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All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) BALI MEDICAL JOURNAL (BMJ) Journal of Tropical Soils Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi AGRIVITA, Journal of Agricultural Science Jurnal Farmasi Klinik Indonesia Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Penelitian Karet The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmaseutik Dinamika : Jurnal Ilmiah Ilmu Administrasi Negara Prosiding Seminar Nasional Sains dan Teknologi Terapan EDUKATIF : JURNAL ILMU PENDIDIKAN Klorofil: Jurnal Penelitian Ilmu-Ilmu Pertanian Ideas: Jurnal Pendidikan, Sosial dan Budaya Akta Agrosia Jurnal Kefarmasian AKFARINDO Journal of Intelligent Decision Support System (IDSS) Enrichment : Journal of Management PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) INVEST : Jurnal Inovasi Bisnis dan Akuntansi Sasambo Journal of Pharmacy Jurnal Manajerial Dan Kewirausahaan Warta Perkaretan BIOVALENTIA: Biological Research Journal Golden Ratio of Human Resource Management Gesture: Jurnal Seni Tari TANDIK: Jurnal Seni dan Pendidikan Seni Clavia: Journal of Law Jurnal Ilmu Hukum, Humaniora dan Politik (JIHHP) Journal Research of Social Science, Economics, and Management COREAI: Jurnal Kecerdasan Buatan, Komputasi dan Teknologi Informasi Ranah Research : Journal of Multidisciplinary Research and Development International Journal of Application on Economics and Business Hikmayo: Jurnal Pengabdian Masyarakat Journal Of Artificial Intelligence And Software Engineering Jurnal Serina Ekonomi dan Bisnis NGARSA: Journal of Dedication Based on Local Wisdom JAR'S (Journal of Advanced Research in Informatics) Indonesian Journal of Islamic Law (IJIL) Jurnal Cerdas Mendidik Proceeding Of International Conference On Education, Society And Humanity EduImpact: Jurnal Pengabdian dan Inovasi Masyarakat Mumtaza: Journal of Community Engagement Jurnal Serina Abdimas
ANDI WIJAYA
Universitas Ahmad Dahlan Yogyakarta
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Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3407

Abstract

One of the most serious side effects of diabetes is diabetic foot ulceration (DFU). It is a severe and extremely morbid illness that has been linked to higher mortality on its own. The development of effective wound therapeutics in the future may be influenced by our current and developing understanding of wound pathophysiology. By reestablishing cellular functioning, small extracellular vesicles (sEVs), a crucial medium for intercellular communications, exhibit encouraging therapeutic potential in the treatment of DFU. Mesenchymal stem cell (MSC) derived exosomes and engineered extracellular vesicles (EVs) have the potential to aid in the healing of wounds. Along with encouraging the growth and stimulation of endothelial cells, keratinocytes, and fibroblasts, they also have immunomodulatory and anti-inflammatory properties. They help prevent damaged cells from dying, revitalize senescent cells, and boost angiogenesis. MSC-EVs can be a safe, effective and ethical therapy for DFU by increasing M2 macrophages polarization, improving the proliferation, reducing scar, and improving angiogenesis.KEYWORDS: mesenchymal stem cell, extracellular vesicle, diabetic wound, wound healing
Molecular Mechanisms of Methylglyoxal in Diabetes-related Macrovascular Complications Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3242

Abstract

Diabetes mellitus (DM) is a chronic endocrine and metabolic disease indicated by the presence of hyperglycemia. It has been known that hyperglycemia and oxidative stress are the main culprit of all DM complications, including macrovascular complications. As a byproduct of lipid, protein, and carbohydrate metabolism, methylglyoxal (MGO) is a highly reactive substance which plays a positive signaling role in helping cells regain redox balance under oxidative stress circumstances. DM-related problems lead to an excess of mitochondrial superoxide in the heart and big and small vascular endothelial cells. Elevated intracellular reactive oxygen species induce impaired angiogenesis in reaction to ischemia, trigger several proinflammatory pathways, and result in enduring epigenetic modifications that propel the continuous expression of proinflammatory genes even after glucose levels return to normal. Over time, the significance of the extremely quick advanced glycation end-products (AGE) production caused by the extremely reactive MGO has been clarified. It is now evident that MGO causes vascular tissue to react maladaptively. Glyoxalase 1 (GLO1) is the primary enzyme in an organism's enzymatic glyoxalase defense mechanism, which converts MGO to D-lactate in order to counteract the harmful effects of MGO. Understanding the role of the MGO–GLO1 pathway in the etiology of vascular disease in diabetes has advanced significantly. Therefore, it can be summarized that vascular damage are linked to diabetes. The AGE precursor MGO are important in determining the connection between diabetes and vascular damage. MGO and AGEs play a role in several phases of the development of diabetes complications. MGO and AGEs may be useful therapeutic targets for diabetes's macrovascular problems.KEYWORDS: hyperglycemia, AGE, methylglyoxal, glyoxalase, D-lactate, gluthatione, oxidative stress
Obesity: A Multi Perspective of Physiology and Neurobiology Energy Regulation Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 1 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i1.2840

Abstract

BACKGROUND: World Health Organization has reported four million people die every year due to obesity comorbidity, and the prevalence of obesity is keep increasing, especially after COVID-19. Obesity has been defined as a chronic disease involving adipose tissue dysfunction which leads to metabolic diseases and psychosocial consequences. The review article will highlight some recent researches regarding the new conceptual framework that integrates both metabolic drives, as well as to summarize the numerous discussions about the current understanding of hypothalamic control of food intake and energy homeostasis.CONTENT: Obesity apparently is not simply regulated only by food and exercise. Hypothalamus takes part in controlling energy intake and expenditure via appetite regulation. Hedonic control in cortical and subcortical brain areas process cognitive, reward, information, and executive function. Managing metabolic adaptation, browning the white adipose tissue, and preserving lean mass can be another strategy to safely manage obesity.SUMMARY: Obesity need to be managed in a multimodal strategy including neurophysiology and physiology approach, together with environment support. Thus, a weight regain can be prevented. Commitment from both scientific and regulation point of view can shed a light to eradicate obesity.KEYWORDS: adipocyte, appetite, nutrition, obesity, physical activity, reward, satiety
Irisin, A Fascinating and Multifunctional Protein: Implication for Health Defi, Irma Ruslina; Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2996

Abstract

BACKGROUND: Fibronectin type III domain-containing protein 5 (FNDC5), or also known as irisin, has been identified for two decades but almost completely disregarded for 10 years. It is present in skeletal muscle, heart, and brain, and in reaction to exercise can transform white adipose tissue into brown. Since then, irisin has gained a lot of attention for its potencies in treating metabolic disorders. In this review article, the potential future of irisin especially on metabolism and aging process will be discussed.CONTENT: Sedentary lifestyle is acknowledged as risk factor for type 2 diabetes mellitus, obesity, immune system issues, asthma, and neurological or heart illness. Irisin is secreted by muscle cells when exercising, produced after the proteolytic cleavage of FNDC5 protein. Irisin has positive impacts on maintaining physiological balance including reducing inflammation, keeping the bone homeostasis, as well as influencing metabolic processes and the neurological system function. Due to these many and advantageous characteristics, irisin could be a possible choice for preventing and managing disorders associated with modern society, and finding the agents to increase irisin can be beneficial.SUMMARY: Irisin offers a fresh potential basis for kinesitherapy and shows promise as a therapeutic target due to its various biological activities. Irisin pathway can be activated through dietary changes, the use of natural substances and drugs and can interact with this signalling pathway which involved peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and uncoupling protein mRNA 1 (UCP1) to resolve obesity and its metabolic comorbidities.KEYWORDS: irisin, FNDC5, exercise, inflammation, obesity, nervous system
Roles of Mesenchymal Stem Cell-derived Extracellular Vesicles in Cancer: Development and Target Therapy Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3408

Abstract

Extracellular vesicles (EVs) are membrane structures that enclose proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs derived from mesenchymal stem cells (MSCs) can either stimulate or inhibit tumor growth in various malignancies through paracrine signaling. Tumor-associated MSCs (TA-MSCs), often described as "wounds that never heal," actively participate in the development, propagation, and metastasis of tumors, impacting the immunological state of the tumor microenvironment. For instance, TA-MSCs can alter immune cell recruitment and cytokine production, leading to a pro-tumorigenic environment. Consequently, both the tumor and its microenvironment undergo functional alterations, the cargo of exosomes is modified, and an abnormal tumor-associated MSC phenotype is acquired. MSC-EVs contain exosome microRNA with both tumor-inhibitory and tumor-supportive effects. For example, MSC-EVs have been shown to deliver tumor-suppressive microRNAs that inhibit cancer cell proliferation and induce apoptosis. This review outlines the criteria for the modification, isolation, and characterization of exosomes, as well as their application in cancer, providing insights for clinical use. By understanding these mechanisms, we can better harness MSC-EVs for therapeutic purposes.Keywords: mesenchymal stem cell, extracellular vesicle, exosome, cancer therapy, drug delivery
Sarcopenic Obesity: The Underlying Molecular Pathophysiology and Prospect Therapies Meiliana, Anna; Dewi, Nurrani Mustika; Defi, Irma Ruslina; Rosdianto, Aziiz Mardanarian; Qiantori, Adziqa Ammara; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3176

Abstract

BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of obesity (excess fat mass) and sarcopenia (reduced skeletal muscle mass) clinical form and function.CONTENT: The primary cause of SO is insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results in impaired fatty acids oxidation. Decreased muscle mass results in lower mitochondria number and volume. Both will increase oxidative stress. Together with altered myokines in SO, oxidative stress was promoted and lead to higher M1 macrophages and failure in autophagy. The pro-inflammatory condition and dysbiosis links SO to a variety of cardiometabolic conditions, including non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. The mortality, comorbidities, cardiometabolic diseases, and disability or impairment of SO is higher compare to obesity or sarcopenia alone. Some treatments have been developed for SO including adequate dietary intake, vitamin D and antioxidant supplementation, and exercises.SUMMARY: SO is more prevalent among the elderly and has a significant negative impact on their quality of life. Therefore, maintaining muscle mass and strength as well as preventing obesity should be the key goals of initiatives to support healthy aging.KEYWORDS: aging, body composition, obesity, sarcopenia, skeletal muscle, metabolic syndrome
The Impact of Pruning Intensities and Non-Nutrient Ameliorants on Brazilian Spinach Growth in Floating Cultivation System Muda, Strayker Ali; Lakitan, Benyamin; Wijaya, Andi; Susilawati, Susilawati
AGRIVITA Journal of Agricultural Science Vol 46, No 2 (2024)
Publisher : Faculty of Agriculture University of Brawijaya in collaboration with PERAGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17503/agrivita.v46i2.4219

Abstract

Brazilian spinach is a highly nutritious leafy vegetable containing vitamins, minerals, and dietary fiber. This study assesses the impact of pruning intensities and non-nutrient ameliorants on Brazilian spinach growth in a floating cultivation system. The research follows a factorial randomized block design, with pruning intensity as the first factor and non-nutrient ameliorant as the second factor. Pruning intensity was categorized as light, moderate, and heavy, while the non-nutrient ameliorant included control, fine sand, rice-husk biochar, and fine sand + rice-husk biochar. The results show that moderate and heavy pruning effectively improved the response to NPK fertilization. Moderate pruning is proven to trigger the canopy area, especially starting 2 to 4 weeks after pruning. The Brazilian spinach canopy area demonstrated exponential growth and positively correlated with canopy diameter. The photosynthesis distribution in branch and shoot on moderate pruning was higher than heavy pruning, as indicated by dry weight. Moderate pruning produced a higher marketable yield than other pruning intensities. Regarding non-nutrient ameliorants, there are similarities in SPAD value, canopy area, index, dry weight, and yield. Therefore, moderate pruning is an effective practice to improve the growth and yield of Brazilian spinach, while the selected non-nutrient ameliorants have no impact.
Dapodik Application-Based Management Information System at The Malinau Regency Education Office (Teacher Certification Study) Aini, Sarifa; Rulinawaty, Rulinawaty; Wijaya, Andi
Ideas: Jurnal Pendidikan, Sosial dan Budaya Vol 10 No 2 (2024): Ideas: Pendidikan, Sosial, dan Budaya (Mei)
Publisher : Ideas Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32884/ideas.v10i2.1724

Abstract

The implementation of management information systems based on the Dapodik Application System at the Malinau District Education Office is a challenge considering that it is located in a border area and there are still many schools that are not reached by the internet or electricity. This research discusses the implementation of the management information system based on the dapodik application system in the education office of Malinau district (teacher certification study) and the inhibiting factors in the implementation of the system. The research method used is descriptive qualitative. The inhibiting factors of the implementation are limited internet network in some schools, delays in data inputting or updating school data and/or teachers who make changes to certification data, electricity is still limited to some education units, schools and teachers still have difficulties in using the dapodik application, and changes in school dapodik operators so that they must be re-socialiser.
Evaluation Of Office Relocation of PT. PLN (Persero) Unit Execution Project Nusa Tenggara 2 Wijaya, Andi; Silaban, Jeffry Frans Rinaldo; Ertyastono, Adrian
Journal Research of Social Science, Economics, and Management Vol. 3 No. 6 (2024): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jrssem.v3i6.612

Abstract

The location of the office of PT PLN (Persero) UPP Kitring Nusra 2 is in Ende Regency approximately 200 kilometers from the project locations currently managed. This makes the process of supervision and coordination with relevant stakeholders difficult. Throughout 2022 until now, work supervision, certification, land, ROW, and licensing activities have dominated the West Flores area. Therefore, for effective and efficient implementation of the main duties and functions, consideration of moving the office location to Labuan Bajo City needs to be done. This study aims to evaluate the feasibility of moving the office. The analysis method was carried out using factor rating and SWOT methods. The results of the comparison of 2 locations using the factor rating method show that the potential office location is in Labuan Bajo with a value of 95.81 and the existing location of Ende City is worth 84.19. Meanwhile, based on SWOT analysis, it was obtained that the location of the office in Labuan Bajo was in quadrant 1, so it can be concluded that the transfer is said to be feasible.
Diseminasi Optimalisasi Lahan melalui Budidaya Sayuran-Ikan Secara 3-in-1 di Lahan Perkotaan Lakitan, Benyamin; Rizar, Fitra Fadhilah; Nurshanti, Dora Fatma; Ria, Rofiqoh Purnama; Gustiar, Fitra; Fadilah, Lya Nailatul; Wijaya, Andi; Aidifitri, Siti Nurul; Muda, Strayker Ali
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 2 (2024): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.10.2.183-191

Abstract

The 3-in-1 vegetable-fish cultivation is an innovative cultivation system that integrates floating and climbing vegetable cultivation with fish culture. This cultivation is a solution to the problem of narrow land in urban areas for vegetable-fish cultivation to create: a) Fish farming in a concrete pool at the bottom position, b) Shade-tolerant vegetables cultivated using a floating culture system, and c) Climbing vegetables on a dedicated netted-frames as high as 2 meters above the pool. The dimensions of the pool correspond to the available land. The floating raft was constructed using 69 units of 1.5 L plastic bottles as floaters, assembled into a raft with a surface area of 2 m2. The buoyancy capacity of the raft is 120 kg. The raft has been patented with Granted patent No. IDP 000065141. The community service activities are a) Open demonstrations for 3-in-1 vegetable-fish farming installations; b) Socialization and assistance to communities interested in implementing it; and c) Collection of data and information for evaluation and publication materials. Static demonstration activities during one cycle of cultivation and socialization to three potential community groups, namely: a) Urban communities as the primary target; b) Journalists for more enlarging coverage of the dissemination; and c) Agricultural students for the learning process. Urban communities can adopt the dissemination of land optimization through 3-in-1 vegetable-fish cultivation on urban land. Community interest in this cultivation system innovation is outstanding, as represented by the community's enthusiasm for this program.
Co-Authors , Susantidiana AA Sudharmawan, AA Abdul Rahman Adi, Nuri P. Afdholiatus Syafaah, Afdholiatus AGUS PRIYANTO Ahmad Faried Aidifitri, Siti Nurul Albar, Muh. Alwi Amarilisa Kusuma, Amarilisa Anan, M. Rifqi Andi Asadul, Andi Andi Nur Cahyo Andi Tira, Andi Andri Hidayat, Andri Andrianti, Sarah Andy Rachman Angelina, Devita Anggrainy, Veriana Angliana Chouw, Angliana Anna Meiliana Apriadi, Ferra Arief Rachmawan, Arief Arif Sugiono Asmawati Asmawati Astuti Kurnianingsih Astuti, Harti As’ad, Suryani Ayu Wulandari Aziz, Vijay Abdul Bachtiar Murtala Bahtiar, Akhmad Seruji Baso Madiong Benyamin Lakitan Bertha Pangaribuan Budiman, Bellinda Candra Ninghayu Chen, David Christopher Christopher Cuaca, Jeffrey Prasetya Cynthia R. Sartika Cynthia Retna Sartika, Cynthia Retna Danang Yulianto Deroes, Kartini M. Djoko Widodo Dwi Hastuti Dwi Putro Priadi Dwiyanto, Muhammad Alvin Edrick, Jon Eka Armas Pailis Eko Purnomo Erizal Sodikin Erma Yunita, Erma Erna Siaga, Erna Ertyastono, Adrian Fadilah, Lya Nailatul Fathur Rizal FETRINA OKTAVIA Firdaus Sulaiman, Firdaus Fitra Gustiar, Fitra Gan, Lady Gatot Lawrence, Gatot Gatot S. Lawrence Haifa, Rima Haniatin, Maimanatin Haniatin Hasyim, Fuadz Herman Ruslim Heryanto, Jacky Hidayat, kemas Muhammad Wahyu Himmah, Hanim Faiqotul Ida P. Sormin Irawan Yusuf Irma Ruslina Defi Irmawati Irmawati Irwan Suhendry, Irwan Jane, Jennie Jennie Jane Johan, Livia Junaidi Junaidi Kadir, Sabaruddin Kartika Kartika Kevin, Nicholas Khairi, Ahmad Khairunnisa Kuncoro, Setyo Kurniawan, Adeline Putri L. Meily Kurniawidjaja Laela Hayu Nurani Laily Ilman Widuri, Laily Ilman LEVIA, SHERLY NUR lhamjaya Patellongi Liviani, Liviani Lubapepita Triananda, Aurellia Lucia Herminawati, Lucia Lukman H Makmun Lukman Samboteng & Rulinawaty Kasmad M. Rial Andrika Mansyur Arief, Mansyur Marshela Maulana, M. Farhan Maulidi, Minan Fikri Mega, Sri Wulan Meihana, Mei Melisa Intan Barliana, Melisa Intan Memen Surahman Mery Hasmeda Mili Purbaya, Mili Moch Arif Maulana Mochlisin Andriyanto, Mochlisin Moh. Roby Trio Darmawanto Ikhsan Muafi Muchtaruddin Mansyur Muda, Strayker Ali Mudita, Natalia Ratna MUHAMAD UMAR HARUN Mulyadi, Jonathan Taniel Mulyana Mulyana Nurkhasa Nurkhasa, Nurkhasa Nurrani Mustika Dewi, Nurrani Mustika Nurshanti, Dora Fatma Octafilia, Yusnita Octariana Sofyan Parlindungan, Effendy Sagala Prajnamitra, Thomas Pranata, Dina Eka Pratami, Vani N. Purnama Asri Adinda, Gita Kinanthi Purwanto, Gilbert Imanuel Putri, Angely Olivia Qiantori, Adziqa Ammara Rahman, Waqi’ Rahmani Rahmani Rahmat Hidayat Rahmawaty, Dwi Renli, Aeron Ria, Rofiqoh Purnama Rianti, Dian Ratna Ridwan, Ridwan Rimawan, M. Rini Setiawati Risal Ardika Rizar, Fitra Fadhilah Ronaldo Michael Go Rosdianto, Aziiz Mardanarian Rujito A. Suwignyo, Rujito A. Rujito Agus Suwignyo Samboteng, Lukman Samuel Oetoro Sanjaya, Nanda Sarifa Aini Sarwana, Atin Sayurandi Sayurandi, Sayurandi Sherly Hanifarianty, Sherly Sholehah, Ari Fatus Shudiq, Wali Ja'far Sigit Ismawanto, Sigit Silaban, Jeffry Frans Rinaldo SITI HERLINDA Siti Masreah Bernas Siti Nurhaliza Siti Nurul Aidil Fitri Steven Delon Herjana Sulaiman Sulaiman Sulistyowati Sulistyowati Suryani As’ad Suryani As’ad SUSANTI DIANA Susilawati, Susilawati Sutardi, Edi Suwandi . SYAIFUL BAHRI Syarifah Aini Tahir, Tahir Teguh A.S. Ranakusuma Terawan Agus Putranto, Terawan Agus Toti Indrawati Treisna, Novita Tri Brata, Joko Tumbelaka, William Stefanus Turangan, Joyce A. Umi Rojiati Widjaja Lukito Wijaya, Carissa Vienna Wijaya, Marvella Wijaya, Septihani Michella Winata, Farrel Ernesto Yani Lina Yazidat, Izatul Yenny Surjawan Yukianti, Chiara Rizka Yuni Elsa Hadisaputri Zainal Arifin Zainul Muttaqin