Murdani Abdullah
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Indonesia/Dr. Cipto Mangunkusumo General National Hospital

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Journal : JOURNAL LA MEDIHEALTICO

In Vitro Anti-inflammatory Effect of Secretome from Umbilical Cord-derived Mesenchymal Stem Cells in COVID-19 Patient Blood: A Study on sIL-6R, sgp130, IL-1RA and Anti/pro Inflammatory Cytokines Asysyifa, Nisrina; Wibowo, Heri; Abdullah, Murdani; Liem, Isabella Kurna; Bustami, Arleni
Journal La Medihealtico Vol. 5 No. 5 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i5.1522

Abstract

COVID-19 exhibits a wide range of clinical manifestations which severity of the disease is linked to uncontrolled escalation of inflammatory mediators. Ongoing research has identified the immunomodulatory effects of the MSC-derived secretome as a potential therapy for COVID-19. However, the precise mechanism by which the secretome exerts its therapeutic effect on COVID-19 remains unclear. This study aims to investigate whether the components of the UC-MSC-derived secretome can alter the inflammatory characteristics of immune cells. To achieve this, an in vitro study will be conducted involving co-incubation of whole blood with secretomes, followed by LPS stimulation. A total of 12 blood samples from severe COVID-19 and healthy subjects were cultured into three groups (RPMI control, 3μl and 9μl secretome group) incubated for 24 hours. Then, the cultures were exposed to LPS for 48 hours. The levels of sIL-6R, sgp130, IL-1RA, IL-6, TNF-α, IFN-γ, and IL-10 were measured. Results showed that LPS increased IL-6, TNF-α, and IL-10 production, while reducing sIL-6R, and sgp130, but no changes seen in IFN-γ in secretome-incubated blood cultures. The post-LPS/pre-LPS ratio analysis was conducted to investigate the anti-inflammatory potential of secretome. It was found that the secretome provides its anti-inflammatory effects through the role of IL-1RA.
Co-Authors A.A. Ketut Agung Cahyawan W Aan Santi Abdul A. Rani Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi Achmad, Ibrahim Adang Bachtiar Adeputri Tanesha Idhayu Adiningsih Srilestari Aditya Rachman, Aditya Adityo Susilo, Adityo Adli, Mizanul Afifah Is Afistianto, Muhammad Fikri Agus Sudiro Waspodo Ahmad Soefyani Ahmar Abyadh Aida Lydia Akmal Taher Alexander, Reinaldo Ali Djumhana Ali Imron Yusuf Amanda P Utari, Amanda P Amanda Pitarini Utari Anastasia Yoveline Andri Sanityoso Angraeni, Sri Ari F Syam Ari F. Syam Ari Fahrial Syam Ari Wijayanti Ariadi Humardani Arleni Bustami Arman A Abdullah Arnelis Arnelis Artati Murwaningrum, Artati Ascobat, Purwantyastuti Asysyifa, Nisrina Aziz Rani Azzaki Abubakar, Azzaki Birry Karim Bisuk, Batara Bona Adhista Budhi Setianto Budi Tan Oto Budiman Bela Budiman Budiman Budimutiar, Felix C Martin Rumende Ceva W. Pitoyo Chairul R Nasution Chatarina Umbul Wahyuni Chudahman Manan Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Chyntia Olivia MJ Cleopas Martin Rumende Cosphiadi Irawan Czeresna Heriawan Soejono Dadang Makmun Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Dante Saksono Harbuwono Dasril Nizam Deddy Gunawanjati Dewantoro, Okto Dharmeizar Dharmeizar Dharmika Djojoningrat Diah Rini Handjari Diani Kartini Diany N Taher Diding Heri Prasetyo Djumhana A Dolly Dolven Kansera Dono Antono Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edy Rizal Wahyudi Ekowati Rahajeng Ellen Susanti Elli Arsita Em Yunir, Em Ening Krisnuhoni Eric Daniel Tenda Evy Yunihastuti Fauzi Ahmad Muda Fiastuti Witjaksono Firsyada, Fajar Fransiska Hardi Fumiaki Kitahara Gaol, Donnie Lumban Giri Aji, Giri Guntur Darmawan Haloho, Raja Mangatur Harini Oktadiana, Harini Harmani Kalim Harry Isbagio Haryana, Sofia M Haryanto Surya Hasan Maulahela Hasan Mihardja Hayatun Nufus Hazim, Ahmad Herdiman T Pohan Herdiman T. Pohan Heri Wibowo Hiroyuki Otsuka Hotmen Sijabat I. D.N. Wibawa Ibrahim Basir Ibrahim Basyir Ibrahim, Febiansyah Idrus Alwi Ifransyah Fuadi, Ifransyah Ika Prasetya Wijaya Ikhwan Rinaldi Ilum Anam, Ilum Ilyas, Mohammad Imelda Maria Loho, Imelda Maria Indra Marki Inge Sutanto Ingrid S. Surono Irfan Maulani Iris Rengganis Irsan Hasan Irwin Tedja Iskandar, Rizka Puteri Ivo Novita Sah Bandar Jacobus Albertus Jamhari Jamhari Jane Estherina Jeanne Adiwinata Pawitan Jeffri Gunawan Jeffry Beta Tenggara Jimmy Posangi Jonlean, Reganedgary Joseph JY Sung Judo Prihartono Julwan Pribadi Jumhana Atmakusuma Jusman, Sri W Kahar Kusumawidjaja, Kahar Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Khie Chen Khomimah Khomimah, Khomimah Kuntjoro Harimurti Laras Budiyani, Laras Lianda Siregar Liem, Isabella Kurna Liem, Isabella Kurnia Lies Luthariana Lili Indrawati Lusiani Rusdi, Lusiani Lutfiah, Evah M Purnomo Isnaeni M Usman SM Maharani, Shabrina Mansur, M. Tasrif Marcellus Simadibrata Marcellus Simadibrata K Margaluta, Ariansah Marthino Robinson Martin, Cleopas Maruhum B.H. Marbun Masayuki A Fujino Masayuki A. Fujino Masdalina Pane Maulana Suryamin, Maulana Meriza, Tanggo Minarma Siagian Moch Ikhsan Mokoagow Mochamad Iqbal Hassarief Putra, Mochamad Iqbal Hassarief Mohammad Adi Firmansyah Mondrowinduro, Prionggo Muhadi Muhadi, Muhadi Muhammad Artisto Adi Yussac MUHAMMAD SYAFIQ Muhammad Yamin Muhammad Yamin Lubis, Muhammad Yamin Mulia Mulia Mustikarani, Dewi Mutiara, Rizka Muzellina, Virly Nanda Nababan, Saut Horas H. Nana Supriana Nanda N. Muhammad, Nanda N. Nata Pratama Nikko Darnindro Novie Rahmawati Zirta Nully Juariah M Nur Rasyid Nur Riviati, Nur Nury Dyah, Nury Oktarina, Caroline Pambudi, Joko Rilo Pamela Abineno Pamela Abineno Damaledo Pangarapen Tarigan Pangestu Adi Parhusip, Santi Sumihar Rumondang Pattiiha, Arief Paulus Kusnanto Paulus Simadibrata Pradipta, Saraswati Primariadewi Rustamadji Purwantyastuti Purwantyastuti Purwita W Laksmi, Purwita W Purwoko, Reza Yuridian Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi Ralph Girson Rambe, Dirga S. 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Rampengan Steven Sumantri Sudirman Katu, Sudirman Sugita, Peter Suhardjono Suhardjono Suharko Soebardi Suhendro Suhendro Suhendro Suwarto, Suhendro Sukamto Koesnoe Sumariyono Sumariyono Surono, Ingrid S Suryantini Suryantini Susanto, Liana W SUWIJIYO PRAMONO Suzana Ndraha Suzanna Immanuel Syari, Lucky Novita Tadashi Sato Tanadi, Caroline Tandan, Manu Tandarto, Kevin Telly Kamelia Tito Ardi Tjahjadi Robert Tedjasaputra Toman L Toruan Tonny Loho TR Fitriyani, TR Tri Juli Edi T Ummi Ulfah Madina, Ummi Ulfah Ummu Habibah, Ummu Velma Herwanto Vera Yuwono Wijaya, Anthony Eka Wirasmi Marwoto Wismandari Wisnu Wulandari, Yohannessa Wulyo Rajabto Yoga, Vesri Yohana Sitompul, Yohana Yonathan, I Wayan Murna Yuichiro Kojima Yundari, Yundari Yustar Mulyadi Zubairi Djoerban