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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN ASAM KANDIS (Garcinia xanthochymus Hook.f. ex T. Anderson) DENGAN METODE ABTS Hanafis Sastra Winata; Hendri Faisal; Muhammad Andry; Ayu Wulan Putri Selayan; Muhammad Amin Nasution
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.931

Abstract

Antioksidan adalah zat yang memiliki kemampuan untuk memperlambat, mencegah, atau menghilangkan kerusakan oksidatif terhadap molekul target seperti protein, lipid, dan deoxyribonucleic acid (DNA). Antioksidan memainkan peran penting dalam menetralkan dan menghancurkan radikal bebas. Beberapa tanaman diketahui dapat berperan sebagai antioksidan, salah satunya adalah tanaman asam kandis. Tujuan penelitian ini adalah untuk menentukan aktivitas antioksidan ekstrak etanol daun asam kandis serta kandungan senyawa kimia ekstrak etanol daun asam kandis. Studi eksperimental ini bertujuan untuk mengetahui sifat antioksidan ekstrak daun asam kandis (Garcinia xanthochymus) dalam pelarut etanol, dalam penelitian ini menggunakan metode ABTS. Hasil analisis nilai IC50 menunjukkan bahwa ekstrak etanol daun asam kandis memiliki nilai IC50 sebesar 31,32 μg/mL pada metode ABTS yang artinya memiliki aktivitas antioksidan dalam kategori sangat kuat (IC50. < 50 mcg/ml). Pada vitamin c sebagai pembanding dengan metode ABTS memiliki nilai IC50 sebesar 48,81 μg/mL yang artinya memiliki aktivitas antioksidan dalam kategori sangat kuat. Hal ini menunjukkan sampel ekstrak etanol daun asam kandis Garcinia xanthocymus memiliki potensi untuk menjadi alternatif sebagai penggunaan aktivitas antioksidan alami. kesimpulan dalam penelitian ini adalah Ekstrak etanol daun asam kandis menunjukkan adanya aktivitas antioksidan berdasarkan pengujian dengan metode pemerangkapan radikal bebas ABTS dengan nilai IC50 adalah 31,32 μg/ml kategori sangat kuat.
FORMULASI DAN EVALUASI SEDIAAN KRIM PELEMBAB DAN ANTIOKSIDAN EKSTRAK ETANOL BUAH ARA (Ficus racemosa L.) Muhammad Andry; Hanafis Sastra Winata; Indra Ginting; Khairani Fitri; Tetty Noverita Khairani; Ulfa Melyza; Muhammad Amin Nasution
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.932

Abstract

Tumbuhan ara (Ficus racemosa L.) sangat memiliki khasiat sebagai antidiare, antiinflamasi, antioksidan dan lain sebagainya. Antioksidan dalam krim berfungsi sebagai pelembab untuk melindungi kulit dari radikal bebas dengan cara membentuk lapisan lemak tipis di permukaan kulit dan memperlambat kerusakan akibat proses oksidasi. Tujuan penelitian adalah untuk membuat formulasi dari sediaan krim pelembab dengan menggunakan  ekstrak etanol buah ara (Ficus racemosa L.) sebagai pelembab alami kulit dan menentukan konsentrasi terbaik yang memenuhi persyaratan standar Farmakope Indonesia. Penelitian ini dilakukan secara eksperimental. pembuatan ekstrak buah ara dilakukan dengan cara maserasi, konsentrasi ekstrak buah ara ditambahkan ke dalam sediaan formulasi krim 10%, 20% dan 30%. Pengujian sediaan meliputi uji organoleptis, homogenitas, pH, daya sebar, tipe krim, viskositas, iritasi, hedonik dan stabilitas. Analisis data menggunakan uji anova. Hasil menunjukkan sediaan krim pelembab memenuhi syarat evaluasi fisik sediaan yaitu memiliki tekstur semi solid, dengan aroma pewangi krim, warna pada setiap formula berbeda beda, F0 berwarna putih, formula F1 (10%) coklat muda, F2 (20%) coklat pekat, F3 (30%) Coklat hitam. Semua sediaan homogen dan tidak mengiritasi kulit. Memiliki pH berkisar 5-6,3, daya sebar 5-6,7 cm dengan viskositas 9326-13918 Cs, uji stabilitas dengan metode cycling test selama 12 hari memiliki stabilitas yang baik. Hasil rata-rata persentase peningkatan kelembaban pada F0 (17,77%), F1 (35,57%), F2 (49,87%), F3 (51,93%) dan kontrol positif (56,5%). Hasil analisis data menggunakan uji anova menunjukkan ada perbedaan yang signifikan dari ketiga konsentrasi yang diuji. Berdasarkan hasil penelitian dapat disimpulkan sediaan krim pelembab yang diformulasikan dapat melembabkan kulit secara alami, dan disetiap minggunya terjadi peningkatan kelembaban kulit. dan konsentrasi terbaik sediaan krim pelembab yaitu F3 dengan konsentrasi ekstrak 30%.
PROFIL KROMATOGRAM DAN UJI AKTIVITAS ANTIFUNGI TERHADAP Candida albicans DAN ANTIBAKTERI TERHADAP Pseudomonas aeruginosa EKSTRAKETANOL DAUN LEUNCA (Solanum nigrum L.) Aulia Sari; Haris Munandar Nasution; Yayuk Putri Rahayu; Muhammad Amin Nasution
FORTE JOURNAL Vol 5 No 1 (2025): Edisi Januari 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i1.1180

Abstract

Perkembangan dan peningkatan  ketahanan  mikroorganisme terhadap infeksi terus terjadi pada manusia,Infeksi saluran kemih adalah istilah kolektif yang menggambarkan setiap infeksi yang melibatkan setiap bagian dari saluran kemih, yaitu ginjal, ureter, kandung kemih dan uretra. Infeksi saluran kemih paling banyak disebabkan oleh bakteri Pseudomonas aeruginosa, serta infeksi jamur yaitu Candida albicans. Leunca (Solanum nigrum L.) dimanfaatkan sebagai obat  tradisional mengobati infeksi saluran kemih. Tahapan Penelitian ini dimulai dari pengelolaan Daun Leunca (Solanum nigrum L.) Karakterisasi simplisia, pembuatan ekstrak, uji skrining, uji analisis senyawa menggunakan Kromatografi lapis tipis, serta pengujian aktivitas antifungi dan antibakteri digunakan metode difusi agar.Dengan konsentrasi ekstrak etanol daun leunca (Solanum  nigrum L.) 10,  20,  30,  40,  dan  50%,  serta kontrol negatif menggunakan DMSO, dan kontrol positif antifungi menggunakan Ketokenazole 200 mg, kontrol positif bakteri menggukan ciprofloxacin 500 mg. Hasil dari penelitian pada uji Kromatografi  lapis tipis terdapat senyawa di dalam ekstrak etanol daun leunca (Solanum nigrum L), pada uji antibakteri menunjukkan hasil diameter zona hambat pada antifungi pada konsentrasi 10%, 10,5mm, konsentrasi 20% 12, 8mm, konsentrasi 30% 15,9mm, konsentrasi 40% 17,7mm, konsentrasi 50% 20,5mm, pada kontrol negatif tidak memberikan zona hambat, kontrol positif memberikan zona hambat sebesar 29,4 mm. Pada antibakteri konsentrasi 10%, 15,9mm, konsentrasi 20% 20,7mm, konsentrasi 30% 22,9mm, konsentrasi 40% 26,4mm, konsentrasi 50% 27,6mm, kontrol positif memberikan zona hambat sebesar 36,4mm. Dapat disimpulkan bahwa Ekstrak Etanol daun leunca (Solanum nigrum L.) memiliki profil Kromatogram memiliki aktivitas antifungi dan antibakteri.
Integrating Maqāṣid al-Sharī‘ah into the Legal Framework of Child Adoption in Indonesia Muhammad Alifza; Nasution, Muhammad Amin
Al-Risalah VOLUME 25 NO 2, NOPEMBER (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-risalah.vi.58136

Abstract

This study aims to analyze the alignment of child adoption regulations in the Child Protection Law and its implementing regulations with the principles of maqāṣid al-sharī‘ah, particularly in relation to ḥifẓ al-nafs (protection of life) and ḥifẓ al-naṣl (protection of lineage). The widespread practice of informal child adoption without court authorization—especially in rural areas—raises legal concerns regarding lineage, identity, and the rights of child protection from both positive legal and Islamic perspectives. This research employs a normative-juridical method with a statutory and Islamic jurisprudence approach, supported by secondary data obtained from a field study in Beji Village, Banyumas. The analysis uses al-Ghazālī’s maqāṣid al-sharī‘ah framework to assess the compatibility between existing regulations and Islamic values on child protection. The findings indicate that the national legal framework essentially accommodates the principles of safeguarding life and lineage; however, there remain implementation gaps due to limited legal literacy, the influence of local traditions, and economic factors. The study’s original contribution lies in its proposal of a “structured kafālah” model as an integrative approach combining positive law and Islamic law, along with a recommendation for Islamic-based legal training for village officials and communities. The implication is that strengthening regulations and education that integrate maqāṣid al-sharī‘ah into adoption practices is crucial to ensure lawful, just, and contextually relevant child protection in accordance with both legal and religious values.
DAMPAK GAME ONLINE TERHADAP PERILAKU SOSIAL SISWA SMPN 1 PUNCAK SORIK MARAPI: SEBUAH ANALISIS FENOMENOLOGIS [IMPACT OF ONLINE GAMES ON SOCIAL BEHAVIOR OF SMPN 1 PUNCAK SORIK MARAPI STUDENTS: A PHENOMENOLOGICAL ANALYSIS] Nasution, Muhammad Amin; Januri, Muhammad Rizal; Shodikin, Marwan Ali
Acta Islamica Counsenesia: Counselling Research and Applications Vol 2, No 2 (2022): Desember
Publisher : Perkumpulan Ahli Bimbingan Konseling Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59027/aiccra.v2i2.194

Abstract

Adolescence is a period of transition between children and adults, at this time teenagers are also known as periods of difficulty. The current era of technology has received a lot of attention from the wider community, one of which is the problem of online games. This research is motivated by the existence of very rapid technological developments that cause students to experience changes in social behavior. The basic purpose of this study is to explain the positive and negative impacts of online games on the social behavior of students at SMP Negeri 1 Puncak Sorik Marapi. The research method used is a qualitative method. The approach used by the researcher is a phenomenological approach. This study will focus on the impact of online games on students' social behavior. The results of this study are the negative impact of students who are considered addicted to online games, of course, very diverse including students sometimes speak impolite and polite, some students also forget time for school because of the fun of playing, students also often spend time playing games at school, stealing time. during study hours so that it has an impact on social change which often forgets the surrounding environment, while the positive impact of online games on the social behavior of SMP Negeri 1 Puncak Sorik Marapi students is in the form of adding relationships, means of refreshing, collaborating, and students can express their emotions through playing online games.
Penyuluhan Pentingnya Mengetahui Kadar Antibiotik Dalam Penggunaan Secara Bijak dan Efektif Pertiwi, Nia Novranda; Hindri Syahputri; Syilvi Rinda Sari; Muhammad Amin Nasution
Jurnal Pengabdian Magister Pendidikan IPA Vol 8 No 2 (2025): April-Juni 2025
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v8i2.11109

Abstract

Antibiotik merupakan salah satu obat yang sangat penting dalam dunia medis untuk mengobati infeksi yang disebabkan oleh bakteri. Namun, penggunaan antibiotik yang tidak bijak dan tanpa memperhatikan kadar atau dosis yang tepat dapat menyebabkan masalah kesehatan yang serius, termasuk resistensi antibiotik. Penyuluhan ini bertujuan untuk meningkatkan pengetahuan siswa kelas 6 Sekolah Dasar (SD) Yayasan Pendidikan Ar-Ridha, sebagai kelompok yang masih dalam tahap pembelajaran dan memiliki potensi untuk menerima edukasi sejak dini mengenai pentingnya mengetahui kadar antibiotik agar penggunaannya lebih tepat sasaran, aman, dan efektif. Kegiatan penyuluhan dilakukan dengan metode ceramah, diskusi dan tanya jawab. Penilaian terhadap keberhasilan kegiatan dilakuakan dengan menggunakan kuesioner. Hasil kuesioner menunjukkan ketertarikan peserta akan kegiatan sebesar 93, 35%, pemahaman terkait informasi kadar obat sebesar 85, 52%, dan pengetahuan peserta terhadap penggunaan antibiotik secara bijak dan efektif sebesar 90, 50%. Penyuluhan ini terbukti dapat meningkatkan pemahaman siswa tentang penyuluhan pentingnya mengetahui kadar antibiotic dalam penggunaan secara bijak dan efektif.
Pengaruh Perbedaan Metode Ekstraksi Maceration dan Microwave Assisted Extraction (MAE) Terhadap Penetapan Kadar Flavonoid Total Buah Ara (Ficus racemosa L.) Andry, Muhammad; Ligo, Azzura; Anggi, Reza Destri; Pradita, Diding; Luthvia, Luthvia; Nasution, Muhammad Amin; Pertiwi, Nia Novranda; Arifin, Arfiani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.859

Abstract

Figs (Ficus racemosa L.) are an essential source of bioactive components such as phenols, terpenoids, flavonoids, and alkaloids with antioxidant properties. Two extraction methods are used to extract flavonoids from figs: conventional and non-conventional. This study aimed to determine the effect of different extraction methods—maceration and Microwave Assisted Extraction (MAE)—on the total flavonoid content in figs (Ficus racemosa L.). The research was conducted using a laboratory experimental method. The procedures included collecting and preparing plant materials, producing simplicia, evaluating simplicia characteristics, conducting phytochemical screening, preparing extracts, and determining total flavonoid content. The results showed that the maximum wavelength of quercetin was 438 nm, with a regression equation of Y = 0.0669x + 0.0084. The average absorbance values of fig extract using the maceration method were 0.216 with methanol, while the MAE method was 0.280 with methanol. The average percentage of flavonoid content using the maceration method was 0.1245% with methanol, while with the MAE method, it was 0.1623% with methanol. The total flavonoid content of fig extract using the maceration method was 1.2451 mgQE/g extract with methanol, while with the MAE method, it was 1.6238 mgQE/g extract with methanol. The study concluded that the highest total flavonoid content was found in the methanol extract obtained through MAE. This extract had a value of 1.6238 mgQE/g extract.
Pengaruh Metode Ekstraksi Daun Jarak Cina (Jatropha multifida L.) Secara Maserasi dan Microwave-Assisted Extraction (MAE) Terhadap Aktivitas Antijamur Pada Candida albicans Aryunda, Divia; Nasution, Muhammad Amin; Nasution, Haris Munandar; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.868

Abstract

Introduction: Indonesia possesses high biodiversity, including the Jatropha multifida L. plant, which contains secondary metabolites with potential antimicrobial properties. Traditionally, the leaves of Jatropha multifida have been used as herbal medicine, particularly for inhibiting the growth of microorganisms. Objective: This study aims to determine the total flavonoid content in the ethanol extract of Jatropha multifida leaves and to compare the effectiveness of two extraction methods, maceration and Microwave-Assisted Extraction (MAE), in inhibiting the growth of Candida albicans. Methods: The research stages included the characterization of the powdered simplicia, extraction of Jatropha multifida leaves using 96% ethanol by maceration and MAE methods, and phytochemical screening. The total flavonoid content was determined using UV-Vis spectrophotometry at a wavelength of 431 nm. Antifungal activity against Candida albicans was tested for each extract at specific concentrations. Results: The ethanol extract obtained through maceration showed a total flavonoid content of 34.7089 ± 0.1206 mg QE/g, while the MAE method yielded 32.1923 ± 0.1113 mg QE/g. The highest antifungal activity was observed in the MAE extract at a 75% concentration, producing an inhibition zone of 24.7 mm. The maceration extract at the same concentration produced an inhibition zone of 23.7 mm. As a positive control, 2% ketoconazole resulted in an inhibition zone of 31.4 mm. Conclusion: Although the maceration method produced a higher total flavonoid content, the extract obtained through the MAE method demonstrated more potent antifungal activity against Candida albicans at the same concentration.
Formulasi dan Uji Mutu Fisik Krim Antiperspirant dari Ekstrak Kunyit Putih (Curcuma zedoaria (Berg.) Roscoe) Syafira, Nona; Dalimunthe , Gabena Indrayani; Lubis, Minda Sari; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.916

Abstract

Background: Curcuma zedoaria (Berg.) Roscoe, commonly known as white turmeric, is a plant from the Zingiberaceae family that contains bioactive compounds such as curcumin, flavonoids, alkaloids, saponins, and tannins. These compounds have potential as natural antiperspirants due to their astringent and antimicrobial properties, which can reduce sweat production and prevent body odor. The use of synthetic antiperspirants containing aluminum chloride often causes skin irritation, highlighting the need for safer, natural alternatives. Objective: This study aims to formulate an antiperspirant cream using white turmeric (Curcuma zedoaria (Berg.) Roscoe) extract with good physical quality and to evaluate the effectiveness of various concentrations in inhibiting sweat production. Methods: This experimental study involved extracting white turmeric using 96% ethanol through maceration, followed by concentration with a rotary evaporator. The antiperspirant cream was formulated with varying extract concentrations. Physical quality evaluations included organoleptic testing, homogeneity, pH, stability, viscosity, adhesion, spreadability, cream type, as well as irritation and antiperspirant tests on volunteers. Results: Phytochemical screening showed that the white turmeric extract contains alkaloids, flavonoids, saponins, and tannins. The cream with a 17.5% extract concentration demonstrated the highest antiperspirant effectiveness compared to 7.5% and 12.5% concentrations. All formulations met physical quality standards, including pH (4.5–6.5), viscosity (2,700–23,020 cP), and 14-day stability without significant changes. Conclusion: The white turmeric-based antiperspirant cream met physical quality standards and exhibited significant antiperspirant effects, particularly at a 17.5% concentration. This study demonstrates the potential of white turmeric as a safe and effective natural active ingredient in antiperspirant formulations.
Retrospective Study Of Vitamin Purchases During The Pandemic In UMI FARMA Pharmacy Manik, Umi Chairani; Nasution, Muhammad Amin; Octania, Adelia Dwi
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.29

Abstract

In early 2020, the world was shocked by the outbreak of a new pneumonia that started in Wuhan, China, and then spread rapidly to more than 190 countries and territories. This outbreak was named coronavirus disease 2019 (COVID-19), which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SA RS-CoV-2). The spread of this disease has had a broad social and economic impact.The COVID-19 pandemic that has occurred since March 2020 has affected all aspects of life. The aim of the research is to determine the purchase of vitamins during the pandemic in July–December 2021 at the UMI FARMA Pharmacy. This research was conducted retrospectively. Data collection was obtained from recording several vitamin products purchased by patients. Data was obtained from the sales and purchases book at the UMI FARMA Pharmacy. The targeted output is purchasing vitamins during the pandemic in July–December 2021.
Co-Authors Abadi, Hafizhatul Ade Shindy F Br Sembiring Ade Sumiardi Adek Chan Afra, Mauliza Akmal Muhni Anggi, Reza Destri Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Apmarja, Sarah Utami Aqmal Ramadhan Pasaribu Arfiani Arifin Aris Ma'ruf Aryunda, Divia Asparyzha, Rhyzha Asyifa, Cut Nella Asyrun Alkhairi Lubis Aulia Sari Awanis, Safirah Ayu Wulan Putri Selayan Cut Nella Asyifa Didi Nurhadi Illian Dwiyarina Margarisa Fahma Shufyani Faisal, Hendri Fajar Fakri Ferina Septiani Damanik Fira Safitri Fithri Pulungan, Ainil Gabena Indrayani Dalimunthe Hanafis Sastra Winata Hari Hariadi Haris Munandar Nasution Hasibuan, Supia Indah Hendra Jaya Hendri Faisal Hendri Faisal Hendri Faisal Hendri Faisal Hindri Syahputri Humaira, Yara Humaira, Zaura Ika Julianti Tambunan Ika Yeni Siahaan Indra Ginting Iryana, Mirdha Isti Dwi Pruschia Januri, Muhammad Rizal Jefri Naldi Khairani Fitri Khairani, Tetty Noverita Kiki Rawitri Leni Halimatusyadiah Lestari, Seri Ligo, Azzura Lilik Septiana Lubis, Minda Sari Luthvia, Luthvia M. Fariz Fadillah M. Fariz Fadillah M. Pandapotan Nasution Mambang, D Elysa Putri Manik, Umi Chairani Mayang Sari Melia Sari Melia Sari Melia Sari, Melia Mirdha Iryana Mirna Mirna Muhammad Alifza Muhammad Andry Muhammad Andry Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Mutia Muhardiyanti Nazirah, Nazirah Naziyah, Syifa Nia Novranda Pertiwi Nia Novranda Pertiwi Nidia Rizka Niswa, Khairun Nurul Aulia Octania, Adelia Dwi Pradita, Diding Pricella Ginting Purba, Juvantri Fablo Puteri, Cut Intan Annisa Putri , Adilla Rasyidah Azzahra Rida Evalina Tarigan Ridwanto Ridwanto Rinda Sari, Sylvi Rudang, Singgar Ni Rufina Rumanti, Ruth Mayana Sahliah Sahliah, Sahliah Sandrina, Syura Sari, Syilvi Rinda Selfia Lestary Seri Rezeki Shodikin, Marwan Ali Simanjuntak, Monica Nelly Siregar , Runisya Maugin Utami Siregar, Rina Paramitha Siska Dwi Anggraeni Suseno Amien Syafira, Nona Tanjung, M. Fadli Tetty Noverita Khairani Tetty Noverita Khairani Tia Nazilla Tri Damaiyanti Ulfa Melyza Vannissa Andriani Irawan Wan Tisya Muhaira Winata, Hanafis Sastra Yadi, Hervi Yanti, Rahma Yayuk Putri Rahayu Yayuk Putri Rahayu Yulia Nanda Putri Yuniarti , Rafita Yuniarti, Rafita Yusep Ikrawan Zahara, Fitria Siti Zhafirah, Rana Zikra Maqfirah Ziza Putri Aisyia Fauzi Zulmai Rani