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Hendra Susanto

Universitas Negeri Malang

Author-ID : 2685407

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Potential of Single Garlic to Prevent Pro Inflammatory Macrophage and Inflammation in HFD Mice Putri Diyah Anggraini; Miftahul Mufinadiroh; Hendra Susanto; Betty Lukiati; Sri Rahayu Lestari
Journal of Tropical Life Science Vol. 12 No. 1 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.01.10

A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat diet. This research aimed to investigate the effect of single bulb garlic extract (SBGE) on the pro-inflammatory cytokines TNF-Î± (CD11b+TNF-Î±+) and IL-1b (CD11b+IL-1b+) in the spleen, spleen weight, and TNF-Î± secretion in HFD mice. Twenty-four mice were divided into six groups: normal (healthy mice); HFD (HFD mice without any treatment); HFD + Simvastatin (HFD mice receiving simvastatin); HFD + SBGE 100; HFD + SBGE 200; and HFD + SBGE 400 (HFD mice receiving 100, 200, and 400 mg/kg BW of SBGE for 4 weeks). Blood serum was collected at the end of treatment, and macrophage was isolated from the spleen. The relative number of CD11b+TNF-Î±+ and CD11b+IL-1b+ were examined using flow cytometry. SBGE treatment significantly (p<0.05) reduced the spleen weight and the relative number of CD11b+TNF-Î±+ and CD11b+IL-1b+ in the spleen of HFD mice. SBGE treatment also prevents the elevation of TNF- Î± levels in the blood serum. The optimal dose of SBGE to diminish the relative number of CD11b+TNF-Î±+, CD11b+IL-1b+ in the spleen, and TNF-Î± in the serum was 100 mg/kg BW.

Differences of alt-ast level and snail gene expression between patients with metastasis and non-metastasis colorectal cancer Chrisna Budi Satriyo; Hendra Susanto; Adeodatus Yuda Handaya; Nurcahya Setiawan; Imam Sofii; Agus Barmawi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art5

Background: Colorectal cancer (CRC) is a malignant epithelial tumour in the colon and rectum, and its main cause is distant metastasis. The main process of distant metastasis is the epithelial-mesenchymal transition (EMT) that may cause mesenchymal phenotype and malignant capabilities of tumour cells. Then it is regulated by one of transcription factors, the Snail.Objective: This study aims to determine differences between Snail gene expression in CRC that has not metastasized and Snail gene expression in CRC that has metastasized. Methods: The subjects of this study consisted of two groups of patients. The first group consisted of 20 patients with CRC (tumour), and the second group consisted of 12 patients with CRC with metastasis (metastasis tumour). The Snail gene expression was measured in both groups by using the RT-qPCR method and supported by laboratory examination to measure ALT and AST. Then all obtained data were analysed by using a statistical software analysis.Results: This study indicated that there were differences of the Snail gene expression between both the groups, and the highest expression was in the metastatic tumour group with a significance level of 0.002 (p<0.05). This was also supported by AST and ALT which were significantly correlated between both the groups. The correlation value on the AST was 0.506 with a significance level of 0.003, and the ALT correlation value was 0.532 with a significance level of 0.002. Conclusion: This study suggested that the Snail was a potential marker of metastasis in the CRC. Therefore, further research is needed to determine the role of Snail regulation in the CRC metastasis.

Definition and conceptual model of genetics literacy: a systematic literature review Hidayati Maghfiroh; Siti Zubaidah; Susriyati Mahanal; Hendra Susanto
International Journal of Public Health Science (IJPHS) Vol 12, No 2: June 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i2.22679

Genetic literacy is essential for promoting health and well-being in modern society. Although its importance is increasingly recognised, the definition and crucial dimension to construct a conceptual model are unclear, limiting the possibilities for measurement and comparison intervention. The study aims to review definitions and the conceptual models of genetics literacy and develop a new comprehensive definition and conceptual model based on the discovered dimensions that are relevant in the post-genomic era. We performed a systematic literature review using the Crossref, PubMed, and Scopus databases with Publish or Perish software. An automated content analysis was conducted to identify and develop conceptual model genetics literacy using NVivo 12 software. The review resulted in 10 definitions and 12 conceptual models. Automated content analysis showed that genetic literacy is defined as the ability of an individual to comprehend, use, correlate, assess, and propose genetic information to make arguments, reason, and decide on genetic issues in maintaining or improving the quality of personal and social well-being. Genetic literacy was conceptualised as a set of knowledge, a set of skills or interconnected. The conceptual model of genetics literacy covers two dimensions. i) Knowledge dimension: conceptual (nature of genetic material, transmission, genetic expression, genetic regulation, genetic determinism, genetic technology); sociocultural; epistemic. ii) Skills dimension: argumentation, informal reasoning, and decision-making skills. This definition and conceptual model can serve as a basis for developing interventions and measurements to support regulating, preventing, as well as promoting health and well-being.

Pemanfaatan Teknologi Sel Surya untuk Optimalisasi Budidaya Ikan Lele Berbasis Sistem Biofloc-Aquaponic Sunaryono Sunaryono; Markus Diantoro; Ahmad Taufiq; Hendra Susanto; Muhammad Ikhwan Najmi; Futri Yuliana
JPM: Jurnal Pengabdian Masyarakat Vol 5 No 1 (2023): Dedikasi: Jurnal Pengabdian Masyarakat, Januari-Juni 2023
Publisher : Pusat Pengabdian Masyarakat (PPM) Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) Institut Agama Islam Negeri (IAIN) Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32332/d.v5i1.5684

Gadingkasri Village is one of the villages located in the Klojen District of Malang City which is located in the downtown area of Malang. The location of the village surrounded by a business center and several universities makes this village very strategic because it is a densely populated residential area with a combination of residential communities and students as boarding house residents. With this condition, Gadingkasri Village has considerable economic zone potential for its people. Gadingkasri Village, especially residents in RW. 3, there is a community of PKK mothers who are members of the Urban Farming Group who have a vision to green residential areas by gardening around settlements. One of the potentials that can be developed is to develop community activities in the Urban Farming community towards optimizing energy and increasing residents' income by raising catfish. The community service program through funding from the State University of Malang aims to maximize the existing potential through the use of appropriate technology. The method used in this service is a method of empowering catfish farming by utilizing appropriate technology engineering for sustainable alternative energy. The activities that have been carried out are in the form of mentoring, designing, installing aquaponic systems, and biofloc pools, and solar panels which will be alternative energy in supplying aquaponic pump electrical systems and biofloc ponds. The results of this service activity are expected to be an alternative energy source solution that can be used independently by RW residents. 3 Gadingkasri village. The empowerment of catfish with a biofloc system is also expected to be able to increase the economic income of residents

Detecting miRNAs expression as the early prognostic factor for patients with colorectal cancer in Dr. Sardjito Hospital Yogyakarta : A preliminary study Adeodatus Yuda Handaya; Didik Setyo Heriyanto; Hendra Susanto; Yudi Susanto; Kamal Agung Yudayana; Ida Ayu Setyawati Sri Krisna Dewi; Aditya Rifqi Fauzi; Joshua Andrew; Kevin Radinal; Azriel Farrel Kresna Aditya
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art9

Background: Colorectal cancer (CRC) is the third highest-ranked cancer and causes high mortality in patients with a low survival rate. The lack of sensitivity and specificity of clinical and other diagnostic modalities results in a higher mortality rate. Therefore, the exploration of potential early biomarkers for CRCs is necessary.Objective: We aimed to evaluate the local expressions of potential tumor suppressor and oncogenic miRNAs in CRC patients in Indonesia. Methods: This retrospective cohort study involving thirty-one colorectal carcinoma patients at Dr. Sardjito Hospital Yogyakarta from January 2014-December 2017. Total RNA was isolated, and the expressions of miR-21, miR-92a, miR-96, miR-26b, miR144, and miR-195 were measured by real-time quantitative PCR. The correlation between miRNAs and other predictors was determined by Spearman correlation, and the association of miRNA expression and other clinical parameters used logistic regression.Results: The local expression of miR-195 decreased significantly in the tumor sites. In contrast, miR-21 activity tends to increase in the local tumor. Meanwhile, the expressions for miR-92a, miR-96, miR26b, and miR-144 in the same subjects were non-significant. MiR-195 was also significantly associated to cancer stage (r=-0.570, p=0.001) with significant odds ratio (OR=0.892, 95% CI=0.804–0.990, p=0.031).Conclusion: Our study was the first to report aberrant expressions of miRNA-21, miRNA-195, miRNA-92a, miRNA-26b, miRNA-96, and miRNA-144 in Indonesian CRC patients. The tumor suppressor miRNA-195 expression was superior among others to serve as an early biomarker in detecting and predicting CRC disease progression.

The Development of Electronic Modules Based on Problem Based Learning Integrating Disaster Mitigation in Environmental Change Material to Increase Critical Thinking Skills of Students Sinta Kusuma Dewi; Hadi Suwono; Hendra Susanto
BIOEDUKASI Vol 21 No. 3 (2023)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v21i3.41064

An e-module is a learning media designed to assist students in discovering and solving problems independently and can be used practically and flexibly. The purpose of this paper is to produce a PBL-based integrated disaster mitigation e-module on environmental change material that is valid, practical and effective. The e-module development used the development model by (Lee & Owens, 2004). E-modules were validated by material experts, learning media experts, biology education experts and practitioners. Furthermore, the e-modules were tested on students in individual, small group and field trials. In the field trial, the e-module was applied in biology learning. Based on the N-Gain test score between pretest and posttest, it is known that the experimental class is in the high category and the control class is in the medium-high category. The results prove that the e-module developed is valid, practical and effective, so it can be used in learning activities that can improve students' critical thinking skills.

Revolutionary Biology Education: Development of Advanced Biology Learning Through Websites and Learning Kits Hendra Susanto; Ibrohim; Andi Basuki; Wiedia Carullina Purwanti; Ari Gunawan; Afis Baghiz Syafruddin
International Journal of Science and Society Vol 5 No 5 (2023): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v5i5.882

Biology education has become essential in developing students' scientific understanding and skills in facing global challenges. Advanced biology learning can be introduced to students as an effort to apply science in everyday life and innovative research. This field of biology has opportunities for promising career paths and jobs in science and technology. However, this learning has yet to be widely introduced regarding innovations in the field of biology in various aspects so that it can deepen students' understanding and competence in solving problems. This research aimed to develop websites and learning kits in advanced biology education. The method used was ASSURE, including analysis of student characteristics, setting performance targets, media development, material exploration, evaluation, and revision. The results obtained in the research, covering the validation analysis of biological material, had met the aspects of depth, feasibility, clarity, suitability for purpose, and use of language. Validation analysis of video-based learning media had fulfilled the aspects of video quality, audio clarity, content suitability, text readability, and context connectedness. The learning platform validation analysis had met user experience, content availability, and visual quality. Recommendations for further research include a validation process by experts and field implementation to determine the effectiveness of learning media.

Pelatihan Penerapan Ilmu Pertanian Dasar Menggunakan Massive Open Online Course Hendra Susanto; Jasmine Nurul Izza; Alby Aruna; Eka Putri Surya
GERVASI: Jurnal Pengabdian kepada Masyarakat Vol. 7 No. 3 (2023): GERVASI: Jurnal Pengabdian kepada Masyarakat
Publisher : LPPM IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/gervasi.v7i3.6605

Proses penerapan massive open online course (MOOC) sebagai wujud implementasi penerapan teknologi abad 21 yang terstruktur harus didukung semua lapisan masyarakat. Kelompok pertanian Desa Pacet, Mojokerto mempunyai masalah dasar tentang standarisasi pengetahuan dan pemahaman pertanian dasar. Implementasi penerapan teknologi tepat guna MOOC ini menggunakan metode asset-based community development dengan tujuan pemahaman pertanian dasar, standarisasi pendidikan pertanian dasar kepada masyarakat, dan proses inklusivitas pembelajaran yang bersifat terbuka. Proses penerapan MOOC terbukti efektif dengan standar materi pertanian dasar. Pelaksanaan program pengabdian berupa pendampingan dan pelatihan penggunaan MOOC Materi Ilmu Pertanian Dasar bagi kelompok tani desa Pacet, Kabupaten Mojokerto dinyatakan berhasil dan berdampak positif kepada masyarakat. Hal ini diketahui dari meningkatnya pengetahuan dan kemampuan warga mengenai konten yang disajikan maupun keterampilan abad 21 berupa literasi digital.

Students’ ICT literacy and conceptual knowledge correlation: from a genetic course and a gender perspective Dewi Murni; Sri Rahayu Lestari; Sri Endah Indriwati; Siti Zubaidah; Hendra Susanto; Paidi Paidi
International Journal of Evaluation and Research in Education (IJERE) Vol 13, No 1: February 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijere.v13i1.25237

The correlation between students’ information communication technology (ICT) literacy and conceptual knowledge from a gender perspective is essential to understanding the causal effects of student learning. Therefore, this study aimed to describe the relationship between students’ ICT literacy and conceptual knowledge in a genetics course, especially from a gender perspective. This study employed a descriptive research method that used randomized sampling. The instruments used were conceptual knowledge and ICT literacy test sheets. The data were analyzed by using analysis of variance (ANOVA) and Pearson correlational statistics. The results showed male students have higher ICT literacy than females. Otherwise, male students have a lower conceptual knowledge than females. Furthermore, male students’ ICT literacy and conceptual knowledge showed a strong relationship, while female students showed a weak relationship. The findings support the idea that integrating ICT into genetics curricula might help students develop their ICT literacy and conceptual knowledge more effectively, especially female students.

Peningkatan Nilai Tambah Buah Lokal di Desa Bangunsari melalui Pendampingan dan Pelatihan dalam Pengembangan Kue Buah Agung Witjoro; Ajeng Daniarsih; Hendra Susanto; Zahra Firdaus; Alby Aruna; Adinda Marcelliantika; M Iqbal Najib Fahmi; Eka Putri Surya
Prosiding Seminar Nasional Unimus Vol 6 (2023): Membangun Tatanan Sosial di Era Revolusi Industri 4.0 dalam Menunjang Pencapaian Susta
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Tujuan dari kegiatan pengabdian masyarakat ini untuk meningkatkan nilai tambah produk buah lokaldengan memberikan pelatihan praktis tentang cara mengolah buah menjadi kue buah. Kegiatan ini berhasilmeningkatkan pengetahuan dan keterampilan masyarakat lokal dalam mengolah buah-buahan lokal yangunik melalui pudding buah dengan pendekatan berbasis Asset Based Comunnity Development (ABCD).Hasil evaluasi menunjukkan peningkatan ekonomi masyarakat melalui peningkatan pendapatan daripenjualan kue buah. Kegiatan ini juga membantu menjaga keanekaragaman hayati buah lokal dan membukapeluang untuk pasar kue buah lokal yang lebih besar melalui produk unggulan dan partisipasi aktif petanibuah lokal Desa Bangunsari. Kata Kunci: Pemanfaatan, Nilai Tambah, Buah, Desa Bangunsari

Co-Authors *Ali Mustofa Achmada, Putra Fernanda Dwi Adeodatus Yuda Handaya Adim Firmansah Adinda Marcelliantika Aditya Rifqi Fauzi Afis Baghiz Syafruddin Agung Witjoro Agus Barmawi Agus Subagyo Agusta Rakhmat Taufani Agustina Tri Endharti Agustina, Rena Silvia Ahmad Hapiz Ahmad Khanali Ahmad Taufiq Ahmad Taufiq Ainul Mardiah Ajeng Daniarsih Alby Aruna Aldri Frinaldi Almas Dwi Khairana Amaliyah Firdaus, Sa’diyatul Rizqie Ananda, Oriny Tri Anastya Eka Kharisma Andi Basuki Andi Muharni Anggarani, Dinar Arsy Anggarani, Dinar Arsy Arsy Annisa, Yuslinda Anugrah Ricky Wijaya Arbin Janu Setiyowati, Arbin Ardana, I Kade Karisma Gita Ari Gunawan Ari Gunawan Ari Gunawan ARIF HIDAYAT Arif Hidayat Aripriharta - Arisatya Bharotoyakti Aruna, Alby Aulanni'am, Aulanni'am Aulanni’am Aulanni’am Azriel Farrel Kresna Aditya Bagus Priambodo Bahrullah Akbar Betty Lukiati Bogi Pratomo cahya, uci dwi Celiacika Gustisiwi Puteri Chang, Chun-Yen Choirunisa', Nindiana Chrisna Budi Satriyo Chusna, Nadiya Miftachul Claresia Tsany Kusmayadi Deny Setiawan Deny Setiawan Dewi Murni Dewi Sekar Miasih Diah Setiawati Didik Dwi Prastyo Didik Setyo Heriyanto Dinar Arsy Anggarani Dwi Listyorini Dyah Ika Krisnawati Dyah Kinasih Wuragil Eka Putri Surya El Baroroh, Alif Rosyidah Facthur Rohman Fatchur Rohman Fatchur Rohman Faturrahman Fauzi, M Imam Fitrah Amalia Salim Friska, Renny Futri Yuliana Fuzani, Sri Dinasyah Ratna H. Hardianto Hadi Suwono Hadi, Sholihul Hani Susianti HARDIANTO - Hari Rudijanto. IW Hermansyah Heru Wahyu Herwanto Hidayati Maghfiroh Husna Nur Wanah I Kade Karisma Gita Ardana I Made Wirawan Ibrohim Ida Ayu Setyawati Sri Krisna Dewi Ida Rohmah Susiani Ika Sasti Ferina, Ika Sasti Ikramina Yusti Amina Imam Sofii Indah Nur Laili Izza, Jasmine Nurul Janiar Pitulima Jasmine Nurul Izza Jasmine Nurul Izza Jerry Dwi Trijoyo Purnomo Joshua Andrew Judhiastuty Februhartanty Kamal Agung Yudayana Kevin Radinal Kharomah, Sinta Kormil Saputra Kristianty, Grace Triana Kusmahardhika, Noviansyah Kusmayadi, Claresia Tsany Kusnunnahari Kusnunnahari, Kusnunnahari Kustiariyah Tarman Lianto Lianto Linggasari, M.I. Dewi Lulik Inggarwati Lusttilanang, Pius Lya Rizka Herawati M Iqbal Najib Fahmi M. Ikhsan M. Rasjad Indra Maghfiroh, Hidayati Mariya Sulfa, Devi Markus Diantoro Marshanda Putri, Anggia Marwan Marwan Masruroh MASRUROH Mega Safithri Mega Ywana, Satya Miasih, Dewi Sekar Miftahul Hasanah Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Moch Sholeh Moch Sholeh Mochammad Imron Awalludin Moh. Zainul Falah Mohamad Amin Mohammed, Najib Muhammad Adib Amin Muhammad Rifqi Hariri Muhammad Saefi Muharni, Andi Murni Sapta Sari Najmi, M. Ikhwan Nik Ahmad Nizam Nik Malek Nik Malek, Nik Ahmad Nizam Nurcahya Setiawan Nurlita Indah Wahyuni, Nurlita Indah Nurul Izza, Jasmine Oktavia, Silvi Tri Oriny Tri Ananda Paidi Paundra Wangsa Fajar Kusuma Pramono, Agus Joko Prayogi, Moch. Bagus Putri Diyah Anggraini Putri, Kuntum Kinanthi Rachmawati , Hidajah Radhiyah, Rizqa Rajib Muhammad Basthony Rasjad Indra Ratnapuri, Adisti Rawe, Nining Sahara H A Restianto, Yanuar Retna Apsari Ricadonna Raissa Rizqa Radhiyah Robi, Fikri Syahir Rony Irawanto Rui Alfadel Saputra Rusdatul Isma S, Muh Akbar Sabrina, Andiani Salsa Salim, Fitrah Amalia Satia Nur Maharani Satria Adiguna Setyarini, Ni Luh Putu Shinta Setyawati Karyono Setyohadi, Taat Sholeh , Moch sholeh, moch Sholihah, Nida Anisatus Sholihul Hadi Sinta Kusuma Dewi Siti Maisaroh Siti Zubaidah Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Soenar Soekopitojo Sri Endah Indriwati Sri Rahayu Lestari Sri Rahmawati ST. Ulfawanti Intan Subadra Subadra, ST. Ulfawanti Intan Sudjari Sudjari Sudjari Sudjari Suharti Sujito . Sukiman . Sulfa, Devi Mariya Sunaryono Sunaryono Sunaryono, Sunaryono Supratman Tabba Susriyati Mahanal Suwarno Suwarno Suwistika, Rima Sya'rawi, Muhammad Akram Thahura, Farahdiba Tjahyono, Seto Tono, E.P.S.B Taman Tri Endharti, Agustina Umi Fitriyati Utami Sri Hastuti Verdamil, Ainun Cornelia Wahyu Pratama, Ade Wandreina, Lucky Meisya Wibi Riawan Wiedia Carullina Purwanti Wijiasih, Wijiasih Wira Eka Putra Wisnubroto Wisnubroto Wisnubroto, Wisnubroto Wiwin Apriani Yuda Handaya, Adeodatus Yudi Susanto Yuliana, Futri Yunita Rakhmawati Yuslinda Annisa Zahra Firdaus Zihan Novita Sari

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