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All Journal Biospecies Jurnal Kedokteran Brawijaya JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) BERITA BIOLOGI Lantanida Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas Window of Health : Jurnal Kesehatan Indonesian Journal of Medicine Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Keperawatan Priority Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Jurnal Ners An-Nadaa: Jurnal Kesehatan Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Jurnal Ilmiah METADATA Eureka Herba Indonesia Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal EduHealth Journal of Current Health Sciences International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) International Journal of Science and Environment Eduvest - Journal of Universal Studies Journal of Pharmaceutical and Sciences. Blantika : Multidisciplinary Journal Malahayati International Journal of Nursing and Health Science
Chiuman, Linda
Universitas Prima Indonesia
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Anti-inflammatory Activity of Lemon Pepper Nanoemulsion on Carrageenan-Induced Male Wistar Rat Chiuman, Linda; Sebayang, Dwi Putri Agita; Chiuman, Veranyca; Suhartomi, Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6292

Abstract

Lemon pepper does not only have a unique taste but also has some active compounds, which has anti-inflammatory activity. This study intended to investigate the anti-inflammatory effect of lemon pepper nanoemulsion on carrageenan-induced Wistar rats. This experimental study used Twenty-five male Wistar rats that were grouped into five different groups, including control, standard, lemon pepper nanoemulsion dose of 25, 50, and 75 mg/ kgBW. Initially, all rats received air injection in the back area for 5 days to form an air pouch. After that, all rats were injected with 1% carrageenan solution, and received treatment based on the groups for 48 hours via oral route. Then, it counted the number of white blood cells by Giemsa Stain that was expressed as a number of cells per High Power Field (HPF). The increasing of Lemon pepper nanoemulsion dose significantly decreased the number of leucocytes in the carrageenan aspiration after 48 hours of treatment (P-Value < 0.001). The lowest number of leucocytes was found in the Lemon Pepper Nanoemulsion dose of 75 mg/kgBW (2.40 leukocytes per HPF). Hence, it can be deducted that the lemon pepper nanoemulsion has an anti-inflammatory effect, especially at a dose of 50-75 mg/kgBW.
UV-Protection Effect of Nanoemulgel Formulation from Moringa oleifera Lam. Leaf Extracts in Rattus novergicus Anditha, Arie Tika; Chiuman, Linda; Ginting, Chrismis Novalinda
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8497

Abstract

Exposure to sunlight (UV radiation) can harm the skin, leading to cancer and tissue damage. The body’s natural defense involves activating hormones that stimulate melanin synthesis to reduce cellular damage. Moringa oleifera Lam. leaves, rich in flavonoids and phenolic compounds, are promising UV-protection agents. This study assessed the efficacy of nanoemulgel formulations containing M. oleifera leaf extract through in vitro and in vivo assays. Twenty-five rats were divided into five groups, including formulations with 2%, 3%, and 4% M. oleifera extract, a negative control, and a positive control with Azarine Sunscreen Gel SPF 45. The nanoemulsions had appropriate size and quality, with the highest SPF observed at 4% concentration (7.95±0.06). According to FDA classification, these formulations fall within the 'extra' SPF category (6<SPF<8). However, melanin scores in the nanoemulgel groups were comparable to the untreated control, and the 4% concentration (44.4±16.3) did not match the protection provided by commercial sunscreen (10.0±1.58). These findings suggest M. oleifera has potential for photoprotection, but further optimization is needed.
Effectiveness of Andaliman Extract on Blood Sugar Levels of White Mice Induced by STZ HOMA-IR Dhillon, Jessyca Manishwer Kaur; Chiuman, Linda; Rusip, Gusbakti
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9163

Abstract

The increasing cases and treatment costs have triggered the search for alternatives, such as Andaliman, which is believed to have antidiabetic and antioxidant activities, induced by Streptozotocin (STZ). Objective: to determine the effectiveness of Andaliman nanoemulsion extract in lowering blood sugar levels, overcoming insulin resistance as measured by HOMA-IR, in white mice induced by Streptozotocin (STZ). The study employed a posttest only controlled group design, using sic groups of mice, each of which had five mice weighing 150–260 grams in STZ induction (65 mg/kg), the positive control group used STZ + Metformin, the treatment group used a dose of Nanoandaliman of 25.50 & 75 mg/KgBB. KGD examination was carried out after 7.14 and 21 days after STZ induction. Results: Based on the lowest KGD measurement on day 21 in the STZ65mg/kgBB + NA50 mg/kgBB treatment group, in the HOMA-IR measurement, the highest value was found in the negative control (STZ 65mg/kgBB) on day 21. This indicates that the decrease in blood glucose levels with STZ65mg/kgBB + NA50 mg/kgBB treatment is better than other treatments on day 21. Conclusion: STZ65mg/kgBB + NA50 mg/kgBB treatment has been proven to be effective in lowering blood sugar levels. It is expected that the results of this study can become an alternative treatment for diabetes in the future
Antidiabetic Activity of Cep-Cepan Leaf Extract Nanoparticles (Castanopsis costata) in Streptozotocin-Induced White Rat Models Ginting, Astriani Natalia Br; Ginting, Chrismis Novalinda; Rusip, Gusbakti; Chiuman, Linda
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9408

Abstract

The cep-cepan plant (Castanopsis costata) from the Fagaceae family is traditionally used by the Karo community in Medan, North Sumatra, to treat diabetes mellitus, although its efficacy has not yet been scientifically proven. This study aimed to evaluate the effectiveness of the antidiabetic activity of cep-cepan leaf extract nanoparticles (Castanopsis costata) in a streptozotocin-induced white rat model. A total of 25 male white rats were divided into five treatment groups: a positive control group, a negative control group, and three experimental groups treated with extract concentrations of 25, 75, and 150 mg/kg body weight, respectively. Plasma glucose levels were measured every 72 hours for 15 days using blood samples taken from the tail. Pancreatic tissue was then examined, and the data were analyzed using one way anova. The findings showed significant antidiabetic activity in all treatment groups, with p < 0.001. The nanoparticle extract of cep-cepan leaves exhibited the highest antidiabetic potential at a dosage of 150 mg/kg, reducing blood glucose levels by 59.39%. These results suggest that the nanoparticle extract of cep-cepan leaves demonstrates antidiabetic activity in the streptozotocin-induced white rat model, and it has the potential to be developed as an alternative treatment for diabetes mellitus.
Effectiveness of Durian Seed Extract (Durio zibethinus Murr) on Blood Sugar Levels and Pancreatic Histopathology in Streptozotocin-Induced Wistar Rats Halim, Valencia Angelina; Suyono, Tan; Chiuman, Linda; Tambunan, Andika Z; Nadia, Felanda A
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9785

Abstract

Diabetes mellitus is a global health problem with a growing prevalence. Blood glucose levels that remain high can cause damage to various body tissues. including the pancreas. Durian seeds contain bioactive compounds such as alkaloids. triterpenoids. phenolics. and flavonoids that can reduce blood sugar levels. This study is an experimental study with a posttest only controlled group design conducted at the Pharmacology Laboratory of the Faculty of Pharmacy. University of North Sumatra and the Anatomical Pathology Laboratory of the Royal Prima Medan Hospital for more than 3 months. From the results of this study. durian fruit seed extract (Durio zibethinus Murr) in the phytochemical compound test contained alkaloids. saponins. flavonoids. and glycosides. With doses of 150 mg. 300 mg. and 450 mg proven to reduce blood sugar levels (KGD) in streptozotocin-induced Wistar rats. The highest dose in reducing blood sugar levels (KGD) with a dose of 450 mg. The group with a dose of 300 mg showed the best results in increasing the diameter of the islets of Langerhans.
The Effect of Andaliman Fruit Extract (Zanthoxylum acanthopodium DC) on α-Synuclein Levels in Rotenon-Induced Wistar Rats Maulidza, Citra Puan; Halim, Binarwan; Chiuman, Linda; Nasution, Atika Rimalda; Theresia, Yohani
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10362

Abstract

Parkinson's disease is a neurodegenerative disorder characterized by loss of dopamine and formation of α-synuclein aggregates in the substantia nigra pars compacta (SNpc). This study aims to evaluate α-synuclein levels in the plasma of rotenone-induced Wistar rats as a model of Parkinson's disease and the therapeutic effect of Andaliman fruit extract. The design of this study was experimental with 25 male Wistar rats divided into five groups, negative control group (K-, only given distilled water), positive control (K+, induced rotenone 3 mg/kgBB/day for two weeks), and three treatment groups (P1, P2, P3) induced rotenone and given Andaliman extract orally at a dose of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB respectively for 14 days. Measurement of levels was performed using ELISA on day 14 after induction and day 28 after therapy. The results of one-way ANOVA analysis showed that Andaliman extract significantly reduced α-synuclein levels at all doses compared to the positive control (p=0.000). The decrease in α-synuclein levels indicates the potential of Andaliman fruit extract in reducing Parkinson's disease-related pathology in mouse models.
Analyzing Ethanol’s Antioxidant Extract of Pandanus Leaves through DPPH Method Hardianti, Siti; Chiuman, Linda; Ginting, Chrismis Novalinda; Adrian, Adrian
Interdisciplinary Social Studies Vol. 1 No. 5 (2022): Special Issue
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/iss.v1i5.128

Abstract

Background: Aging is a natural process and no one can avoid it. The aging process is also a physiological process that will occur in all living things. This process covers all organs of the body including the skin which is one of the body tissues that directly shows the occurrence of the aging process Aim: This research aims to analyze ethanol’s antioxidant extract of pandanus leaves through DPPH method. Method: This type of research is using experimental research designs to determine the antioxidant activity affected by time, and temperature with the DPPH method, a formulation of the effects of the ethanol extract of fragrant pandan leaves (Pandanus amaryllifous Roxb). Findings: It has active antioxidant activity and IC50 extract of fragrant pandan ethanol on the 5th day with a temperature of 50° C and on the 3rd day with a temperature of 35° C which is the best antioxidant activity.
- EFEKTIVITAS PRP TERHADAP PERUBAHAN PROFIL LIPID DARAH TIKUS PUTIH JANTAN (Rattus Norvegicus) DIABETES MELITUS YANG DI INDUKSI STREPTOZOTOCIN: EFEKTIVITAS PRP TERHADAP PERUBAHAN PROFIL LIPID DARAH TIKUS PUTIH JANTAN (Rattus Norvegicus) DIABETES MELITUS YANG DI INDUKSI STREPTOZOTOCIN Simarmata, Hans Pangestu; Saragih, Reyini Namora L.; Pasaribu, Jelita Pebriani; Sitorus, Josua Panangian; Chiuman, Linda; Janice, Janice
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11252

Abstract

Diabetes mellitus is a disease problem in Indonesia due to the inability of the pancreas to produce insulin so the body's metabolic processes are disrupted. Platelet Rich Plasma is widely known to be a treatment in various fields of medicine because it contains many growth factors (GFs) which are useful for triggering growth, tissue, and cell regeneration. This study was conducted to determine the effectiveness of PRP at doses of 0.5, 1.0, and 1.5 ml/kg BW for improving lipid profiles. This study used an experimental method where PRP was made twice centrifugation, then divided into each treatment, each group was given twice a week for three weeks. The Shapiro-Wilk test was used for normally distributed data followed by the Kruskal-Wallis test followed by the analysis Mann-Whitney with a significant value of P <0.05, that is, there was an effect of PRP administration on improving levels of lipid profiles. The PRP dose of 0.5 ml/kg BW gave the effect of increasing the lipid profile except for HDL levels and a higher PRP dose was required to significantly increase HDL levels compared to the control group.  
Effectiveness of Single Garlic Extract on Fatty Liver and Liver Enzymes in Rattus Norvegicus Wistar Syahputra, Fahmi; Suandy, Suandy; Chiuman, Linda
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52285

Abstract

This study investigated the hepatoprotective efficacy of ethanol-extracted single garlic (EEBPT) on fatty liver and hepatic enzymes in rats. A true experimental design with pretest-posttest control group approach was employed. Twenty-four male Wistar rats (Rattus norvegicus) were randomly allocated into four groups: negative control (distilled water), positive control (simvastatin 2.1 mg/kg body weight), low-dose EEBPT (200 mg/kg body weight), and high-dose EEBPT (400 mg/kg body weight). All animals received high-fat diet supplementation for four weeks. Serum aspartate aminotransferase (SGOT/AST) and alanine aminotransferase (SGPT/ALT) were measured on days 0, 14, 21, and 28. Hepatic histopathology was assessed using hematoxylin and eosin staining. One-way ANOVA with Tukey post-hoc test and Kruskal-Wallis test were applied for statistical analysis (p<0.05). Results demonstrated that high-dose EEBPT significantly reduced SGOT and SGPT levels equivalent to simvastatin treatment and ameliorated hepatic steatosis, hepatocyte ballooning, and inflammatory infiltration. Ethanol-extracted single garlic at 400 mg/kg body weight exhibited hepatoprotective effects comparable to conventional statin therapy through antioxidative and anti-inflammatory mechanisms. Garlic extract represents a promising natural hepatoprotective agent for NAFLD management
Clinical Functional Profile of the Hands of Patients with Rheumatoid Arthritis at Royal Prima Hospital Medan Coray Carolyn Ruth Pardede, Eifel; Alexander, Rico; Chiuman, Linda
International Journal of Science and Environment (IJSE) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijse.v5i4.284

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease that frequently causes progressive joint damage, particularly in the hands, resulting in impaired functional ability in daily activities. This study aims to describe the hand function of patients with rheumatoid arthritis based on age, gender, and family history at Royal Prima Hospital Medan. This research employed a descriptive quantitative design with a cross-sectional approach involving 55 respondents who met the inclusion criteria. Data were collected using a structured hand function questionnaire assessing right hand, left-hand, and bilateral hand function across various activities. Data analysis was conducted using univariate and bivariate descriptive methods through cross tabulation. The results showed that hand function impairment was most prominent in patients aged >40 years, who predominantly fell into the “poor” function category. Female respondents demonstrated a higher level of functional limitation compared to males. Meanwhile, a family history of RAcontributed as a predisposing factor but did not directly correlate with the severity of functional impairment. Patients with a family history tended to fall within the “moderate” category, while more severe impairment was observed among those without a family history. Older age and female gender are major factors associated with reduced hand function in RA patients, whereas family history serves as a predisposition rather than a determinant of severity.
Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Akalili, Cory Cintia Alexander Simanjuntak Alexander, Rico Amir, Widya Pasca Anditha, Arie Tika Anggraeni, Wenti Arif, Maria Nisaul Aulia, Rumi Azah, Yunita Wannur Bagas Dwi Sanjaya Bangun, Chrismas Gideon Bangun, Primta Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal Colin, Vito Coray Carolyn Ruth Pardede, Eifel Datitha Alodia Br Kaban, Karina DEWI SARTIKA Dhillon, Jessyca Manishwer Kaur Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Edy Fachrial Erika Erika Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Febriani Simanjuntak, Lorena Felix, Jesslyn Fentia, Lia Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Astriani Natalia Br Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Girsang, Ermi Gozali, Juliana Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Haicha Pritama, Irza Halim, Angel Jonathane Halim, Michael Halim, Valencia Angelina Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hestina Hidayatti, Mustika Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul Irwan Irwan irza Haicha Pratama Janice Janice Jannah, Ratu Mutiara Raudhatul Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Leony, Catherine Levinna, Levinna Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Marfitania, Taranipa Maswarni Maulidza, Citra Puan Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Mukti, Ade Indra Muna Soraya Putri Nadapdap, Thomson Nadia, Felanda A Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Ongko, Nicolas Xavier Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Reyini Namora L. Sebayang, Dwi Putri Agita Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Stanliko, Stanliko Suandy, Suandy SUHARTOMI . Sulistijanto, Eddy Suyono, Tan Syahputra, Fahmi Syahputra, Hariyadi Dharmawan Tambunan, Andika Z Tambunan, Andika Zayani Tambunan, Ridhona Tanamal, Claudia Tandiono, Michelle Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Theresia, Yohani Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban vera vera, vera VERONICA VERONICA Virgoh, Livia WAHYU WIDOWATI Wardhani, Fiska Maya Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yulita, Emi Yusmaini, Yusmaini Zendrato, Ronauli Muliani