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Irisin, A Fascinating and Multifunctional Protein: Implication for Health Defi, Irma Ruslina; Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2996

Abstract

BACKGROUND: Fibronectin type III domain-containing protein 5 (FNDC5), or also known as irisin, has been identified for two decades but almost completely disregarded for 10 years. It is present in skeletal muscle, heart, and brain, and in reaction to exercise can transform white adipose tissue into brown. Since then, irisin has gained a lot of attention for its potencies in treating metabolic disorders. In this review article, the potential future of irisin especially on metabolism and aging process will be discussed.CONTENT: Sedentary lifestyle is acknowledged as risk factor for type 2 diabetes mellitus, obesity, immune system issues, asthma, and neurological or heart illness. Irisin is secreted by muscle cells when exercising, produced after the proteolytic cleavage of FNDC5 protein. Irisin has positive impacts on maintaining physiological balance including reducing inflammation, keeping the bone homeostasis, as well as influencing metabolic processes and the neurological system function. Due to these many and advantageous characteristics, irisin could be a possible choice for preventing and managing disorders associated with modern society, and finding the agents to increase irisin can be beneficial.SUMMARY: Irisin offers a fresh potential basis for kinesitherapy and shows promise as a therapeutic target due to its various biological activities. Irisin pathway can be activated through dietary changes, the use of natural substances and drugs and can interact with this signalling pathway which involved peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and uncoupling protein mRNA 1 (UCP1) to resolve obesity and its metabolic comorbidities.KEYWORDS: irisin, FNDC5, exercise, inflammation, obesity, nervous system
Sarcopenic Obesity: The Underlying Molecular Pathophysiology and Prospect Therapies Meiliana, Anna; Dewi, Nurrani Mustika; Defi, Irma Ruslina; Rosdianto, Aziiz Mardanarian; Qiantori, Adziqa Ammara; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3176

Abstract

BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of obesity (excess fat mass) and sarcopenia (reduced skeletal muscle mass) clinical form and function.CONTENT: The primary cause of SO is insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results in impaired fatty acids oxidation. Decreased muscle mass results in lower mitochondria number and volume. Both will increase oxidative stress. Together with altered myokines in SO, oxidative stress was promoted and lead to higher M1 macrophages and failure in autophagy. The pro-inflammatory condition and dysbiosis links SO to a variety of cardiometabolic conditions, including non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. The mortality, comorbidities, cardiometabolic diseases, and disability or impairment of SO is higher compare to obesity or sarcopenia alone. Some treatments have been developed for SO including adequate dietary intake, vitamin D and antioxidant supplementation, and exercises.SUMMARY: SO is more prevalent among the elderly and has a significant negative impact on their quality of life. Therefore, maintaining muscle mass and strength as well as preventing obesity should be the key goals of initiatives to support healthy aging.KEYWORDS: aging, body composition, obesity, sarcopenia, skeletal muscle, metabolic syndrome
The Impact of Pruning Intensities and Non-Nutrient Ameliorants on Brazilian Spinach Growth in Floating Cultivation System Muda, Strayker Ali; Lakitan, Benyamin; Wijaya, Andi; Susilawati, Susilawati
AGRIVITA Journal of Agricultural Science Vol 46, No 2 (2024)
Publisher : Faculty of Agriculture University of Brawijaya in collaboration with PERAGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17503/agrivita.v46i2.4219

Abstract

Brazilian spinach is a highly nutritious leafy vegetable containing vitamins, minerals, and dietary fiber. This study assesses the impact of pruning intensities and non-nutrient ameliorants on Brazilian spinach growth in a floating cultivation system. The research follows a factorial randomized block design, with pruning intensity as the first factor and non-nutrient ameliorant as the second factor. Pruning intensity was categorized as light, moderate, and heavy, while the non-nutrient ameliorant included control, fine sand, rice-husk biochar, and fine sand + rice-husk biochar. The results show that moderate and heavy pruning effectively improved the response to NPK fertilization. Moderate pruning is proven to trigger the canopy area, especially starting 2 to 4 weeks after pruning. The Brazilian spinach canopy area demonstrated exponential growth and positively correlated with canopy diameter. The photosynthesis distribution in branch and shoot on moderate pruning was higher than heavy pruning, as indicated by dry weight. Moderate pruning produced a higher marketable yield than other pruning intensities. Regarding non-nutrient ameliorants, there are similarities in SPAD value, canopy area, index, dry weight, and yield. Therefore, moderate pruning is an effective practice to improve the growth and yield of Brazilian spinach, while the selected non-nutrient ameliorants have no impact.
Dapodik Application-Based Management Information System at The Malinau Regency Education Office (Teacher Certification Study) Aini, Sarifa; Rulinawaty, Rulinawaty; Wijaya, Andi
Ideas: Jurnal Pendidikan, Sosial dan Budaya Vol 10 No 2 (2024): Ideas: Pendidikan, Sosial, dan Budaya (Mei)
Publisher : Ideas Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32884/ideas.v10i2.1724

Abstract

The implementation of management information systems based on the Dapodik Application System at the Malinau District Education Office is a challenge considering that it is located in a border area and there are still many schools that are not reached by the internet or electricity. This research discusses the implementation of the management information system based on the dapodik application system in the education office of Malinau district (teacher certification study) and the inhibiting factors in the implementation of the system. The research method used is descriptive qualitative. The inhibiting factors of the implementation are limited internet network in some schools, delays in data inputting or updating school data and/or teachers who make changes to certification data, electricity is still limited to some education units, schools and teachers still have difficulties in using the dapodik application, and changes in school dapodik operators so that they must be re-socialiser.
Evaluation Of Office Relocation of PT. PLN (Persero) Unit Execution Project Nusa Tenggara 2 Wijaya, Andi; Silaban, Jeffry Frans Rinaldo; Ertyastono, Adrian
Journal Research of Social Science, Economics, and Management Vol. 3 No. 6 (2024): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jrssem.v3i6.612

Abstract

The location of the office of PT PLN (Persero) UPP Kitring Nusra 2 is in Ende Regency approximately 200 kilometers from the project locations currently managed. This makes the process of supervision and coordination with relevant stakeholders difficult. Throughout 2022 until now, work supervision, certification, land, ROW, and licensing activities have dominated the West Flores area. Therefore, for effective and efficient implementation of the main duties and functions, consideration of moving the office location to Labuan Bajo City needs to be done. This study aims to evaluate the feasibility of moving the office. The analysis method was carried out using factor rating and SWOT methods. The results of the comparison of 2 locations using the factor rating method show that the potential office location is in Labuan Bajo with a value of 95.81 and the existing location of Ende City is worth 84.19. Meanwhile, based on SWOT analysis, it was obtained that the location of the office in Labuan Bajo was in quadrant 1, so it can be concluded that the transfer is said to be feasible.
Diseminasi Optimalisasi Lahan melalui Budidaya Sayuran-Ikan Secara 3-in-1 di Lahan Perkotaan Lakitan, Benyamin; Rizar, Fitra Fadhilah; Nurshanti, Dora Fatma; Ria, Rofiqoh Purnama; Gustiar, Fitra; Fadilah, Lya Nailatul; Wijaya, Andi; Aidifitri, Siti Nurul; Muda, Strayker Ali
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 2 (2024): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.10.2.183-191

Abstract

The 3-in-1 vegetable-fish cultivation is an innovative cultivation system that integrates floating and climbing vegetable cultivation with fish culture. This cultivation is a solution to the problem of narrow land in urban areas for vegetable-fish cultivation to create: a) Fish farming in a concrete pool at the bottom position, b) Shade-tolerant vegetables cultivated using a floating culture system, and c) Climbing vegetables on a dedicated netted-frames as high as 2 meters above the pool. The dimensions of the pool correspond to the available land. The floating raft was constructed using 69 units of 1.5 L plastic bottles as floaters, assembled into a raft with a surface area of 2 m2. The buoyancy capacity of the raft is 120 kg. The raft has been patented with Granted patent No. IDP 000065141. The community service activities are a) Open demonstrations for 3-in-1 vegetable-fish farming installations; b) Socialization and assistance to communities interested in implementing it; and c) Collection of data and information for evaluation and publication materials. Static demonstration activities during one cycle of cultivation and socialization to three potential community groups, namely: a) Urban communities as the primary target; b) Journalists for more enlarging coverage of the dissemination; and c) Agricultural students for the learning process. Urban communities can adopt the dissemination of land optimization through 3-in-1 vegetable-fish cultivation on urban land. Community interest in this cultivation system innovation is outstanding, as represented by the community's enthusiasm for this program.
BUSINESS FEASIBILITY STUDY ON THE DEVELOPMENT OF THE LOCAL FASHION INDUSTRY THROUGH TECHNOLOGY INNOVATION USING KITA LOKAL Wijaya, Septihani Michella; Yukianti, Chiara Rizka; Johan, Livia; Wijaya, Andi
International Journal of Application on Economics and Business Vol. 1 No. 2 (2023): May 2023
Publisher : Graduate Program of Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ijaeb.v1i2.745-757

Abstract

Kita Lokal is a custom-made clothing service that is equipped with an expedition service, where Kita Lokal uses an application as a consumer intermediary to meet local tailors. Kita Lokal is here as a solution for consumers who want to realize their dream clothes, on the other hand also empowering the talents of local tailors. By using the Business to Consumer model, Kita Lokal presents a fashion quiz containing a number of questions to understand user preferences so that it can be developed in the application, Kita Cart provides history and likes features that can be seen by user followers, Artificial Intelligence (AI) features that can make it easier consumer. Kita Lokal will be the pioneer of applications that provide custom-made and expedition services at the same time as well as presenting an e-commerce platform and fashion community which is realized by increasing support for local fashion, providing outreach services to local fashion producers who do not understand technology, gathering talented local tailors. to change the perception that international brands are better than local brands to be able to compete and even excel in the fashion sector, expand the business market to the national realm, connect consumers with local tailors through the Kita Lokal platform and provide shipping services that make it easier for consumers to receive the results they have received. design with the motto bring life to your design with us.
ANALYSIS AND STRATEGY FOR PROVIDING CLEAN WATER TO THE SURROUNDING COMMUNITY IN THE MUARA ANGKE AREA Wijaya, Septihani Michella; Putri, Angely Olivia; Wijaya, Andi
International Journal of Application on Economics and Business Vol. 1 No. 2 (2023): May 2023
Publisher : Graduate Program of Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ijaeb.v1i2.736-744

Abstract

The environment provides a number for humans, one of which is providing clean water that can meet human needs. Earth as a place for human life provides 97.5 percent of water and the rest is land for living. Of the 97.5 percent figure, only 2.5 percent of the water has quality for human consumption. This means that the availability of clean water consumed by humans is very limited. In addition to this, there are many other factors that cause the availability of clean water to dwindle. For this reason, efforts are needed to reduce the clean water crisis. Researchers have formulated several strategies to address clean water in the Muara Angke area. Suggested strategic programs: Educate to increase awareness about clean water aims to provide the community with the importance of keeping the environment clean to help reduce and prevent the scarcity of clean water in the community, Ultrafiltration Technology which creates and provides water suitable for use for various daily household activities -days, Reverse Osmosis System to improve water quality with a reverse osmosis system, namely water filtration processing to neutralize tastes, odors and harmful substances, Pipeline systems related to the distribution of clean water to be distributed to every community settlement, Collaboration with Air Si Biru to obtain facilities and access to drinking water from Si Biru more easily and at a more affordable price, Integrated Marketing Communication which educates the message that the importance of clean water and the condition of clean water is limited in its availability in several areas of Indonesia waste, and CSR which will improve water quality which will later be processed into water that will be used by the community.
MARKETING STRATEGY INNOVATION IN THE FRAMEWORK TOWARDS EXPANSION OF DIGITAL BANK ACCESS AROUND STUDENTS (A CASE STUDY ON BLU BCA) Wijaya, Septihani Michella; Putri, Angely Olivia; Wijaya, Andi
International Journal of Application on Economics and Business Vol. 1 No. 3 (2023): Agustus 2023
Publisher : Graduate Program of Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ijaeb.v1i3.957-967

Abstract

Blu is a mobile banking service from BCA Digital which is designed and developed to make it easier for its customers to make financial and non-financial transactions via mobile phones. Currently, Blu already has a BI Fast Payment system for its services. BI Fast Payment is infrastructure. A national retail Payment System that can facilitate retail payments in real-time, safe, efficient, and available at any time. With the BI Fast Payment system, customers can make inter-bank transfers more efficiently and effectively than usual, which is IDR 2,500 per transaction. Not only can it be used to make payments, Blu can also be used for various purposes related to banking with various features such as: Blu Account for making purchases and withdrawals, Blu Saving for saving, Blu Gether which can plan finances with other users, and Blu Deposit opens a time deposit service of at least IDR 1,000,000. Due to the Covid-19 pandemic, the use of digital banks is increasing in Indonesia due to the cashless system when making payments. Therefore, Blu is here to support the system. Blu still has many systems and features that need to be developed to make users more comfortable.
COMPARATIVE ANALYSIS OF COMPANY PERFORMANCE BEFORE AND AFTER MERGERS AND ACQUISITIONS IN COMPANY LISTED ON IDX 2018-2021 Edrick, Jon; Wijaya, Andi
International Journal of Application on Economics and Business Vol. 1 No. 3 (2023): Agustus 2023
Publisher : Graduate Program of Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/ijaeb.v1i3.1537-1547

Abstract

The purpose of this study is to examine how companies trading on the Indonesia Stock Exchange fared before and after M&A deals were made in the years 2018 through 2021. In this Study, we employed a comparable quantitative approach called "purposive sampling" to collect our data. There are seven suitable businesses to use as examples. Descriptive statistics, a normality test, and the Wilcoxon signed-rank test were employed to analyze the data. There was no discernible change in the financial performance of companies listed on the Indonesia Stock Exchange (IDX) before and after the announcement of mergers and acquisitions, as measured by three financial ratios: return on assets (ROA), return on equity (ROE), and debt to equity ratio (DER), for the period of 2018-2021. Several elements, according to the findings of this research, determine the ultimate fate of mergers and acquisitions. Investors should be aware that mergers and acquisitions do not always improve business efficiency.
Co-Authors , Susantidiana AA Sudharmawan, AA Abdul Rahman Adi, Nuri P. Afdholiatus Syafaah, Afdholiatus AGUS PRIYANTO Ahmad Faried Aidifitri, Siti Nurul Albar, Muh. Alwi Amarilisa Kusuma, Amarilisa Anan, M. Rifqi Andi Asadul, Andi Andi Nur Cahyo Andi Tira, Andi Andri Hidayat, Andri Andrianti, Sarah Andy Rachman Angelina, Devita Anggrainy, Veriana Angliana Chouw, Angliana Anna Meiliana Apriadi, Ferra Arief Rachmawan, Arief Arif Sugiono Asmawati Asmawati Astuti Kurnianingsih Astuti, Harti As’ad, Suryani Ayu Wulandari Aziz, Vijay Abdul Bachtiar Murtala Bahtiar, Akhmad Seruji Baso Madiong Benyamin Lakitan Bertha Pangaribuan Budiman, Bellinda Candra Ninghayu Chen, David Christopher Christopher Cuaca, Jeffrey Prasetya Cynthia R. Sartika Cynthia Retna Sartika, Cynthia Retna Danang Yulianto Deroes, Kartini M. Djoko Widodo Dwi Hastuti Dwi Putro Priadi Dwiyanto, Muhammad Alvin Edrick, Jon Eka Armas Pailis Eko Purnomo Erizal Sodikin Erma Yunita, Erma Erna Siaga, Erna Ertyastono, Adrian Fadilah, Lya Nailatul Fathur Rizal FETRINA OKTAVIA Firdaus Sulaiman, Firdaus Fitra Gustiar, Fitra Gan, Lady Gatot Lawrence, Gatot Gatot S. Lawrence Haifa, Rima Haniatin, Maimanatin Haniatin Hasyim, Fuadz Herman Ruslim Heryanto, Jacky Hidayat, kemas Muhammad Wahyu Himmah, Hanim Faiqotul Ida P. Sormin Irawan Yusuf Irma Ruslina Defi Irmawati Irmawati Irwan Suhendry, Irwan Jane, Jennie Jennie Jane Johan, Livia Junaidi Junaidi Kadir, Sabaruddin Kartika Kartika Kawuryan, Megandaru Widhi Kevin, Nicholas Khairi, Ahmad Khairunnisa Kuncoro, Setyo Kurniawan, Adeline Putri L. Meily Kurniawidjaja Laela Hayu Nurani Laily Ilman Widuri, Laily Ilman LEVIA, SHERLY NUR lhamjaya Patellongi Liviani, Liviani Lubapepita Triananda, Aurellia Lucia Herminawati, Lucia Lukman H Makmun Lukman Samboteng & Rulinawaty Kasmad M. Rial Andrika Mansyur Arief, Mansyur Marshela Maulana, M. Farhan Maulidi, Minan Fikri Mega, Sri Wulan Meihana, Mei Melisa Intan Barliana Memen Surahman Mery Hasmeda Mili Purbaya, Mili Moch Arif Maulana Mochlisin Andriyanto, Mochlisin Moh. Roby Trio Darmawanto Ikhsan Muafi Muchlis Hamdi Muchtaruddin Mansyur Muda, Strayker Ali Mudita, Natalia Ratna MUHAMAD UMAR HARUN Mulyadi, Jonathan Taniel Mulyana Mulyana Nenchi, Galih Jelita Nurkhasa Nurkhasa, Nurkhasa Nurrani Mustika Dewi, Nurrani Mustika Nurshanti, Dora Fatma Octafilia, Yusnita Octariana Sofyan Parlindungan, Effendy Sagala Prajnamitra, Thomas Pranata, Dina Eka Pratami, Vani N. Pudjianto, Widodo Sigit Purnama Asri Adinda, Gita Kinanthi Purwanto, Gilbert Imanuel Putri, Angely Olivia Qiantori, Adziqa Ammara Rahman, Waqi’ Rahmani Rahmani Rahmat Hidayat Rahmawaty, Dwi Renli, Aeron Ria, Rofiqoh Purnama Rianti, Dian Ratna Ridwan, Ridwan Rimawan, M. Rini Setiawati Risal Ardika Rizar, Fitra Fadhilah Ronaldo Michael Go Rosdianto, Aziiz Mardanarian Rujito A. Suwignyo, Rujito A. Rujito Agus Suwignyo Samboteng, Lukman Samuel Oetoro Sanjaya, Nanda Sarifa Aini Sarwana, Atin Sayurandi Sayurandi, Sayurandi Sherly Hanifarianty, Sherly Sholehah, Ari Fatus Shudiq, Wali Ja'far Sigit Ismawanto, Sigit Silaban, Jeffry Frans Rinaldo SITI HERLINDA Siti Masreah Bernas Siti Nurhaliza Siti Nurul Aidil Fitri Soepriatna, Angelica Steven Delon Herjana Sulaiman Sulaiman Sulistyowati Sulistyowati Suryani As’ad Suryani As’ad SUSANTI DIANA Susilawati, Susilawati Sutardi, Edi Suwandi . SYAIFUL BAHRI Syarifah Aini Tahir, Tahir Teguh A.S. Ranakusuma Terawan Agus Putranto, Terawan Agus Toti Indrawati Treisna, Novita Tri Brata, Joko Tumbelaka, William Stefanus Turangan, Joyce A. Umi Rojiati Widjaja Lukito Wijaya, Carissa Vienna Wijaya, Marvella Wijaya, Septihani Michella Winata, Farrel Ernesto Yani Lina Yazidat, Izatul Yenny Surjawan Yukianti, Chiara Rizka Yuni Elsa Hadisaputri Zainal Arifin Zainul Muttaqin