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All Journal BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Journal of Agromedicine and Medical Sciences Jurnal Biologi Tropis Jurnal Biotek Jurnal Dunia Farmasi Indonesian Journal of Global Health research Jurnal Gizi Kerja dan Produktivitas Jurnal Ilmiah Agribios FORTE JOURNAL Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Journal of Health and Medical Science Jurnal Farmasi Sains dan Praktis Prosiding Seminar Nasional Rekayasa Teknologi Industri dan Informasi ReTII Gunung Djati Conference Series Journal of Applied Plant Technology Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Ilmu Kesehatan Media Penelitian dan Pengembangan Kesehatan
Muhammad Andry
Program Studi Farmasi, Fakultas Farmasi Dan Kesehatan, Institut Kesehatan Helvetia, Medan, Sumatera Utara, Indonesia.
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Isolasi senyawa flavonoid dari daun bakung (Crinum asiaticum L.) Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.322

Abstract

Introduction Sprains and fractured bones are treated with spider lily leaves (Crinum asiaticum L.). Alkaloids, flavonoids, tannins, steroids, and triterpenoids are among the chemical components found in spider lily leaves. The most significant phytochemicals in plants with wide biological advantages for humans are bioactive flavonoids. The purpose of: The study aimed to isolate flavonoid components from spider lily leaves. Methods: This study was descriptive, using the following steps: plant material collection and preparation, sample processing, simplicia characterization, extract preparation, phytochemical screening, hydrolysis, fractionation, analysis using paper chromatography (KKt), and compound isolation using preparative paper chromatography. The isolates were tested for purity using one-way and two-way KKt, and they were identified using UV-Vis spectrophotometry with a shear reagent. The results: The results of the characterization showed that the water content was 7.21%, the water-soluble extract was 11.21%, the ethanol-soluble extract was 9.23%, the total ash content was 1.99%, and the acid-insoluble ash content was 0.81%. The screening findings indicated the presence of flavonoid chemicals. The KKt analysis results revealed that the best mobile phase was 5% acetic acid with ammonia vapor specks, and the preparative KKt isolation results yielded a single blue isolate, which was then identified by UV-Vis spectrophotometry using a shear reagent, resulting in maximum wavelength absorption (max) at band II of 253nm, presumably identifying the isoflavone group of flavonoids. Conclusion: The conclusion showed the ethyl acetate fraction of spider lily leaves could be separated using paper chromatography and that identification by spectrophotometry UV-Vis using a shear reagent wasolate, which was assumed to be an isoflavone group component.
Analisa Kromatografi Gas Spektrometri Massa dan Gugus Fungsi Ekstrak Metanol Daun Bidara (Ziziphus mauritiana): Analisa Kromatografi Gas Spektrometri Massa dan Gugus Fungsi Ekstrak Metanol Daun Bidara (Ziziphus mauritiana) Widiarti, Leni; Febriani, Husnarika; Dur, Sajaratud; Ningrum, Nurlian Augustin; Nurcahyani, Nadya; Andry, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.449

Abstract

Bidara leaves are a plant that is quite abundant in Medan and has many benefits in the health sector. The aim of this research is to predict the content of secondary metabolite compounds in bidara leaf extract, through qualitative tests by screening using specific reagents, functional group analysis with FT-IR and mass analysis with GC-MS. The screening results showed that the methanol extract of bidara leaves contained alkaloids, flavonoids, tannins, saponins and phenols. Functional group analysis shows that the wavelength area is 3300 cm-1, namely OH absorption, 2700 - 2900 cm-1 shows C-H absorption, 1600 - 1700 cm-1 shows C=O absorption, 1400 - 1450 cm-1 shows C-H absorption, 1365 - 1385 cm-1 shows CH3 bent absorption, and 1000 – 1100 cm-1 shows C-O absorption. The results of mass analysis using GC-MS showed four dominant peaks from the compound, namely Z-5-Methyl-6-heneicosen-11-one, 17-Pentatriacontene, Ethyl iso-allocholate and Pentacosane.
Uji aktivitas antioksidan ekstrak etanol, etil asetat, dan n-heksan akar kayu manis hutan (Cinnamomum Iners) Reinw. EX Nees & T. Nees Blume dengan Metode DPPH Faisal , Hendri; Andry, Muhammad; Winata, Hanafis Sastra; Panjaitan, Yuli Cahyani
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.450

Abstract

Background: Forest cinnamon (Cinnamomum iners) Reinw. Ex Ness & T. Ness Blume has been used traditionally to kill microorganisms, diarrhea and dismonere. Forest cinnamon contains compounds that act as antioxidants, including flavonoids, alkaloids, tannins, and phenolics. The antioxidant effects of vitamin C, E, carotene, and phenolic compounds (especially polyphenols and flavonoids) can potentially reduce the risk of degenerative diseases. Objective: compounds from forest cinnamon roots and determine the yield based on the level of polarity to DPPH with the IC50 value. Method; eksperimental di laboratorium yaitu melakukan percobaan terhadap aktivitas antioksidan dari ekstrak akar kayu manis hutan (Cinnamomum Iners) dengan Metode DPPH (1,1- difenil -2 pikrihidrazil). Penelitian meliputi pengumpulan akar kayu manis hutan, pembuatan ekstrak akar kayu manis hutan, uji skrining fitokimia terhadap akar kayu manis hutan, dan uji antioksidan dari ekstrak akar kayu manis hutan dengan Metode penangkalan radikal bebas DPPH (1,1-difenil –2 pikrihidrazil) menggunakan alat spektrofotometer. Results: The antioxidant activity of the ethanol solvent showed a very strong category, the ethyl acetate solvent showed medium category activity, and the n-hexane solvent showed weak category antioxidant activity. The average IC50 value of ethanol extract was 9.1 ppm, ethyl acetate extract was 77.58 ppm, and n-hexane extract was 185.08. Conclusion: forest cinnamon root (Cinnamomum Iners) Reinw. Ex Ness & T. Ness Blume has strong antioxidant activity in ethanol solvents.
Formulasi dan uji aktivitas repellent lilin aromaterapi dari minyak atsiri serai wangi (Cymbopogon Nardus L.) dengan cengkeh (Syzygium Aromaticum L.) Ginting , Indra; Rudang , Singgar Ni; Andry, Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.515

Abstract

Background: Aromatherapy candles are an alternative to inhalation therapy applications, namely the inhalation of aroma vapors produced from essential oils. Fragrant Lemongrass (Cymbopogon nardus L.) and Clove (Syzygium aromaticum L.) contain essential oil compounds that have the potential as natural pesticides. This study aims to formulate aromatherapy candles from essential oils of citronella and clove flowers as mosquito repellents with various concentrations, namely negative control, F1:1%:3%, F2: 2%:2%, and F3: 3%:1 %. The research was done experimentally by making preparations of aromatherapy candles, with preparation evaluation tests including organoleptic tests, air bubble tests, burn time tests, and melting point tests. The candle quality test includes a scent preference test, a candle effectiveness test against mosquitoes, and a therapeutic test on sleep quality using the Mi Band 5 Smartwatch. The results of the preparation evaluation test met the requirements. The most preferred scent was F2 (2%:2%). The effectiveness of wax as a repellent was very optimal in killing mosquitoes, with the best value affecting mosquito mortality shown by F3 treatment (3%:1%). The effectiveness of candles as a therapy for sleep quality showed that there was a change in the quality of sleep that was getting better, with the best value affecting sleep quality shown by the F2 treatment (2%:2%). The conclusion from the researchers of the study is that aromatherapy candle formulations from citronella and cloves can be used as mosquito repellents and also improve sleep quality.
Uji Aktivitas Antioksidan Kombucha Daun Alpukat (Persea americana Mill.) Berdasarkan Lama Fermentasi dengan Metode ABTS Andry, Muhammad; Karo-Karo, Sry Ulina; Lubis, Indah Pertiwi; Lubis, Ervina Syahfitri; Lubis, Meiva Amalia; Nasution, Halimnah Raina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1171

Abstract

Kombucha tea is a widely consumed herbal beverage. Avocado leaves (Persea americana Mill.) are known to contain various bioactive compounds such as flavonoids, quercetin, and polyphenols, which play an important role in providing health benefits, particularly as antioxidants. Objective: This study aimed to evaluate the antioxidant activity of avocado leaf kombucha using the Azinobis Ethylbenzothiazoline Sulfonic Acid (ABTS) method. Methods: This research employed an experimental design with quantitative antioxidant activity testing using the ABTS method. The IC₅₀ values were determined through linear regression analysis based on the relationship between sample concentration and percentage inhibition of the ABTS radical. Results: The IC₅₀ value of non-fermented avocado leaf kombucha was 106.40 ppm, which falls within the moderate antioxidant category (IC₅₀: 100–150 ppm). Fermentation for 9 days produced an IC₅₀ of 67.99 ppm (strong), 12 days resulted in 49.91 ppm (very strong), and 14 days resulted in 40.18 ppm (very strong). Vitamin C, used as a positive control, showed an IC₅₀ of 9.160 ppm (very strong). Conclusion: The antioxidant activity of avocado leaf kombucha increased with the duration of fermentation. Non-fermented kombucha exhibited moderate antioxidant activity, while fermentation for 9, 12, and 14 days resulted in strong to very strong antioxidant capacity. Keywords: Kombucha Tea, Avocado Leaves, Antioxidant, ABTS, IC₅₀.
Effectiveness of Ointment Therapy Products Based on Snakehead Fish Extract (Channa Striata) Combined with Black Honey (Epis Dorsata) on Post-Operative Wound Patients Mulidan Mulidan; Muhammad Andry
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4654

Abstract

Snakehead fish (Channa striata) is a type of freshwater fish that is widely known by the public. The efficacy and benefits of this fish, especially in increasing albumin which is important for the body, have been scientifically proven. Snakehead fish has a very high protein content and is a source of albumin for patients with hypoalbuminemia and wounds. Black honey is also known to have great benefits in the process of tissue formation in wounds. The purpose of this study was to evaluate the effectiveness of therapeutic ointments based on snakehead fish extract combined with black honey in post-operative patients. Methods: This study used a quasi-experimental method with a post-test only with control group design, a sampling technique with purposive sampling with inclusion criteria involving 30 participants who were divided into control and intervention groups. The intervention group was given snakehead fish extract ointment and black honey for 2 weeks. Observations of the wounds were carried out before and after the application of the ointment in both groups. Pre and post intervention scores were measured using the REEDA (Redness, Edema, Ecchymosis, Discharge, Approximation) instrument, with a score range of 0-2 for good wounds and 9-15 for bad wounds. Statistical analysis used the Paired T-test with a significance level of p<0.005. Results: The results showed that patients who received the intervention experienced an increase in wound healing scores. In the intervention group, 7 respondents (56.7%) showed good wound healing and 8 respondents (53.3%) showed moderate healing. Concentration F1 was proven to be more effective than F2 and F3. Based on statistical tests, there was a significant difference between the intervention and control groups, with the Paired Sample Test showing a p value <0.000 in the intervention group, while the control group was not significant (p>0.334) with an average intervention value (12.86) and control (11.53). Conclusion: Ointment based on snakehead fish extract combined with black honey has been proven to be effective in accelerating wound healing in postoperative patients.
Co-Authors Abadi, Hafizhatul Abas, Mohd Ihsanuddin Bin Ade Shindy F Br Sembiring Ade Sumiardi Adek Chan Agustiansyah, Lucky Dita Aji, Andrey Akmal Muhni Anggi, Reza Destri Arfiani Arifin Aris Ma'ruf Asyrun Alkhairi Lubis Ayu Safitri Ayu Safitri Ayu Safitri Ayu Wulan Putri Selayan Bakri , Tedy Kurniawan Budiadi Diana, Vivi Eulis Dini Permata Sari Dominica, Dwi Dwiyarina Margarisa Erina Candra Wati Ervina Syahfitri Lubis Fahma Shufyani Faisal , Hendri Faisal, Hendri Fajar Fakri Fajar Hidayanto, Fajar Fira Safitri Fitri, Khairani Ginting , Indra Ginting, Indra Gumilar, Roni Hafid Syahputra Hanafis Sastra Winata Hanafis Satra Winata Hari Hariadi Hari Hariadi Hari Hariadi, Hari Hartini, Putri Tri Hendra Jaya Hendri Faisal Hendri Faisal Hendri Faisal Hendri Faisal Hindri Syahputri Husaini, Fahri Husnarika Febriani, Husnarika Ika Julianti Tambunan Illian , Didi Nurhadi Indra Ginting Isnaini , Nadia Isti Dwi Pruschia Jashima Ukhtia Jefri Naldi Jefri Naldi Karo-Karo, Sry Ulina Khairani Fitri Khairani, Tetty Noverita Leni Halimatusyadiah Leni Widiarti, Leni Leny Leny, Leny Ligo, Azzura Lilik Septiana Lubis, Indah Pertiwi Lubis, Meiva Amalia Lucky Dita Agustiansyah Lucky Dita Agustiansyah Lumbantoruan, Jernih Marisatua Luthvia Luthvia Luthvia, Luthvia M. Fariz Fadillah M. Fariz Fadillah M. Fariz Fadillah M. Fariz Fadillah M. Fariz Fadillah M. Fariz Fadillah Mardianto Maritha, Vevi Marseli, Cindy Mayang Sari Melia Sari Melia Sari Melia Sari, Melia Mochammad Imron Awalludin Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Fauzan Lubis Muhammad Yunus Mukhali, Hassan Basri bin Mulidan Mulidan Mutia Muhardiyanti Nabila, Nabila Naldi, Jefri Nasution , Muhammad Amin Nasution, Halimnah Raina Naziyah, Syifa Ngete, Ani Florida Nia Novranda Pertiwi Nidia Rizka Ningrum, Nurlian Augustin Ningtias, Anggitha Nurcahyani, Nadya Nurfitriyana Nurfitriyana Nurjanah, Ayu Nurul Aulia Pamungkas, Barolym Tri Panjaitan, Yuli Cahyani Pradita, Diding Pricella Ginting Puteri, Cut Intan Annisa Rachelli, Rachelli Rafifah Azzahra Raisa Fadila Ramadaini, Tiara Ratna Fitri Yenny, Ratna Fitri Rida Evalina Tarigan Rizqi Muhammad Mahbub Rudang , Singgar Ni Rudang, Singgar Ni Rumanti, Ruth Mayana Rustini Sajaratud Dur, Sajaratud Sari, Syilvi Rinda Sarumaha, Paska Eli Shaum Shiyan Shufyani, Fahma Sibero, Jitasari Tarigan Simahate, Sadjnah Simanjuntak, Monica Nelly Siska Dwi Anggraeni Situmorang, Renni Paska Surbakti, Chemayanti Suseno Amien Susiyanti Susiyanti Syariful Mubarok Tetty Noverita Khairani Tetty Noverita Khairani Tetty Noverita Khairani Tri Mayanti Ulfa Melyza Utama, Rezza Fikrih Vannissa Andriani Irawan Vevi Maritha Wijayanti, Fitria Eka Resti Winata, Hanafis Sastra Yudianto, Tri Yusep Ikrawan Ziza Putri Aisyia Fauzi