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Uji Uji Aktivitas Antibakteri Ekstrak Etanol, Fraksi n-Heksan Dan Etil Asetat Daun Seminyak (Champereia manillana (Blume) Merr.) Terhadap Bakteri Enterococcus faecalis Pratama, Alvin; Nasution, Haris Munandar; Pulungan, Ainil Fithri; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1200

Abstract

Background: Bacterial resistance to antibiotics has become a global concern, prompting the exploration of alternative antibacterial agents derived from natural sources. Enterococcus faecalis is a pathogenic bacterium frequently associated with root canal treatment failure due to its high resistance level. Seminyak leaves (Champereia manillana (Blume) Merr.) are known to contain secondary metabolites with potential antibacterial activity; however, studies based on solvent fractionation remain limited. Objective: This study aimed to evaluate the antibacterial activity of the ethanol extract, n-hexane fraction, and ethyl acetate fraction of seminyak leaves against Enterococcus faecalis. Methods: An experimental study was conducted through plant identification, preparation of simplicia, extraction using the maceration method with 96% ethanol, and liquid–liquid fractionation using n-hexane and ethyl acetate. Phytochemical screening was performed qualitatively and confirmed by thin-layer chromatography (TLC). Antibacterial activity was assessed using the disc diffusion method at concentrations of 15%, 30%, and 45% with three replications. Dimethyl sulfoxide (DMSO) 10% was used as the negative control, while chlorhexidine (standard concentration) served as the positive control. Data were analyzed using One-Way ANOVA followed by Tukey HSD post hoc test. Results: Phytochemical screening revealed that the ethanol extract contained alkaloids, flavonoids, tannins, saponins, and steroids. The n-hexane fraction predominantly contained nonpolar compounds (alkaloids and steroids), while the ethyl acetate fraction contained more diverse semi-polar compounds. Antibacterial testing showed that all samples exhibited activity against Enterococcus faecalis. The highest inhibition zone diameters at 45% concentration were 14.1 ± 0.21 mm (ethanol extract), 10.3 ± 0.17 mm (ethyl acetate fraction), and 8.5 ± 0.14 mm (n-hexane fraction). Statistical analysis indicated significant differences among treatments (p < 0.05). Conclusion: The ethanol extract, ethyl acetate fraction, and n-hexane fraction of seminyak leaves exhibit antibacterial activity against Enterococcus faecalis. The ethanol extract showed the highest activity, followed by the ethyl acetate and n-hexane fractions. These findings suggest that antibacterial compounds are more dominant in polar to semi-polar fractions.
Co-Authors A'dilah, Nur Abadi, Hafizhatul Adjelie, Tiara Adli Nuzula Rahmah Adyani Maulinda Afriati, Nelsi Afridah, Nurul Ilmi Ahmad Rasyid Ridho Ainil Fithri Pulungan Alviana, Liya Amelia Kudadiri Andi Syahputra, Ricky Andjelie, Tiara Ani Sutiani Ani Sutiani Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Aprilia, Hijjatun Arifin, Khairil Fikri Arrosty, Muflizah Athaillah, Athaillah Audry Pratiwi Aulia Fitri Aulia Fitri, Aulia Auza , Maharani Azhar, Gustika Bambang Hermanto Bambang Hermanto Beby Noplya Wulandari BJ Sutrisna Chandra, Putra Dama Yanti, Fradilla Daulay, Anny S. Dea Anggreini Denny Satria Dewi, Sri Harti Dikki Miswanda Dikki Miswanda Dinda Sari Utami Dwi Jati, Fatma Erma Susanti Evi Depiana Gultom Evi Depiana Gultom Fadhlah Al-Uyun Nasution Fahmi Fahmi Fajri, Fajrilda Aqilah Falah Rambe, Raudhotul Fanny Anggreany Santosa Fauziah Erna Witular Panggabean Ferendina, Imelda Fithri Pulungan, Ainil Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunthe Gabena Indrayani Dalimunthe Ginting, Grace Anastasia br Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Gultom, Evi Depiana H., Fathur Rahman Hanafis Sastra Winata Harahap, Sumiyarni Haris Munandar Nasution Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hasibuan , Fika Miah Sasmitha Hasibuan , Nabila Hasim Hasibuan, Zulfiana Ramadhani Hindri Syahputri Humaira, Annisa Husna, Miftahul Hutagalung, Victor H Indrayani, Gabena Inna Myesha Julia Reveny Karo Sekali, Elva Swandi Kasta Gurning Khairunnisa , Ardina Khan, Sahrani Nazwa Kiki Rawitri Kiki Rawitri Latifah Hanum Lestari, Amanda Putri Lestari, Kurnia Dwi Lilik Septiana Lilik Septiana Linda, Rosa Lubis, Asira Lubis, Minda Sari lubis, muhammad fauzan Lubis, Nurazizah M. Alfaruqi Maghfirah, Dini Mainal Furqan Malahayati Malahayati Maryanti Yuza Matondang , Fikriyah Hafni Maulana Putri, Yasinta Maysaro Sitompul Mira Febrina, Mira Monica Suryani Moondra Zubir Muhammad Agus Muljanto Muhammad Fauzan Lubis Muhammad Yunus Muhammad Yunus Mukti, Ridho Munandar, Verissa Nadila Indra Sepvina Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Nasution, Wardah Nazuhra, Oca Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggita Ningtias, Anggitha Nomi Noviani Nur Ain Thomas Nur, Hijrotun Nurdalilah, Nurdalilah Nurhayati Nurhayati Nurmazela, Virda Nursyafira, Arini Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Paramitha, Ratih Parapat , Anjarlit Romiyuliana Br Pasar Maulim Silitonga Pertiwi, Rahma Pitaloka, Syifa Amilia Pratama, Alvin Puspita, Dinda Dila Puteri, Cut Intan Annisa Putra, Andhika Dharma Putri Khairani Rafita Yuniarti Rahma Dona, Rahma Raissa Fitri Rambe, Robiatun Rawitri, Kiki Reza Irma Ricky Andi Syahputra Ridho, Ahmad Rasyid Ridwanto Ridwanto Ridwanto Rinda Sari, Syilvi Rinda Sari, Sylvi Ritonga , Nur Sakina Rizki, Dewi Rizki, Vitri Dea Robiatun Rambe Robiatun, Robiatun Rambe Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Rukmana, Siti Sagala, Hasel Untung Bersinar Samran, Samran Sari Lubis, Winda Sari, Farida Sari, Syilvi Rinda Sari, Sylvi Rinda Sartika Daulay, Anny Savitri, Novia Herma Septiana, Lilik silalahi, zahra salsabila Sindi, Sindi Sipahutar, Rizki Anjani Siregar , Misbah Siti Anisa Siti Rahmah Siti Rahmi Ningrum Sony , Suyefri Sri Wahyuni Sri Wahyuni Suci, Nurul Sulwiyatul K Sani Supiyani, Supiyani SURBAKTI, CHRISTICA ILSANNA Syafa Nadira Ashiilah Syahputra, Ricky Andi Syarifah Nadia Syilfia Hasti Tania, Chyntia Glori Tarigan, Eni Surabini Trizaldi, Asep Urip Harahap Uswatun Nisa, Uswatun Vera Estefania Kaban Vera Estefania Kaban Widya, Rizka Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Haryani Yuliatil Adawiyah Harahap Yuniarti , Rafita Yuniarti, Rafita Zahira Ahmad, Madani Ziza Putri Aisyia Fauzi Zulfikri Zulfikri Zulhij, Fizrya