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Journal : AKSONA

Determinants of Executive Dysfunction: Serum NRF2 and Sociodemographic Profiles in Lombok Island’s Coastal Population Wulandari, Inayah; Nurhidayati, Nurhidayati; Hunaifi, Ilsa; Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Octaviana; Suryani, Dini; Zubaidi, Fitriannisa Faradina; Rosyidi, Rohadi Muhammad
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.74449

Abstract

Highlight: Coastal communities show high prevalence of cognitive decline. There is no correlation between NRF2 levels and executive function. Gender and education level were significantly associated with executive dysfunction.   ABSTRACT Introduction: Elderly people frequently suffer from neurodegenerative conditions that affect cognitive function. Redox homeostasis dysregulation plays a significant role in neurodegenerative diseases. Oxidative stress activates the transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2), which is essential for regulating the expression of genes involved in cellular defense mechanisms. Objective: This study aimed to determine the relationship between serum NRF2 levels and executive function, as well as to identify other variables that may influence executive function among residents of coastal villages on Lombok Island. Methods: The study used a cross-sectional design with consecutive sampling. Data on sociodemographic characteristics, hypertension, diabetes mellitus, smoking status, and physical activity were collected. Statistical analyses employed Spearman's rank correlation test, Fisher's exact test, and logistic regression test. Results: A total of 39 participants were included, with an average age of 53.38 years. Most participants were female, had a low educational level, did not have hypertension or diabetes mellitus, had high physical activity levels, and were non-smokers. The average NRF2 level was 0.54 ng/mL. The correlation test showed no significant relationship between serum NRF2 levels and executive function. Fisher's exact test showed a significant relationship between gender and education with executive function. Furthermore, logistic regression analysis identified education level as a predictor of executive dysfunction. Conclusion: Serum NRF2 levels were not correlated with executive dysfunction. Educational level was identified as a predictive factor for executive dysfunction.
Co-Authors Abdurrachim Abdurrachim Achmad Mujahidin Irham Adre Mayza Afif, Zamroni Agustin, Aisyiyah Alviana Aisya Nur Abida Aisya Yafis Iqlima Alaydrus, Raisya Hasina Alfhina, Luluk Alkautsar, Mohammad Saddam Almuthiiah, Khadijah Amalia, Emmy Amalia, Emmy - Amaliya, Annisa Risqi Amanda Halimi Amin, Hasan Anak Agung Ayu Niti Wedayani Andhera, Athalita Andi Alfian Zainuddin Andi Alfian Zainuddin Andi Kurnia Bintang, Andi Kurnia andi, Silmi chairan Andina Nabilah Mario Andiyani, Dinda Zahra Putri Anggoro, Joko Annafi, Muhammad Ibnu Anthony, Lalu Muhammad Anugrah, M. Fardi Ardiana Ekawanti Ario Danianto Asriningrum Asriningrum Asriningrum, Asriningrum Aulia Dwi Hendriani Ayu Susilawati, Ayu Azizaturrahmah, Gina Aulia Azmy Mujahid, Sabila Izzatina Badrul Munir Baiq Dewi Sartika Baiq Hilya Kholida Baiq Hilya Kholida Baiq Kania Kartika Yaksa Balqis, Ananda Amirah Bayanaka, Aldhiya Azmy Belynda Rahmalia Sanceska Wahyudi Briliansy Briliansy Briliansy, Briliansy Cahyadi, Anabel Cahyadi, Anabel Catarina Budyono, Catarina Catur Ari Setianto, Catur Ari Chivan Agustinus Siregar Christabella Natalia Wijaya Claudya, Astrid Danesh Hadyljinan Utomo Dara Asyfiya Iyoega Darmaningrat, Cokorda Istri Agung Asvini Deasy Irawati Decky Aditya Zulkarnaen Devi Chandra Kirana Dewi Suryani Dewi, Artu Alycia Laksmi Diayanti Tenti Lestari Didit Yudhanto Dimas Zul Fariqhan Dini Suryani, Dini Dion Setiawan Dwi Atri, Ausi Mutiara Eko Arisetijono Emmy Amalia Enny Ratna Indriyani Evelin, Shierly Kencana Eviana Norahmawati Fachry Prasetyo Hutomo Faizah, Lillah Fatarosdiana Fatarosdiana Fatarosdiana, Fatarosdiana Fitriantoro, Santo Gea, Endah Irnanda Ulfa ghalvan sahidu Gina Syafinatunnajah Gina Zahro Ambarah Grandis Cristagalli Habib, Phillip Haditya Novan Kasprata Hamsu Kadriyan Haq, Abiyyu Didar Hasina, Raisya Hendra Susana Putra Hendra Susana Putra Hifdzil Hilam, Muhammad I Dewa Bagus Ketut Widya Pramana I Gede Yasa Asmara I Gusti Ayu Trisna Aryani I Made Brama Atmaja Ilsa Hunaifi Ilsa Hunaifi Ilsa Hunaifi, Ilsa Indah Retnowati Indah Retnowati Indah Retnowati Indah Sapta Wardani Indradayana, Yanna Indrayana, Yanna Indrayana, Yanna Indrayana, Yanna Indrayana, Yanna Indriyana, Yanna Irnanda, Miranthi Irsyadina Hasana Bharata Ismaya, Ferium Trah Ismiana, Baiq Holisatul Iyoega, Dara Asyfiya Izza Mufida Jacob, Lusye Diana Jihan Alifa Rahma Joko Anggoro Jumraini Tammasse Kasprata, Haditya Novan Khaula Karima Laksmana, Ngakan Putu Proudy Landapa, Raditya Rachman Lasmi, Anjely Doni Lestari, Diayanti Tenti Lestari, Rizka Vidya Linggabudi, I Gusti Bagus Widiamtara Loeki Enggar Fitri Luh Made Ita Purwani Maharani, Amelia Wahyu Maharani, Nyoman Ayu Anindya Mahardika, Fransisca Ika Maida sania salsabila Maliga, Helnida Anggun Mega Adwiatin Miraditi, Ni Komang Mochammad Dalhar Muhammad Akbar Muhammad Akbar Muhammad Azrul Uzmi Muhammad Ghalvan Sahidu Muhammad Ghalvan Sahidu Muhammad Sutan Maulana Muhammad Zaariq Prasetyo Mukhlisatunnafsi, Latifah Muliyana, Hifdzil Haq Munirah, Ira Muttaqin, Syihabul Nafisya Ayu Evana Neila Raisa Ni Nyoman Ayu Susilawati Ni Nyoman Ayu, Susilawati Ni Wayan Sekar Ratih Nikmahtustsani, Mulika Ade Fitria Novita, Adela Novrita Padauleng Nur Syamsu, M.Diaz Nurarafah Andika Putri Nurfadia, Muhammad Fabian Nurhayati, Putri Nurhayati, Rohmatul Hajiriah Nurhayati, Rohmatul Hajiriah Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Padauleng, Novrita Padauleng, Novrita Padauleng, Novrita Paniatul Hiwala Pintaningrum, Yusra Praditna, Ardi Prafica, Adisti Prasetya, Rangga Cahya Pratiwi, Baiq Bunga Citra Prawiro, Aurellia Wongso Pujiarohman Pujiarohman Pujiarohman, Pujiarohman Putra, Hendra Susana Putri Nurhayati Putri, Firda Aunidiah Putri, Setyawati Asih Putri, Siti Noururrifqiyati Juna Qisthinadia Hazhiyah Setiadi Rahma, Jaini Raisa, Neila Rifky Maulana Ackbar Rike Delya Rizqina Rina Lestari Rina Lestari Ristia, Ovia Intan Rivarti, Arina Windri Rizki, Mohammad Rizki, Mohammad Rohadi Muhammad Rosyidi Rosmalasari Rosmalasari Rosyidi, Rohadi Muhammad Rusdi, Yudika Ilhami Safat Wahyudi Safat Wahyudi Safat Wahyudi Sahidu, Muhammad Ghalvan Sahly, Aliza Raudatin Saputri, Legis Octaviana Sari Dianita Purnama Sari, Putu Suwita Satriawan, Wira Semadi, I Kadek Setiadi, Qisthinadia Hazhiyah Setiadi, Qisthinadia Hazhiyah Setyawati Asih Putri Shafa C, Cloresta Silmina Alifiya Sri Budhi Rianawati Sri Budhi Rianawati, Sri Budhi Sri Susilawatin Stephanie Elizabeth Gunawan Stephanie Elizabeth Gunawan Stephanie Elizabeth Gunawan Stephen, Mishael Enoch Sulistyaningrum, Dwi Suryantarini, Ni Wayan Puspa Wijaya Susilawati, N Nyoman Ayu Susilawati, Ni Nyoman Ayu Syifa, R.R Ditya Mutiara Tammasse , Jumraini Tammasse, Jumraini Tinny Endang Endang H Ulfa Gea, Indah Ernanda Vinni Dianggita Wa Ode Nur Intan Octina Wahyudi, Safat Wardi, Baiq Prita Riantiani Wedayani, AA Ayu Niti Wiracakra, I Gusti Lanang Krisna Wulandari, Inayah Yanna Indrayana Yusra Pintaningrum Zamroni Afif Zubaidi, Fitriannisa Faradina