Article Per Year (5 Year)
p-Index From 2021 - 2026
7.508
P-Index
This Author published in this journals
All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Education and Learning (EduLearn) Jurnal Bahan Alam Terbarukan Jurnal Teknik Mesin Elkawnie Jurnal Litbang Industri Al-Jabar : Jurnal Pendidikan Matematika Jurnal Hasil Penelitian Industri JMM (Jurnal Masyarakat Mandiri) Scientific Journal of Reflection : Economic, Accounting, Management and Business Bio-Lectura Astonjadro Jurnal Math Educator Nusantara: Wahana Publikasi Karya Tulis Ilmiah di Bidang Pendidikan Matematika Adimas : Jurnal Pengabdian Kepada Masyarakat Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat LINIMASA: JURNAL ILMU KOMUNIKASI ASEAN Journal of Chemical Engineering Abdi Laksana : Jurnal Pengabdian Kepada Masyarakat Jurnal Mandala Pengabdian Masyarakat Jurnal Ilmiah Wahana Pendidikan Djtechno: Jurnal Teknologi Informasi Jurnal Hurriah: Jurnal Evaluasi Pendidikan dan Penelitian Jurnal Simki Pedagogia Narra J Leibniz: Jurnal Matematika Jurnal PKM Manajemen Bisnis NUSRA: Jurnal Penelitian dan Ilmu Pendidikan Journal of Education Research Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal Litbang Industri Journal of Educational Sciences Edumatica: Jurnal Pendidikan Matematika Aceh International Journal of Science and Technology Journal of Business, Management and Social Studies Electronic Journal of Education, Social Economics and Technology Teknologi dan Industri Pertanian Indonesia Journal of Pharmaceutical and Sciences. Bulletin of Chemical Reaction Engineering & Catalysis MARAS : Jurnal Penelitian Multidisplin Liwaul Dakwah: Jurnal Kajian Dakwah dan Masyarakat Islam AMANAH : Jurnal Ilmiah Ilmu Manajemen JURNAL REKAYASA KIMIA & LINGKUNGAN Amanah Mengabdi JUKEMAS : Jurnal Pengabdian Kepada Masyarakat
- Darmadi
Department Of Chemical Engineering, Faculty Of Engineering, Universitas Syiah Kuala, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 80 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Narra J

 1 
CTLA-4 +6230G>A polymorphism and its impact on CTLA-4 level and risk of hepatocellular carcinoma: A case-control study in Batak patients with chronic hepatitis B Darmadi, Darmadi; Rey, Imelda; Lubis, Masrul; Lindarto, Dharma; Muzasti, Riri A.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1959

Abstract

Genetic polymorphisms in cytotoxic T-lymphocyte-associated protein 4 gene (CTLA-4) vary by ethnic background, necessitating population-specific studies. The aim of this study was to assess the association between the CTLA-4 +6230G>A polymorphism, serum CTLA-4 level, and hepatocellular carcinoma (HCC) in Batak patients with chronic hepatitis B, a group with high hepatitis B virus (HBV) endemicity. A case-control study was conducted among cases (Batak patients with chronic hepatitis B and HCC) and controls (chronic hepatitis B without HCC). Genotyping of the CTLA-4 +6230G>A polymorphism was performed using the TaqMan SNP Genotyping Assay. Serum CTLA-4 level was quantified using enzyme-linked immunosorbent assay (ELISA). Patient’s demographic, clinical and laboratory data were recorded and assessed including age, sex, body mass index (BMI), smoking history, cirrhosis status, HBV DNA level, liver function markers (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)), hepatitis B e-antigen (HBeAg) status, smoking history, and alcohol consumption. This study found that G allele was significantly associated with an increased risk of HCC (OR: 2.69; 95%CI: 1.21–6.00; p=0.013). Individuals with GG/AG genotypes had a 2.89-fold higher risk of developing HCC compared to those with the AA genotype (p=0.032). Serum CTLA-4 level was significantly elevated in G allele carriers (GG: 159.9±57.1 pg/mL vs AA: 83.7±44.7 pg/mL; p<0.001). Multivariate analysis identified cirrhosis as the strongest predictor of HCC (OR: 7.60; p<0.001), followed by elevated ALT (OR: 3.42; p=0.018) and high HBV DNA levels (OR: 2.31; p=0.024). In conclusion, the CTLA-4 +6230G>A GG/AG genotype and elevated serum CTLA-4 level were significantly associated with an increased risk of HCC in Batak individuals with chronic HBV infection. Further research is needed to explore additional CTLA-4 polymorphisms and immune regulatory mechanisms in HBV-related HCC to improve risk stratification and therapeutic strategies.
Co-Authors - Jalaluddin Abrar Muslim Adi Wibowo Adisalamun Adisalamun Adisalamun Adisalamun Adisalamun Adisalamun Adisalamun Adisalamun Adisalamun Adisalamun Agus Suhartono Agustin, Adinda Eka Ahyani, Ahyani Alhuda Anwar Thaib Anwar Thaib Ariska, Maiata Devi Arnentis Arnentis, Arnentis Asiska Permata Dewi Asmara, Josi Farda Khafid Asri Gani Astuti, Indra Puji Aula Chairunnisak Aula Chairunnisak Aula Chairunnisak Aula Chairunnisak Ayu, Giovanni Ayuningtias, Ratih Azhari Azhari Balqist, Tanaya Bastian Arifin Benny Handoyo, Benny Budiono Budiono Budiyono Budiyono Choirunnisa, Nastiti Chuah T.G Cut Meurah Rosnelly Dahnilsyah, Dahnilsyah Daliani, Putri Darmawati Darmawati Debby Widya Kusuma Destiana, Ristian Diva dharma Lindarto, dharma Dhoti, Shofi Ma'rifaturriya Diana Natalia Dianti, Putri Rahma Dipuja, Diah Anugrah Diyah, Anggraeni Donalizarti, Donalizarti Dzikri Hamzah Edi Sudrajat Endang Purwaningsih Ermina Sari Eti Indarti Evi Suryawati Fadhilla, Febriana Nor Fadila, Sarah Farid Farid, Farid Farid Nanda Fatihah, Salsabilla Rima Fatimah, Dafina Febrianty, Rahmatika Feriandi, Yoga Ardian Fitri, Ailsa Fitriana, Elza Fitriana, Nimas Nur Fitriyadi, Enjah Pipit Gaho, Daratul Aini Giovanni, Giovanni Gontar Alamsyah Siregar Guruh, Muhamad Hafit, Muhammad Fairuz Asra Hafni Putri Indriani Indra Halomoan, Yan Kristian Hariyanti, Mariya Keke Hasan, Dedy Haryadi Helmi, Afri Herlina, Sara Hery Widijanto Hesti Meilina Hesti Meilina Hisbullah Hisbullah Hizir Hizir Husni Husin Husni Husin, M.T. Ibrahim, Ishak - Imelda Rey Indah, Erika Irda Sayuti IRWANTO Isa, M Ishak Ishak Jelita, Aulia Vinda Junaedi Abdillah, Junaedi Junizar, Herdya Juwita, Sellia Kamaruzzaman, Suraiya Kustini, Endang Kusuma, Debby Widya Kusuma, Laila Kusuma, Rinda Tri Laila Kusuma lakantina, Sherly Leonardo Basa Dairi M, Iqhramullah M, Irfan M. Yogi Riyantama Isjoni Mahidin Mahidin Mahidin Mahidin Mariani Natalina Mariani Natalina L, Mariani Marwan Marwan Masrul Lubis Medyan Riza Mirna Lubis Mirna Rahmah Lubis Mitri Irianti Muhammad - Muhammad Muhammad Dani Supardan Muhammad Hatta Muhammad Saleh Muhammad Syam, Azhari - Muhammad Zaki Muhammad Zaki Muhammad Zaki Muhammad, Muhammad - Mujiastutik, Dhea Putri Mukramah Yusuf Murtafi’ah, Wasilatul Muslim*, Abrar Musriyani, Iin Muzasti, Riri A. Nabil Nabil, Nabil Napitupulu, Romauli Juliana Nasrullah RCL Nur Aysah, Ervinda Ika Nur, Doni Haidar Nurfarida - Nurfarida Nurfarida, Nurfarida - Nurhazanah Nurhazanah Nurhazanah, Nurhazanah Nursal Nursal, Nursal Opie Azza Shafira Pertiwi, Hernin Diah Permata Pocut Nurul Alam Pratama, Guruh Dwi Pratikso Pratikso Priyandani, Marisa Ayu Purbayani, Dina Rizky Putri, Aldila Rahma Putri, Karisma Anisa Rahmad Setiawan Rahmat, Mudiyono Rahmawati, Alfina Pristya Ramona, Nadia Rasdiansyah Rasdiansyah Rasulyanti, Amalia Rivalino, Ricky Robiah Yunus Robiah Yunus Robiah Yunus Rofi, Latifa Hammimatu Rosyida, Dina Ruka Yulia Saiful Saiful Saiful Saiful Saniya, Saniya Sanusi Sanusi Septiyaningrum, Fina Dwi Putri Serly, Widya Ambar Setiawan Setiawan Setiawan, Johan Siahaan, R. Fanry Silowati, Mintut Siti Mardiana Siti Qomariah, Siti Siti Sarah Siti Sarah, Siti Solihin, Dede Solikah, Nurul Islami Solikin Solikin Sri Adi Widodo Sri Wulandari Suadi Zainal Suraiya Kamaruzzaman Suryani, N Lilis Susanto, Noto Swasti Maharani, Swasti Syatoto, Iman Syavela, Gea Syawaliah Mukhtar T. G. Chuah T. G. Chuah Taufik Rinaldi Taufiq Y.H. Yap Taufiq Y.H. Yap Thomas S.Y Choong Thomas S.Y. Choong Thomas S.Y. Choong Trisna Ningsih Ula, Khayranil Ulfa Rijal Safitri Vera Roni Setiawan Vera Roni Setiawan Wahyu Rinaldi Wahyu, Eka Wahyuni, Liya Tri Wahyuni, Resma Wardani, Yulia Nindi Wasilatul Murtafiah Wiwi Sartika Wulandini, Putri Y.H. Taufiq Yap Yose Rizal Yulia Yesti, Yulia Yulia, Ruka Yulianti, Lia Mustika Novita Yusmadi, Y Yustina Yustina Zamzam, Zamzam Zulfah Zulfah Zulfarina, Zulfarina