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All Journal Jurnal Pendidikan Kimia Undiksha Journal of Education and Learning (EduLearn) Biology, Medicine, & Natural Product Chemistry PROSIDING SEMINAR KIMIA Alotrop Jurnal Pendidikan dan Ilmu Kimia Lantanida Journal SEJ (Science Education Journal) INKUIRI : Jurnal Pendidikan IPA Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Journal of Chemistry Jurnal Ilmiah Manuntung Paedagoria : Jurnal Kajian, Penelitian dan Pengembangan Kependidikan JOPS (Journal Of Pharmacy and Science) Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia JURNAL PENDIDIKAN MIPA Edukimia JPM: JURNAL PENGABDIAN MASYARAKAT Hydrogen: Jurnal Kependidikan Kimia Jurnal Kependidikan: Jurnal Hasil Penelitian dan Kajian Kepustakaan di Bidang Pendidikan, Pengajaran dan Pembelajaran CHEDS: Journal of Chemistry, Education, and Science Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Educational Sciences Arfak Chem: Chemistry Education Journal Research and Development in Education (RaDEn) Jurnal Pengabdian Pada Masyarakat Chimica Didactica Acta : Journal of Chemistry and Chemistry Education Jurnal Akademik Pengabdian Masyarakat Bulletin of Chemical Reaction Engineering & Catalysis Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Rahmadani, Agung
Departement Of Chemistry Education, Faculty Of Teaching And Education, Mulawarman University, Samarinda 75123, Kalimantan Timur, Indonesia
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Sintesis, Molecular Docking dan Aktivitas Sitotoksik Senyawa Analog Kalkon Berbasis Alfa Tetralone terhadap Sel Kanker Payudara MCF-7: Synthesis, Molecular Docking, and Cytotoxic Activity of Alpha Tetralone Based Chalcone Analogue Compounds against MCF-7 Breast Cancer Cells Rahmadani, Agung; Tasya, Indriana; Lestari, Wahyu Yunita; Kadir, Nurdianah Abdul; Saputri, Mitha; Erika, Farah; Usman, Usman; Sukemi, Sukemi; Arifian, Hanggara; Salam, Supriatno; Herman, Herman; Rijai, Laode
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2092

Abstract

The chalcone compound is a precursor of flavonoid and pyrazoline compounds. Chalcone has two aromatic rings (A and B) and one ?,?-unsaturated carbon atom. Chalcone compounds can be synthesized via the Claisen Schmidt condensation reaction. Chalcone synthesis uses the basic ingredients of alpha tetralone and benzaldehyde analogues. In this research, chalcone synthesis took place for 48 hours at room temperature. Synthetic materials using ethanol solvent and sodium hydroxide catalyst, as well as basic ingredients alpha tetralone, 3,4-dimethoxybenzaldehyde and 4-methoxybenzaldehyde. Characterization of synthesized compounds using spectroscopic methods, including 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) and mass spectroscopy. Characterization results using spectroscopic methods showed that the two chalcone analogue compounds were successfully synthesized with yields above 70%. Both chalcone compounds showed low activity against MCF-7 cancer cells. Molecular docking simulations showed that both chalcone analogues produced energy levels and intramolecular interactions that were no better than 4-hydroxytamoxifen. Keywords:          chalcone analogues, alpha tetralone, cytotoxic   Abstrak Senyawa kalkon merupakan salah satu prekursor dari senyawa flavonoid dan pirazolina. Kalkon mengandung dua cincin aromatis (A dan B) dan satu atom karbon ?,?-tak jenuh. Senyawa kalkon dapat disintesis melalui reaksi kondensasi Claisen Schmidt. Kalkon disintesis menggunakan bahan dasar alfa tetralone dan analog benzaldehida. Dalam penelitian ini senyawa kalkon disintesis selama 48 jam pada suhu ruang menggunakan pelarut etanol dan katalis natrium hidroksida serta bahan dasar alfa tetralone, 3,4-dimetoksibenzaldehida dan 4-metoksibenzaldehida.  Senyawa hasil sintesis dikarakterisasi menggunakan metode spektroskopi meliputi 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) dan spektroskopi massa. Karakterisasi menggunakan metode spektroskopi menunjukkan kedua senyawa analog kalkon berhasil disintesis dengan rendemen diatas 70%. Hasil pengujian sitotoksik menunjukkan bahwa kedua senyawa analog kalkon tidak aktif terhadap sel kanker payudara MCF-7. Simulasi penambatan molekuler menunjukkan bahwa kedua analog kalkon menghasilkan tingkat energi dan interaksi intramolekuler yang tidak lebih baik dibandingkan dengan 4-hidroksitamoksifen. Kata Kunci:         analog kalkon, alfa tetralone, sitotoksik
Pengaruh Teknik Round Robin dalam Model Pembelajaran Team Assisted Individualization terhadap Hasil Belajar Siswa Nurdianah Abdul Kadir; Usman Usman; Agung Rahmadani
JURNAL PENDIDIKAN MIPA Vol. 15 No. 2 (2025): JURNAL PENDIDIKAN MIPA
Publisher : Pusat Publikasi Ilmiah, STKIP Taman Siswa Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37630/jpm.v15i2.2770

Abstract

Rendahnya partisipasi siswa dalam pelajaran kimia dan kurang bervariasinya model pembelajaran menyebabkan hasil belajar yang rendah. Penerapan teknik Round Robin dalam model Team Assisted Individualization (TAI) diharapkan mampu menjadi alternatif guna menghadapi persoalan ini. Penelitian ini dilakukan untuk menguji pengaruh teknik Round Robin dalam model TAI terhadap hasil belajar siswa pada topik hukum dasar kimia. Penelitian ini menggunakan jenis penelitian kuasi eksperimen dengan desain nonequivalent control group design dan sampel dipilih secara purposive, dimana kelas X-F sebagai kelas eksperimen dan kelas X-G sebagai kontrol. Data dikumpulkan melalui observasi dan tes. Hasil penelitian dianalisis dengan software SPSS 26 dan menunjukkan rata-rata hasil posttest untuk kelas kontrol yaitu 61,39 dan kelas eksperimen sebesar 70,97. Berdasarkan hasil uji Mann Whitney didapatkan nilai signifikansi 0,018 ≤ 0,05 menandakan adanya pengaruh penggunaan teknik Round Robin dalam model pembelajaran TAI terhadap hasil belajar siswa mengenai materi hukum dasar kimia. Penggunaan teknik Round Robin dalam model TAI ini dapat membuat diskusi siswa lebih berjalan sehingga keaktifan siswa meningkat yang akan mempengaruhi hasil belajar karena tukar pikiran antar siswa yang membuat siswa menerima materi lebih mudah.
Synthesis and In Silico Study of 5’-Chloro-2’,4-Dihydroxy-3-Methoxychalcone as Potential Inhibitors of Estrogen Receptors Alpha Putri, Rizka Amalia; Nurramadhani, Aisyah Zahra; Islami, Agustina Amalia; Tristania, Auriel Wafiq; Aulia, Isma; Farah, Harra Ismi; Arifian, Hanggara; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 2 (2025): April 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i2.15546

Abstract

The high prevalence of breast cancer necessitates the discovery of new, more effective, and safer anticancer compounds. Chalcone, a flavonoid with promising anticancer activity, is limited by poor bioavailability and rare natural occurrence. In this study, a novel chalcone derivative, 5'-chloro-2',4-dihydroxy-3-methoxychalcone, was synthesized on a laboratory scale via Claisen-Schmidt condensation using 5-chloro-2-hydroxyacetophenone and 4-hydroxy-3-methoxybenzaldehyde as starting materials. The structure of the synthesized compound was confirmed by mass spectrometry and NMR analysis. Pharmacokinetic and toxicity profiles were predicted in silico using SwissADME, while molecular docking simulations with the ERα receptor were performed using AutoDockTools. The compound was obtained as a yellow solid with a yield of 70.15%, showed favorable ADME properties based on Lipinski’s and Veber’s rules, and demonstrated a binding energy of -7.82 kcal/mol to the ERα receptor, indicating potential as an anticancer agent. The novelty of this research is the successfully synthesized and characterized of this specific chalcone, which is structurally different from previously reported analogs. These findings enrich the diversity of chalcone derivatives and provide a new basis for developing synthesis-based drug candidates targeting breast cancer.
The Effect of Collaborative Problem Solving Learning Model on Students' Collaboration Skills in Chemistry Learning Lestari, Wahyu Yunita; Erika, Farah; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.15784

Abstract

The low collaboration skills of students are due to the less-than-optimal role of the teacher in fostering interpersonal skills and cooperation in the classroom. Selecting an appropriate learning model is key to effectively enhancing students' collaboration skills. Therefore, the Collaborative Problem Solving (CPS) learning model optimizes students' collaboration skills. This study aims to determine the effect of the Collaborative Problem Solving (CPS) model on students' collaboration skills in elements, compounds, and mixtures. The approach employed is a quasi-experimental design utilizing a non-equivalent control group format. All 8th-grade junior high school students in Samarinda for the 2023/2024 academic year served as the population in this study. Class VIII A was assigned as the experimental group, whereas Class VIII B was the control group. The sample was selected using purposive sampling based on the subject teacher’s considerations, including classroom participation, group collaboration, and peer interaction. The instrument used was a collaboration skills questionnaire consisting of 25 statement items, utilizing a 5-point Likert scale. Data collection was also carried out using an observation sheet developed based on the indicators of collaboration skills. The data were analyzed descriptively after being collected through observations and collaboration skill questionnaires. The findings indicated that the experimental group achieved a higher average score than the control group, indicating that the CPS model syntax positively improved students' collaboration skills.
Toxicity and Antioxidant Activity Test of Rambutan Seeds (Nephelium lappaceum L.) Arum, Alvionita Puspa; Rahmadani, Agung; Rijai, Laode; Farah, Harra Ismi
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.16376

Abstract

Rambutan (Nephelium lappaceum L.) seeds have long been utilized in traditional medicine due to their potential therapeutic properties. This study aimed to determine the secondary metabolite profile, toxicity, and antioxidant activity of the methanolic extract and ethyl acetate fraction of rambutan seeds to strengthen their potential application in traditional medicine. The powdered of rambutan seed was extracted with a maceration technique using methanol, followed by fractionation using n-hexane and ethyl acetate. The methanol extract and ethyl acetate fraction were tested for toxicity using the Brine Shrimp Lethality Test (BSLT) and for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Phytochemical screening was performed using standard qualitative method to identify secondary metabolites, which confirmed the presence of phenols, tannins, and flavonoids in both samples. Toxicity testing indicated LCâ‚…â‚€ values of 688.86 ppm for the methanol extract and 825.68 ppm for the ethyl acetate fraction. Antioxidant activity assessment revealed ICâ‚…â‚€ values of 328.61 ppm for the methanol extract and the higher activity for ethyl acetate fraction of 32.78 ppm. These results indicate that the ethyl acetate fraction of rambutan seeds may serve as a promising natural source of antioxidants for therapeutic development.
Learners’ Needs Analysis for the Development of Reaction Rate Experimental Videos Marganingtyas, Arinda; Hartati, Yuli; Erika, Farah; Kusumaningtyas, Pintaka; Rahmadani, Agung
SEJ (Science Education Journal) Vol. 9 No. 2 (2025): November
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/sej.v9i2.1723

Abstract

Understanding chemical reaction rates requires practical experiences that allow students to observe factors influencing reaction speed. However, limited laboratory equipment and materials in many schools hinder the implementation of meaningful experiments. This study aims to determine the learning media needs of Class XI students for the development of reaction rate experimental videos at SMA Negeri 7 Malinau. A total of 17 students (n = 17) and one science teacher participated in the study. Data were collected using questionnaires and interviews, then analyzed through descriptive, qualitative, and quantitative approaches. The results show that 88.24% of students experience difficulties in learning reaction rate concepts, 76.47% perceive that videos help their understanding, and 100% agree that experimental videos are needed as learning resources. These findings highlight the urgent need for offline, visually engaging, and easy-to-understand experimental videos to support students’ conceptual understanding in contexts with limited laboratory facilities. The results of this needs analysis will directly inform the content design, structure, and visual features of the reaction rate experimental videos to be developed.
Co-Authors Abdul Aziz Adam M. Ramadhan Adam M. Ramadhan Adhani, Aidhil Aditya Fridayanti Afif Ruchaemi Ahmed Jhordy Almeida, Maria Amanuddin Amanuddin Angga Cipta Narsa Anggraeni, Egi Syahrah Anjarwati, Dewi Arief Fadillah Arifian, Hanggara Arjuna Pramana Arum, Alvionita Puspa Asiyah, Mely Nor Ata, Putri Fritami Atin Nuryadin Atria Kent Aulia, Isma Awaliah, Meisya Adelia Salsabila Awaliyah, Nabilah Nailah Bayu Heris Apriyanto Bela Apriliana Ningsih Cahayani, Mega Cahyo, Risky Nor Debbi Pasedan Dewi Noorjannah Utami Dewi Rahmawati DEWI RAHMAWATI Dewi Rahmawati Diana Kurnia Apriani Diana Ntowe Didi Fadilla Eka Rizky Meilinda Elisa Yunita Emma Susilowati Shabir Enggar Wijayanti Erlin Dwi Nurrohimi Erwin Erwin Fairul Muflihah Fajar Prasetya Fajar Prasetya Farah Erika Farah Erika Farah Erika Farah, Harra Ismi Fika Aryati Firman Shantya Budi, Firman Shantya Firnanda Zuni Fransiska Ganjar Firmansyah Hadi Kuncoro Hadi Nur Hajrah Hajrah Hajrah Hajrah Hanggara Arifian Hanggara Arifian Harra Ismi Farah Hartandi, Dimas Hartati, Yuli Hasan, Hafia Hazlina, Nur Helmi Helmi Herman Herman Herman Hilalliyah, Nur Husnul Khatimah Indah Silvia Sugiyamin Indriana Tasya Indriana Tasya Islami, Agustina Amalia Isyra, Klara Wahyu Jaka Fadraersada Jeremia Giawa, Agusto Kadir, Nurdianah Abdul Kama Tasawa, Gymnastiyar Laode Rijai Laode Rijai Laode Rijai Laras Indah Wulandari Larasati, Herlin Alfiana Lestari Lestari Lestari, Wahyu Yunita Lisna Meylina Lita Yulianti Lizma Febrina Lizma Febrina M Arifuddin M. Ari Prayogo Marganingtyas, Arinda Masruhim, Muh. Amir Maulina, Tiara Mega Cahayani Mega Rizky Novitasari Meiliawati, Ruli Mirhansyah Ardana Mitha Saputri Muhammad Ansar Muhammad Choirul Muhammad Ridwansyah Muhammad, Ridwansyah Mukhamad Nurhadi, Mukhamad Myra Puspha Hardina Myra Puspha Hardina Ni'mah, Fatchiyatun Nisa Naspiah Nova Yunita Putri Olii Nur Awaliah Nur Masyithah Zamruddin Nur Shidiq Nurdianah Abdul Kadir Nurdianah Abdul Kadir Nurlaili Nurlaili Nurramadhani, Aisyah Zahra Nursilawati, Nursilawati Nurul Fitriyah Sulaeman, Nurul Fitriyah Nurul Khotimah Olii, Nova Yunita Putri Pakaenoni, Frederich Palapa, Kaleb Gideon Pandiangan, Masda Pintaka Kusumaningtyas Prastika, Nanda Diah Purwita Sari, Regina Putri Fritami Ata Putri, Rizka Amalia Rachma Nadya Utami Rahayu, Rosika Rahman, Karisa Apriyani Rahman, Zainur Arif Ramadani, Pino Rengganis, Ajeng Ayu RISKA OKTAVIANI Risna Agustina Rizki Nur Analita Rolan Rusli Romisa, Fahmi Salam, Supriatno Saputri, Mitha Sarifah, Awalus Siburian, Putri Dela Silalahi, Yoisi Fortuna Simangunsong, Ari Putra Wijaya Sin Yuan Lai Sinaga, Hilga Natasya Sri Agung Fitri Kusuma Sri Lestari Sri Lestari Sri Wulandari Sriwidodo Sriwidodo Suandi Sidauruk Sukartiningsih Sukartiningsih Sukemi Sukemi Sukemi Sukemi sukmawati Supriatno Salam Supriatno Salam Susanti, Revi Syahputri, Salsabila Dia Tasya, Indriana Teguh Wirawan Tiara Maharani, Tiara Tri Woro Widyanti Tristania, Auriel Wafiq Turista, Dora Dayu Rahma Usman Usman Usman Usman VICTORIA YULITA FITRIANI Vina Maulidya Vina Maulidya Wahyu Yunita Lestari Watulingas, Maasje Catherine Wijaya, Viriyanata Wirhanuddin, Wirhanuddin Yulian, Satifa Ananda Yulianti, Ayu Dwi Yuniar Ponco Prananto Yurika Sastyarina Yuspian Nur Zhiying Zhu