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All Journal Jurnal Pendidikan Kimia Undiksha Journal of Education and Learning (EduLearn) Biology, Medicine, & Natural Product Chemistry PROSIDING SEMINAR KIMIA Alotrop Jurnal Pendidikan dan Ilmu Kimia Lantanida Journal INKUIRI : Jurnal Pendidikan IPA Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Journal of Chemistry Jurnal Ilmiah Manuntung Paedagoria : Jurnal Kajian, Penelitian dan Pengembangan Kependidikan JOPS (Journal Of Pharmacy and Science) Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia Edukimia JPM: JURNAL PENGABDIAN MASYARAKAT Hydrogen: Jurnal Kependidikan Kimia Jurnal Kependidikan: Jurnal Hasil Penelitian dan Kajian Kepustakaan di Bidang Pendidikan, Pengajaran dan Pembelajaran CHEDS: Journal of Chemistry, Education, and Science Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Arfak Chem: Chemistry Education Journal Research and Development in Education (RaDEn) Jurnal Pengabdian Pada Masyarakat Chimica Didactica Acta : Journal of Chemistry and Chemistry Education Jurnal Akademik Pengabdian Masyarakat Bulletin of Chemical Reaction Engineering & Catalysis Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Rahmadani, Agung
Departement Of Chemistry Education, Faculty Of Teaching And Education, Mulawarman University, Samarinda 75123, Kalimantan Timur, Indonesia
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Analisis Secara GC-MS Senyawa Aktif Antioksidan Fraksi N-Heksana Daun Libo (Ficus variegata Blume) Vina Maulidya; Myra Puspha Hardina; Lizma Febrina; Rolan Rusli; Agung Rahmadani
Jurnal Sains dan Kesehatan Vol. 1 No. 10 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i10.101

Abstract

Tanaman Libo (Ficus variegata Blume) merupakan salah satu tumbuhan liar khas Kalimantan Timur sebagai sumber bahan larvasida dan antioksidan. Penelitian bertujuan untuk mengetahui komponen senyawa aktif antioksidan dalam fraksi n-heksana daun Libo dengan metode GC-MS. Interpretasi spektrum GC-MS dilakukan menggunakan database standar National Institute Standard and Technology (NIST). Komponen mayor fraksi n-heksana yang memiliki aktivitas antioksidan antara lain: cyclotetracosane; 1-heneicosanol; 1-docosene; 1,2-benzenedicarboxilic acid; 1-heptacosanol; octacosanol; dan cyclooctacosane.
Sintesis, Molecular Docking dan Aktivitas Sitotoksik Senyawa Analog Kalkon Berbasis Alfa Tetralone terhadap Sel Kanker Payudara MCF-7: Synthesis, Molecular Docking, and Cytotoxic Activity of Alpha Tetralone Based Chalcone Analogue Compounds against MCF-7 Breast Cancer Cells Agung Rahmadani; Indriana Tasya; Wahyu Yunita Lestari; Nurdianah Abdul Kadir; Mitha Saputri; Farah Erika; Usman Usman; Sukemi Sukemi; Hanggara Arifian; Supriatno Salam; Herman Herman; Laode Rijai
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2092

Abstract

The chalcone compound is a precursor of flavonoid and pyrazoline compounds. Chalcone has two aromatic rings (A and B) and one ?,?-unsaturated carbon atom. Chalcone compounds can be synthesized via the Claisen Schmidt condensation reaction. Chalcone synthesis uses the basic ingredients of alpha tetralone and benzaldehyde analogues. In this research, chalcone synthesis took place for 48 hours at room temperature. Synthetic materials using ethanol solvent and sodium hydroxide catalyst, as well as basic ingredients alpha tetralone, 3,4-dimethoxybenzaldehyde and 4-methoxybenzaldehyde. Characterization of synthesized compounds using spectroscopic methods, including 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) and mass spectroscopy. Characterization results using spectroscopic methods showed that the two chalcone analogue compounds were successfully synthesized with yields above 70%. Both chalcone compounds showed low activity against MCF-7 cancer cells. Molecular docking simulations showed that both chalcone analogues produced energy levels and intramolecular interactions that were no better than 4-hydroxytamoxifen. Keywords:          chalcone analogues, alpha tetralone, cytotoxic   Abstrak Senyawa kalkon merupakan salah satu prekursor dari senyawa flavonoid dan pirazolina. Kalkon mengandung dua cincin aromatis (A dan B) dan satu atom karbon ?,?-tak jenuh. Senyawa kalkon dapat disintesis melalui reaksi kondensasi Claisen Schmidt. Kalkon disintesis menggunakan bahan dasar alfa tetralone dan analog benzaldehida. Dalam penelitian ini senyawa kalkon disintesis selama 48 jam pada suhu ruang menggunakan pelarut etanol dan katalis natrium hidroksida serta bahan dasar alfa tetralone, 3,4-dimetoksibenzaldehida dan 4-metoksibenzaldehida.  Senyawa hasil sintesis dikarakterisasi menggunakan metode spektroskopi meliputi 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) dan spektroskopi massa. Karakterisasi menggunakan metode spektroskopi menunjukkan kedua senyawa analog kalkon berhasil disintesis dengan rendemen diatas 70%. Hasil pengujian sitotoksik menunjukkan bahwa kedua senyawa analog kalkon tidak aktif terhadap sel kanker payudara MCF-7. Simulasi penambatan molekuler menunjukkan bahwa kedua analog kalkon menghasilkan tingkat energi dan interaksi intramolekuler yang tidak lebih baik dibandingkan dengan 4-hidroksitamoksifen. Kata Kunci:         analog kalkon, alfa tetralone, sitotoksik
Student experiences and effectiveness of project-based learning in an organic practicum chalcone synthesis experiments Nova Yunita Putri Olii; Muhammad Choirul; Indriana Tasya; Sri Lestari; Agung Rahmadani
Research and Development in Education (RaDEn) Vol. 4 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/raden.v4i2.36737

Abstract

Practicum serves as the main support for organic chemistry learning, enhancing both conceptual comperand strengthening students' practical skills through learning experiences. The purpose of this study is to analyze students' learning experiences and the effectiveness of project-based learning (PjBL) in organic chemistry practicum on chalcone synthesis experiment. This study used a mixed method that included both quantitative and qualitative data. The study's findings indicate that project-based learning significantly improves student learning outcomes, as evidenced by an N-Gain of 0.92 and a presentase of 91.97%, as well as an effect size that indicates a significant impact of project-based learning on student learning outcomes. Qualitative data from student surveys also indicated that PjBL not only improved understanding and practical skills, but also added fun to the learning process. This research confirms the importance of innovation in teaching methods to improve student engagement and learning outcomes.
Kajian Literatur Penggunaan Multimedia untuk Mengatasi Miskonsepsi Materi Kimia di Sekolah Menengah Atas sebagai Upaya Peningkatan Pemahaman Siswa Nursilawati, Nursilawati; Sinaga, Hilga Natasya; Yulianti, Lita; Rahman, Karisa Apriyani; Rahmadani, Agung
INKUIRI: Jurnal Pendidikan IPA Vol 13, No 3 (2024): INKUIRI: Jurnal Pendidikan IPA
Publisher : Magister Pendidikan Sains Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/inkuiri.v13i3.88063

Abstract

Miskonsepsi materi kimia di Sekolah Menengah Atas seringkali terjadi di setiap sekolah, salah satu penyebab miskonsepsi tersebut adalah kurangnya pemahaman siswa terkait materi yang diajarkan. Kajian literatur ini bertujuan untuk memberikan pandangan mengenai penggunaan multimedia dalam mengatasi miskonsepsi pada materi kimia sebagai upaya peningkatan pemahaman siswa. Metode yang digunakan pada penulisan kajian literatur ini adalah metode narrative literature review (NLR) dengan mengumpulkan data berupa artikel terkait miskonsepsi materi kimia yang diterbitkan dalam kurun waktu 2016-2023. Beberapa studi menunjukkan efektivitas multimedia dalam mereduksi miskonsepsi serta meningkatkan pemahaman siswa terhadap konsep-konsep kimia. Berdasarkan hasil kajian literatur tersebut menunjukkan bahwa miskonsepsi masih menjadi subjek penelitian saat ini dan masalah miskonsepsi kimia masih sering terjadi pada siswa Sekolah Menengah Atas. Penggunaan multimedia sebagai media pembelajaran di Sekolah Menengah Atas telah terbukti sangat efektif untuk mengatasi miskonsepsi dan meningkatkan pemahaman siswa tentang materi kimia.
Kajian Literatur Penerapan Kimia Hijau dan Tujuan Pembangunan Berkelanjutan dalam Pembelajaran Kimia Anggraeni, Egi Syahrah; Putri, Rizka Amalia; Tristania, Auriel Wafiq; Maharani, Tiara; Wirhanuddin, Wirhanuddin; Rahmadani, Agung
Arfak Chem: Chemistry Education Journal Vol. 7 No. 2 (2024): Arfak Chem
Publisher : Universitas Papua, Manokwari, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/accej.v7i2.739

Abstract

Penerapan konsep kimia hijau dan tujuan pembangunan berkelanjutan (Sustainable Development Goals) dalam pembelajaran kimia menjadi sangat penting untuk menghadapi tantangan global saat ini, seperti pemanasan global dan kerusakan lingkungan. Kajian literatur ini bertujuan untuk mengeksplorasi prinsip-prinsip kimia hijau yang dapat diintegrasikan ke dalam kurikulum pendidikan, sehingga meningkatkan pemahaman siswa tentang dampak kimia terhadap keberlanjutan. Metode yang digunakan dalam kajian ini adalah narrative literature review yang mengumpulkan dan menganalisis berbagai sumber literatur terkait penerapan kimia hijau dan SDGs dalam pendidikan. Hasil kajian menunjukkan bahwa integrasi prinsip-prinsip keberlanjutan dalam pembelajaran kimia tidak hanya mendorong praktik pendidikan yang inovatif dan interdisipliner, tetapi juga memungkinkan pendidik dan peserta didik untuk berkontribusi secara aktif dalam menciptakan solusi berkelanjutan. Dengan demikian, pengembangan kurikulum yang relevan sangat diperlukan untuk memastikan generasi mendatang lebih sadar akan isu-isu keberlanjutan.
PEWARNAAN SERAT DAUN DOYO MENGGUNAKAN PEWARNA ALAMI DARI EKSTRAK DAUN KETAPANG Nursilawati, Nursilawati; Awaliyah, Nabilah Nailah; Pakaenoni, Frederich; Larasati, Herlin Alfiana; Hartandi, Dimas; Rahmadani, Agung; Wirhanuddin, Wirhanuddin; Sukemi, Sukemi
PROSIDING SEMINAR KIMIA Vol 3 No 1 (2024): Prosiding SNK 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ulap Doyo is a traditional woven fabric of the Dayak Benuaq tribe in East Kalimantan. Ulap Doyo is made from doyo (Curculigo latifolia) leaf fibers with the base color of whitish cream. Natural dye is used to create patterns. Ketapang (Terminalia catappa L.) leaves contain tannins that can be used as natural dyes. This study aimed to determine the color change of doyo leaf fibers dyed using aqueous ketapang leaf extract. The natural dye was extracted by decoction technique with distilled water as solvent. Tannin content was analyzed using phytochemical tests and permanganometric titration. The dyeing process used the dye bath technique at 92°C of dyeing temperature, 1:100 (w/v) of MLR, and 135 minutes of dyeing time. Before dyeing process, the extract and fibers were treated using 5 mL of 1 M acetic acid (AA) and 5 mL of 1 M ammonia (Am). The color change of the dyed fibers: untreated fiber - untreated extract (UF-UE), treated fiber - untreated extract (TFAA-UE, TFAm-UE), untreated fiber - treated extract (UF-TEAA, UF-TEAm), and treated fiber - treated extract (TFAA-TEAA, TFAm-TEAm) were measured using ImageJ application and shown in term of ∆I. This research results shows that the extract was dark brown solution with 0,280 ± 0,001 % (w/w) of tannin content. The color shade of the dyed doyo leaf fibers is pale brown to brown. The treatment of the extract using acetic acid (UF-TEAA) produce the highest colour shade and ∆I value. This study shows that the ketapang leaf extract can be used as dye for ulap doyo. Keywords : ulap doyo, Curculigo latifolia, Terminalia catappa L., dyeing bath technique
Pelatihan Karya Tulis Ilmiah Sebagai Sarana Pengembangan Diri Siswa SMA Prayogo, M. Ari; Rahmadani, Agung; Nuryadin, Atin; Palapa, Kaleb Gideon
JPM: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jpm.v5i2.2192

Abstract

Scientific writing training is an important means of student self-development, especially in terms of writing skills and critical thinking skills. This community service activity aims to provide scientific writing training to students of State Senior High School 1 Sangasanga. This training was held for two days, Wednesday and Thursday, September 25-26, 2024 at State Senior High School 1 Sangasanga starting at 08.30 WITA until finished. The training participants were 50 students from grade eleven (XI). The methods used in this training activity include providing materials, intensive guidance, and direct practice in compiling scientific papers. The results of this training showed a significant increase in students' abilities in compiling scientific papers systematically, critically, and based on facts obtained in the field. In addition, this training also motivated students to be more courageous in conveying creative and solution-oriented ideas. Thus, this training makes a positive contribution to improving students' academic quality. The results obtained after the end of this training were to provide input to participants, namely students, in writing scientific papers by training students' writing and critical thinking skills, as well as encouraging creative and innovative attitudes.
SINTESIS DAN UJI TOKSISITAS SENYAWA 2’,4’-DIKLORO-4-METOKSIKALKON Mega Cahayani; Agung Rahmadani; Dewi Rahmawati; Rolan Rusli
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.186

Abstract

Chalcone is one of secondary metabolites included into the class of flavonoid. Chalcone can be obtained from isolation plant and have various biological activities. Chalcones are known as the key intermediate in the synthesis of various biologically important heterocyclic compounds. The aims of these research was to syntheses 2’,4’-dichloro-4-methoxychalcone. by Claisen–Schmidt condensation. These compound was characterized by 1H-NMR, 13C-NMR and mass spectroscopy. LC50 value of these compound was 864,97 ppm
An In Silico Evaluation of the Anti-Wrinkling Potential of Certain Peptides in Relation to the Catalytic Domain of Matrix Metalloproteinase-1 Rahmadani, Agung; Sukemi, Sukemi; Tasya, Indriana; Olii, Nova Yunita Putri; Ridwansyah, Muhammad; Turista, Dora Dayu Rahma; Arifian, Hanggara
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2518

Abstract

Skin wrinkles are caused by the cleavage of collagen fibers by the major collagenase enzyme matrix metalloproteinase-1 (MMP-1). Peptide-based matrix metalloproteinase-1 inhibitors present a potential new therapeutic strategy to prevent MMP-1-mediated collagenolysis, which is induced by UV-induced MMP-1 overexpression. This in silico study investigated the MMP-1 inhibitory capacity of carefully selected and well-designed hexapeptides. A molecular docking method was employed to screen 14 hexapeptides. The target ligands were observed to interact non-covalently. The LYYYGP peptide sequence was found to form three hydrogen bonds (H-bonds) with amino acid (AA) residues in the catalytic domain of MMP-1. Additionally, hydrophobic interactions between these peptides and the protein were observed at certain sites. The maximum binding affinity was observed for the LYYYGP sequence (binding free energy, ?G = -9.00 kcal/mol). These sequences exhibited binding energies comparable to those of the LSYYGP sequence (-8.48 kcal/mol) and YSGYYP sequence (-8.27 kcal/mol). The YSGYGY sequence demonstrated a lower binding affinity for the target receptor, with ?G = -5.59 kcal/mol. This study indicates that specific peptide sequence components are crucial for forming hydrogen bonds that link proteins to peptides. Further investigation, encompassing chemical synthesis and laboratory experimentation, is requisite to substantiate the efficacy of the two hexapeptides.
Kajian Literatur Jenis Asesmen dalam Pembelajaran Kimia Ramadani, Pino; Hilalliyah, Nur; Maulina, Tiara; Syahputri, Salsabila Dia; Ridwansyah, Muhammad; Rahmadani, Agung
Edukimia Vol 7, No 1 (2025): Edukimia - Vol. 07, Issue 01
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/ekj.v7.i1.a569

Abstract

Pembelajaran kimia di sekolah sering kali menggunakan teknik asesmen yang kurang tepat untuk mengukur hasil belajar. Pendidik memerlukan asesmen yang tepat untuk mengevaluasi hasil belajar peserta didik yang ingin diukur. Tujuan kajian literatur ini untuk mengidentifikasi jenis-jenis asesmen dalam pembelajaran kimia. Metode yang digunakan ialah narrative literature review. Terdapat 6 jenis asesmen yang dapat digunakan dalam mengevaluasi hasil belajar dalam pembelajaran kimia. Jenis asesmen tersebut yakni asesmen formatif, sumatif, diagnostik, autentik, teman sejawat, dan diri. Setiap asesmen dapat mengukur hasil belajar yang berbeda-beda. Penggunaan teknik asesmen yang tepat dapat membantu pendidik dalam mengevaluasi kelebihan dan kekurangan selama proses pembelajaran kimia sehingga ketercapaian tujuan pembelajaran kimia dapat dievaluasi
Co-Authors Abdul Aziz Adam M. Ramadhan Adam M. Ramadhan Adhani, Aidhil Aditya Fridayanti Afif Ruchaemi Ahmed Jhordy Almeida, Maria Amanuddin Amanuddin Angga Cipta Narsa Anggraeni, Egi Syahrah Arief Fadillah Arifian, Hanggara Arjuna Pramana Asiyah, Mely Nor Ata, Putri Fritami Atin Nuryadin Atria Kent Awaliyah, Nabilah Nailah Bayu Heris Apriyanto Bela Apriliana Ningsih Cahayani, Mega Cahyo, Risky Nor Debbi Pasedan Dewi Noorjannah Utami Dewi Rahmawati Dewi Rahmawati DEWI RAHMAWATI Diana Kurnia Apriani Diana Ntowe Didi Fadilla Eka Rizky Meilinda Elisa Yunita Emma Susilowati Shabir Enggar Wijayanti Erlin Dwi Nurrohimi Erwin Erwin Fairul Muflihah Fajar Prasetya Fajar Prasetya Farah Erika Farah Erika Farah Erika Fika Aryati Firman Shantya Budi, Firman Shantya Firnanda Zuni Fransiska Ganjar Firmansyah Hadi Kuncoro Hadi Nur Hajrah Hajrah Hajrah Hajrah Hanggara Arifian Hanggara Arifian Harra Ismi Farah Hartandi, Dimas Hasan, Hafia Hazlina, Nur Helmi Helmi Herman Herman Hilalliyah, Nur Husnul Khatimah Indah Silvia Sugiyamin Indriana Tasya Indriana Tasya Islami, Agustina Amalia Isyra, Klara Wahyu Jaka Fadraersada Jeremia Giawa, Agusto Kadir, Nurdianah Abdul Kama Tasawa, Gymnastiyar Laode Rijai Laode Rijai Laode Rijai Laras Indah Wulandari Larasati, Herlin Alfiana Lestari Lestari Lisna Meylina Lisna Meylina Lita Yulianti Lizma Febrina Lizma Febrina M Arifuddin M. Ari Prayogo Masruhim, Muh. Amir Maulina, Tiara Mega Cahayani Mega Rizky Novitasari Meiliawati, Ruli Mirhansyah Ardana Mitha Saputri Muhammad Ansar Muhammad Choirul Muhammad Irfan Muhammad Ridwansyah Muhammad, Ridwansyah Mukhamad Nurhadi, Mukhamad Myra Puspha Hardina Myra Puspha Hardina Ni'mah, Fatchiyatun Nisa Naspiah Nova Yunita Putri Olii Nur Awaliah Nur Masyithah Zamruddin Nur Shidiq Nurdianah Abdul Kadir Nursilawati, Nursilawati Nurul Fitriyah Sulaeman, Nurul Fitriyah Nurul Khotimah Olii, Nova Yunita Putri Pakaenoni, Frederich Palapa, Kaleb Gideon Pandiangan, Masda Prastika, Nanda Diah Purwita Sari, Regina Putri Fritami Ata Putri, Rizka Amalia Rachma Nadya Utami Rahman, Karisa Apriyani Rahman, Zainur Arif Ramadani, Pino Rengganis, Ajeng Ayu RISKA OKTAVIANI Risna Agustina Rizki Nur Analita Rolan Rusli Romisa, Fahmi Sarifah, Awalus Siburian, Putri Dela Silalahi, Yoisi Fortuna Simangunsong, Ari Putra Wijaya Sin Yuan Lai Sinaga, Hilga Natasya Sri Agung Fitri Kusuma Sri Lestari Sri Lestari Sri Wulandari Sriwidodo Sriwidodo Suandi Sidauruk Sukartiningsih Sukartiningsih Sukemi Sukemi Sukemi Sukemi sukmawati Supriatno Salam Supriatno Salam Susanti, Revi Syahputri, Salsabila Dia Tasya, Indriana Teguh Wirawan Tiara Maharani, Tiara Tri Woro Widyanti Tristania, Auriel Wafiq Turista, Dora Dayu Rahma Usman Usman Usman Usman VICTORIA YULITA FITRIANI Vina Maulidya Vina Maulidya Viriyanata Wijaya Wahyu Yunita Lestari Watulingas, Maasje Catherine Wirhanuddin, Wirhanuddin Yulian, Satifa Ananda Yulianti, Ayu Dwi Yuniar Ponco Prananto Yurika Sastyarina Yuspian Nur Zhiying Zhu