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Sukarno
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Journal : Open Access Indonesian Journal of Medical Reviews

 1 
Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations Sukarno; Ilham Kuncahyo; Endang Dyah Ikasari
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.451

Abstract

Fenofibrate is a third-generation fibric acid derivative included in BCS (biopharmaceutical classification system) class II, namely high permeability, low solubility. This research aims to obtain the optimum formula for miglyol oil, cremophor RH 40 and PEG 400 according to characterization tests of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research is an experimental study by formulating fenofibrate in the form of SNEDDS, which was made in 16 formulas using the D-optimal method, which was formulated in the form of SNEDDS with the composition miglyol, cremophor RH 40 and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, size. globules, zeta potential to obtain the optimum formula, and then analyzed using the one sample T-Test. The optimization results obtained the optimum formula, namely miglyol at 4%; cremophor RH 40 is 5%, and PEG 400 at 1%. Characterization test: emulsification time was 24 seconds, Transmittance % was 98.7%, Drug loading was 181 mg, globule size was 126 nm, and zeta potential of 12.26 mV. The dissolution test of the fenofibrate capsule dissolved 57.05%, while the fenofibrate SNEDDS capsule was 64.86%. This means that the dissolution of the optimum formula for SNEDDS fenofibrate is better than pure fenofibrate.
Formulation and Characterization of Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) Preparations Farrah Bintang Sabiti; Sukarno
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.461

Abstract

Mefenamic acid is included in BCS (biopharmaceutical classification system) class II, namely high permeability and low solubility. This research aims to obtain a good formula for oleic acid oil, tween 80, and PEG 400 according to the characterization test of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research was an experimental study by formulating mefenamic acid in the form of SNEDDS which was made 1 formula was made in the form of SNEDDS with the composition of oleic acid, tween 80, and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, globule size, zeta potential. The yield of the oleic acid formula is 1%, tween 80 is 8%, and PEG 400 is 1%. The emulsification time characterization test resulted in 17 seconds, % transmittance of 97%, drug loading of 179.81 mg, globular size of 85.8 nm and zeta potential of -1.6 mV.
Co-Authors Abdul Kodir Al-Baekani Adam Sugiharto, Adam Agustin, Ririn Ahmad Rifai Aina Khoirida Ainuddin Alfian Alim, Aprilia Helmiyati Alsamiri , Yasir Alvina Beti Maulia Andriyanto Anita Triastuti Annis Rahmawaty Anwar Ardityasmiyati, Siska Arif, Dara Nabila Ary Wahyudi Asmoro, Nurcahya Dwi Asri Wijayanti Atuzahra, Arvanilla Fitri Azizi, M. Riza A’yuni, Qurrata Budi Susilo C Hanny Wijaya Cindi Syaharani Deliza, Annisa Dewi Kusumaningsih Dhina Megayati Dwiyani Pratiwi Eka Citra, Desy Eka Susylowati Elih Sutisna Yanto Ella Wulandari Elvi Damayanti Endang Dyah Ikasari Erlizah Erwin Setyo Kriswanto Evi Karlina Farrah Bintang Sabiti Fitriana Fortuna, Avika Dara Fransiska Faberta Kencana Sari Gendis Purno Yudanti Gilang Huzzatul Akmam Gipta Galih Widodo Gusti Ayu Ratih Damayanti Hamdan Yuafi Abdillah Hasan Mahfud Herlangga, Ogie Yudha Hidayani, Masrifa Hidayat, Rezaldi Hikmah Hilmansyah Saefullah Ikhsan Kamil, Muhammad Ilham Kuncahyo, Ilham Indah Purnama Dewi Irma Istihara Zain Isma Azis Riu JAMILAH Jenny I. S Poerwanti Jenny Indrastoeti Siti Poerwanti, Jenny Indrastoeti Siti Juni Astuti, Dina Putri Kadar Ismah Khairul Aswadi Kusumaningrum, Aprilia Dwi Wahyu Laili, Faiqotul Lalu Muhamad Isnaeni Laylatul Sifa, Nurul Hidayah Luthfiana Nurulin Nafi’ah Luthfiyah, Endah M. Zamroni M.Ikhsan Kamil Maimum Makhrup , Abdul Gani Malika Dhita Shalaika Maman Suryaman Mansyur Srisudarso Marningsih, Tri Mas’ud Maya Rahmawati Meilisa Nurhana Melly Latifah Minta Harsana Mobit, Mobit Muhlis Fajar Wicaksana Nadhifah, Fitriatin Naimah, Myatun Nanang Qosim Al Masquri Ni Nyoman Aprianti Novia Anggraini Nur Khasanah, Dwi Faradylla Nur, Indrayansyah Nurmawati, Fulusia Nurul anisa Nurul Widyawati Islami Rahayu Okta Handika Palupi, Diah Pardyatmoko Poerwanti, Jenny I S Poerwanti, Jenny I.S. PUJI LESTARI Purwanti, Jenny I. S. Rafitri, Desvia Cinta Rauzi, Fathur Reviani, Nia Rian Hidayat Riyadini, Maria Vineki Roemintoyo Rosmawati Saputri, Yasinta Eka Sari , Nala Sasmita Sari, Nurratri Kurnia Sepri Yunarman, Sepri Septa Hardini Setiarso, Budi Siti Istiyati Sitorus, Heri Franata Sri Marmoah Sri Wahono Saptomo Sridadi Supianto Susanto, Arpan Suyud Tiana, Melly Titri S. Mastuti Totoh Tauhidin Abas Tri Murwaningsih Umi Setyoningrum Vivi Irzalinda Wawan Anshori Yusuf Setyawan Wawan Setiawan Wicaksana, Muhlis Widatin, Tri Windi Kartika Wati Wulan Guritno Yanulia Handayani Yousef Bani Ahmad Yulisetiani, Septi Yunita Galih Yudanari