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All Journal Biology, Medicine, & Natural Product Chemistry Journal of Islamic Pharmacy Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Inovasi Farmasi Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat HERBAPHARMA : Journal of Herb Farmacological Borneo Journal Of Pharmascientech Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Mandala Pengabdian Masyarakat Well Being Jurnal EduHealth PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah STIKES Yarsi Mataram Jurnal Lentera International Journal of Science and Environment Journal of Engineering Science and Technology Management Business and Economic Publication Jurnal Ilmiah Multidisiplin Indonesia Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Media Akademik (JMA) Assoeltan: Indonesian Journal of Community Research and Engagement Contemporary Journal of Applied Sciences (CJAS) International Journal of Global Sustainable Research Indonesian Journal of Community Empowerment Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Penelitian Sains dan Kesehatan Avicenna IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia SEARCH: Science Education Research Gotong Royong Jurnal Pengabdian Kepada Masyarakat Al-Amin Interaksi : Jurnal Pengabdian Kepada Masyarakat Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara Jurnal Ilmu Kesehatan J-CEKI Joong-Ki Amaluna: Jurnal Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian HelFin Journal Multicore International Journal of Multidisciplinary (MIJM) International Journal of Science and Society (IJSS) Jurnal Kajian dan Inovasi Ilmu (JKII) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service Journal Abdimas Paspama Service Jurnal Bioteknologi & Biosains Indonesia
Fendy Prasetyawan
Prodi Pendidikan Profesi Apoteker, Fakultas Ilmu Kesehatan, Universitas Kadiri
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Education on the Use of Over-the-Counter Drugs as Preventive Health for Students at SMP Muhammadiyah 2 Kediri Fendy Prasetyawan; Lisa Savitri; Yuneka Saristiana; Novyananda Salmasfattah
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 4 No. 2: Februari 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v4i2.7743

Abstract

This community service activity was conducted on September 20, 2024, to raise awareness among students about the safe and responsible use of over-the-counter (OTC) medications. The primary objective was to educate students on the types of OTC medications available, their proper use, potential side effects, and the importance of reading medication labels. The event involved 20 students, comprising 4 from Grade 8, 7 from Grade 9, and 9 from Grade 7, who actively participated in interactive discussions and Q&A sessions. The educational session was delivered using a combination of presentations, visual aids, and real-life examples to enhance comprehension. A post-activity evaluation through a quiz was conducted to assess the participants' understanding of the material. The results showed an average quiz score of 82.3%, with an accuracy rate of 87.6%, indicating a significant improvement in the students' knowledge of OTC medication use. The activity also included discussions on the importance of adopting healthy lifestyle habits as a preventive health measure, which resonated well with the students, reflecting their growing interest in maintaining overall health.
Edukasi Pembuatan Pakan Silase Ruminansia dengan Kultur Campuran Lactobacillus sp., Rhodopseudomonas sp., Actinomycetes sp., Streptomyces sp., dan Yeast Savitri, Lisa; Prasetyawan, Fendy; Saristiana, Yuneka; Juwita, Syntia Tanu; Yanti, Novirma; Edda, Ilda Rambu
Abdimas Galuh Vol 7, No 1 (2025): Maret 2025
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v7i1.18152

Abstract

Pada musim kemarau, ketersediaan tumbuhan alami seperti rumput dan kacang-kacangan menurun, menyebabkan kesulitan bagi peternak dalam memenuhi kebutuhan pakan ternak ruminansia. Hal ini dapat berdampak negatif pada kesehatan dan produktivitas hewan ternak. Pakan ternak ruminansia terdiri dari berbagai jenis makanan, terutama tumbuhan, seperti rumput, kacang-kacangan, dan tanaman lain yang kaya serat dan nutrisi. Tumbuhan ini merupakan sumber utama energi bagi hewan ternak ruminansia seperti sapi, domba, dan kambing. Namun, selama musim kemarau, kekurangan tumbuhan menjadi tantangan utama. Salah satu solusi yang diusulkan adalah pembuatan silase. Silase adalah jenis pakan yang dihasilkan dari proses ensilase, di mana tumbuhan seperti rumput diawetkan dengan mengurangi kadar oksigen dan meningkatkan kadar asam laktat. Proses ini membantu mengawetkan nutrisi dalam tumbuhan dan menyediakan pakan tambahan untuk ternak saat musim kemarau. Program pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada peternak mengenai teknik pembuatan silase ruminansia menggunakan kultur campuran bakteri tertentu. Diharapkan program ini dapat meningkatkan pengetahuan dan keterampilan peternak dalam memproduksi pakan silase untuk memenuhi kebutuhan ternak ruminansia selama musim kemarau. Universitas Kadiri melalui program Pengabdian Masyarakat ini dapat ikut berkontribusi dalam upaya untuk mendukung program pemerintah yaitu “Making Indonesia 4.0” dalam peningkatan kualitas sumber daya manusia (SDM) dan pembangunan ekosistem inovasi. Melalui publikasi ilmiah, panduan, dan peningkatan pemahaman masyarakat, program ini diharapkan dapat memberikan dampak positif bagi peternak dan ekonomi lokal.
Prediction of Activity Spectra for Substances (PASS) Technology From Sambung Nyawa (Gynura procumbens (Lour) Merr) Saristiana, Yuneka; Prasetyawan, Fendy; Savitri, Lisa
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.206

Abstract

This study investigates the activity of various compounds as inhibitors, enhancers, agonists, antagonists, and substrates in biochemical pathways. The results indicate that the highest activity is observed in chlordecone reductase inhibition (Pa: 0.984, Pi: 0.001), followed by HIF1A expression inhibition (Pa: 0.969, Pi: 0.002) and membrane integrity agonist activity (Pa: 0.968, Pi: 0.002). Notably, several compounds exhibit significant inhibitory effects on enzymes such as peroxidase (Pa: 0.966), kinase (Pa: 0.958), and NADPH oxidase (Pa: 0.939). Additionally, CYP1A substrates and inducers demonstrate relevant metabolic interactions, indicating potential roles in drug metabolism. These findings provide insights into the pharmacological significance of these compounds, which may contribute to the development of novel therapeutic agents.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
Effect of Most Favored Regions of Estrogen Receptor β (ERβ) Molecules on MolDock Score Using Tamoxifen Ligand Salmasfattah, Novyananda; Permata, Agung; Prasetyawan, Fendy
JIKES : Jurnal Ilmu Kesehatan Vol. 3 No. 1 (2024): Juli-Desember 2024
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The estrogen receptor β (ERβ) molecule is one of the target proteins in cancer treatment. The type of ERβ molecule in the protein data bank (PDB) determines the value of most favored regions and MolDock score. The purpose of this study was to determine the effect of most favored regions of ERβ molecules on MolDock score using Tamoxifen ligand. There are 37 molecules that have ERβ protein, 7 molecules were selected to be analyzed for the value of most favored regions and MolDock score, based on the r table value, pearson correlation value 0.548 < 0.754 (r table). This is also the same when viewed from the significance value of 0.203 > 0.05. It can be concluded that there is no correlation between the value of most favored regions and MolDock score.
Increasing Awareness Among Teenagers About Preventing Non-Communicable Diseases Through The Use Of Multimedia At Karang Taruna Wates Bandhi Prasetya Nugroho; milda, ratna; Fendy Prasetyawan; Baarik Lana Fadli; Yuneka Saristiana; Isma Oktadiana; Arsiaty Sumule
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3408

Abstract

Non-Communicable Diseases (NCDs) are currently a serious health problem in the world, because these diseases are one of the most common causes of death. Community empowerment in preventing PTM through community components, one of which is youth organizations or youth organizations which have an important role in taking part, is expected to be able to prevent PTM through various more interesting media. The aim of this community service is to provide PTM education through the use of multimedia. The method used is to convey information accompanied by posters, pictures and discussions. After providing education, it is hoped that youth organizations will be able to be more critical about PTM and be able to provide further education to the wider community, especially in the Wates area, by utilizing multimedia. Keywords: Non-communicable diseases, Karang Taruna, Multimedia
Education about worms through animated videos for early childhood Ana Amalia; milda, ratna; Fendy Prasetyawan; Yuneka Saristiana; Isma Oktadiana; Arsiaty Sumule
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3431

Abstract

This worm disease can infect all ages, but those who are most susceptible to infection are children under five and elementary school age (SD) aged 5 to 14 years. To be able to break the chain of worm infections and reduce the number of worm infections in schools, this can be done by providing information or education. Providing education about worms can increase students' knowledge regarding preventing worms. The aim of this activity is to increase the knowledge of students and girls in preventing worms. The method of this service is to provide education using animated video media about worm disease and hand washing demonstrations. After counseling and demonstrations, the results of the education that has been provided will be evaluated using a questionnaire to evaluate students' knowledge of worms and their prevention after 1 week of providing counseling via educational video media. The results of the activity showed an increase in knowledge and psychomotor skills after being given education regarding worms and washing hands. It is hoped that increasing understanding of the dangers of worms can foster awareness and independence in preventing worms in families and communities. Keywords: Worms, education, animated video
Community Education on Hypertension in Batua Dua Village's Simalungun Regency Area Arsiaty Sumule; okta, isma; Maswan Daulay; Salim Efendy; Fendy Prasetyawan; Ratna Mildawati
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3520

Abstract

According to the 2018 Indonesian Basic Health Research Statistics (Riskesdas), 34.11% of Indonesians aged 18 or older have hypertension, with 8.36% of those affected based on diagnosis. According to the American Heart Association, the number of individuals with hypertension rises annually, and the average death rate from the condition increased by almost 21% between 2000 and 2010. Additionally, the death rate significantly increases in at least 46% of individuals with hypertension. The purpose of this service is to educate clients both before and after counseling on lifestyle compliance. The strategy is to distribute information on hypertension, which can raise public awareness by demonstrating positive answers and accuracy in responding to the questions. There was a difference in knowledge between the 20 respondents who participated in the counseling before and after it was provided.
Molecular Docking of Hygrophila auriculata (Schum.) Heine Compounds Targeting PBP2 Protein in Neisseria gonorrhoeae Salmasfattah, Novyananda; Prayogi, Syaiful; Prasetyawan, Fendy
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31740

Abstract

Antibiotic resistance in gonorrhoea cases and patients is detrimental. Amidst the rising cases of gonorrhoea caused by Neisseria gonorrhoeae, Hygrophila auriculata (Schum.) Heine has activity as an antibiotic for the disease. The penicillin-binding protein 2 (PBP2) is a transpeptidase that catalyses the formation of cross-bridges on bacterial cell wall peptidoglycan, which will be the target of this plant. The purpose of molecular docking study is to see the binding affinity, compounds in Hygrophila auriculata (Schum.) Heine and ceftriaxone which is used as a comparison drug, will be targeted at PBP protein. Discovery studio visualizer v21.1.0.20298 was used for PBP2 protein preparation and visualisation. DoG Site Scorer was used to predict ligand binding sites on PBP2 proteins. PyRx 0.8 was used for virtual screening, validating of the docking method, and ligand preparation. Compounds in Hygrophila auriculata (Schum.) Heine as ligands were derived from MPDB 2.0 and the following PubChem codes; apigenin CID 5280443, luteolin CID 5280445, allagic acid CID 5281855, gallic acid CID 370, quercetin CID 5280343, lupeol CID 259846, lupenone CID 92158, betulin CID 72326, stigmasterol CID 5280794, and comparator drug ceftriaxone CID 447043. The binding affinity of ellagic acid -9,8 from Hygrophila auriculata (Schum.) Heine was lower than ceftriaxone -9,4 on the target PBP2 protein. Some of the amino acid residues that appear in protein-ligand docking include: ALA A:310, THR A:500 and 347, LYS A:313, and SER A:362. These amino acid residues owned by the PBP2 protein serve as the bonding bridge. Ellagic acid, the compound has potential as an antibiotic in gonorrhoea. Further testing and studies are needed to strengthen the evidence of the findings in this study
Protective Role of Paederia foetida L. Against Hepatic Inflammatory Response in a Mice Model of Escherichia coli-Induced Sepsis Savitri, Lisa; Freitas, Maria Do Carmo Da Costa; Prasetyawan, Fendy; Saristiana, Yuneka; Mebung, Konradus Klala; Amanda, Cornelia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.363-368

Abstract

Sepsis is a severe medical condition characterized by a systemic immune response to infection, often leading to multi-organ failure and death if not treated effectively. This study aimed to investigate the antiseptic properties of Paederia foetida leaf extract in male mice induced with sepsis using Escherichia coli. A total of 24 mice were divided into six groups: a normal group (no treatment), a negative control group (distilled water), a positive control group (ciprofloxacin), and three treatment groups receiving P. foetida leaf extract at doses of 100, 300, and 500 mg/kg BW. After 15 days of oral administration, liver tissue samples were analyzed for IL-6 expression, a pro-inflammatory cytokine associated with sepsis. The results revealed a significant reduction in IL-6 expression in the treatment groups, particularly at the 500 mg/kg BW dose. This dose showed the most effective anti-inflammatory response, with IL-6 expression levels comparable to those of the positive control group treated with ciprofloxacin. However, the 100 mg/kg BW dose demonstrated minimal effects, similar to the negative control. These findings suggest that P. foetida leaf extract, especially at higher doses, has potential as an anti-inflammatory agent in sepsis management. The bioactive compounds in the extract, including flavonoids, alkaloids, and terpenoids, likely contribute to its efficacy. This study provides preliminary evidence supporting the use of P. foetida as a potential herbal alternative for managing sepsis, but further clinical research is necessary to confirm its therapeutic potential.
Co-Authors Abd Rofiq Achmad Wahdi Adiyansyah Lukman Hakim Akhmal Muslikh, Faisal Akhmal, Faisal Alshol, Mohammad Firdaus Althaf Rajahala B Sinun Alves, Silvina Sandra X. Amanda, Cornelia Ana Amalia Anak Agung Indah Krisnadewi Anis Akhwan Dhafin Anis Akhwan Dhafin Anis Akwan Dhafin Anita Dwi Setyarini Apriliyani, Fitria Ardianto, Nanda Arifani Siswidiasari arikha ayu susilowati Arista Wahyu Ningsih Arsiaty Sumule Ary Kristijono Asrizal Azis Astutik, Widhi Ayu Angger Putri M. Soleh Azis, Asrizal Baarik Lana Fadli Bandhi Prasetya Nugroho Besan, Ema Jayanti Besan, Emma Jayanti Candra Arifin, Candra Chadra Arifin Chandra Arifin Charliandri Saputra Wahab Dafin, Anis Akhwan Dahbul, Nura Ali Dameria, Gempita Hutami Datin An Nisa Sukmawati Deo Rudita Febrian Waly Dewi Retno Puspitosari Dian Permatasari, Yunita Dyah Aryantini, Dyah Edda, Ilda Rambu Eka Hayati Rhomah Eka Nur Fatmawati Elfred Rinaldo Kasimo, Elfred Rinaldo Elsa Mahardika Dhafin Elsa Mahardika Putri Elsa Mahardika Putri Elsa Mahardika Putri Ema Tri Wulan Emma Jayanti Besan Erawati, Dyah Anisa Indri Evi Kurniawati, Evi Evi Nurul Hidayati Faisal Akhmal Muslihk Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fita Sari Fita Sari, Fita Fitrani Khansa Fitriani, Evi Tunjung Freitas, Maria Do Carmo Da Costa Gunawan Pamudji Widodo Hakim, Adiyansyah Lukman Hamzah, Hasyrul Hasriyani Hasriyani Hasriyani, Hasriyani Herman Hilmi, Mochammad Hanif Ibrahim Fadlannul Haq Ibrahim Irsyadul Ibad Ibrahim Iskandar Alfaris Ika Purwidyaningrum Ilhawa Zahra Imran, Arlan K Indrayanti, Dian Iramadona, Putri Ayu Isma Oktadiana Ivan Junius Mesak Juan Vega Mahardhika Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Karingga, Devangga Darma Kholis, Muhammad Akbar Nur Khumaeni, Eko Hidayaturrohman Koernia, Lilik Wahidah Kristjono, Ary Laili, Nur Fahma Leny Witaning Kusumati Lily Aina Lusiana Aprillia M. Wahyu Ariawan Ma'arif, Burhan Maharani Dwi Pratiwi Marhenta, Yogi Bhakti maswan daulay Ma’arif, Burhan Mebung, Konradus Klala Megasari, Elly Meri, Meri milda, ratna Mildawati, Ratna Mildwati, Ratna Muhammad Alviyan Shutiawan Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Muslihk, Faisal Akhmal Muslikh, Faisal Nanda Ardianto Nanda Ardianto Neni Probosiwi Nimas Ayu Rahardini Nina Nur Jannah Nisa Azzahra Dentika Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Octavian Ashido Nababan Okky Intan Mawarni Okky Intan Mawarni okta, isma Oktadiana, Isma Permata, Agung Prasetyo Nugroho, Bandhi Prayoga Fery Yuniarto Prayogi, Syaiful Purnomo Puspitosari, Dewi Retno Putri, Elsa Mahardika Raharjo, Susilo Margining Ratna Mildawati Ratno Setyobudi Restyana, Anggi Rhomah, Eka Hayati Rika Wahyu Pujiastini Rochmad Krissanjaya Rofiq, Abd Rohmah, Eka Hayati Rosa Juwita Hesturini Sado, Yosep Mansen Salim Efendy Salmasfattah, Novyananda Salmasfattah, Novynanda savitri, Lisa Setyawan, Ferdinta Daniasta Shinta Mayasari Shinta Mayasari Shutiawan, Muhammad Alviyan Siti Nur Maulita Sugeng Rianto Sugeng Santoso Susilo Margining Raharjo Syntia Tanu Juwita Tri Wulan, Ema Tsamrotul Ilmi Wahab, Charliandari Saputra Widhi Astutik Widiyastuti, Asih Winartiana Winartiana, Winartiana Wisnu Haryo Widyoko Wulan, Ema Tri Yanti, Novirma Yogi Bhakti Marhenta Yosep Mosse Yuneka Sarisitiana Yuneka Saristiana Yuniarto, Prayoga Feri Yunita Dian Permatasari Zahra, Ilhawa Zenmas, Syendriva Zeptyan