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All Journal International Journal of Public Health Science (IJPHS) International Journal of Evaluation and Research in Education (IJERE) HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Lahan Suboptimal Proceedings of Annual International Conference Syiah Kuala University - Social Sciences Chapter Jurnal Kedokteran Brawijaya Jurnal Pendidikan Sains Biogenesis: Jurnal Ilmiah Biologi Current Biochemistry Research Journal of Life Science Jurnal Wasian Jurnal Pendidikan Biologi Indonesia Buletin Keslingmas Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Science and Technology Indonesia JOIV : International Journal on Informatics Visualization Jurnal Manajemen Jurnal Kajian Akuntansi Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUKASI Biosfer: Jurnal Pendidikan Biologi Jurnal Administrasi dan Manajemen Pendidikan JMM (Jurnal Masyarakat Mandiri) JURNAL EKSAKTA PENDIDIKAN (JEP) at-tamkin: Jurnal Pengabdian kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Owner : Riset dan Jurnal Akuntansi Amerta Nutrition Biota Bioedusiana: Jurnal Pendidikan Biologi GERVASI: Jurnal Pengabdian kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Jurnal Pengabdian Kepada Masyarakat (Mediteg) Prosiding Seminar Nasional Teknik Mesin Dedikasi: Jurnal Pengabdian Masyarakat Business Journal : Jurnal Bisnis Dan Sosial JAMP : Jurnal Administrasi dan Manajemen Pendidikan Diseminasi : Jurnal Pengabdian kepada Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Journal Informatic, Education and Management (JIEM) Jurnal Pengabdian kepada Masyarakat Nusantara Yumary: Jurnal Pengabdian kepada Masyarakat Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Masyarakat Indonesia Journal of Community Development ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Berkala Penelitian Hayati Journal of Research in Instructional Jurnal Ilmiah Kesehatan (JIKA) International Journal of Science and Society (IJSOC) Journal of Disruptive Learning Innovation (JODLI) Jurnal Pijar MIPA Sci-Tech Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram MINERAL Semanggi: Jurnal Pengabdian kepada Masyarakat Research and Development in Education (RaDEn) Journal of Global Nutrition Jurnal Keuangan dan Bisnis Research Horizon Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Journal International Journal of Teaching and Learning (INJOTEL) VISA: Journal of Vision and Ideas Prosiding Seminar Nasional Unimus Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Exhibition and Seminar on Science and Creative Technology – Al Azhar Proceeding Media for Empowerment, Mobilization, and Innovation in Research & Community
Hendra Susanto
Universitas Negeri Malang
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Journal : HAYATI Journal of Biosciences

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Increased Anti-Proliferation Performance of NanoChitosan-Moringa Seeds Extract and Co-Treatment with Doxorubicin in Liver Cancer Cells Susanto, Hendra; Sholeh, Moch; Tri Endharti, Agustina; Nik Malek, Nik Ahmad Nizam; Amaliyah Firdaus, Sa’diyatul Rizqie; Yuda Handaya, Adeodatus; Taufiq, Ahmad
HAYATI Journal of Biosciences Vol. 32 No. 2 (2025): March 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.2.414-425

Abstract

Hepatocellular carcinoma (HCC) with high epidemiological report data. Pathogenesis in HCC also involves several signaling pathways. This study aims to evaluate the in vitro activity of Moringa seed NanoChitosan against Hep G2 liver cancer cells and Co-Treatment with Doxorubicin. Initially, nanoparticles were prepared by extracting Moringa seeds, formulating them into nano chitosan, and then characterizing the compounds and particle sizes. The IC50 dose was investigated using the MTT assay. Then, the IC50 dose was confirmed in more detail through immunofluorescence, betatrophin gene, several genes in the Wnt-βcatenin-CyclinD1 proliferation pathway, and the addition of the apoptotic effector Caspase-3 using RT-qPCR analysis. Each treatment used a single dose of NCH-Mosee and co-treatment or combination with 4 μg/ml doxorubicin. The IC50 dose was 994 μg/ml in single treatment and 649 μg/ml in combined treatment with Dox. Hep G2 showed a decrease in the expression level of each parameter measured with increasing single dose and combination treatment (p < 0.050). Histologically, cells shrank, betatrophin expression was inhibited, and luminescence was seen, which decreased with increasing dose. In conclusion, NCH-Mosee with dose-tracking toxicity combined with Dox can suppress the viability of Hep G2 cells.
Characterization of SNEDDS Formulated with Single Bulb Garlic and its Anti-Inflammatory Effect on 3T3-L1 Lestari, Sri Rahayu; Sunaryono, Sunaryono; Susanto, Hendra; Rachmawati , Hidajah; Irawanto, Rony; Miasih, Dewi Sekar; El Baroroh, Alif Rosyidah; Annisa, Yuslinda; Djati, Muhammad Sasmito
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.793-804

Abstract

Inflammation is an early symptom of a disease that reduces the level of health. Single-bulb garlic (Allium sativum L.) is used medicinally as a plant with a broad pharmacological effect, especially anti-inflammatory activity. Self-nanoemulsifying drug delivery systems (SNEDDS) have offered opportunities to improve drug delivery. The current study aimed to characterize SNEDDS-single bulb garlic extract (SBGE) and determine its potential as an anti-inflammatory agent in 3T3-L1 cells. SNEDDS was formulated from tween-80, glycerol, canola oil, and SBGE. The formula characterization is done using droplet size, polydispersity index, zeta potential, physical stability test, and antioxidant assay. The cytotoxicity test of SNEDDS-SBGE was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The anti-inflammatory activity was examined using 3T3-L1 cell methylglyoxal (MG) induction, and the expression of cytokines was measured using immunocytochemistry (ICC). The SNEDDS-SBGE had a nanoemulsion size of 42.30±1.39 nm, 0.6±0.03 for the polydispersion index, and -22.63±0.75 mV for the zeta potential. SNEDDS-SBGE was physically stable and had a high antioxidant level (47.579±8.017 %). SNEDDS-SBGE exhibited no toxic effect on 3T3-L1 cells. The administration of 62.5 µg/ml and 125 µg/ml SNEDDS-SBGE could inhibit (p<0.05) the expression of IL-1β after methylglyoxal induction. Thus, SNEDDS-SBGE may have potential anti-inflammatory properties.
Co-Authors Achmada, Putra Fernanda Dwi Adeodatus Yuda Handaya Adim Firmansah Adinda Marcelliantika Aditya Rifqi Fauzi Afis Baghiz Syafruddin Agung Witjoro Agus Barmawi Agus Subagyo Agusta Rakhmat Taufani Agustina, Rena Silvia Ahmad Hapiz Ahmad Khanali Ahmad Taufiq Ahmad Taufiq Ainun Nikmah Ajeng Daniarsih Alby Aruna Aldri Frinaldi Ali Mustofa Almas Dwi Khairana Amaliyah Firdaus, Sa’diyatul Rizqie Amirah, Asriwati Ananda, Oriny Tri Anastya Eka Kharisma Andi Basuki Andi Muharni Anggarani, Dinar Arsy Anggarani, Dinar Arsy Arsy Annisa, Yuslinda Anugrah Ricky Wijaya Arbin Janu Setiyowati, Arbin Ardana, I Kade Karisma Gita Ari Gunawan Ari Gunawan Ari Gunawan ARIF HIDAYAT Arif Hidayat Aripriharta - Arisatya Bharotoyakti Aruna, Alby Aulanni'am, Aulanni'am Aulanni’am, Aulanni’am Azriel Farrel Kresna Aditya Bagus Priambodo Bahrullah Akbar Betty Lukiati cahya, uci dwi Chang, Chun-Yen Choirunisa', Nindiana Chrisna Budi Satriyo Chusna, Nadiya Miftachul Claresia Tsany Kusmayadi Deny Setiawan Deny Setiawan Dewi Murni Dewi Sekar Miasih Diah Setiawati Didik Dwi Prastyo Didik Setyo Heriyanto Dwi Listyorini Eka Putri Surya El Baroroh, Alif Rosyidah Facthur Rohman Fatchur Rohman Fatchur Rohman Faturrahman Fauzi, M Imam Fitrah Amalia Salim Friska, Renny Futri Yuliana Fuzani, Sri Dinasyah Ratna H. Hardianto Hadi Suwono Hadi, Sholihul HARDIANTO - Hari Rudijanto. IW Hermanto, Yanto Heru Wahyu Herwanto Hidayati Maghfiroh Husna Nur Wanah I Kade Karisma Gita Ardana I Made Wirawan Ibrohim Ida Ayu Setyawati Sri Krisna Dewi Ida Rohmah Susiani Ika Sasti Ferina, Ika Sasti Ikramina Yusti Amina Imam Sofii Indah Nur Laili Isma, Rusdatul Izza, Jasmine Nurul Janiar Pitulima Jasmine Nurul Izza Joshua Andrew Judhiastuty Februhartanty Kamal Agung Yudayana Kevin Radinal Kormil Saputra Kosasih, Andro Krisnawati, Dyah Ika Kristianty, Grace Triana Kusmahardhika, Noviansyah Kusmayadi, Claresia Tsany Kusnunnahari Kusnunnahari, Kusnunnahari Kustiariyah Tarman Lathiful Anwar Lianto Lianto Linggasari, M.I. Dewi Lulik Inggarwati Lusttilanang, Pius Lya Rizka Herawati M Iqbal Najib Fahmi M. Ikhsan M. Rasjad Indra Maghfiroh, Hidayati Mariya Sulfa, Devi Markus Diantoro Marshanda Putri, Anggia Marwan Marwan Masruroh MASRUROH Mega Safithri Miasih, Dewi Sekar Miftahul Hasanah Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Moch Sholeh Mochammad Imron Awalludin Moh. Zainul Falah Mohamad Amin Mohammed, Najib Muhammad Adib Amin Muhammad Rifqi Hariri Muhammad Saefi Muharni, Andi Mukhtaruddin Mukhtaruddin Murni Sapta Sari Muslihati Najmi, M. Ikhwan Nasution, Ramadhani Syafitri Nik Ahmad Nizam Nik Malek Nik Malek, Nik Ahmad Nizam Nurcahya Setiawan Nurlita Indah Wahyuni, Nurlita Indah Nurul Izza, Jasmine Nurullah, Asfeni Oktavia, Silvi Tri Oriny Tri Ananda Paidi Pramono, Agus Joko Prayogi, Moch. Bagus Putri Diyah Anggraini Putri, Kuntum Kinanthi Rachmawati , Hidajah Radhiyah, Rizqa Rajib Muhammad Basthony Rasjad Indra Ratnapuri, Adisti Rawe, Nining Sahara H A Restianto, Yanuar Retna Apsari Ricadonna Raissa Riwu , Herison Rizqa Radhiyah Robi, Fikri Syahir Rony Irawanto Rui Alfadel Saputra S, Muh Akbar Sabrina, Andiani Salsa Salim, Fitrah Amalia Satia Nur Maharani Satria Adiguna Setyarini, Ni Luh Putu Shinta Setyohadi, Taat Sholeh , Moch sholeh, moch Sholihah, Nida Anisatus Sholihul Hadi Sinta Kusuma Dewi Siti Maisaroh Siti Zubaidah Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Soenar Soekopitojo Sri Endah Indriwati Sri Rahayu Lestari Sri Rahmawati ST. Ulfawanti Intan Subadra Subadra, ST. Ulfawanti Intan Sudjari Sudjari Sudjari Sudjari Suharti Sujito . Sukiman . Sulfa, Devi Mariya Sunaryono Sunaryono Sunaryono, Sunaryono Supratman Tabba Susriyati Mahanal Suwarno Suwarno Suwistika, Rima Sya'rawi, Muhammad Akram Syalwa, Mutiara Tjahyono, Seto Tono, E.P.S.B Taman Tri Endharti, Agustina Trijoyo Purnomo, Jerry Dwi Umi Fitriyati Utami Sri Hastuti Verdamil, Ainun Cornelia Wahyu Pratama, Ade Wandreina, Lucky Meisya Wibi Riawan Wiedia Carullina Purwanti Wijiasih, Wijiasih Wira Eka Putra Wisnubroto Wisnubroto Wisnubroto, Wisnubroto Wiwin Apriani Wuragil, Dyah Kinasih Yuda Handaya, Adeodatus Yudi Susanto YULIA SAFTIANA, YULIA Yuliana, Futri Yunita Rakhmawati Yuslinda Annisa Ywana, Satya Zahra Firdaus Zahratunnisa