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All Journal ACTA VETERINARIA INDONESIANA Media Veteriner Jurnal Kedokteran Brawijaya Jurnal Edukasi dan Sains Biologi Jurnal Ilmiah Mahasiswa Veteriner AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Jurnal Medika Veterinaria Jurnal Agripet
Muslim Akmal
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Association between tumor necrosis factor-α gene polymorphism and interleukin-6 level with mortality of neonatal sepsis Darnifayanti, Darnifayanti; Akmal, Muslim; Nur, Syahrun; Yusuf, Sulaiman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1234

Abstract

Sepsis is a systemic infection that significantly causes morbidity and mortality among neonates, which is associated with immature immune response. Variations in the tumor necrosis factor-alpha gene (TNF-α) -308G/A may be linked to neonatal sepsis mortality by modulating interleukins (ILs) involved in the immune response cascade, such as IL-6. The aim of this study was to investigate the association between TNF-α -308G/A gene variation and IL-6 level with mortality of neonatal sepsis. A cohort of 30 neonates diagnosed with clinical sepsis was recruited. Blood culture was performed for all patients and serum IL-6 levels were examined 24 hours after suspected sepsis. Genetic analysis of TNF-α single nucleotide polymorphisms (SNP) -308G/A was conducted using polymerase chain reaction and DNA sequencing. The association was assessed based on bivariate logistic regression. We found that 12 (40%) of 30 patients had blood culture-proven sepsis. Genotype of TNF-α -308G/A stratified of the patients was 56.7% for GA and 43.3% for GG. There were no AA variations found in this study. There was no significant association between the TNF-α -308 G/A genotype and mortality in neonatal sepsis (p=0.211). Similarly, the allelic model of TNF-α -308 gene had no association with mortality (p=0.325). Additionally, there was no association between serum IL-6 level and mortality in neonatal sepsis (p=0.253). In conclusion, SNP of TNF-α -308 gene and IL-6 level are not associated with mortality in neonatal sepsis.
The number of Leydig cells in highfat diet-fed rats after administration of kepok banana peel extract Zulkifli, Baidillah; Akmal, Muslim; Wahyuni, Sri; Gholib, Gholib; Adam, Mulyadi; Zainuddin, Zainuddin; Lubis, Triva Murtina; Usrina, Nora; Nirmala, Fadya
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v7i2.30689

Abstract

The impact of free radicals on testicular Leydig cells can result in the disruption of male reproductive health. The present study aimed to evaluate the effects of a high-fat diet on Leydig cells and the potential of kepok banana peel extract as a medication to mitigate these effects. In total of 20 adult male Wistar rats were assigned to five groups and treated with standard feed (P1), high-fat feed (P2), high-fat feed with simvastatin (P3), and high-fat feed with banana peel extract at doses of 100 and 200 mg/kg BW (P4 and P5). After 60 days of treatment, the number of Leydig cells was determined using HE staining methods. Data were analyzed using an One Way ANOVA test. The results showed that the administration of 100 mg/kg BW of kepok banana peel extract (P4) was able to maintain the number of Leydig cells and counteract the negative effects of a high-fat diet. These findings suggest that kepok banana peel extract may have the potential as a herbal medicine for supporting male reproductive health.
Effects of Black Garlic Extract Against Monosodium Glutamate-Induced Liver Damage in Rats: Macroscopic Studies Maulina, Nora; Zachreini, Indra; Gholib, Gholib; Akmal, Muslim
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v11i1.18815

Abstract

Monosodium glutamate (MSG) enhances flavor during food processing by providing an umami taste, but its metabolic by-products can cause liver injury. The liver is crucial for the metabolism of xenobiotics including glutamate. Black garlic, derived from fresh garlic (Allium sativum L.) through chemical reactions and heat treatment, may have hepatoprotective properties; however, studies are limited. This study assessed the hepatoprotective effects of black garlic extract (BGE) on MSG-induced liver damage. Twenty-five Wistar rats (Rattus norvegicus) were divided into five groups (n = 5): P0 (negative control); P1 (MSG group), 8 mg/kg MSG for 21 days; and P2, P3, and P4, receiving the same MSG protocol as P1 plus BGE doses of 200, 400, and 600 mg/kg body weight, respectively, for 16 days. After the experiment, rats were euthanized for liver tissue extraction. Although liver weights in the BGE-treated groups were lower than those in the MSG group, the difference was not statistically significant. These results indicated that a BGE dose of 200 mg/kg body weight mitigated MSG-induced hepatic damage. Further biochemical and histological studies are required to elucidate the mechanism of BGE's hepatoprotective action of BGE against MSG-induced hepatotoxicity.
Treatment Of Prolapsus Bulbus Oculi In Domestic Cats Sukma, Zahwa Tamara; Darmawi, Darmawi; Sayuti, Arman; Amiruddin, Amiruddin; Syafruddin, Syafruddin; Daud, Razali; Erwin, Erwin; Panjaitan, Budianto; Ferdian, Riyan; Zamzami, Rumi Sahara; Usrina, Nora; Akmal, Muslim; Balqis, Ummu
Jurnal Medika Veterinaria Vol 19, No 1 (2025): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v19i1.37430

Abstract

Bulbus oculi prolapse is a condition characterized by the protrusion of the eyeball from the eye socket, which can be caused by various factors such as trauma, elevated intraocular pressure, and abnormalities in the eye muscles. This case study aimed to examine the treatment of bulbus oculi prolapse in domestic cats. A female calico cat named Mici presented with a chronic left eye injury that had become infected, leading to inflammation and persistent ocular discharge. The cats body weight was 0.7 kg, and its temperature was 38.2C. Surgical treatment was performed using an enucleation technique. The procedure involved an incision along the mid-anterior eyelid, extending to the lower eyelid. Dissection was carried out to expose the bulbus oculi, which was then ligated and excised. The eyelid margins were sutured using simple interrupted sutures. Postoperatively, the cat was administered antibiotics and antihistamines.
Karakteristik Semen dan Komposisi Kimia Plasma Seminalis Sapi Aceh yang Dipelihara di BIBD Saree Aceh Besar Zulyazaini, Zulyazaini; Dasrul, Dasrul; Wahyuni, Sri; Akmal, Muslim; Abdullah, Mohd. Agus Nashri
Jurnal Agripet Vol 16, No 2 (2016): Volume 16, No. 2, Oktober 2016
Publisher : Faculty of Agriculture

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17969/agripet.v16i2.5803

Abstract

ABSTRAK. Penelitian ini bertujuan untuk menentukan karakteristik dan komposisi plasma semen sapi aceh. Sampel semen dikoleksi dari 2 ekor sapi aceh jantan sehat berumur 3,0-3,5 tahun menggunakan vagina buatan. Koleksi semen dilakukan satu kali dalam seminggu selama enam minggu. Evaluasi karakteristik semen meliputi volume, warna, konsistensi, pH, konsentrasi spermatozoa, motilitas, viabilitas, abnormalitas spermatozoa dan komposisi kimia plasma semen. Data kualitas dan komposisi kimia plasma semen yang diperoleh dianalisa secara diskriptif. Hasil penelitian menunjukkan semen segar sapi aceh memiliki volume 3,82 0,47 ml, warna krem keputihan, konsistensi kental, pH 6,84 0,17, konsentrasi 1194 4,80 106sp/ml, persentase motilitas 77,28 3,17 % dan abnormalitas 5,98 1,77%. Plasma seminalis semen segar sapi aceh mengandung protein total sebanyak 1,51 0,21 g/100ml, Kalium 75,80 22,63 mg/100 ml dan Magnesium 32,30 17,64 mg/100 ml lebih tinggi, tetapi Natrium 170,00 81,60 mg/100 ml; kalsium 40,00 12,76 mg/100 ml, Fosfor 16,70 6,17 mg/100 ml, dan Mangan 7,08 2,48 mg/100 ml lebih rendah dibandingkan dengan sapi potong. Secara umum kuantitas dan komposisi plasma seminalis semen sapi aceh yang dihasilkan cukup baik, dan memenuhi syarat untuk diproses sebagai semen beku.(The characteristics of semen and chemical composition of the seminal plasma of aceh cattle maintaned in BIBD Saree Aceh Besar)ABSTRACT. This study aim were to determine characteristics and composition of semen plasma Aceh cattle. Semen samples were collected from two healthy Aceh bulls that aged from 3.0 to 3.5 year. Samples were yielded by using an artificial vagina. Samples collecting were conducted once a week for six consecutive weeks. The evaluation of semen characteristics includes volume, color, consistency, pH, sperm concentration, motility, viability, abnormal spermatozoa and seminal plasma chemical composition. Data of semen quality and chemical composition of seminal plasma were analyzed descriptively. The evaluation showed that Aceh Cattle semen had 3.82 0.47 ml volume, beige whitish color, thick consistency, 6.84 0.17 pH, 1194 4.80106 sp/ml sperm concentration, 77.28 3.17% motility and 5.98 1.77% abnormal spermatozoa. Plasma seminalis fresh semen of Aceh Cattle contained 1,51 0,21 g/100ml total protein; 75,80 22,63 mg/100ml potassium and 32,30 17,64 mg/100ml magnesium higher than the heifer, but 170,00 81,60 mg/100ml sodium; 40,00 12,76 mg/100ml calcium, 16,70 6,17 mg/100ml fosfor, and 7,08 2,48 mg/100ml mangan lower. It was concluded that quality and composition of seminal plasma Aceh cattle semen could be made as frozen semen.
Co-Authors Abdul Harris Abdullah, Mohd Agus Nashri Agik Suprayogi Al Azhar Al Azhar Amiruddin . Amiruddin A Amiruddin Amiruddin Andi Novita Arman Sayuti Arman Sayuti Arman Sayuti Aulanni'am, Aulanni'am Awaluddin Awaluddin Bagus Dwijayanti Bani, Ika I. Basuki B. Purnomo Boni Anggara budianto panjaitan Chintya Desfariza Cut Dahlia Iskandar Cut Nila Thasmi Cut Nila Thasmi Darmawi . Darnifayanti, Darnifayanti Dasrul Dasrul Dedy Syahrizal Denny Irmawati Dewi Ratna Sari Dian Masyitah, Dian Dian Masyitha Dian Masyitha Dwinna Aliza Dwinna Aliza Eka Meutia Sari Erdiansyah Rahmi Erwin Erwin Fadli A. Gani Farida Athaillah Ferdian, Riyan Fitriani Fitriani Fitriani Fitriani Fitriani Fitriani Fitriani Fitriani Gholib Gholib Gholib Gholib, Gholib Hafizuddin Hafizuddin Hamdan - Hamdan H Hamdan Hamdan Hamdani Budiman Hamdani H Hamny Sofyan Herlina Dimiati, Herlina Hermawaty Tarigan Husmimi Husmimi Husmimi Husmimi Husnurrizal . Idawati Nasution Idawati Nasution Imran Imran Indra Sitorus Joharsyah J Juli Melia Ketut Adnyane Mudite Listin Handayani M Nur Salim M Nur Salim M. Aris Widodo Mahdi Abrar Mauliza , Mauliza Mauliza, Mauliza Mohd. Agus Nashri Abdullah Morteza Almuthahhar MUHAMMAD AGIL Muhammad Hambal Muhammad Jalaluddin Muhammad Jalaluddin Muhammad Toras Mulyadi Adam Mulyadi Adam Mulyadi Adam, Mulyadi Mulyadi M Mustafa Sabri Nanda Yulian Syah Nazaruddin N Nirmala, Fadya Nora Maulina, Nora Nora Usrina Nuzul Asmilia Patrick Flaggellata Rahma Melinda Rahmandi r Ramadhan, Akmal Rastina Rastina Razali Daud Razali R Rina Aulia Barus Rinidar - Rinidar R Roslizawaty R Rusli - Sariadi Sariadi Satria Tanjung Siswandy Siswandy Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Srihadi Agungpriyono Sugito Sugito Sugito Sugito Sukma, Zahwa Tamara Sulaiman Yusuf Sultan Fadhilla Taqwa Suriadi S Susi Darmayanti Sutiman B. Sumitro Suwandi, Abdulhadi Syafruddin S Syafruddin S Syafruddin Syafruddin Syafruddin Syafruddin Syahrun Nur T. Armansyah T. Armansyah T. Armansyah, TR T. Reza Ferasyi Taufiq P. Nugraha, Taufiq P. Teuku Reza Ferasyi Tongku N Siregar Tongku Nizwan Siregar Tongku Nizwan Siregar Triva Murtina Lubis Triva Murtina Lubis Tuty Laswardi Yusuf Ummu Balqis Wahono Esthi Prasetyaningtyas Wahyu Sihombing Wahyuni, Sri Wibi Riawan Yuza Al Iqwal Zachreini, Indra Zainuddin Z Zainuddin, Zainuddin Zamzami, Rumi Sahara Zuhrawaty Zuhrawaty Zulkarnain Zulkarnain Zulkifli, Baidillah Zulyazaini Zulyazaini Zulyazaini, Zulyazaini