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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Rheumatology Journal of Stem Cell Research and Tissue Engineering The New Ropanasuri Journal of Surgery JOURNAL LA MEDIHEALTICO The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal Medical Informatics Technology
Murdani Abdullah
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Indonesia/Dr. Cipto Mangunkusumo General National Hospital
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Health Related Quality of Life and Associated Factors of Inflammatory Bowel Disease Outpatient Unit in Dr. Cipto Mangunkusumo Hospital Afistianto, Muhammad Fikri; Simadibrata, Marcellus; Putranto, Rudi; Abdullah, Murdani; Setiati, Siti; Wisnu, Wismandari; Antono, Dono; Susilo, Adityo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, August, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025107-113

Abstract

Background: Inflammatory Bowel Disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is an inflammatory digestive tract condition with unknown causes. Its unpredictable symptoms affect quality of life. In Indonesia, the quality of life of IBD patients remains unreported. Factors such as advanced age, long disease duration, active disease, corticosteroid use, comorbidities, unemployment, and poor sleep quality may reduce quality of life. This study aims to assess the quality of life profile of IBD patients and its associated factors.Methods: This cross-sectional study collected data from October to November 2024 through interviews at the outpatient unit of Dr. Cipto Mangunkusumo Hospital (RSCM). Quality of life was measured using the Inflammatory Bowel Disease Questionnaire 9 (IBDQ-9), and sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Both tools were validated in Indonesian. Eligible participants met inclusion and exclusion criteria. Bivariate and multivariate logistic regression analyses identified factors associated with quality of life.Results: Among 201 participants, 95% reported a good quality of life. Multivariate analysis identified active disease (PR 4.072 [1.133–14.633], p = 0.031) and combination therapy (PR 12.803 [1.423–115.147], p = 0.023) as factors associated with poor quality of life. Age, disease duration, comorbidities, employment status, and sleep quality showed no significant associations.Conclusion: Most IBD patients (95%) in the RSCM outpatient unit reported a good quality of life. Active disease and combination therapy were linked to poorer quality of life.
The Effectiveness of a High-Protein Liquid Dietary Supplementation in Improving Nutritional Status of Malnourished Patients in Hospital Care: a Preliminary Study Simadibrata, Marcellus; Abdullah, Murdani; Witjaksono, Fiastuti; Muzellina, Virly Nanda; Utari, Amanda Pitarini; Wulandari, Yohannessa; Wijayanti, Ari; Mustikarani, Dewi; Haloho, Raja Mangatur; Rachman, Aditya; Simadibrata, Daniel Martin; Mutiara, Rizka; Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.108 KB) | DOI: 10.24871/231202243-51

Abstract

Background: Malnutrition is a very common problem in hospitalized patients. Based on studies conducted in various countries, the prevalence of hospital malnutrition ranges from 20-45%. Hospital malnutrition can occur as a result of insufficient nutrient intake, impaired absorption of nutrients in the gastrointestinal (GI) tract, loss of nutrients due to disease, or increased metabolic requirement during illness. Nutrition is the basis for the healing process as it requires good nutrients through various enzymatic reactions. Some studies have shown that hospital malnutrition increases morbidity, mortality, prolongs the duration of hospitalization, and delays recovery. To improve nutritional status, a high-protein diet can be given. Liquid diet is one of the alternative forms of nutrition because it is easier to swallow.Method: This study was a double-blind randomized controlled trial conducted to assess the effectiveness of high protein liquid dietary supplementation in malnourished hospitalized patients. The patients were assessed for their nutritional status based on ESPEN 2015 criteria. Patients who experienced malnutrition will be divided into 2 groups, namely the control group which was given normal protein liquid diet, while the intervention group was given high protein liquid diet supplementation as much as 2 bottles (200 mL) per day for 7-10 days. Furthermore, the nutritional status of the patient was assessed.Results: By administering high-protein liquid diet supplementation, there was a tendency to increase the strength of the right handgrip in 3 subjects (50%), the tendency to increase body mass index (BMI) in 3 subjects (50%), Subjective Global Assessment (SGA) score improved in 2 subjects with mild/moderate malnutrition (33.3%) and 1 subject with normal nutrition (16.7%), and the tendency to increase the fat-free mass in 3 subjects (50%).Conclusion: The administration of high protein liquid dietary supplementation tended to increase the strength of the right handgrip, BMI, SGA score, and body fat-free mass index.
Effectivity of Extracorporeal Shock Wave Lithotripsy (ESWL) and Stenting vs. Stenting Only for Difficult Common Biliary Duct Stones: A Retrospective Analysis Maulahela, Hasan; Rumagesan, Djahalia; Abdullah, Murdani; Makmun, Dadang; Renaldi, Kaka; Simadibrata, Marcellus; Shatri, Hamzah; Fauzi, Achmad; Tandan, Manu
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202323-29

Abstract

Background: Endoscopic retrograde cholangiopancreatography (ERCP) alone may not be sufficient for treating difficult common bile duct stones. To address this challenge, several other modalities exist, including extracorporeal shock wave lithotripsy (ESWL) and biliary stent placement. This study aims to investigate the effectiveness of ESWL following biliary stent placement, in comparison to biliary stent placement alone , in the treatment of difficult common bile duct stones.Methods: A retrospective cohort study was conducted using medical record data from the Gastrointestinal Endoscopy Center Registry of Dr. Cipto Mangunkusumo General National Hospital. This study evaluated 126 subjects with difficult bile stones, who were divided into two groups: one group received biliary stent placement alone, while the other underwent extracorporeal shock wave lithotripsy (ESWL) following biliary stent placement. The effectiveness of each treatment was assessed based on the rate of complete clearance of bile stones.Results: Of the total participants, 72 underwent ESWL following biliary stent placement, while 54 received biliary stent placement alone. The rate of complete stone clearance was 69.1% in the ESWL group and 64.8% in the stent-only group. However, the addition of ESWL as an adjuvant therapy did not result in a statistically significant improvement (p = 0.703; 95% CI: 0.816–1.351). Normal body mass index was a factor that influences the effectiveness of ESWL after biliary stent placement (p = 0.002).Conclusion: The ESWL procedure as adjuvant therapy following biliary stent placement has the same level of effectiveness as biliary stent placement alone.
Combination Treatment in Ulcerative Colitis using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum Mycelium Extract Simadibrata, Marcellus; Rachman, Aditya; Budimutiar, Felix; Simadibrata, Paulus; Abdullah, Murdani; Haloho, Raja Mangatur; Wijaya, Anthony Eka; Bisuk, Batara; Maharani, Shabrina; Mustikarani, Dewi; Simadibrata, Daniel Martin; Sugita, Peter
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/24120232-11

Abstract

Background:  Inflammatory bowel disease (IBD) is idiopathic disease characterized by chronic inflammation of the gastrointestinal tract. Polysaccharide peptide of Ganoderma lucidum mycelium extract (PPGL) is considerably a good option for adjunctive therapy of IBD. This study aims to evaluate the benefit of PPGL in patients treated with 5-ASA.Method: A retrospective observational cohort study was conducted to examine the medical records of 124 ulcerative colitis patients. There were 80 patients in intervention group who were treated with a combination of 5-ASA and PPGL, and there were 44 patients in the control group who were treated with 5-ASA only. Clinical and laboratory endpoints were observed at the baseline and after 30, 60, and 90 days. Clinical endpoints included abdominal pain, bloody diarrhea, aphthous stomatitis, and polyarthritis; meanwhile, laboratory endpoints included hemoglobin level, ESR, CRP, fecal calprotectin, M2-pyruvate kinase (MP2K), fecal culture, C. difficile culture, and colonoscopy results. Clinical trials conducted after patient enrollment with registry number ClinicalTrials.gov NCT04029649.Results: On day-30 there was a significant difference between intervention group 45.6%  and control group 2.3% in abdominal pain complaints (p 0.001). Moreover, laboratory parameters of fecal calprotectin (p 0.001), fecal MP2K (p = 0.015), and hemoglobin (p 0.001) were considerably better in intervention group on day-30. These differences were consistently found on day 60 and 90.Conclusion: The study implies potential correlation between PPGL administration and improvement of clinical and laboratory endpoints up to 90 days. A larger randomized, blinded, prospective study is required to confirm these effects in ulcerative colitis.
Accidentally Case of Chilaiditi’s Syndrome in COVID-19 Geriatric Patient Yoga, Vesri; Abdullah, Murdani; Arnelis, Arnelis
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022249-252

Abstract

Chilaiditi’s syndrome is a rare disease with an incidence of 0.025-0.28% cases, where it shows colon interposition between diaphragm and right lobe of liver. Usually related to congenital malformation include the absence, weakness, or elongation of suspensory ligaments of transversal colon or falciform ligaments. The 83-year-old woman was admitted with 1-week history of fatigue, lacked the will to eat and drink. Nausea and vomiting were sometimes accompanied with abdominal pain. Patient often had difficulty in defecating even though she had been eating fruits, she often needed laxatives. Patient had a history of osteoarthritis and hypertension.Physical examination appeared moderately-ill, with gasglow coma scale (GCS) 14 and blood pressure 150/90 mmHg. From abdomen epigastric tenderness (+). From thoracic X-ray found visible interposition of colon at right-upper quadrant of abdomen. Geriatric index fall risk assessment = 11 and mini mental state examination (MMSE) = 22. This patient was a geriatric patient with multiple diagnosis and frailty. Patient had a history of osteoarthritis contributes to patient’s instability. Chronic constipation was also quite disturbing cause an interposition of colon. Patient had coincidence with COVID-19 with comorbidity and geriatric syndrome. Thorough care, close monitoring, and optimal management should be applied.
Association between Food Specific IgG Antibodies with Clinical Activity of Disease in Patients with Inflammatory Bowel Disease Parhusip, Santi Sumihar Rumondang; Rengganis, Iris; Simadibrata, Marcellus; Abdullah, Murdani; Shatri, Hamzah; Yunihastuti, Evy; Wibowo, Heri
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202341-48

Abstract

Background: Inflammatory bowel disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile.Method: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo index and Crohn's disease activity index.Results: The highest proportion of dietary IgG in Crohn's disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347; p = 0.041) and chickpeas IgG (r = -0.473; p = 0.017) with clinical disease activity; while in Crohn's disease, a weak positive correlation with disease activity was seen in barley (r = 0.261; p = 0.042).Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Crohn's disease clinical activity. 
The Role of Circulating Tumour Cells and Carcinoembryonic Antigen as Diagnostic Tool for Metastatic Colorectal Cancer in Indonesia Angraeni, Sri; Abdullah, Murdani; Hasan, Irsan; Rinaldi, Ikhwan; Fauzi, Achmad; Martin, Cleopas; Shatri, Hamzah; Irawan, Cosphiadi; Nursyirwan, Saskia Aziza; Ibrahim, Febiansyah; Siregar, Lianda; Loho, Imelda Maria; Waspodo, Agus Sudiro; Margaluta, Ariansah; Firsyada, Fajar; Darnindro, Nikko; Lutfiah, Evah; Tanadi, Caroline; Ilyas, Mohammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025245-254

Abstract

Background: Patients with metastatic colorectal cancer (CRC) have a poor prognosis, with a 5-year survival rate of only 14%. Early detection and early intervention may improve outcome. Both circulating tumour cells (CTC) and serum carcinoembryonic antigen (CEA) have been suggested as diagnostic biomarkers for metastatic CRC. This study explored the performance of CTC and CEA as a tools for the detection of metastatic colorectal cancer in Indonesia.Methods: This study was conducted from December 2024 to April 2025 on metastatic colorectal cancer patients from three hospitals in Jakarta. CTC was analysed using the gradient density method and flow cytometry. CEA was analysed using chemiluminescent microparticle immunoassay.Results: This study recruited 160 patients with colorectal cancer patients of whom, 45% were known to have metastatic colorectal cancer. The median age was 57 (47—66) years and analysis was done at one time point only. The area under the curve (AUC) for CTC, CEA, and the combination of both CTC and CEA in diagnosing metastatic colorectal cancer was 0.579, 0.811, and 0.703, respectively. CTC showed 56.94% sensitivity and 50.00% specificity in detecting metastatic colorectal cancer. Meanwhile, CEA showed higher sensitivity (72.22%) and specificity (72.72%). Combination of both CTC and CEA increased sensitivity to 91.67%, but with a lower specificity of 37.50%. The optimal cut-off for CTC and CEA were 34.5 cells/3 ml and 18.31 ng/ml, respectively.Conclusion: CEA showed a better performance than CTC in diagnosing metastatic colorectal cancer. Combination of CTC and CEA showed promising potential as a valuable surveillance tool for detecting metastasis in colorectal cancers, but not as a primary diagnostic tool. 
Co-Authors A.A. Ketut Agung Cahyawan W Aan Santi Abdul A. Rani Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi Achmad, Ibrahim Adang Bachtiar Adeputri Tanesha Idhayu Adiningsih Srilestari Aditya Rachman, Aditya Adityo Susilo, Adityo Adli, Mizanul Afifah Is Afistianto, Muhammad Fikri Agus Sudiro Waspodo Ahmad Soefyani Ahmar Abyadh Aida Lydia, Aida Akmal Taher Alexander, Reinaldo Ali Djumhana Ali Imron Yusuf Amanda P Utari, Amanda P Amanda Pitarini Utari Anastasia Yoveline Andri Sanityoso Angraeni, Sri Ari F Syam Ari F. Syam Ari Fahrial Syam Ari Wijayanti Ariadi Humardani Arleni Bustami Arman A Abdullah Arnelis Arnelis Artati Murwaningrum, Artati Ascobat, Purwantyastuti Asysyifa, Nisrina Aziz Rani Azzaki Abubakar, Azzaki Birry Karim Bisuk, Batara Bona Adhista Budhi Setianto Budi Tan Oto Budiman Bela Budiman Budiman Budimutiar, Felix C Martin Rumende Ceva W. Pitoyo Chairul R Nasution Chatarina Umbul Wahyuni Chudahman Manan Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Chyntia Olivia MJ Cleopas Martin Rumende Cosphiadi Irawan Czeresna Heriawan Soejono Dadang Makmun Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Dante Saksono Harbuwono Dasril Nizam Deddy Gunawanjati Dewantoro, Okto Dharmeizar Dharmeizar Dharmika Djojoningrat Diah Rini Handjari Diani Kartini Diany N Taher Diding Heri Prasetyo Djumhana A Dolly Dolven Kansera Dono Antono Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edy Rizal Wahyudi Ekowati Rahajeng Ellen Susanti Elli Arsita Em Yunir, Em Ening Krisnuhoni Eric Daniel Tenda Evy Yunihastuti Fauzi Ahmad Muda Fiastuti Witjaksono Firsyada, Fajar Fransiska Hardi Fumiaki Kitahara Gaol, Donnie Lumban Giri Aji, Giri Guntur Darmawan Haloho, Raja Mangatur Harini Oktadiana, Harini Harmani Kalim Harry Isbagio Haryana, Sofia M Haryanto Surya Hasan Maulahela, Hasan Hasan Mihardja Hayatun Nufus Hazim, Ahmad Herdiman T Pohan Herdiman T. Pohan Heri Wibowo Hiroyuki Otsuka Hotmen Sijabat I. D.N. Wibawa Ibrahim Basir Ibrahim Basyir Ibrahim, Febiansyah Idrus Alwi Ifransyah Fuadi, Ifransyah Ika Prasetya Wijaya Ikhwan Rinaldi Ilum Anam, Ilum Ilyas, Mohammad Imelda Maria Loho, Imelda Maria Indra Marki Inge Sutanto Ingrid S. Surono Irfan Maulani Iris Rengganis Irsan Hasan Irwin Tedja Iskandar, Rizka Puteri Ivo Novita Sah Bandar Jacobus Albertus Jamhari Jamhari Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Jimmy Posangi Jonlean, Reganedgary Joseph JY Sung Judo Prihartono Julwan Pribadi Jumhana Atmakusuma Jusman, Sri W Kahar Kusumawidjaja, Kahar Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Khie Chen Khomimah Khomimah, Khomimah Kuntjoro Harimurti Laras Budiyani, Laras Lianda Siregar Liem, Isabella Kurna Liem, Isabella Kurnia Lies Luthariana Lili Indrawati Lusiani Rusdi, Lusiani Lutfiah, Evah M Purnomo Isnaeni M Usman SM Maharani, Shabrina Mansur, M. Tasrif Marcellus Simadibrata Marcellus Simadibrata K Margaluta, Ariansah Marthino Robinson Martin, Cleopas Maruhum B.H. Marbun Masayuki A Fujino Masayuki A. Fujino Masdalina Pane Maulana Suryamin, Maulana Meriza, Tanggo Minarma Siagian Moch Ikhsan Mokoagow Mochamad Iqbal Hassarief Putra, Mochamad Iqbal Hassarief Mohammad Adi Firmansyah Mondrowinduro, Prionggo Muhadi Muhadi, Muhadi Muhammad Artisto Adi Yussac MUHAMMAD SYAFIQ Muhammad Yamin Muhammad Yamin Lubis, Muhammad Yamin Mulia Mulia Mustikarani, Dewi Mutiara, Rizka Muzellina, Virly Nanda Nababan, Saut Horas H. Nana Supriana Nanda N. Muhammad, Nanda N. Nata Pratama Nikko Darnindro Novie Rahmawati Zirta Nully Juariah M Nur Rasyid Nur Riviati, Nur Nury Dyah, Nury Oktarina, Caroline Pambudi, Joko Rilo Pamela Abineno Pamela Abineno Damaledo Pangarapen Tarigan Pangestu Adi Parhusip, Santi Sumihar Rumondang Pattiiha, Arief Paulus Kusnanto Paulus Simadibrata Pawitan , Jeanne Adiwinata Pradipta, Saraswati Primariadewi Rustamadji Purwantyastuti Purwantyastuti Purwita W Laksmi, Purwita W Purwoko, Reza Yuridian Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi, Rahmad Ralph Girson Rambe, Dirga S. Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Riahdo Saragih Rianto Setiabudy Rino A Gani Rino Alvani Gani Rio Zakaria Risa Ismadewi, Risa Rizki Yaruntradhani Rozaliyan, Anna Rudi Putranto Rumagesan, Djahalia Rumende, Cleopas M. Ryan Ranitya Sabarudin, Adang Saleha Sungkar Salius Silih Sally Aman Nasution, Sally Aman Sari, Nina Kemala Sarwono Waspadji Saskia Aziza Nursyirwan, Saskia Aziza Sedijono Sedijono Seri Mei Maya Ulina Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Sirowanto Inneke Siti Setiati Soleha, Winna Sonar S. Panigoro Sri Wahdini Starry H. Rampengan Steven Sumantri Sudirman Katu, Sudirman Sugita, Peter Suhardjono Suhardjono Suharko Soebardi Suhendro Suhendro Suhendro Suwarto, Suhendro Sukamto Koesnoe Sumariyono Sumariyono Surono, Ingrid S Suryantini Suryantini Susanto, Liana W SUWIJIYO PRAMONO Suzana Ndraha Suzanna Immanuel Syari, Lucky Novita Tadashi Sato Tanadi, Caroline Tandan, Manu Tandarto, Kevin Telly Kamelia Tito Ardi Tjahjadi Robert Tedjasaputra Toman L Toruan Tonny Loho TR Fitriyani, TR Tri Juli Edi T Ummi Ulfah Madina, Ummi Ulfah Ummu Habibah, Ummu Velma Herwanto Vera Yuwono Wijaya, Anthony Eka Wirasmi Marwoto Wismandari Wisnu Wulandari, Yohannessa Wulyo Rajabto Yoga, Vesri Yohana Sitompul, Yohana Yonathan, I Wayan Murna Yuichiro Kojima Yundari, Yundari Yustar Mulyadi Zubairi Djoerban