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All Journal Biospecies Jurnal Kedokteran Brawijaya JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) BERITA BIOLOGI The Indonesian Biomedical Journal Lantanida Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas Window of Health : Jurnal Kesehatan Indonesian Journal of Medicine Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Keperawatan Priority Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains An-Nadaa: Jurnal Kesehatan Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Inovasi Pendidikan dan Sains Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Jurnal Ilmiah METADATA Eureka Herba Indonesia Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal EduHealth Journal of Current Health Sciences International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Jurnal Sains dan Teknologi Buletin Kedokteran dan Kesehatan Prima Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) International Journal of Science and Environment Journal of Pharmaceutical and Sciences. Blantika : Multidisciplinary Journal Malahayati International Journal of Nursing and Health Science

Chiuman, Linda

Universitas Prima Indonesia

Author-ID : 1391724

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Test of Antioxidant And Antibacterial Activity of Ethanol Extract of Andaliman Fruit (Zanthoxylum Acanthopodium Dc.) With Dpph (1.1-Diphenyl-2-Picrylhydrazil) Trapping Method And Minimum Inhibitory Concentration Ira Syaputri; Ermi Girsang; Linda Chiuman
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 2 (2022): May 2022
Publisher : CV. Inara

Utilization of bioavailability according to World Health Organization (WHO) records is very large, it is estimated that almost 80% of mankind, especially in developing countries, still use plants as medicinal ingredients to maintain their health (Nugraheni, 2007). Andaliman (Zanthoxylum acanthopodium DC.) which belongs to the Rutaceae tribe which is one of the plants known to the Batak community, is classified as a wild plant and is a typical plant of Province North Sumatra. The method used in this research is experimental research. The research included collecting and processing andaliman fruit, making simplicia, making ethanol extracts, and examining antioxidant activity tests using the DPPH free radical scavenging method (1,1-diphenyl-2-picrylhydrazil) and antibacterial activity using the minimum inhibitory concentration method. The results of the antibacterial activity test of the ethanolic extract of andaliman fruit showed that the extract had antibacterial activity in the moderate category at a concentration of 300 mg/ml with an inhibition zone of 10.17 mm for Staphylococcus aureus bacteria and a moderate category for Staphylococcus epidermidis bacteria with an inhibition zone of 10.80 mm. The ethanol extract of andaliman fruit can inhibit Staphylococcus aureus and Staphylococcus epidermidis, effective at a concentration of 300 mg/ml with inhibitory diameters of 10.17 mm and 10.80 mm, respectively.

An Effect Virgin Coconut Oil Oral And Topical On Volume Decrease Of Foot Edema Of Male Wistar Flows Induced By –Caragenan Dzil Fikri; Ermi Girsang; Ali Napiah Nasution; Linda Chiuman
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Virgin Coconut Oil(VCO) is virgin coconut oil that is made enzymatically. The content of saturated fatty acids and flavonoid compounds in VCO can be used as an anti-inflammatory drug. This study aims to determine the activity of VCO as an anti-inflammatory. Anti-inflammatory activity was tested using the method of calculating the percentage of inflammation inhibition in white rat paws induced by intraplantar 1% carrageenan solution. The decrease in edema in the rat's feet was measured using a plethysmometer for 360 minutes. The results showed that VCO at a dose of 0.4 ml/200 g BW and 0.8 ml/200 g BW gave anti-inflammatory activity with the percentage of inflammation inhibition of 64.34 ± 9.90 and 52.66 ± 8, respectively. 94. The anti-inflammatory activity of VCO at a dose of 0.4 ml/ 200 g BW and a dose of 0.

Changes In Gait, Balance and Comfort That Is Felt in The Use of Shoes with Height-Elevating Insole with A Height Of 5, 7 and 9 Cm Lawrence, Christopher; Novalinda, Chrismis; Chiuman, Linda; Girsang, Ermi
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

The Use of shoes with height-elevating insole lately has been rife in the community. Use sol high this can affect the function of static and dynamic body, where physical changes in the body. As a result, generate a posture which is not stable, not balanced, and less comfortable when used in daily activities. Have many kinds of shoes with high soles with distinctions high pedestal the soles of shoes that allow the existence of different effects for the body. Objective, Prove the change of gait, balance and comfort in use of the shoe with a height-elevating the insole at the height of 5, 7, 9 cm. Material and Methods, experimental Research with pre and post test design. Subjects are men aged 20-22 years with a Body Mass Index (BMI) normal. Thirty people who are willing to follow the study and meet the inclusion and exclusion criteria were divided randomly into 3 groups, group a 5 cm, 7 cm and 9 cm, which respectively amounted to 10 people. Each group performed a walk test to test gait, one leg stands and tandemstand to test the balance with the barefoot/barefoot, shoes with height- elevating the insole with the same high. Results, the Results of this study show a change in gait and balance that are significant between barefoot and wearing shoes high soles (p=0.005). But the difference between the shoes with the height-elevating insole with a height of 5, 7 and 9 cm is not significant on the parameters of gait (p=0.329) but there is a change of balance in between shoes high soles 5, 7, 9 cm on the parameters of the balance (p=0.000). Conclusion, there are differences in the balance and there was no difference in gait on the use of the shoe’s height-elevating insole different (5, 7, 9 cm).

Handgrip Strength as an Indicator of Quality of Life in Chronic Kidney Disease Patients Undergoing Hemodialysis Amalia, Tiara; Lumbantobing, Christina J.R Esmaralda; Chiuman, Linda; Rajagukguk, Samuel Joshua Hamonangan Tua
JURNAL INOVASI PENDIDIKAN DAN SAINS Vol 6 No 3 (2025): December
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Nahdlatul Wathan Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51673/jips.v6i3.2768

Handgrip strength has been associated with various chronic diseases, length of hospitalization, cognitive decline, and even mortality. Hemodialysis administered to patients with chronic kidney disease affects their physical functioning, manifested as fatigue, mobility limitations, and a decline in the ability to perform daily activities. The goal of this study was to look at how hemodialysis patients at Rasyida Kidney Specialty Hospital Medan felt about their quality of life in relation to their grip strength. The research team used a cross-sectional analytical observational design to compile their findings. At Rasyida renal Hospital Medan, 52 patients with chronic renal disease who were receiving hemodialysis were included in the study. All participants had to meet the inclusion and exclusion criteria that were previously established. The research team used a handgrip dynamometer to measure grip strength, and the WHOQOL-BREF to assess quality of life. Processing of the data involved both bivariate and univariate analyses. Findings: There was a statistically significant correlation between age (p = 0.001) and both sex and quality of life (p = 0.003). Nevertheless, neither handgrip strength (p = 0.156), comorbidities (p = 0.618), nor the length of time on hemodialysis (p = 0.746) were significantly associated with quality of life. Conclusion: Physical strength as measured by handgrip, comorbid diabetes mellitus, and length of dialysis treatment do not seem to have a significant impact on quality of life among hemodialysis patients with chronic kidney disease. However, demographic characteristics, such as age and sex, do affect quality of life. Physical capacity as measured by handgrip strength is less important than demographic determinants in determining quality of life, according to these studies. Therefore, interventions aimed at improving quality of life are required, including social support and a care approach that focuses particularly on elderly patient groups rather than solely on physical aspects

Autologous Dendritic Cell Immunotherapy Modulates Renal Perfusion and Hemodynamics in Diabetic Kidney Soekardi, Adi; Chiuman, Linda; Ginting, Chrismis Novalinda
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3878

BACKGROUND: Diabetic kidney disease (DKD) is driven by chronic inflammation and endothelial dysfunction, which often persist despite standard pharmacological treatments. Autologous dendritic cell (DC) immunotherapy offers a novel approach to restore immune homeostasis and improve renal vascular function. While the use of autologous DC for immune homeostasis has been previously discussed, not many studies have explicitly reported on the modulation of renal perfusion parameters, such as peak systolic velocity (PSV) and resistive index (RI), following DC immunotherapy. Therefore, this study was conducted to evaluate the effect of autologous DC administration on renal hemodynamics, including PSV and RI, as well as inflammatory biomarkers, including tumor necrosis factor (TNF)-α and vascular cell adhesion molecule (VCAM-1) in DKD patients.METHODS: Thirty-one DKD patients were selected via simple random sampling. All subjects underwent autologous DC therapy, which was administered via intravenous infusion at a concentration of approximately 1×107 cells suspended in 100 mL of normal saline. PSV and RI were measured using Renal Doppler Ultrasonography, while TNF-α and VCAM-1 were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method. All measurements were conducted before intervention and 60 days after intervention to evaluate the therapeutic efficacy.RESULTS: DC therapy led to significant alterations in renal hemodynamic parameters. The mean PSV decreased from 52.74 to 38.21 cm/s (p=0.016), while RI showed a modest increase from 0.7350 to 0.7550 (p=0.028). Greater hemodynamic effects were observed in patients with well-controlled glycemia, lower serum urea, and microalbuminuria. In contrast, no significant changes were detected in TNF-α and VCAM-1 levels.CONCLUSION: Autologous DC therapy delivers measurable, statistically significant benefits in renal vascular parameters for DKD, particularly in early-stage disease and metabolically stable patients. These findings may support DC therapy as a promising adjunctive strategy to improve renal microcirculation in DKD. KEYWORDS: diabetic kidney disease, dendritic cell therapy, TNF-α, VCAM-1, PSV, RI

The Effect of Single Garlic Extract (Allium Sativum Var. Solo Garlic) Administration on Weight Gain in Male Rattus Wistar Rats with Dyslipidemia Miranda Winda Sari Sitorus; Suandy, Suandy; Linda Chiuman
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 5 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i5.6494

Background: Dyslipidemia is an abnormal condition (increase or decrease) in cholesterol lipoproteins, including an increase in total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels, as well as a decrease in high-density lipoprotein (HDL) levels. Metabolism plays a role in converting nutrients into compounds necessary for life processes, such as energy sources (ATP). Research Objective: To determine the effect of administering single garlic extract (Allium sativum var solo garlic) on weight gain in male Rattus winstar rats with dyslipidemia. Research Methods: This quasi-experimental study used 24 male Wistar rats, single garlic extract, butter, quail eggs, used cooking oil, and scales. The study population consisted of 24 male Wistar rats, which were divided into four groups of six rats each using Federer's formula. The treatments in this study were: the positive group was given standard feed and simvastatin; the negative group was given standard feed and aquabides; treatment group 1 was given 200 mg/kgBW of single garlic extract; and treatment group 2 was given 400 mg/kgBW of single garlic extract. Body weight assessments were conducted four times, namely on days 7, 14, 21, and 28. The research data analyzed were total cholesterol, LDL count, HDL count, triglyceride count, and body weight. Data were analyzed for normality using the Shapiro-Wilk test, and if normally distributed, continued with a one-way parametric ANOVA test and Tukey HSD post-hoc test. Data were analyzed using IBM SPSS 23 for Windows, with P values < 0.05 interpreted as statistically significant. Research Results: The mean values and standard deviations for the positive group were 234±13.20 on day 7, 223±12.29 on day 14, 231.83±11.99 on day 21, and 227.5±10.15 on day 28. Negative group on day 7 (237.33±18.52), day 14 (240±7.84), day 21 (238.5±17.28) and day 28 (239.16±9.62). Treatment 1 on day 7 (261.5±27.22), day 14 (296±21.63), day 21 (316.33±21.05) and day 28 (334.16±17.03). Treatment 2 on day 7 (290±10.62), day 14 (327.16±7.41), day 21 (344.33±45.39) and day 28 (385.83±13.43). Administration of 400 mg/kgBW single garlic extract significantly (P = 0.02 < 0.05) increased the body weight of rats compared to the positive and negative control groups. Conclusion: Based on the results of this study, single garlic extract in test animals showed an increase in body weight in dyslipidemic rats, indicating the need for further research on the mechanism of weight gain due to the administration of single garlic extract.

Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Agung Adha Witasa Dewana Akalili, Cory Cintia Alexander Simanjuntak Alexander, Rico AMALIA, TIARA Amir, Widya Pasca Andika Zayani Tambunan Anggraeni, Wenti Arif, Maria Nisaul Azah, Yunita Wannur Bagas Dwi Sanjaya Bangun, Chrismas Gideon Bangun, Primta Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal Colin, Vito Coray Carolyn Ruth Pardede, Eifel Datitha Alodia Br Kaban, Karina DEWI SARTIKA Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Dzil Fikri Edy Fachrial Erika Erika Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Felix, Jesslyn Fentia, Lia Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Girsang, Ermi Gozali, Juliana Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Haicha Pritama, Irza Halim, Angel Jonathane Halim, Michael Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hidayatti, Mustika Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul Ira Syaputri Irwan Irwan irza Haicha Pratama Janice Janice Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Lawrence, Christopher Leony, Catherine Levinna, Levinna Lie, Veronica Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Lumbantobing, Christina J.R Esmaralda Marfitania, Taranipa Maswarni Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Miranda Winda Sari Sitorus Mukti, Ade Indra Nadapdap, Thomson Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Novalinda, Chrismis Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Puspita, Sunny Putri, Muna Soraya Rajagukguk, Samuel Joshua Hamonangan Tua Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Reyini Namora L. Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Soekardi, Adi Stanliko, Stanliko Stefenie Suandy, Suandy Sulistijanto, Eddy Suyono, Tan Syahputra, Hariyadi Dharmawan Tambunan, Ridhona Tan Suyono Tanamal, Claudia Tandiono, Michelle Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban vera vera, vera Virgoh, Livia WAHYU WIDOWATI Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yulita, Emi Yusmaini, Yusmaini Zendrato, Ronauli Muliani

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