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All Journal JDM (Jurnal Dinamika Manajemen) E-Journal Widya Kesehatan dan Lingkungan Journal of English and Arabic Language Teaching Indonesian Journal of Integrated English Language Teaching Jurnal Ilmiah Pendidikan Dasar Jurnal Kesehatan Andalas Indonesian Journal of Pharmaceutical Science and Technology Majalah Kedokteran Gigi Indonesia JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Majalah Obat Tradisional J-PAI: Jurnal Pendidikan Agama Islam MNJ (Malang Neurology Journal) Management Analysis Journal JRPM (Jurnal Review Pembelajaran Matematika) ELSE (Elementary School Education Journal) : Jurnal Pendidikan dan Pembelajaran Sekolah Dasar JURNAL PENDIDIKAN TAMBUSAI Jurnal Informatika Global AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Media Manajemen Pendidikan Cendekia : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Profesi Pendidikan Jurnal Ilmiah Manajemen Kesatuan Community Development Journal: Jurnal Pengabdian Masyarakat Natural Science: Jurnal Penelitian Bidang IPA dan Pendidikan IPA Awwaliyah SANGAJI: Jurnal Pemikiran Syariah dan Hukum Media Jurnal Informatika Jurnal Wawasan Pendidikan Experiment: Journal of Science Education Ahmar Metastasis Health Journal (AMHJ) Journal of Tourism Sustainability Jurnal Pengabdian Masyarakat Aufa (JPMA) Journal of Integrated Elementary Education Jurnal Ilmu Pendidikan (SOKO GURU) JUSTER: Jurnal Sains dan Terapan Journal of Mandalika Review JURNAL PENELITIAN TERAPAN KESEHATAN ANWARUL: Jurnal Pendidikan dan Dakwah International Journal of Educational Research Excellence (IJERE) Journal of Artificial Intelligence and Digital Business Mahir : Jurnal Ilmu Pendidikan dan Pembelajaran Ekasakti Matua Jurnal Manajemen Cendikia: Jurnal Pendidikan dan Pengajaran Socius: Social Sciences Research Journal Community Service Journal Of Economic Education Masyarakat Pariwisata: Journal of Community Services in Tourism Jurnal Pharmacia Mandala Waluya Journal of Environment and Sustainability Education Al-Bidayah : Jurnal Pendidikan Dasar Islam Journal of Multidisciplinary Inquiry in Science, Technology and Educational Research CONSTITUO: Jurnal Riset Hukum Kenegaraan dan Politik Prosiding Dedikasi: Pengabdian Mahasiswa Kepada Masyarakat Indonesian Journal of Emerging Trends in Community Empowerment Journal of Research on Community Engagement Jurnal Info Kesehatan SEMINAR TEKNOLOGI MAJALENGKA (STIMA)
Rizki Amelia
Burapha University, Chonburi, Thailand and Graduate School Trisakti Institute of Tourism, Jakarta, Indonesia
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Journal : MNJ (Malang Neurology Journal)

 1 
DOES THE COMBINATION OF ROSMARINUS OFFICINALIS AND CENTELLA ASIATICA NANOEMULSIONS AFFECT BDNF EXPRESSION IN THE GESTATIONAL DIABETES MELLITUS MODEL IN ZEBRAFISH LARVAE Khotimah, Husnul; Lamadi, Sutini; Amelia, Rizki; Arista, Devi Maya; Prastiwi, Fajar Dwi; Raras, Tri Yudani Mardining
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.08

Abstract

Background: Pancreatic β-cells compensate for the increased insulin demand due to increasing glucose levels during pregnancy or in gestational diabetes mellitus (GDM). The enzyme that regulates the rate of gluconeogenesis production is PEPCK. Circulatory and metabolic disturbances in the brain caused by hyperglycemia could affect brain-derived neurotrophic factor (BDNF) expression as an agent for neurodevelopment. Objective:  The purpose of this work is to ascertain the impact of combining nanoemulsions of Rosmarinus officinalis and Centella asiatica on the expression of BDNF and PEPCK. Methods: This study was a true experimental laboratory using zebrafish larvae. The larvae were exposed to 3% glucose and a combination of nanoemulsion extracts. The study sample of zebrafish larvae at 72 hpf (hour post fertilization) was divided into control, glucose, treatment 1, 2, and 3, with the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions at 2.5 μg/ml, 5 μg/ml, and 10 μg/ml, respectively. PEPCK and BDNF expression were measured by the real-time PCR method. Results: The expression of PEPCK increased significantly in the glucose group (3.05 ± 0.27). The combination of Rosmarinus officinalis and Centella asiatica nanoemulsions significantly decreased PEPCK (p-value 0,001 < 0.05). The BDNF level did not significantly differ (p-value 0.253 >0.05) among groups, but the highest level (1.06 ± 0.60) was gained in the T2 group, which received an embryonic medium (EM), 3% glucose, and the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions at 5μg/ml. Conclusion: The combination of Rosmarinus officinalis and Centella asiatica nanoemulsions significantly reduces PEPCK expression but does not affect BDNF expression.
Co-Authors ABAH, Joshua Abah Abdul Rozak Adi, Antonius Agnesia, Bella Rizki Dwi Agus Mukti Wibowo Ahmad Rayhan Ahmad Riyadi Aini, Aniswatul Lathifah Alfred Irambona, Alfred Amalia Mustika, Amalia Ambar Yunita Nugraheni Andhi Wijayanto Any Guntarti Aprianto, Iwan Ardi Mardiana Ariati, Nining Arista, Devi Maya Asep Syaiful Bahri, Asep Syaiful Asy’ari , Hasyim Aszari, Erina Ayuningsih, Sri Fajar Aziz, Isfah Abidal Bakkareng, Bakkareng Bustari Bustari Chahnia, Juwi Chatarina Umbul Wahyuni Citra Ariani Edityaningrum, Citra Delfita, Netti Diana, Nailah Nur Emilia Susanti F, Fauzan Fadrian, Fadrian Farhana, Nur Fathir, Nabila Fikriyah, Fikriyah Haerani, Rosita Putri Rahmi Hasanuddin, Silviana Hasyim Asyari Hendratono, Tonny Hendrayadi, Hendrayadi Heni Pujiastuti Herlina Nasir, Nur Hidayati, Sholihatil ibrahim, nelvia Imam Rofiki Irma Setyawati Islamy, Muhammad Irfan Ismail Mulia Hasibuan Ismail, Ilfan Hajar Jainuddin Jason, Jason Julianti, Eniza Juni Handajani Laela Hayu Nurani laila Lamadi, Sutini Latif, A. Lestari, Henny Setyo Lestari, Nurul Indah Luthfiyah, Hilmi Mahmud, Nur U. Marasabessy, Fachria Yamin Martin Kustati Masriadi, Masriadi Miftahul Jannah Moch Saiful Bachri Muhammad Ma'ruf Mujiwati, Sri Nada, Shofwatun Nadisah, Sylvania Noor, Rofida Nova Begawati Novia Sari, Wira Noviarni Noviarni, Noviarni Nur Fitriana Nurdin, Erdawati Nurhaliza, Yusmalia Nurhasnah Nurhasnah Nurpiatun, Nurpiatun Nursifa, Niknik Nursyahid Siregar Nurwahita, Nurwahita Prastiwi, Fajar Dwi Pratama, Bayu Aji Prima Aswirna Priyahita, Fatnuraini Putri Oktariani Putri, Viona Frediana Putri, Windy Hesti Rahayu, Windi Rahmad Fauzi Rahmawati, Ati Ratna Rintaningrum, Ratna Reza Fahmi Rini Maya Puspita Rini Sulistyawati Rizki, Inesya Febrianing Rochmat, Saeful Rohani Rohani Romadhoni, Khoirul Laila Rozhy, Mochamad Fahruol Saepudin, Muhammad Fahmi Santi Palupi, Santi Saputra, Ramadhan Sari, Riana Trinovita Sayekti, Yasinta Sapta Shela Agustini Sigit Priatmoko Siregar, Chikadetry Syalomita Sondara, Muhammad Raka Sri Maryati Sri Rahmi Srikandi, Dewi Ayu Subakti, Nastyazka Subandi Subandi Sugiarto Suhertina, Suhertina Sukatin Sulistyorini, Dwi Agustin Supriatin Supriatin, Supriatin Susi Indriyani Syarafina, Hafizhah Dini Tortop, Hasan Said Tri Yudani MR Waty, Rizka Wiku Aji Sugiri Wulandari, Nadya Yarni Yarni Yenisbar Yenisbar Yuliana Yuliana Yulianti, Vina Yunelda, Diffa Zega, Aldika Putra