Haris; Rani, Zulmai; Fahmi, Fahmi
International Journal of Science, Technology & Management Vol. 3 No. 3 (2022): May 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i3.510

Abstract

The buas buas (Premna pubescens Blume) plant is from the Lamiaceae family. The use of ethanol extract of buas buas leaf (Premna pubescens Blume) as soap is because soap is one of the health products needed by many people to maintain a healthy body. It is used as an antibacterial because buas buas leaves contain secondary metabolites that can be used as antibacterial.The Buas buas leaf Simplicia (Premna pubescens Blume) was extracted using 96% ethanol by maceration and concentrated with a rotary evaporator to evaporate the solvent. The concentrated extract obtained was tested by phytochemical screening, formulated into liquid soap with concentrations of 5%, 10%, 15% and tested for pH, foam height, viscosity, specific gravity and irritation test, and antibacterial activity against staphylococcus aureus bacteria. The results of the phytochemical screening test of the ethanol extract of buas buas leaf (Premna pubescens Blume) contained secondary metabolites in the form of alkaloids, flavonoids, saponins, tannins and steroids/triterpenoids. Liquid soap made with concentrations of 5%, 10%, and 15% has a pH of 10-10.3; foam height 50-90 mm; viscosity 1210-1290 cP; specific gravity 1-1.08 and did not cause irritation to volunteers; and have inhibitory power of 14.2 mm, 15.0 mm, 16.0 mm, and 20.0 mm against Staphylococcus aureus bacteria, respectively.
Antioxidant Activity Test of Barangan Banana Hump’s Ethanol Extract (Musa Paradisiaca (L.)) with DPPH (1,1 Diphenyl-2-Picrylhydrazyl) Method Nurmazela, Virda; Ridwanto, Ridwanto; Rani, Zulmai
International Journal of Science, Technology & Management Vol. 3 No. 5 (2022): September 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i5.610

Abstract

This study aims to determine the secondary metabolites contained in Barangan banana weevil (Musa paradisiaca (L.)) and antioxidant activity based on the IC50 value. The stages of this research include processing plant materials, making ethanol extracts, characterization examinations, phytochemical screening, and testing the antioxidant activity of Barangan banana weevil. The ethanol extract of Barangan banana weevil was processed by the maceration method using 96% ethanol, and the antioxidant activity was tested using the DPPH method. The results showed that the ethanol extract of Barangan banana weevil contained chemical compounds such as alkaloids, glycosides, flavonoids, saponins, tannins, and triterpenoids. The determination of the antioxidant activity of Barangan banana weevil obtained an IC50 value of 180.8 µg/mL. This means that the ethanol extract of Barangan banana weevil contains secondary metabolites and has the potential as an antioxidant with a weak category.
Utilization Of Chitosan As A Natural Preservative Against Catfish Nurhayati, Nurhayati; Ridwanto, Ridwanto; Sartika Daulay, Anny; Andi Syahputra, Ricky; Rani, Zulmai
International Journal of Science, Technology & Management Vol. 3 No. 5 (2022): September 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i5.614

Abstract

Shrimp in Indonesia are generally exported abroad after removing the head, tail, and skin. One alternative to the use of shrimp shell waste that has high economic value is processing shrimp shells into chitosan. The purpose of this study was to determine the shelf life of catfish using chitosan and to determine the optimal concentration of chitosan in catfish preservation. Chitosan applied to catfish showed that in the addition of a 0% chitosan solution, it had a shelf life of up to day 2 for 48 hours for a 0.5 solution; 1; 1.5 and 2% shelf life up to day 5 or for 120 hours. The most optimal concentration of chitosan for use in catfish is a 2% chitosan solution, and the total plate number (ALT) test meets the requirements of the SNI standard so that it can still be consumed.
Evaluation Of Drug Storage System In A Pharmacy Of Medan City Based On Pharmaceutical Services Standards Rinda Sari, Syilvi; Yunus, Muhammad; Rawitri, Kiki; Wahyuni, Sri; Rani, Zulmai; Syahputri, Hindri
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.872

Abstract

Pharmacy is a place where pharmaceutical services are held by pharmacists who are responsible for patients. Pharmaceutical services in pharmacies are related to drugs with the aim of achieving definite results to improve the quality of life of patients. So the management of drugs in pharmacies needs to be done properly and precisely to ensure the availability of sufficient and quality drugs in order to achieve optimal service goals by implementing a storage system that is in accordance with pharmaceutical service standards no.73 of 2016. Therefore the purpose of this research is to evaluate the drug storage system in one of the Medan city pharmacies based on pharmaceutical service standards. This research is descriptive with retrospective data collection. The data obtained were grouped into quantitative data presented in tabular form to see visual comparisons, and qualitative data obtained through observation and interviews with informants. The results showed that in several indicators of drug storage in one of the Medan city pharmacies based on Permenkes No. 73 of 2016 there are still those that have not complied with, namely in the preparation of LASA drugs and writing document numbers on drug stock cards. Meanwhile, the standard drug storage indicators are the columns on the stock card consisting of receipt or dispensing date, receipt or disbursement document number, source of origin of the drug, no. batch/no. Lot, expiry date, receipt and disbursement amount, remaining stock, and officer's initials, as well as suitability for drug storage based on dosage form, alphabetical order, and FEFO and FIFO storage methods. Based on the results of the study it was concluded that the drug storage system carried out in one of the pharmacies in the city of Medan did not meet pharmaceutical service standards based on Permenkes No. 73 of 2016.
Sosialisasi Penggunaan Obat dengan Cara Khusus di Kecamatan Percut Sei Tuan, Deli Serdang, Sumatera Utara Rani, Zulmai; Dalimunthe, Gabena Indrayani; Nasution, Haris Munandar; Yuniarti, Rafita; Lubis, Minda Sari; Pulungan, Ainil Fithri; Kaban, Vera Estefania; Nasri, Nasri; Utami, Dinda Sari
Jurnal Bakti Nusantara Vol. 3 No. 1 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i1.107

Abstract

Seiring dengan kemajuan teknologi, semakin banyak sediaan farmasi yang dikembangkan. Ini termasuk inhaler, pen insulin, suppositoria, obat mata, telinga, dan lain-lain.  Tetes mata (oculoguttae), salep mata (oculenta), pencuci mata (colyria), dan bentuk lain dari obat mata dikenal sebagai optalmika. Penggunaan obat dengan alat khusus ini dapat menimbulkan efek samping dan hal yang tidak diiinginkan jika tidak digunakan secara benar. Hal ini disebabkan kurangnya informasi tentang penggunaan obat, cara penyimpanan dan lama penyimpanan obat pada masyarakat di Desa Kolam. Penyuluhan mengenai penggunaan obat dengan alat khusus ini untuk mencegah terjadinya efek samping atau hal yang tidak diinginkan. Kegiatan pengabdian dilakukan di Dusun I Desa Kolam, masyarakat dilibatkan dalam kegiatan yang dibantu oleh Kader Posyandu Kamboja dan pihak terkait lainnya.  Penyuluhan ini menggunakan ceramah, diskusi, dan pemutaran video. Selain itu, untuk mengetahui seberapa puas masyarakat dengan materi yang disampaikan, dan kuesioner. Pengabdian masyarakat yang dilakukan tim diharapkan dapat memberikan pemahaman yang baik kepada masyarakat, serta cara penggunaan obat dengan alat khusus secara tepat dan benar. Informasi akan pentingnya penggunaan obat, cara penyimpanan obat dan lama penyimpanan obat setelah kemasan dibuka. Hal ini akan berhubungan dengan efek terapi yang diharapkan serta untuk mencegah terjadinya efek samping obat.
Co-Authors A'dilah, Nur Abadi, Hafizhatul Adjelie, Tiara Adli Nuzula Rahmah Adyani Maulinda Afriati, Nelsi Ahmad Rasyid Ridho Ainil Fithri Pulungan Alviana, Liya Alvin Pratama Amelia Kudadiri Andhika Dharma Putra Andi Syahputra, Ricky Andjelie, Tiara Ani Sutiani Ani Sutiani Anjarlit Romiyuliana Br Parapat Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Apriana Ulan Dari MS Aprilia, Hijjatun Arifin, Khairil Fikri Arifna Luthfianida Arrosty, Muflizah Asep Trizaldi Athaillah, Athaillah Audry Pratiwi Aulia Fitri Aulia Fitri, Aulia Auza , Maharani Azhar, Gustika Bambang Hermanto Bambang Hermanto Beby Noplya Wulandari BJ Sutrisna Chandra, Putra Dama Yanti, Fradilla Daulay, Anny S. Dea Anggreini Denny Satria Dewi, Sri Harti Dikki Miswanda Dikki Miswanda Dinda Dila Puspita Dinda Sari Utami Dwi Jati, Fatma Elmi Sariani Hasibuan Eni Surabini Tarigan Erma Susanti Evi Depiana Gultom Evi Depiana Gultom Fadhlah Al-Uyun Nasution Fahmi Fahmi Fajri, Fajrilda Aqilah Falah Rambe, Raudhotul Fanny Anggreany Santosa fatimah Fauziah Erna Witular Panggabean Fithri Pulungan, Ainil Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunte Gabena Indrayani Dalimunthe Ginting, Grace Anastasia br Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Gultom, Evi Depiana H., Fathur Rahman Hanafis Sastra Winata Haris Munandar Nasution Haris Munandar Nasution Haris Munandar Nasution Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hasibuan , Fika Miah Sasmitha Hasibuan , Nabila Hasim Hasibuan, Zulfiana Ramadhani Hindri Syahputri Humaira, Annisa Husna, Miftahul Hutagalung, Victor H Indrayani, Gabena Inna Myesha Julia Reveny Karo Sekali, Elva Swandi Kasta Gurning Khairunnisa , Ardina Kiki Rawitri Latifah Hanum Lestari, Amanda Putri Lestari, Kurnia Dwi Lilik Septiana Linda, Rosa Lubis, Asira Lubis, Minda Sari lubis, muhammad fauzan Lubis, Nurazizah Lusi Grasia Situmorang M. Alfaruqi Maghfirah, Dini Mainal Furqan Malahayati Malahayati Maryanti Yuza Matondang , Fikriyah Hafni Maulana Putri, Yasinta Minda Sari Minda Sari Lubis Mira Febrina, Mira Misbah Siregar Misna Rosalinda Hutabarat Monica Suryani Moondra Zubir Muhammad Agus Muljanto Muhammad Amin Nasution Muhammad Fauzan Lubis Muhammad Yunus Muhammad Yunus Mukti, Ridho Munandar, Verissa Nadila Indra Sepvina Najwa Nadzira Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Nasution, Wardah Nazuhra, Oca Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggita Ningtias, Anggitha Nomi Noviani Novia Herma Savitri Nur Ain Thomas Nur, Hijrotun Nurdalilah Nurdalilah Nurhayati Nurhayati Nurmazela, Virda Nursyafira, Arini Nurul Arafah Nurul Hasanah Nurul Ilmi Afridah Oneayu One Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Paramitha, Ratih Pasar Maulim Silitonga Pertiwi, Rahma Pitaloka, Syifa Amilia Puspita, Dinda Dila Puteri, Cut Intan Annisa Putri Khairani Rafita Yuniarti Rafita Yuniarti Rafita Yuniarti Rahmadani Rahmadani Raissa Fitri Rambe, Robiatun Reza Irma Ricky Andi Syahputra Ricky Andi Syahputra Ridho, Ahmad Rasyid Ridwanto Ridwanto Ridwanto Rinda Sari, Sylvi Ritonga , Nur Sakina Rizki, Dewi Rizki, Vitri Dea Robiatun Rambe Robiatun, Robiatun Rambe Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Rukmana, Siti Sagala, Hasel Untung Bersinar Sahrani Nazwa Khan Samran, Samran Sari Lubis, Winda Sari, Farida Sari, Syilvi Rinda Sari, Sylvi Rinda Sartika Daulay, Anny silalahi, zahra salsabila Sindi, Sindi Sipahutar, Rizki Anjani Siti Anisa Siti Rahmah Siti Rahmi Ningrum Sitompul, Maysaro Sony , Suyefri Sri Wahyuni Sri Wahyuni Sri Wahyuni Suci, Nurul Sulaiman Sulaiman Sulwiyatul K Sani Sumiyarni Harahap Supiyani, Supiyani SURBAKTI, CHRISTICA ILSANNA Syafa Nadira Ashiilah Syahputra, Ricky Andi Syarifah Nadia Syilfia Hasti Syofyan Syofyan Urip Harahap Uswatun Nisa, Uswatun Vera Estefania Kaban Vera Estefania Kaban Wanda Elvia Putri warhamni anatasya sirait Widya, Rizka Yayuk Putri Rahayu Yayuk Putri Rahayu Yufri Aldi Yuli Haryani Yuliatil Adawiyah Harahap Yuliawati Yuniarti , Rafita Yuniarti, Rafita Zahira Ahmad, Madani Ziza Putri Aisyia Fauzi Zola Efa Harnis Zulfikri Zulfikri Zulhij, Fizrya