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All Journal International Journal of Public Health Science (IJPHS) International Journal of Evaluation and Research in Education (IJERE) HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Lahan Suboptimal Proceedings of Annual International Conference Syiah Kuala University - Social Sciences Chapter Jurnal Kedokteran Brawijaya Jurnal Pendidikan Sains Biogenesis: Jurnal Ilmiah Biologi Current Biochemistry Research Journal of Life Science Jurnal Wasian Jurnal Pendidikan Biologi Indonesia Buletin Keslingmas Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Science and Technology Indonesia JOIV : International Journal on Informatics Visualization Jurnal Manajemen Jurnal Kajian Akuntansi Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUKASI Biosfer: Jurnal Pendidikan Biologi Jurnal Administrasi dan Manajemen Pendidikan JMM (Jurnal Masyarakat Mandiri) JURNAL EKSAKTA PENDIDIKAN (JEP) at-tamkin: Jurnal Pengabdian kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Owner : Riset dan Jurnal Akuntansi Amerta Nutrition Biota Bioedusiana: Jurnal Pendidikan Biologi GERVASI: Jurnal Pengabdian kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Jurnal Pengabdian Kepada Masyarakat (Mediteg) Prosiding Seminar Nasional Teknik Mesin Dedikasi: Jurnal Pengabdian Masyarakat Business Journal : Jurnal Bisnis Dan Sosial JAMP : Jurnal Administrasi dan Manajemen Pendidikan Diseminasi : Jurnal Pengabdian kepada Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Journal Informatic, Education and Management (JIEM) Jurnal Pengabdian kepada Masyarakat Nusantara Yumary: Jurnal Pengabdian kepada Masyarakat Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Masyarakat Indonesia Journal of Community Development ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Berkala Penelitian Hayati Journal of Research in Instructional Jurnal Ilmiah Kesehatan (JIKA) International Journal of Science and Society (IJSOC) Journal of Disruptive Learning Innovation (JODLI) Jurnal Pijar MIPA Sci-Tech Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram MINERAL Semanggi: Jurnal Pengabdian kepada Masyarakat Journal of Global Nutrition Jurnal Keuangan dan Bisnis Research Horizon Journal International Journal of Teaching and Learning (INJOTEL) VISA: Journal of Vision and Ideas Prosiding Seminar Nasional Unimus Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Exhibition and Seminar on Science and Creative Technology – Al Azhar Proceeding Media for Empowerment, Mobilization, and Innovation in Research & Community
Hendra Susanto
Universitas Negeri Malang
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Mutation Analysis and Single Nucleotide Polymorphism of TP53 Gene in Breast Cancer in East Java Radhiyah, Rizqa; Ardana, I Kade Karisma Gita; Wisnubroto, Wisnubroto; Listyorini, Dwi; Susanto, Hendra
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.12

Abstract

The Incidence of Indonesia breast cancer case in 2018 was reported at 20.7% or 160,653 in number. The factors that caused breast cancer is TP53 gene mutation and Single Nucleotide Polymorphism (SNP). This study aimed to determine the mutation and Single Nucleotide Polymorphism (SNP) of TP53 gene in breast cancer. Samples of this study were 9 people chosen based on a purposive technique. The methods include total DNA isolation, DNA quantification, PCR, and sequencing. The results of the sequencing were then analyzed using alignment and blast. The SNP is browsed by the SNP finder on NCBI both followed by protein modeling. The results of this study indicate the existence of mutation in the exon and intron regions. Substitution of Guanine (G) to base Adenine (A) is occur in codon 496 which is a coding region. SNP was also obtained in exon of sample 12. The conclusion of this study is breast cancer can be caused by mutations that occur in the exon and altered the structur of protein structure, so then affect the binding affinity between p53 and its target domain. Tp53 gene mutation is not the only cause of breast cancer staging development, there are other genes that also contribute to the development of cancer stage. In addition, Single Nucleotide Polymorphism in the TP53 gene can be used as a predisposition marker of breast cancer that has potential to be inherited
Mutation Analysis and Single Nucleotide Polymorphism of TP53 Gene in Breast Cancer in East Java Rizqa Radhiyah; I Kade Karisma Gita Ardana; Wisnubroto Wisnubroto; Dwi Listyorini; Hendra Susanto
Journal of Tropical Life Science Vol. 11 No. 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.12

Abstract

The Incidence of Indonesia breast cancer case in 2018 was reported at 20.7% or 160,653 in number. The factors that caused breast cancer is TP53 gene mutation and Single Nucleotide Polymorphism (SNP). This study aimed to determine the mutation and Single Nucleotide Polymorphism (SNP) of TP53 gene in breast cancer. Samples of this study were 9 people chosen based on a purposive technique. The methods include total DNA isolation, DNA quantification, PCR, and sequencing. The results of the sequencing were then analyzed using alignment and blast. The SNP is browsed by the SNP finder on NCBI both followed by protein modeling. The results of this study indicate the existence of mutation in the exon and intron regions. Substitution of Guanine (G) to base Adenine (A) is occur in codon 496 which is a coding region. SNP was also obtained in exon of sample 12. The conclusion of this study is breast cancer can be caused by mutations that occur in the exon and altered the structur of protein structure, so then affect the binding affinity between p53 and its target domain. Tp53 gene mutation is not the only cause of breast cancer staging development, there are other genes that also contribute to the development of cancer stage. In addition, Single Nucleotide Polymorphism in the TP53 gene can be used as a predisposition marker of breast cancer that has potential to be inherited
Potential of Single Garlic to Prevent Pro Inflammatory Macrophage and Inflammation in HFD Mice Putri Diyah Anggraini; Miftahul Mufinadiroh; Hendra Susanto; Betty Lukiati; Sri Rahayu Lestari
Journal of Tropical Life Science Vol. 12 No. 1 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.01.10

Abstract

A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat diet. This research aimed to investigate the effect of single bulb garlic extract (SBGE) on the pro-inflammatory cytokines TNF-α (CD11b+TNF-α+) and IL-1b (CD11b+IL-1b+) in the spleen, spleen weight, and TNF-α secretion in HFD mice. Twenty-four mice were divided into six groups: normal (healthy mice); HFD (HFD mice without any treatment); HFD + Simvastatin (HFD mice receiving simvastatin); HFD + SBGE 100; HFD + SBGE 200; and HFD + SBGE 400 (HFD mice receiving 100, 200, and 400 mg/kg BW of SBGE for 4 weeks). Blood serum was collected at the end of treatment, and macrophage was isolated from the spleen. The relative number of CD11b+TNF-α+ and CD11b+IL-1b+ were examined using flow cytometry. SBGE treatment significantly (p<0.05) reduced the spleen weight and the relative number of CD11b+TNF-α+ and CD11b+IL-1b+ in the spleen of HFD mice. SBGE treatment also prevents the elevation of TNF- α levels in the blood serum. The optimal dose of SBGE to diminish the relative number of CD11b+TNF-α+, CD11b+IL-1b+ in the spleen, and TNF-α in the serum was 100 mg/kg BW.
Co-Authors Achmada, Putra Fernanda Dwi Adeodatus Yuda Handaya Adim Firmansah Adinda Marcelliantika Aditya Rifqi Fauzi Afis Baghiz Syafruddin Agung Witjoro Agus Barmawi Agus Subagyo Agusta Rakhmat Taufani Agustina, Rena Silvia Ahmad Hapiz Ahmad Khanali Ahmad Taufiq Ahmad Taufiq Ainun Nikmah Ajeng Daniarsih Alby Aruna Aldri Frinaldi Ali Mustofa Almas Dwi Khairana Amaliyah Firdaus, Sa’diyatul Rizqie Ananda, Oriny Tri Anastya Eka Kharisma Andi Basuki Anggarani, Dinar Arsy Anggarani, Dinar Arsy Arsy Annisa, Yuslinda Anugrah Ricky Wijaya Arbin Janu Setiyowati, Arbin Ardana, I Kade Karisma Gita Ari Gunawan Ari Gunawan Ari Gunawan ARIF HIDAYAT Arif Hidayat Aripriharta - Arisatya Bharotoyakti Aruna, Alby Aulanni'am, Aulanni'am Aulanni’am, Aulanni’am Azriel Farrel Kresna Aditya Bagus Priambodo Bahrullah Akbar Betty Lukiati cahya, uci dwi Chang, Chun-Yen Choirunisa', Nindiana Chrisna Budi Satriyo Chusna, Nadiya Miftachul Claresia Tsany Kusmayadi Deny Setiawan Deny Setiawan Dewi Murni Dewi Sekar Miasih Diah Setiawati Didik Dwi Prastyo Didik Setyo Heriyanto Dwi Listyorini Eka Putri Surya El Baroroh, Alif Rosyidah Facthur Rohman Fatchur Rohman Fatchur Rohman Faturrahman Fauzi, M Imam Friska, Renny Futri Yuliana Fuzani, Sri Dinasyah Ratna Hadi Suwono Hadi, Sholihul HARDIANTO - Hari Rudijanto. IW Hermanto, Yanto Heru Wahyu Herwanto Hidayati Maghfiroh Husna Nur Wanah I Kade Karisma Gita Ardana I Made Wirawan Ibrohim Ida Ayu Setyawati Sri Krisna Dewi Ida Rohmah Susiani Ika Sasti Ferina, Ika Sasti Ikramina Yusti Amina Imam Sofii Indah Nur Laili Isma, Rusdatul Izza, Jasmine Nurul Janiar Pitulima Jasmine Nurul Izza Joshua Andrew Judhiastuty Februhartanty Kamal Agung Yudayana Kevin Radinal Kormil Saputra Kosasih, Andro Krisnawati, Dyah Ika Kristianty, Grace Triana Kusmahardhika, Noviansyah Kusmayadi, Claresia Tsany Kusnunnahari Kusnunnahari, Kusnunnahari Kustiariyah Tarman Lianto Lianto Linggasari, M.I. Dewi Lulik Inggarwati Lusttilanang, Pius Lya Rizka Herawati M Iqbal Najib Fahmi M. Ikhsan M. Rasjad Indra Maghfiroh, Hidayati Mariya Sulfa, Devi Markus Diantoro Marshanda Putri, Anggia Marwan Marwan Masruroh MASRUROH Mega Safithri Miasih, Dewi Sekar Miftahul Hasanah Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Moch Sholeh Mochammad Imron Awalludin Moh. Zainul Falah Mohamad Amin Mohammed, Najib Muhammad Adib Amin Muhammad Rifqi Hariri Muhammad Saefi Muharni, Andi Mukhtaruddin Mukhtaruddin Murni Sapta Sari Muslihati Najmi, M. Ikhwan Nik Ahmad Nizam Nik Malek Nik Malek, Nik Ahmad Nizam Nurcahya Setiawan Nurlita Indah Wahyuni, Nurlita Indah Nurul Izza, Jasmine Nurullah, Asfeni Oktavia, Silvi Tri Oriny Tri Ananda Paidi Paidi Pramono, Agus Joko Prayogi, Moch. Bagus Putri Diyah Anggraini Putri, Kuntum Kinanthi Rachmawati , Hidajah Radhiyah, Rizqa Rajib Muhammad Basthony Rasjad Indra Ratnapuri, Adisti Rawe, Nining Sahara H A Restianto, Yanuar Retna Apsari Ricadonna Raissa Riwu , Herison Rizqa Radhiyah Robi, Fikri Syahir Rony Irawanto Rui Alfadel Saputra S, Muh Akbar Sabrina, Andiani Salsa Salim, Fitrah Amalia Satia Nur Maharani Satria Adiguna Setyarini, Ni Luh Putu Shinta Setyohadi, Taat Sholeh , Moch sholeh, moch Sholihah, Nida Anisatus Sholihul Hadi Sinta Kusuma Dewi Siti Maisaroh Siti Zubaidah Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Soenar Soekopitojo Sri Endah Indriwati Sri Rahayu Lestari Sri Rahmawati ST. Ulfawanti Intan Subadra Subadra, ST. Ulfawanti Intan Sudjari Sudjari Sudjari Sudjari Suharti Sujito . Sukiman . Sulfa, Devi Mariya Sunaryono Sunaryono Sunaryono, Sunaryono Supratman Tabba Susriyati Mahanal Suwarno Suwarno Suwistika, Rima Sya'rawi, Muhammad Akram Syalwa, Mutiara Tjahyono, Seto Tono, E.P.S.B Taman Tri Endharti, Agustina Trijoyo Purnomo, Jerry Dwi Umi Fitriyati Utami Sri Hastuti Verdamil, Ainun Cornelia Wahyu Pratama, Ade Wandreina, Lucky Meisya Wibi Riawan Wiedia Carullina Purwanti Wijiasih, Wijiasih Wira Eka Putra Wisnubroto Wisnubroto Wisnubroto, Wisnubroto Wiwin Apriani Wuragil, Dyah Kinasih Yuda Handaya, Adeodatus Yudi Susanto YULIA SAFTIANA, YULIA Yuliana, Futri Yunita Rakhmawati Yuslinda Annisa Ywana, Satya Zahra Firdaus Zahratunnisa