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All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) BALI MEDICAL JOURNAL (BMJ) Journal of Tropical Soils Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi AGRIVITA, Journal of Agricultural Science Jurnal Farmasi Klinik Indonesia Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Penelitian Karet The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmaseutik Dinamika : Jurnal Ilmiah Ilmu Administrasi Negara Prosiding Seminar Nasional Sains dan Teknologi Terapan EDUKATIF : JURNAL ILMU PENDIDIKAN Klorofil: Jurnal Penelitian Ilmu-Ilmu Pertanian Ideas: Jurnal Pendidikan, Sosial dan Budaya Akta Agrosia Jurnal Kefarmasian AKFARINDO Journal of Intelligent Decision Support System (IDSS) Enrichment : Journal of Management PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) INVEST : Jurnal Inovasi Bisnis dan Akuntansi Sasambo Journal of Pharmacy Jurnal Manajerial Dan Kewirausahaan Warta Perkaretan BIOVALENTIA: Biological Research Journal Golden Ratio of Human Resource Management Gesture: Jurnal Seni Tari TANDIK: Jurnal Seni dan Pendidikan Seni Clavia: Journal of Law Jurnal Ilmu Hukum, Humaniora dan Politik (JIHHP) Journal Research of Social Science, Economics, and Management COREAI: Jurnal Kecerdasan Buatan, Komputasi dan Teknologi Informasi Ranah Research : Journal of Multidisciplinary Research and Development International Journal of Application on Economics and Business Hikmayo: Jurnal Pengabdian Masyarakat Journal Of Artificial Intelligence And Software Engineering Jurnal Serina Ekonomi dan Bisnis NGARSA: Journal of Dedication Based on Local Wisdom JAR'S (Journal of Advanced Research in Informatics) Indonesian Journal of Islamic Law (IJIL) Jurnal Cerdas Mendidik Proceeding Of International Conference On Education, Society And Humanity EduImpact: Jurnal Pengabdian dan Inovasi Masyarakat Mumtaza: Journal of Community Engagement Jurnal Serina Abdimas
ANDI WIJAYA
Universitas Ahmad Dahlan Yogyakarta
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Uji Antihipertensi Seduhan Bunga Rosella (Hibiscus sabdariffa.L ) Pada Tikus Putih Jantan Galur Wistar Hastuti, Dwi; Wijaya, Andi
Majalah Farmaseutik Vol 21, No 4 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i4.103205

Abstract

Bunga rosella banyak digunakan sebagai obat hipertensi karena sifat kardioprotektif dari flavonoid antosianin. Tujuan penelitian ini adalah untuk mengetahui pengaruh seduhan bunga rosella terhadap aktivitas antihipertensi tikus putih jantan galur wistar. Penelitian ini merupakan eksperimental Pretest-Posttest Control Group Design menggunakan 25 tikus jantan galur wistar yang dibagi menjadi kelompok kontrol negatif (CMC Na 1%), kontrol positif (Captopril 2,25 mg/kgBB), dan tiga kelompok perlakuan (seduhan bunga rosella dengan dosis 90 mg/kgBB, 180 mg/kgBB, dan 360 mg/kgBB). Pengecekan tekanan darah dilakukan sebanyak 3 kali yaitu sebelum penginduksian, setelah penginduksian, dan setelah diberikan larutan uji. Analisis data dilakukan menggunakan One-Way Anova SPSS dan diperoleh penurunan tekanan darah perlakuan seduhan bunga rosella dosis 90 mg/kgBB dan 360 mg/kgBB berbeda dengan kontrol negatif dan kontrol positif. Penurunan tekanan darah kelompok perlakuan berupa seduhan bunga rosella dosis 180 mg/kgBB menunjukkan tidak ada perbedaan dengan kontrol positif. Berdasarkan hasil penelitian dapat disimpulkan bahwa seduhan bunga rosella memiliki aktivitas antihipertensi terhadap tikus jantan galur wistar. Konsentrasi dosis seduhan bunga rosella berpengaruh terhadap aktivitas antihipertensi pada tikus uji dengan dosis seduhan bunga rosella 180 mg/KgBB, yang memiliki efek antihipertensi sama dengan Captopril 2,25 mg/kgBB dan dosis seduhan bunga rosella 360 mg/KgBB memberikan efek lebih tinggi dibandingkan Captopril 2,25 mg/kgBB.
KARAKTERISTIK DAN SIFAT MEKANIK KARET IRR SERI 300 UNTUK KARET SPESIFIKASI TEKNIS WIJAYA, Andi; ISMAWANTO, Sigit; SYAFAAH, Afdholiatus; OKTAVIA, Fetrina
Jurnal Penelitian Karet JPK: Volume 43, Nomor 2, Tahun 2025
Publisher : Pusat Penelitian Karet - PT. Riset Perkebunan Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/ppk.jpk.v43i2.1277

Abstract

Penelitian ini bertujuan untuk mengevaluasi karakteristik dan sifat mekanik karet alam dari klon IRR seri 300 sebagai kandidat unggul untuk produksi karet spesifikasi teknis (TSR). Terdapat 21 klon IRR seri 300 yang merupakan hasil seleksi peneliti pemuliaan Pusat Penelitian Karet. Sampel lateks diperoleh dari Kebun Percobaan dan Produksi Sembawa, Banyuasin, Sumatera Selatan. Sampel kemudian dianalisis untuk karet mentah dan kompon karet dengan parameter, yaitu kadar karet kering (KKK), plastisitas awal (Po), indeks ketahanan plastisitas (PRI), viskositas Mooney, kadar abu, dan kadar zat menguap serta parameter sifat fisik mekanik. Hasil penelitian menunjukkan bahwa KKK klon IRR 300 berada pada rentang 39,68–46,33%. Klon IRR 309 menunjukkan performa terbaik pada parameter Po (49), PRI (76,83), dan viskositas Mooney (80). Parameter tersebut mengindikasikan ketahanan oksidatif dan stabilitas proses yang lebih baik. Seluruh klon IRR seri 300 memenuhi persyaratan SNI 1903:2017 untuk SIR 10 parameter Po/PRI, kadar abu, dan zat menguap. Berdasarkan sifat-sifat tersebut, klon IRR 309 dinilai paling potensial untuk diaplikasikan dalam industri TSR, diikuti IRR 310 yang memiliki performa seimbang. Karakterisasi ini memberikan dasar penting dalam menentukan klon unggul untuk pemenuhan kebutuhan bahan baku karet spesifikasi teknis. Kata kunci: IRR seri 300; sifat mekanik; TSR; SIR 10
Sarcopenia as a Risk of Modern Obesity Treatments: A Review of Molecular Mechanisms and Prevention Strategies Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3583

Abstract

While lifestyle interventions and metabolic surgery for obesity have limitations, incretin-based therapies have emerged as highly effective treatments. However, their success is shadowed by a significant risk, which is the loss of lean skeletal muscle, which can induce sarcopenia or sarcopenic obesity. Given the vital role of skeletal muscle in overall health, it is crucial to accurately assess this condition using standard clinical measures. Exercise stands as the most potent countermeasure, acting as medicine to preserve muscle and improve metabolic health. Its benefits are driven by a complex interplay of mechanisms. Different exercise types trigger the release of myokines and exerkines, while a regulated inflammatory response is essential for muscle adaptation and regeneration. This regenerative process, involving muscle stem cells, is further governed by epigenetic factors and critical molecular pathways like Akt and insulin that maintain muscle mass. To optimize these effects, adequate protein intake and targeted nutritional strategies are essential, supporting muscle protein synthesis and recovery. Supplementation, particularly with leucine-rich amino acids or vitamin D, may further enhance anabolic responses, especially in older adults. Clinical monitoring of muscle mass, strength, and nutritional biomarkers should be integrated into obesity care to detect early signs of sarcopenia and guide individualized interventions. Therefore, it is imperative that obesity therapy evolves to prevent muscle loss. This review highlights the risk of therapy-induced sarcopenia from modern obesity treatments, emphasizing the need for integrated prevention strategies, centered on exercise, and reinforced by nutrition, supplementation, and clinical monitoring to ensure healthy, sustainable weight loss.KEYWORDS: sarcopenia, skeletal muscle, inflammation, obesity, incretin
Co-Authors , Susantidiana AA Sudharmawan, AA Abdul Rahman Adi, Nuri P. Afdholiatus Syafaah, Afdholiatus AGUS PRIYANTO Ahmad Faried Aidifitri, Siti Nurul Albar, Muh. Alwi Amarilisa Kusuma, Amarilisa Anan, M. Rifqi Andi Asadul, Andi Andi Nur Cahyo Andi Tira, Andi Andri Hidayat, Andri Andrianti, Sarah Andy Rachman Angelina, Devita Anggrainy, Veriana Angliana Chouw, Angliana Anna Meiliana Apriadi, Ferra Arief Rachmawan, Arief Arif Sugiono Asmawati Asmawati Astuti Kurnianingsih Astuti, Harti As’ad, Suryani Ayu Wulandari Aziz, Vijay Abdul Bachtiar Murtala Bahtiar, Akhmad Seruji Baso Madiong Benyamin Lakitan Bertha Pangaribuan Budiman, Bellinda Candra Ninghayu Chen, David Christopher Christopher Cuaca, Jeffrey Prasetya Cynthia R. Sartika Cynthia Retna Sartika, Cynthia Retna Danang Yulianto Deroes, Kartini M. Djoko Widodo Dwi Hastuti Dwi Putro Priadi Dwiyanto, Muhammad Alvin Edrick, Jon Eka Armas Pailis Eko Purnomo Erizal Sodikin Erma Yunita, Erma Erna Siaga, Erna Ertyastono, Adrian Fadilah, Lya Nailatul Fathur Rizal FETRINA OKTAVIA Firdaus Sulaiman, Firdaus Fitra Gustiar, Fitra Gan, Lady Gatot Lawrence, Gatot Gatot S. Lawrence Haifa, Rima Haniatin, Maimanatin Haniatin Hasyim, Fuadz Herman Ruslim Heryanto, Jacky Hidayat, kemas Muhammad Wahyu Himmah, Hanim Faiqotul Ida P. Sormin Irawan Yusuf Irma Ruslina Defi Irmawati Irmawati Irwan Suhendry, Irwan Jane, Jennie Jennie Jane Johan, Livia Junaidi Junaidi Kadir, Sabaruddin Kartika Kartika Kevin, Nicholas Khairi, Ahmad Khairunnisa Kuncoro, Setyo Kurniawan, Adeline Putri L. Meily Kurniawidjaja Laela Hayu Nurani Laily Ilman Widuri, Laily Ilman LEVIA, SHERLY NUR lhamjaya Patellongi Liviani, Liviani Lubapepita Triananda, Aurellia Lucia Herminawati, Lucia Lukman H Makmun Lukman Samboteng & Rulinawaty Kasmad M. Rial Andrika Mansyur Arief, Mansyur Marshela Maulana, M. Farhan Maulidi, Minan Fikri Mega, Sri Wulan Meihana, Mei Melisa Intan Barliana, Melisa Intan Memen Surahman Mery Hasmeda Mili Purbaya, Mili Moch Arif Maulana Mochlisin Andriyanto, Mochlisin Moh. Roby Trio Darmawanto Ikhsan Muafi Muchtaruddin Mansyur Muda, Strayker Ali Mudita, Natalia Ratna MUHAMAD UMAR HARUN Mulyadi, Jonathan Taniel Mulyana Mulyana Nurkhasa Nurkhasa, Nurkhasa Nurrani Mustika Dewi, Nurrani Mustika Nurshanti, Dora Fatma Octafilia, Yusnita Octariana Sofyan Parlindungan, Effendy Sagala Prajnamitra, Thomas Pranata, Dina Eka Pratami, Vani N. Purnama Asri Adinda, Gita Kinanthi Purwanto, Gilbert Imanuel Putri, Angely Olivia Qiantori, Adziqa Ammara Rahman, Waqi’ Rahmani Rahmani Rahmat Hidayat Rahmawaty, Dwi Renli, Aeron Ria, Rofiqoh Purnama Rianti, Dian Ratna Ridwan, Ridwan Rimawan, M. Rini Setiawati Risal Ardika Rizar, Fitra Fadhilah Ronaldo Michael Go Rosdianto, Aziiz Mardanarian Rujito A. Suwignyo, Rujito A. Rujito Agus Suwignyo Samboteng, Lukman Samuel Oetoro Sanjaya, Nanda Sarifa Aini Sarwana, Atin Sayurandi Sayurandi, Sayurandi Sherly Hanifarianty, Sherly Sholehah, Ari Fatus Shudiq, Wali Ja'far Sigit Ismawanto, Sigit Silaban, Jeffry Frans Rinaldo SITI HERLINDA Siti Masreah Bernas Siti Nurhaliza Siti Nurul Aidil Fitri Steven Delon Herjana Sulaiman Sulaiman Sulistyowati Sulistyowati Suryani As’ad Suryani As’ad SUSANTI DIANA Susilawati, Susilawati Sutardi, Edi Suwandi . SYAIFUL BAHRI Syarifah Aini Tahir, Tahir Teguh A.S. Ranakusuma Terawan Agus Putranto, Terawan Agus Toti Indrawati Treisna, Novita Tri Brata, Joko Tumbelaka, William Stefanus Turangan, Joyce A. Umi Rojiati Widjaja Lukito Wijaya, Carissa Vienna Wijaya, Marvella Wijaya, Septihani Michella Winata, Farrel Ernesto Yani Lina Yazidat, Izatul Yenny Surjawan Yukianti, Chiara Rizka Yuni Elsa Hadisaputri Zainal Arifin Zainul Muttaqin