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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Hemera Zoa Media Veteriner Media Gizi dan Keluarga Jurnal Sain Veteriner VALENSI Jurnal Veteriner Microbiology Indonesia Dentika Dental Journal Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat Medical Journal of Indonesia Current Biochemistry Majalah Obat Tradisional Padjadjaran Journal of Dentistry Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Justek : Jurnal Sains Dan Teknologi AGROSAINSTEK: Jurnal Ilmu dan Teknologi Pertanian ARSHI Veterinary Letters Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan JURNAL PANGAN Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Jurnal Pembelajaran dan Biologi Nukleus Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Hewan Molekul: Jurnal Ilmiah Kimia Jurnal Veteriner dan Biomedis Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu Jurnal of Syiah Kuala Dentistry Society
Bambang Pontjo Priosoeryanto
Divisi Patologi, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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The efficacy taro leaf extract on wound healing contaminated with Staphylococcus aureus Sjamsudin, Endang; Muharty, Annisya; Riawan, Lucky; Priosoeryanto, Bambang Pontjo
Padjadjaran Journal of Dentistry Vol 33, No 3 (2021): November
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no3.21325

Abstract

Introduction: Taro (Colocasia esculenta (L.) Schott) leaves have been reported to possess wound healing, anti-inflammatory, antibacterial and antioxidant activities. One of the factors that affect wound healing is infection in the wound, wherein the wound is infected by  bacteria, especially Staphylococcus aureus that is mostly found in the oral cavity, the wound healing process will be hampered and become longer healed. The objective of this research was to analyse the efficacy of Colocasia esculenta (L.) Schott extract on the healing process of wounds contaminated with Staphylococcus aureus. Methods: This experimental study on Sprague dawley rats was carried out at the Veterinary Medical Teaching Hospital of the Faculty of Veterinary Medicine of IPB University. Circular excision wounds were applied on 24 Sprague dawley rats with a diameter of 2 cm on the dorsum, and Staphylococcus aureus specimens were contaminated with a dose of 3.4x108 LAC. Rats were randomly divided into 2 groups. Group I (control group) was given a placebo, and group II (treatment group) was given a 25% concentration of Colocasia esculenta (L.) Schott extract on the wound once a day. Four rats from each group were euthanized on the 3rd, 7th, and 14th days. The number of neutrophils, macrophages, re-epithelialization and FGF-2 expression were measured by microscopic observation with visual field control, and comparative data were analysed using the Kruskal-Wallis statistical test. Results: The number of neutrophils on the treatment group on the 7th day was less than the control group (p=0.040). The number of macrophages on the 3rd day was found more in the treatment group than the control group (p=0.032), and on the 14th day, the treatment group was less than the control group (p=0.040). Epithelial cells on the 14th day of the treatment group was found more than the control group (p=.0.017). The level of FGF-2 expression of the treatment group on the 7th day was higher than the control group (p=0.044). Conclusion: Application of Colocasia esculenta (L.) Schott leaf extract is efficacious for healing wounds contaminated with Staphylococcus aureus in the proliferative phase.
In vivo histomorphological evaluation of geopolymer-carbonated apatite nanocomposites implanted on rabbit tibia at early bone healing Sutanto, Dahlia; Satari, Mieke Hemiawati; Hernowo, Bethy Suryawathy; Priosoeryanto, Bambang Pontjo; Septawendar, Rifki; Asri, Lia Amelia Tresna Wulan; Purwasasmita, Bambang Sunendar
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.28899

Abstract

Introduction: Dental implants have become a more desirable treatment for replacing missing teeth. The mechanical properties and biocompatibility of titanium and zirconia are excellent, but they are less bioactive. The chemical composition of the carbonate apatite is similar to enamel and dentin. Geopolymers are inorganic polymers, and they are similar to ceramics. They have excellent mechanical properties, bioactivity, biocompatibility. The purpose of this study was to assess histomorphological evaluation of geopolymer-carbonated apatite nanocomposites implanted on rabbit tibia at early bone healing in vivo. Methods: Geopolymer-CHA nanocomposites with a diameter of 3 mm and length of 6 mm was placed in the tibia of eight male New Zealand White rabbit whose body weight is 3 to 3.5 kg and six-month ages. Experimental subjects were randomly assigned to 2 groups for assessing the bone healing capability around samples to 14 and 28 days histomorphologically. Wilcoxon test was performed, and p<0.05 was considered significant, using Minitab software version 13. Results: Granulation tissue, woven, and lamellar bone was analysed. A reactive bone formation was revealed in the 14th day. Osteoblasts, osteoids, and osteocytes showed more mature and woven bone became denser on the 28th day. Conclusion: Geopolymer-CHA nanocomposites could be considered a candidate for dental implant material from this histomorphological evaluation.
Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic Razi, Fachrul; Hardianto, Andri; Riawan, Lucky; Priosoeryanto, Bambang Pontjo
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.21276

Abstract

Introduction: Fibroblast Growth Factor-2 (FGF-2) have a role in stimulating the proliferation and migration of various types of cells in the wound healing process. Hyperglycemic conditions can disrupt the wound healing process. Lagerstroemia speciosa are known to have antyphyerglycemic and antioxidant effects. Aloe vera is a plant that has been used for long time in topical treatment of wounds.This study was aimed to analyse the FGF-2 after application of Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extracts gel in the wound healing process of hyperglycemia. Methods: A pure experimental study was conducted with simple random sampling. The sample was 27 experimental animals (CI 95%; power test 80%) of Sprague Dawley rat induced to have a hyperglycemic state using alloxan and had their palate injured. The immunohistochemical examination was performed to assess FGF-2 expression level. Samples were divided into three groups with a simple random sampling technique: nine of the rats received the Lagerstroemia speciosa extract gel application; nine rats received the aloe vera extract gel application on the injured palate; another nine rats in the control group. Examination of the FGF-2 expression level was performed on the third, seventh, and fourteenth observation days. Results: Overall, the control group had a significant difference with the Lagerstroemia speciosa and aloe vera extract gel group (p-value<0.05), however, the Lagerstroemia speciosa group did not have any significant difference with the aloe vera group (0.123>0.05). Conclusion: There was no difference in the amount of FGF-2 expressions on the wound healing process of the injured palatal tissue of Sprague-Dawley rats with hyperglycemic after application of the Lagerstroemia speciosa and aloe vera extract gel.
Selection of Four Lamiaceae Species (Ocimum americanum L., Ocimum basilicum L., Leucas lavandulifolia Sm., and Perilla frutescens (L.) Britton) as Antioxidant Sources and Metabolite Profile Wati, Vivi Septya; Batubara, Irmanida; Arifin, Budi; Priosoeryanto, Bambang Pontjo; Kuroki, Yutaka
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13140

Abstract

ABSTRACT. The Lamiaceae family which are widely used in traditional medicine in Indonesia. Plants from this family are known to have antioxidant bioactivity. Therefore, in this study, an antioxidant test was carried out first as an initial screening. This study evaluated the antioxidant capacity of four Lamiaceae species: Ocimum americanum L., Ocimum basilicum L., Leucas lavandulifolia Sm., and Perilla frutescens (L.) Britton. The four Lamiaceae species extracts were evaluated for their antioxidant capacity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), cupric-reducing antioxidant capacity (CUPRAC), and ferric-reducing antioxidant power (FRAP). The highest activity extract was fractionated with n-hexane, ethyl acetate, and ethanol-water, and the results were tested for antioxidant capacity. The most active extract and most active fraction were analyzed for metabolites using liquid chromatography-mass spectrometry (LC-MS/MS). The results show that the ethanol 50% leaves extracts of O. americanum L. have the highest antioxidant capacity of about 0.439 (DPPH); 1.517 (CUPRAC); and 1.021 (FRAP) mmol ascorbic acid equivalent (AAE)/g extract. The highest antioxidant capacity from the partition results was possessed by the ethyl acetate fraction with a value of 1.109 (DPPH); 1.540 (CUPRAC); and 1.551 (FRAP) mmol AAE/g fraction. Metabolite analysis using LC-MS/MS succeeded in identifying 18 metabolites consisting of flavonoids, terpenoids, amino acids, phenolic acids, fatty acids, and other carboxylic acids. Keywords: Antioxidant, Leucas lavandulifolia, Ocimum americanum, Ocimum basilicum, Perilla frutescens
Antitumor activity of Typhonium flagelliforme Ethanol Extract Nanoemulsion in DMBA-Induced Sprague Dawley Rats Rini, Dian Cipta; Priosoeryanto, Bambang Pontjo; Riki Siswandi; Sutardi, Lina Noviyanti
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.167-174

Abstract

Tumors are a leading cause of disease-related deaths in humans and companion animals, including dogs and cats. Typhonium flagelliforme, recognized in Indonesian traditional medicine, exhibits notable antitumor properties, such as inhibiting tumor cell proliferation and enhancing immune response. This study aimed to formulate T. flagelliforme into a nanoemulsion to improve its antitumor eflects and assess its efficacy in Sprague Dawley rats induced with the carcinogen 7,12-dimethylbenz (a) anthracene (DMBA). The nanoemulsion was formulated using the inversion phase method, and its particle size and stability were analyzed using SEM. Phytochemical screening identified active compounds, and toxicity was assessed using the brine shrimp lethality test. In vivo experiments involved five rat groups: untreated (NTC), nanoemulsion solvent (Solv), and three treatment groups receiving 25 μg/kg (TF25), 50 μg/kg (TF50), and 100 μg/kg (TF100) doses of the nanoemulsion, administered via intralesional injection. Results showed significant tumor size reduction in treatment groups compared to controls (p<0.05), with TF25 exhibiting the most eflective antiproliferative activity. Increased body weight across groups indicated low toxicity. The study concludes that T. flagelliforme nanoemulsion eflectively reduces tumor size and angiogenesis, demonstrating its potential as an antitumor agent. 
In Silico Studies: Stigmastan-3,6-dione in the Ethyl Acetate Fraction of Momordica charantia L Fruit has immunostimulant and anti-inflammatory activity Rachmi Ridho; Bambang Pontjo Priosoeryanto; Esti Mumpuni; Andri Prasetiyo; Syamsudin Abdillah
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6865

Abstract

Momordica charantia L fruit provides an immunomodulatory effect by stimulating certain components of the body's immune system. Bioactive phytochemicals from M. charantia L function as anti-inflammatory agents by reducing levels of pro-inflammatory cytokine secretion including IL-1, IL-6, IL-8, TNF-α, NF-kB. This research looks at the insilico mechanism of action of the active ingredient of the EtOAc fraction of M. charantia L fruit as an immunostimulant and anti-inflammatory. The materials and methods used were an Intel Core i7 10 Th Gen laptop, Chem Office Professional 17.1, Chem 2D, Chem 3D software, PDB code (6W9K) and ligand (TUA), Stigmastan-3,6 dione (C29H48O2) from the EtOAc fraction of fruit M. charantia L was docked using MVD software, RMSD and RMSF values ​​were viewed using Yasara Software, pkCSM online tool to predict compound toxicity, toxicity prediction (LD50) was used by Protox online tool. The results of molecular docking of standard compounds, namely Methylprednisolone and Prednisolone and Stigmastan-3,6-dione, have Rerank Score values of -120.62, -121.47, -79.50, respectively. The lower the Rerank score value, the lower the binding energy between the protein and the ligand, causing the protein and ligand bonds to be more stable and it is predicted that the activity of the compound will be greater. The movement of RMSD values ​​between 0.6-1.9 Å for the 3 (three) compounds, is still within stable limits and does not undergo conformation. The RMSF value of the 3 (three) compounds has the same amino acid residue pattern. The insilico toxicity prediction for the 3 (three) compounds is still within safe limits. The EtOAc fraction of M. charantia L fruit with the active compound Stigmastan-3,6-Dione in its mechanism of action in silico shows activity as an anti-inflammatory and immunostimulant that works on the NF-kB pathway.
Co-Authors . CHURIYAH . Darmawi Adhi Rahmat Hariyadi Aditya Primawidyawan Agus Susanto Ahmad Aulia Ahmad Aulia Andra Hendriarto Andri Hardianto Andri Lubis Andri Prasetiyo Anggraeny Putri Sekar Palupi Anggraini, Lutvi Anissa Canintika Anita Esfandiari Annisa Fitriyana Ardi Sandriya Ari Fahrial Syam Ari Fahrial Syam Aria Kekalih Asri, Lia Amelia Tresna Wulan Aulia Andi Mustika Azhari Azhari Bambang Sunendar Purwasasmita, Bambang Sunendar Bayu Febram Bayu Febram Bayu Febram Prasetyo Benny Syariefsjah Latief Bethy Suryawathy Hernowo Betty S.L. J Betty Sri Laksmi Jenie Budi Arifin Chudahman Manan Chudahman Manan Dahlia Sutanto Daldiyono Daldiyono Daldiyono Daldiyono Dara Juliana Deddy Muchtadi Dede Robiatul Adawiyah Deni Noviana Denny Widaya Lukman Dewi Fatma Suniarti Dewi Ratih Agungpriyono Djarot Sasongko Hami Seno Dwi Kesuma Sari Dyah Sulistyani Rahayu Edy Djauhari Purwakusumah Eka Nurul Qomaliyah Endang Prangdimurt Endang Prangdimurti Endang Sjamsudin Erniati, Erniati Esti Mumpuni Eva Harlina Evy Damayanthi Fachriyan Hasymi Pasaribu Fachrul Razi Fadila Raisyadikara Farra Sasmita Franky Oscar Franky Oscar, Franky Fransiska R. Zakaria Fransiska Rungkat Zakaria Fransiska Rungkat Zakaria Gatot T. Mulyadi Gatot Trimulyadi Rekso Gunanati Soedjono Gunanti Gunanti . GUSTAF ADOLF WATTIMENA Hamny Sofyan Hartanti Hartanti Hartanti Hartanti, Hartanti Hasim Hasim Hatibie, Mendy Juniaty Hatta, Isnur Herwin Pisestyani Hidayat Syarief Husnawati, . I Made Kardena I Nyoman Suarsana I Nyoman Suartha I Wayan Gorda I wayan Teguh Wibawan IETJE WIENTARSIH Irmanida Batubara Iwan Harjono Utama Jimmy Pangihutan Juliana, Dara Kazuyuki Uchida Koeswinarning Sigit Komariah Komariah Kreshanti, Prasetyanugraheni Kuroki, Yutaka KUSMARDI KUSMARDI Lanniari, Nafrina Latifah Darusman Lilis Nuraida Lina Noviyanti Sutardi Lisni Noraida Lucky Riawan Lusi Epsilawati Madyastuti, Rini Mahdi Abrar Makmuri Yusuf Makmuri Yusuf MARIA BINTANG Maya Shofa Mieke Hemiawati Satari Mieke Hemiawati Satari Mieke Hermiawati Satari Miksusanti Miksusanti Mirnawati Soedarwanto Mirnawati Soedarwanto Monica Septiani Muharty, Annisya Najmah Najmah Nancy Dewi Yuliana Naoaki Misawa NASRIANTI SYAM, NASRIANTI Nina Kusumawati Nur Fathonah Sadek Nurhidayat - Nurhidayat, Nurhidayat Okabayashi, Tamaki Prangdimurt, Endang Priskila Priskila Putu Angga Wiradana Putu Eka Sudaryatma Rachmi Ridho Rahayu WoroWiranti Rahmadansah Rahmadansah Rahminiwati, Min Rahyussalim Ratna Puspita Rayendra, Raendi Retno Wulansari Rifki Septawendar Riki Siswandi Rimbawan , Rini, Dian Cipta Ripta Mustafa Nugraha Risa Tiuria Riski Rostantinata Riski Rostantinata Rizal Syarief Rizal Syarief Rizki Fitria Rizki Rostantinata Ros Sumarny Rostantinata, Riski Ryoji Yamaguchi Sabri Mustafa Sadek, Nur Fathonah Safrida Safrida Sajida Sajida Samuel Leonardo Silitonga SANTOSO CORNAIN Sarifah, Norlaila Sebayang, Shalina Septina Sabilla Lubis Shafiyyah Az Zahra SILMI MARIYA Slamet Budijanto Sri Anna Marliyati Sri Estuningsih Sri Kayati Widyastuti Subangkit, Mawar Sugeng Supriadi, Sugeng Sukasah, Chaula Luthfia Sunardhi Mangundjaja Sunardhi Mangundjaja, Sunardhi Surachmi Setiyaningsih Surachmi Setyaninigsih Surya Pangidoan Nasution Suryani Suryani Suryani Suryani Susi Susanah Susumu Tateyama Syamsudin Abdillah Takeshi Katayama Tangkonda, Elisabet Tena Djuartina, Tena Toshisada Suzuki Tri Isyana Tungga Dewi Tri Isyani Tungga Dewi Tungga Dewi, Tri Isyani Tutik Wresdiyati Ummu Balqis Vetnizah Juniantito Wahyuni, Sri Waras Nurcholis Wasmen Manalu Wati, Vivi Septya Weko Adhiarto Weko Adhiarto, Weko Yonathan Arderian Mantik Ziad Alaztha