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Journal : Journal of Global Pharma Technology

Effect of Cinnamon (Cinnamomum burmannii) Bark Oil on Testicular Histopathology in Streptozotocin Induced Diabetic Wistar Male Rats Mustofa Helmi Effendi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The purpose of this study was to determine the effect of cinnamon bark oil (CBO) on testicular histopathology. The variables taken were the diameter of the seminiferous tubules and the number of leydig cells in the testes of white male rats (Rattus norvegicus) which had been induced by streptozotocin. Twenty white male rats adult Wistar strains aged 2-3 months with an average weight of 150-250 grams were used in this study. The rats were divided into five experimental groups (4 rats each group) treated with a combination of streptozotocin and cinnamon bark oil (CBO) which were designed as follows: K(-), K(+), P1, P2, and P3. P is white rat injected with streptozotocin with a single dose of 45 mg / kg body weight intraperitonially, followed by therapy. K(-) without streptozotocin and only given drug solvent, K(+) given drug solvent, P1 treated with CBO 100 mg / kgBB orally, P2 treated with CBO 200 mg / kgBB orally, P3 treated orally with CBO 400 mg / kg orally for 14 days. White rat animals were then mutilated and testicular organs were taken for histopathological preparations using HE staining, then the diameter of the seminiferous tubules and the number of Leydig cells were calculated. Data were analyzed with One Way ANOVA and followed by Duncan's test. The results showed that streptozotocin had the potential to reduce the size of the seminiferous tubule diameter and the number of Leydig cells, while CBO at a dose of 400 mg / kgBW could increase the size of the seminiferous tubule diameter and the number of Leydig cells. It can be concluded that CBO can be used to reduce testicular dysfunction induced in diabetic rats.Key words: Cinnamon bark oil, Seminiferous tubule diameter, Leydig cells, Streptozotocin, Male rat.
Co-Authors A. T. Soelih Estoepangestie Adiana Mutamsari Witaningrum Adrenalin, Sruti Listra Al Arif, M Anam Amri, Indah Amalia Anam Al Arif Anas Bad’rosana Prawindi Annisa, Suwaibatul Annise Proboningrat Arifah, Sitti Asri Rizky Asri Rizky Astuti, Elita Sriwidya Bambang Sektiari Lukiswanto Bambang Sumiarto Bambang Sumiarto Bambang Sumiarto Bambang Sumiarto Benjamin Christoffel Tehupuring, Benjamin Christoffel Boedi Setiawan BUDI UTOMO Budiarto Budiarto Bura, Maria Antonia Yersi Dua Chusniati, Sri Dadik Rahardjo, Dadik Dadik Raharjo Dameanti, Fidi Nur Aini Eka Puji Dewi, Aprilia Kurnia Dian Ayu Permatasari Dian Ayu Permatasari Didik Handijatno Didik Handijatno Didik Handijatno Elisa Herina Dimariwu Endah, Tri Endang Suprihati Eriza Rosalina Rochmah Estoepangestie, Agnes Theresia Soelih Fadlilah, Shinta Levea Ni'matul Fatmawati, Mira Fatmawati Fauziah, Ima Fedik Abdul Rantam Habibi, Muhammad Afif Hani Plumeriastuti Harijani, Nenny Hasib, Abdullah Hernanda, Ary Setya Herry Agoes Hermadi Istiana, Izzatul Iwan Sahrial Hamid Kadek Rachmawati Kadek Rachmawati Khairullah, Aswin Rafif Khoiru Indana Kinasih, Kurnia Nisa Kurniawan, Muhammad ‘Ahdi Kusala, Muhammad Khaliim Jati Kusriningrum Rochiman Lailatul Maghfiroh Lilik Maslachah Lucia Tri Suwanti, Lucia Tri Luthfiana, Nurul Masdiana C Padaga Maudika Pamela Fiorenza Mirni Lamid Mohammad Sukmanadi Moses, Ikechukwu Benjamin Mufasirin Muhammad Ikmal Robih Mustika, Yolla Rona Muzhaffar, Adam Maulana Nenny Harijani Nunuk Dyah Retno Lastuti Nusdianto Triakoso Permatasari, Dian Ayu Pradika, Adhitya Yhoga Purbowati, Tri Endah Putri, Mariana Febrilianti Resilinda Rahaju Ernawati Raharjo, Dadik Rahmahani, Jola Rahmandari, Dina Agylia Raissa, Ricadonna Ramandinianto, Sancaka Chasyer Residiwati, Gretania Rochmah Kurnijasanti Sabdoningrum, Emy Koestanti Safitri, Devi Ayu Saputra, Rakan Mahiid Sari, Fifin Kurnia Sarudji, Suryanie Setiawan Koesdarto Sevitasari, Adelita Putri Sheila Marty Yanestria Sitti Arifah Soeharsono Soeharsono Soelih Estoepangestie, Agnes Theresia Sri Hidanah Sri Mulyati Sri Mumpuni Sosiawati Sri Pantja Madyawati Subagyo, Safira Fauziyyah Suherni Susilowati Sukmanadi, Mohammad Supriyadi Suwarno Suwarno Syah Putra, Akyun Rozaqi Syah, Ali Akram Tacharina, Martia Rani Tatik Hernawati Tita Damayanti Lestari Tjuk Imam Restiadi Tri Nurhajati Tri Untari Tri Untari Tri Wahyu Suprayogi Tyasningsih, Wiwiek Tyasningsih, Wiwiek Tyasningsih, Wiwik Veena Vasheene Vijaya Kumar Wardhana, Dhandy Koesoemo Warsito, Sunaryo Hadi Wibawati, Prima Ayu Wibisono, Freshinta Jellia Widi Nugroho Yeni Dhamayanti Yudhana, Aditya Yulianna Puspitasari Yunita, Maya Nurwartanti Zahro, Vida Seanita