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Hendra Susanto

Universitas Negeri Malang

Author-ID : 2685407

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Adiposopathy In Vitro Study The Effect of Toxoplasma Gondii Profilin Induction To The Expression of IL-6 and TNF-a as A Predictor Candidate of Adipocyte Dysfunction on Subcutan Adipocyte Culture Sudjari Sudjari; Hendra Susanto; Rasjad Indra
Research Journal of Life Science Vol 2, No 1 (2015)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Metabolic syndrome is a group of several risk factors consist of hypertension, dyslipidemia, glucose intolerance disorder, obesity, and has a relationship with CVD pathomechanism. WHO was report in 2003 more than 300 million adult in the world suffered from obesity. The role of adipose tissue in infectious diseases and adipocyte quality changes after exposure to pathogen has not been revealed. On the other hand, the prevalence of infectious diseases in developing country is still high. Previous studies proved a relationship between infection of Toxoplasma gondii and tissue dysfunction. Profilin is a membrane component of Toxoplasma gondii that able to stimulate expression of proinflammation cytokines through TLR-11 upregulation, and predicted able to trigger the adipocyte dysfunction. The aim of this study are to knows the effect of profilin exposure in vitro on subcutaneous adipocyte to the expression of IL-6 and TNF-α. The measurement of IL-6 and TNF-a levels was done by ELISA technique. The result showed profilin exposure doses 5, 15 and 25 ng / ml increasing IL-6. Profilin exposure cause adipocyte dysfunction through the increasing proinflammatory adipocytokine levels as pathomechanism of metabolic syndrome associated with adipose tissue.

Effectiveness of Genetic Module to Reduce Misconception Levels and Improve Cognitive Learning Outcomes of Grade XII Students of SMA Negeri 5 Malang Didik Dwi Prastyo; Mohamad Amin; Hendra Susanto
Journal of Disruptive Learning Innovation (JODLI) Vol 2, No 2 (2021)
Publisher : Universitas Negeri Malang

We investigate the effectiveness of module to reduce misconception and improve learning outcomes in genetic material using multiple choice test with CRI. This study using pre-experiment study with one group pretest post test design. This study reports the results of analysis of misconception level of XII grades in SMA Negeri 5 Malang reduce from 33.42 percent to 12.92 percent. Learning outcome increase from 38.30 into 72.96. These results indicate that the genetic module is effective to reducing the level of misconceptions and improving student cognitive learning outcomes.Keywords: Misconception, learning outcomes, genetic

Identification of Edible Macrofungi at Kerandangan Protected Forest & Natural Park, West Lombok Regency, Indonesia Ahmad Hapiz; Sukiman Sukiman; Faturrahman Faturrahman; Bagus Priambodo; Facthur Rohman; Hendra Susanto; Wira Eka Putra
Biota Vol 13 No 1 (2020)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v13i1.250

Indonesia is considered as a mega-biodiversity country that has a massive amount of vascular and non-vascular plants. The tropical environment condition of Indonesia could support the growth of macrofungi. Information about edible macrofungi from the Forest of Lombok Island is based on limited data. This research aims to characterize the edible macrofungi at Kerandangan Protected Forest & Natural Park, West Lombok Regency, Indonesia. This research was a descriptive and explorative study. The edible mushrooms were observed through the Cruise method by following the particular track inside the forest. The sample found in the forest then documented and evaluated. A morphological analysis procedure was performed to assess the profile and similarity between the microscopic evaluations with the mushrooms identification book. In this study, we also offered a phylogeny analysis based on morphological characters similarity. The Dendogram tree was reconstructed using PAST 3.0. software. The result showed that there are eight species of edible mushrooms found that were group into Basidiomycota, namely, Termitomyces clypeatus, Termitomyces umkowaan, Termitomyces sp.1, Pleorotus flabelatus, Pleurotus ostreatus, Coprinus desimenatus, Tremella fuciformis, and Polyporus sp. All of them involved in Basidiomycota. Based on characterization and identification, the species are grouped into three Ordos and five Families. Most of the edible macrofungi found at Kerandangan Protected Forest & Natural Park growth at soil and deadwood.

ANTI-INFLAMMATORY EFFECT OF PORTERWEED (Stachytarpheta Jamaicensis (L.) Vahl) LEAF EXTRACT TO TNF-α EXPRESSION Anastya Eka Kharisma; Hendra Susanto; Muhammad Rifqi Hariri
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 18 No 1 (2012): December 2012
Publisher : The East Java Biological Society

Porterweed (Stachytarpheta jamaicensis (L.) Vahl) contain many fl avonoids compound. It is a potential candidate to supress the inflammatory process through down regulation of TNF-α level as a potent pro-infl ammatory cytokine in chronic infl ammation cases. The aim of this research was to improve the effect of Porterweed leaf extract to the TNF-α level and considered the optimum dosage in wistar rats with chronic infl ammation model. Twenty fi ve rats was divided into negative control group, positive control group, and treatment groups with dosage 50, 100 and 150 mg/kg BW. Data obtained through microscopical histologic observation on aortic organafter immunohistochemistry staining and was analyzed descriptively. The result revealed that Porterweed leaf extract is able to inhibit the increasing of TNF-α level. This phytochemical substance is predicted capable of preventing the oxidation reaction progession ofcyclooxygenase-2 (COX-2) to produce prostaglandins. The decreasing of prostaglandin level causes a negative feedback to TNF-α production and iniciating the declining level of TNF-α. Thus, the Porterweed leaf extract indicates supress chronic infl ammatory process through down regulation of TNF-α and prostaglandin activity in optimum dose 150 mg/kg bw.

Physiological alteration and the expression of fibrogenesis-proinflammatory genes in hepatocellular carcinoma patients with chronic hepatitis C and onset metabolic syndrome: a preliminary report at Saiful Anwar General Hospital Malang Hendra Susanto
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 28 No 1 (2022): December 2022
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/bphjbr.28.1.20225

Hepatocellular carcinoma (HCC) is one type of cancer that is included in the fifth order of cancer that causes death in the world. The highest incidence of liver cancer is found in men. Liver function related to the metabolism of various endogenous and exogenous substances is prone to chronic inflammatory stimulation, one of which is hepatitis C virus (HCV) infection. TGF-β1, NOX4, and TNF-α are three potential genes responsible for regulating chronic inflammation and fibrogenesis. This study aims to describe the profile of potential fibrogenesis and inflammation genes that play a role in the progression of HCC due to chronic hepatitis C. This type of research is a descriptive study with a quantitative approach that was carried out using Quantitative Real-Time PCR analysis. The results of serological tests in the male gender group showed that the average fasting body glucose level was 85.22 mg/dL, total cholesterol 242 mg/dL, triglyceride 158.44 mg/dL, HDL-C 18.56 mg/dL, and LDL-C 172 mg/dL. In the female gender group, the data obtained on average levels of fasting blood glucose 82.33l mg.dL, total cholesterol 350 mg/dL, triglyceride 181 mg/dL, HDL-C 29 mg/dL, and LDL-C 190 mg/dL. All gender groups also showed an increase in AST and ALT levels that had exceeded normal limits. The expression of fibrosis-related genes, namely TGF-β1 was 5.8x higher in male patients than female patients. The NOX4 gene also showed almost the same thing, namely, its expression level was 1.2 times higher in male patients. From the expression of the proinflammatory cytokine TNF-, it is also known that in male patients, the expression level is 2x times higher than in female patients. The difference in expression levels in the two groups involved a repressive mechanism of estrogen. Increased expression levels of TGF-β1, NOX4, and TNF- genes are thought to involve the activity of the HCV core protein, which then induces several signaling pathways such as NF-κB and SMAD3. From these results, the expression levels of TGF-β1, NOX4, and TNF- as the main regulators of chronic inflammation and fibrosis can describe the progression of HCC and can be used as initial data on the profile of inflammation and fibrogenesis in HCC cases that have previously been exposed to HCV infection.

Anti-liver fibrosis of green materials Moringa oleifera seed oils from Madura Island against hepatocellular carcinoma development Hendra Susanto; Ahmad Taufiq; Nik Ahmad Nizam Nik Malek; Wira Eka Putra
Biogenesis: Jurnal Ilmiah Biologi Vol 10 No 1 (2022)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v10i1.27464

Pemberian Dietilnitrosamin dan Karbontetraklorida Pada Gambaran Histologi Ginjal Tikus (Rattus Norvegicus) Almas Dwi Khairana; Ricadonna Raissa; Wibi Riawan; Suharti Suharti; Hendra Susanto; Aulanni’am Aulanni’am
Jurnal Ilmiah Kesehatan (JIKA) Vol. 4 No. 1 (2022): Volume 4 Nomor 1 April 2022
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v4i1.242

Diethylnitrosamine (DEN) is a metabolic product of various foods and beverages in which there are preservatives in the form of nitrate and nitrite. Nitrosamines are found in various products such as alcoholic beverages, processed meats, cigarettes, and cosmetic products. DEN is toxic and carcinogenic to organs such as the liver, lungs, kidneys, skin, stomach, and blood. In addition to giving DEN compounds, there are also CCl4 compounds as tumor promoter agents known as genotoxic substances that can increase the risk of genetic errors and stimulate cells to become malignant neoplasms. Administration of DEN and CCl4 induction can damage various organs of the body, one of which is the kidney. In a healthy body, angiogenesis plays a role in wound healing and the formation of new tissue. However, angiogenesis also contributes to carcinogenesis or the uncontrolled growth of cancer cells, and is malignant when the body is contaminated with toxic substances. Therefore, to determine the effect of the administration of DEN and CCl4 observations were made using the immunohistochemical method, to see differences in the histology of the kidneys of experimental animals, the positive control group, and the negative control group based on the VEGF angiogenesis factor. From these results, there are significant differences. In the negative group, there was no necrosis and high-value VEGF expression, but in the positive group, there was necrosis and a decrease in the value of VEGF expression compared to the negative control group.

PENGARUH KOORDINASI TERHADAP PENINGKATAN KEAMANAN DI KAWASAN WISATA PANTAI ANYER OLEH DITPAMOBVIT POLDA BANTEN Hendra Susanto
Business Journal : Jurnal Bisnis Dan Sosial Vol 8 No 1 (2022): Mei
Publisher : Program Studi Administrasi Bisnis, Fakultas Komunikasi dan Bisnis, Universitas Telkom

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25124/businessjournal.v8i1.5225

Penelitian ini bertujuan mengetahui seberapa besar pengaruh koordinasi oleh Ditpamobvit Polda Banten terhadap peningkatan keamanan di kawasan wisata Pantai Anyer. Penelitian ini menggunakan metode kuantitatif dan korelatif. Permasalahan diteliti secara komprehensif, mendalam dan menelaah variabel-variabel yang ada. Dari populasi yang ada seluruhnya dijadikan responden yaitu sebanyak 48 orang. Pengujian hipotesisi dilakukan dengan menggunakan analisis kuantitatif dan menggunakan pengujian statistik dengan rumus Rank Spearman. Adapun hasil perhitungan untuk hipotesis tentang besar pengaruh koordinasi oleh Ditpamobvit Polda Banten terhadap peningkatan keamanan di kawasan wisata Pantai Anyer menunjukkan angka korelasi 0.9752 artinya hubungan yang sangat kuat. Sedangkan koefisien determinasi koordinasi dengan keamanan di kawasan wisata Pantai Anyer sebesar 95.11%, Sedangkan sisanya yaitu 4.89% keamanan dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells Dewi Sekar Miasih; Yuslinda Annisa; Sri Rahayu Lestari; Hendra Susanto; Sunaryono
Science and Technology Indonesia Vol. 7 No. 4 (2022): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Single bulb garlic (SBG) has the potential as an immunomodulator; however, it has low solubility and bioavailability. A lipid-based delivery system, that is, the self-nanoemulsifying drug delivery system (SNEDDS), offers a novel opportunity in drug delivery. SBG can be a suitable candidate for SNEDDS development. This research aims to describe the physical stability, toxicity test of the SNEDDS, and SNEDDS SBG potential as antiinflammation in 3T3-L1 cells. The SNEDDS is made with various ratios of concentrations of carrier oil, surfactants, and cosurfactants, namely, 0.50: 3.45: 0.96, and added with SBG extract (SBGE) of 20 mg/mL. The results of the response test of SNEDDS SBGE formulation indicate an average and standard deviation of emulsification time of 16.38±3.01 (second), pH 7.21±0.08, and transmittance of 98.40±0.23(%). The average nanoemulsion size is 14.333±0.416 nm, polydispersion index of 0.213±0.056, and zeta potential of -14.67±0.72 mV. The results of the physical stability test indicate no segregation, deposition, cracking, or creaming in all nanoemulsion samples and SNEDDS SBG. The MTT test in a dose of 62.5, 125, 250, 500, 100, 2000, and 4000 µg/mL suggests that the highest viability of the 3T3-L1 cells is at a dose of 2000 µg/mL, which is 97.83%±1.55%. Therefore, SNEDDS SBGE can be a potential candidate for oral preparation by increasing bioavailability and reducing toxicity in the 3T3-L1 cells. An antiinflammatory test on the TNF-???? and IL-1???? expressions influences the 3T3-L1 cells. the SNEDDS of SBGE has the potential to reduce the expression of TNF-???? and IL-1???? and increase IL-10 expression in the methylglyoxal-induced 3T3-L1 cells.

Mutation Analysis and Single Nucleotide Polymorphism of TP53 Gene in Breast Cancer in East Java Rizqa Radhiyah; I Kade Karisma Gita Ardana; Wisnubroto Wisnubroto; Dwi Listyorini; Hendra Susanto
Journal of Tropical Life Science Vol. 11 No. 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.12

The Incidence of Indonesia breast cancer case in 2018 was reported at 20.7% or 160,653 in number. The factors that caused breast cancer is TP53 gene mutation and Single Nucleotide Polymorphism (SNP). This study aimed to determine the mutation and Single Nucleotide Polymorphism (SNP) of TP53 gene in breast cancer. Samples of this study were 9 people chosen based on a purposive technique. The methods include total DNA isolation, DNA quantification, PCR, and sequencing. The results of the sequencing were then analyzed using alignment and blast. The SNP is browsed by the SNP finder on NCBI both followed by protein modeling. The results of this study indicate the existence of mutation in the exon and intron regions. Substitution of Guanine (G) to base Adenine (A) is occur in codon 496 which is a coding region. SNP was also obtained in exon of sample 12. The conclusion of this study is breast cancer can be caused by mutations that occur in the exon and altered the structur of protein structure, so then affect the binding affinity between p53 and its target domain. Tp53 gene mutation is not the only cause of breast cancer staging development, there are other genes that also contribute to the development of cancer stage. In addition, Single Nucleotide Polymorphism in the TP53 gene can be used as a predisposition marker of breast cancer that has potential to be inherited

Co-Authors *Ali Mustofa Achmada, Putra Fernanda Dwi Adeodatus Yuda Handaya Adim Firmansah Adinda Marcelliantika Aditya Rifqi Fauzi Afis Baghiz Syafruddin Agung Witjoro Agus Barmawi Agus Subagyo Agusta Rakhmat Taufani Agustina Tri Endharti Agustina, Rena Silvia Ahmad Hapiz Ahmad Khanali Ahmad Taufiq Ahmad Taufiq Ainul Mardiah Ajeng Daniarsih Alby Aruna Aldri Frinaldi Almas Dwi Khairana Amaliyah Firdaus, Sa’diyatul Rizqie Ananda, Oriny Tri Anastya Eka Kharisma Andi Basuki Andi Muharni Anggarani, Dinar Arsy Anggarani, Dinar Arsy Arsy Annisa, Yuslinda Anugrah Ricky Wijaya Arbin Janu Setiyowati, Arbin Ardana, I Kade Karisma Gita Ari Gunawan Ari Gunawan Ari Gunawan ARIF HIDAYAT Arif Hidayat Aripriharta - Arisatya Bharotoyakti Aruna, Alby Aulanni'am, Aulanni'am Aulanni’am Aulanni’am Azriel Farrel Kresna Aditya Bagus Priambodo Bahrullah Akbar Betty Lukiati Bogi Pratomo cahya, uci dwi Celiacika Gustisiwi Puteri Chang, Chun-Yen Choirunisa', Nindiana Chrisna Budi Satriyo Chusna, Nadiya Miftachul Claresia Tsany Kusmayadi Deny Setiawan Deny Setiawan Dewi Murni Dewi Sekar Miasih Diah Setiawati Didik Dwi Prastyo Didik Setyo Heriyanto Dinar Arsy Anggarani Dwi Listyorini Dyah Ika Krisnawati Dyah Kinasih Wuragil Eka Putri Surya El Baroroh, Alif Rosyidah Facthur Rohman Fatchur Rohman Fatchur Rohman Faturrahman Fauzi, M Imam Fitrah Amalia Salim Friska, Renny Futri Yuliana Fuzani, Sri Dinasyah Ratna H. Hardianto Hadi Suwono Hadi, Sholihul Hani Susianti HARDIANTO - Hari Rudijanto. IW Hermansyah Heru Wahyu Herwanto Hidayati Maghfiroh Husna Nur Wanah I Kade Karisma Gita Ardana I Made Wirawan Ibrohim Ida Ayu Setyawati Sri Krisna Dewi Ida Rohmah Susiani Ika Sasti Ferina, Ika Sasti Ikramina Yusti Amina Imam Sofii Indah Nur Laili Izza, Jasmine Nurul Janiar Pitulima Jasmine Nurul Izza Jasmine Nurul Izza Jerry Dwi Trijoyo Purnomo Joshua Andrew Judhiastuty Februhartanty Kamal Agung Yudayana Kevin Radinal Kharomah, Sinta Kormil Saputra Kristianty, Grace Triana Kusmahardhika, Noviansyah Kusmayadi, Claresia Tsany Kusnunnahari Kusnunnahari, Kusnunnahari Kustiariyah Tarman Lianto Lianto Linggasari, M.I. Dewi Lulik Inggarwati Lusttilanang, Pius Lya Rizka Herawati M Iqbal Najib Fahmi M. Ikhsan M. Rasjad Indra Maghfiroh, Hidayati Mariya Sulfa, Devi Markus Diantoro Marshanda Putri, Anggia Marwan Marwan Masruroh MASRUROH Mega Safithri Mega Ywana, Satya Miasih, Dewi Sekar Miftahul Hasanah Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Moch Sholeh Moch Sholeh Mochammad Imron Awalludin Moh. Zainul Falah Mohamad Amin Mohammed, Najib Muhammad Adib Amin Muhammad Rifqi Hariri Muhammad Saefi Muharni, Andi Murni Sapta Sari Najmi, M. Ikhwan Nik Ahmad Nizam Nik Malek Nik Malek, Nik Ahmad Nizam Nurcahya Setiawan Nurlita Indah Wahyuni, Nurlita Indah Nurul Izza, Jasmine Oktavia, Silvi Tri Oriny Tri Ananda Paidi Paundra Wangsa Fajar Kusuma Pramono, Agus Joko Prayogi, Moch. Bagus Putri Diyah Anggraini Putri, Kuntum Kinanthi Rachmawati , Hidajah Radhiyah, Rizqa Rajib Muhammad Basthony Rasjad Indra Ratnapuri, Adisti Rawe, Nining Sahara H A Restianto, Yanuar Retna Apsari Ricadonna Raissa Rizqa Radhiyah Robi, Fikri Syahir Rony Irawanto Rui Alfadel Saputra Rusdatul Isma S, Muh Akbar Sabrina, Andiani Salsa Salim, Fitrah Amalia Satia Nur Maharani Satria Adiguna Setyarini, Ni Luh Putu Shinta Setyawati Karyono Setyohadi, Taat Sholeh , Moch sholeh, moch Sholihah, Nida Anisatus Sholihul Hadi Sinta Kusuma Dewi Siti Maisaroh Siti Zubaidah Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Soenar Soekopitojo Sri Endah Indriwati Sri Rahayu Lestari Sri Rahmawati ST. Ulfawanti Intan Subadra Subadra, ST. Ulfawanti Intan Sudjari Sudjari Sudjari Sudjari Suharti Sujito . Sukiman . Sulfa, Devi Mariya Sunaryono Sunaryono Sunaryono, Sunaryono Supratman Tabba Susriyati Mahanal Suwarno Suwarno Suwistika, Rima Sya'rawi, Muhammad Akram Thahura, Farahdiba Tjahyono, Seto Tono, E.P.S.B Taman Tri Endharti, Agustina Umi Fitriyati Utami Sri Hastuti Verdamil, Ainun Cornelia Wahyu Pratama, Ade Wandreina, Lucky Meisya Wibi Riawan Wiedia Carullina Purwanti Wijiasih, Wijiasih Wira Eka Putra Wisnubroto Wisnubroto Wisnubroto, Wisnubroto Wiwin Apriani Yuda Handaya, Adeodatus Yudi Susanto Yuliana, Futri Yunita Rakhmawati Yuslinda Annisa Zahra Firdaus Zihan Novita Sari

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