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All Journal Acta Pharmaceutica Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Best Journal (Biology Education, Sains and Technology) PREPOTIF : Jurnal Kesehatan Masyarakat ad-Dawaa : Journal of Pharmaceutical Sciences Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Riset Kefarmasian Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Madaniya Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Chemical Science and Technology Jurnal Kesehatan Tambusai Jurnal Pengabdian Masyarakat (ABDIRA) Indonesian Journal of Pharmaceutical Education JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth FORTE JOURNAL Jurnal Farmanesia Journal of Health and Medical Science International Journal of Health and Pharmaceutical (IJHP) Jurnal Ilmu Psikologi dan Kesehatan Jurnal Farmasi Klinik dan Sains FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Jurnal Ilmu Kesehatan dan Gizi Journal of Pharmaceutical and Sciences. Indonesian Journal of Education And Computer Science FASKES : Jurnal Farmasi, Kesehatan, dan Sains Medic Nutricia : Jurnal Ilmu Kesehatan Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Seroja Husada: Jurnal Kesehatan Masyarakat Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan J-CEKI
Haris Munandar Nasution
Faculty Of Pharmacy, Universitas Muslim Nusantara Al Washliyah, Medan, North Sumatera, Indonesia
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Formulasi dan Evaluasi Sediaan Permen Marshmalow Sari Buah Anggur Merah (Vitis vinifera L.) Nuratika, Eli; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.860

Abstract

Candy serves as a high-calorie source often consumed during activities such as working, exercising, and studying. Typically, the most common candies available in the market are soft candies with a chewy texture. When made with real fruit juice, these candies can provide additional nutrients, minerals, and vitamins to the body. This study aimed to formulate marshmallow candy using red grape juice (Vitis vinifera L.) as the main ingredient, with variations of sucrose and honey, to create a product with appealing taste, texture, and nutritional value suitable for both children and adults. The study also evaluated the physical quality of the formulated marshmallow candy. Methods: This experimental research utilized the open pan method to produce marshmallow candy. The evaluation included organoleptic tests (shape, color, aroma, taste, texture), pH testing, weight uniformity analysis, moisture content measurement, ash content determination, and hedonic testing involving 15-21 panelists. Results: All formulations (F1, F2, F3) met physicochemical quality standards, with a pH of 5, moisture content of 6.5-8.1%, ash content of 1.3-1.8%, and weight variation coefficients of 2.55-2.73%. Based on hedonic testing, formulation F2 (5 g sucrose + 44 g honey) was the most preferred, receiving the highest scores for taste, shape, and texture. Conclusion: Red grape juice was successfully formulated into marshmallow candy that meets standard physicochemical quality requirements. The combination of sucrose and honey significantly influenced product characteristics, with F2 being the optimal formulation based on consumer preference. This study contributes to the development of functional food products using natural, nutrient-rich ingredients.
Pengaruh Metode Ekstraksi Daun Jarak Cina (Jatropha multifida L.) Secara Maserasi dan Microwave-Assisted Extraction (MAE) Terhadap Aktivitas Antijamur Pada Candida albicans Aryunda, Divia; Nasution, Muhammad Amin; Nasution, Haris Munandar; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.868

Abstract

Introduction: Indonesia possesses high biodiversity, including the Jatropha multifida L. plant, which contains secondary metabolites with potential antimicrobial properties. Traditionally, the leaves of Jatropha multifida have been used as herbal medicine, particularly for inhibiting the growth of microorganisms. Objective: This study aims to determine the total flavonoid content in the ethanol extract of Jatropha multifida leaves and to compare the effectiveness of two extraction methods, maceration and Microwave-Assisted Extraction (MAE), in inhibiting the growth of Candida albicans. Methods: The research stages included the characterization of the powdered simplicia, extraction of Jatropha multifida leaves using 96% ethanol by maceration and MAE methods, and phytochemical screening. The total flavonoid content was determined using UV-Vis spectrophotometry at a wavelength of 431 nm. Antifungal activity against Candida albicans was tested for each extract at specific concentrations. Results: The ethanol extract obtained through maceration showed a total flavonoid content of 34.7089 ± 0.1206 mg QE/g, while the MAE method yielded 32.1923 ± 0.1113 mg QE/g. The highest antifungal activity was observed in the MAE extract at a 75% concentration, producing an inhibition zone of 24.7 mm. The maceration extract at the same concentration produced an inhibition zone of 23.7 mm. As a positive control, 2% ketoconazole resulted in an inhibition zone of 31.4 mm. Conclusion: Although the maceration method produced a higher total flavonoid content, the extract obtained through the MAE method demonstrated more potent antifungal activity against Candida albicans at the same concentration.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Sabun Cair Ekstrak Etanol Daun Kopi Arabika (Coffea arabica L.) Terhadap Bakteri Staphylococcus aureus Amaliana, Amaliana; Nasution, Haris Munandar; Lubis, Minda Sari; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.872

Abstract

Coffee leaves (Coffea arabica L.) are a part of the coffee plant that is not widely used. Coffee leaves contain flavonoids, alkaloids, saponins, caffeine and polyphenols. Coffee leaves are a natural ingredient that has antibacterial and antioxidant activity, so they need to be used. develop it into pharmaceutical preparations to increase ease of use, one of which is liquid soap preparations The aim of this research was to determine the secondary metabolite content of simplicia powder and ethanol extract of coffee leaves, formulate ethanol extract of coffee leaves into liquid soap, determine the physical quality of the preparation and test the activity against Staphylococcus aureus bacteria. The method used in this research is to make a liquid soap formulation from Arabica coffee leaves and test its effectiveness as an antibacterial against Staphylococcus aureus bacteria. This research was carried out experimentally with the independent variable being the concentration of Arabica coffee leaf ethanol extract: F1 contains 2.5 grams of active substance, F2 contains 5.0 grams of active substance, F3 contains 7.5 grams of active substance, dependent variable: leaf simplicia phytochemical screening test Arabica coffee, antibacterial activity test against Staphylococcus aureus bacteria. Quality of liquid soap preparations from ethanol extract of Arabica coffee leaves using stability tests (pH of the preparation, homogeneity, viscosity and height of foam) and antibacterial tests using the agar diffusion method (well method). The research results show that simplicia powder and ethanol extract of coffee leaves contain alkaloid, flavonoid, tannin and saponin chemical compounds. The organoleptic test results of liquid soap have a distinctive smell, a combination of coffee and rose leaves, are blackish brown in color, and are in the form of a thick liquid. The stability test results of all formulas are stable. The pH test ranges from 9.05 to 9.43. Test foam height 35- 40 mm. The viscosity test results ranged from 735.0-894.8 cpoise, antibacterial activity had an k- (Blanko) concentration inhibition zone of  13,6 mm FI concentration liquid soap obtained a result of 15.7 mm, FII concentration liquid soap obtained a result of 18.4 mm, FIII concentration liquid soap obtained a result of 18.75 mm compared to the control positive obtained a result of 18.8 mm.
Konsentrasi Hambat Minimum dan Konsentrasi Bunuh Minimum Ekstrak dan Nanopartikel Ekstrak Etanol Daun Kubis (Brassica oleracea L.) Terhadap Malassezia furfur Rafika, Intan Maya; Rahayu , Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.874

Abstract

Background: Dandruff is a condition characterized by excessive shedding of dead skin cells on the scalp, often accompanied by itching and inflammation. The causes of dandruff can be related to excessive secretion of sweat glands or the presence of microorganisms on the scalp that produce specific metabolites that trigger dandruff formation. The organism believed to be the leading cause of dandruff is Malassezia furfur. Treatment for dandruff can be done through various methods, one of which is using natural extracts, such as ethanol cabbage extract, known for its antifungal properties. In this study, the ethanol cabbage extract will be synthesized into nanoparticle form to enhance its effectiveness. Objective: The objective of this study is to create nanoparticles from ethanol cabbage extract and to compare the antifungal activity of the cabbage extract and the nanoparticle extract of cabbage against Malassezia furfur, focusing on the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). Method: This study was conducted experimentally, and two variables were tested. The independent variables included the concentration of cabbage extract (6.25%, 12.5%, 25%, and 50%) and nanoparticle cabbage extract (0.625%, 1.25%, 2.5%, and 5%). The dependent variables were the antifungal activity measured by MIC and MFC tests against Malassezia furfur. Nanoparticles were synthesized using the top-down method with high-speed homogenization (HSH) technique. The particle size characterization was performed using a Particle Size Analyzer (PSA). Results: Particle size characterization showed that the particle size of cabbage extract was 2203.45 nm, while the nanoparticle size after synthesis was 408.33 nm. Based on the MIC and MFC tests, it was found that the nanoparticle ethanol cabbage extract at a concentration of 1.25% was more effective than the ethanol cabbage extract at 12.5%. Additionally, the MFC value of the nanoparticle ethanol cabbage extract at a concentration of 5% was more effective than that of the ethanol cabbage extract at 50%. Both preparations demonstrated good sensitivity against Malassezia furfur. Conclusion: Nanoparticle ethanol cabbage extract showed better antifungal activity than the ethanol cabbage extract at higher concentrations. These results indicate that using nanoparticles can reduce the required dosage to achieve optimal effectiveness, thus improving the efficiency of the drug in dandruff treatment.
Konsentrasi Hambat Minimum dan Konsentrasi Bunuh Minimum Ekstrak Dan Nanopartikel Ekstrak Daun Pometia pinnata Terhadap Staphyloccocus aureus dan Escherichia coli Sony , Suyefri; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.885

Abstract

Background: Infectious diseases caused by bacteria such as Escherichia coli and Staphylococcus aureus have become a global health issue. Matoa leaves (Pometia pinnata) are known to contain antibacterial compounds that hold potential as alternative treatments. Objective: This study aimed to produce nanoparticles from the ethanol extract of matoa leaves and compare the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values of both the extract and its nanoparticles against Escherichia coli and Staphylococcus aureus. Methods: This experimental research used different concentrations of matoa leaf ethanol extract (6.25%, 12.5%, 25%, 50%) and nanoparticle extract (0.625%, 1.25%, 2.5%, 5%). Nanoparticle characterization was performed using a Particle Size Analyzer (PSA). Results: The nanoparticle characterization showed a size of 528.95 nm. The MIC value of the matoa leaf extract against Escherichia coli and Staphylococcus aureus was 12.5%, while for the nanoparticles, it was 1.25%. The MBC value of the matoa leaf extract was 50%, and for the nanoparticles, it was 5%. The highest antibacterial activity of the ethanol extract was 18.3 mm and 18.4 mm, while for the nanoparticles, it was 18.5 mm and 19.0 mm. Conclusion: The nanoparticle extract of matoa leaves was more effective in inhibiting and killing bacteria compared to the regular extract, with a lower dose (1:10), showing its potential as an efficient antibacterial alternative.
Formulasi, Evaluasi dan Penentuan Nilai SPF Serta Uji Kelembaban Perona Pipi Stik Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb Hutagalung , Septi Ratna Cempaka; Yuniarti , Rafita; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.886

Abstract

Background: Blush is traditionally used to add color to cheeks, but UV exposure poses significant skin damage risks. Dayak onion (Eleutherine palmifolia), containing anthocyanins as natural pigments and photoprotective compounds, shows potential as a multifunctional blush ingredient. Objectives: The aim of this study is to determine whether Bawang Dayak can be formulated as a natural colorant for blushers, whether Bawang Dayak extract possesses sun protection properties, and whether the ethanol extract of Bawang Dayak blusher has sun protection and skin moisturizing abilities. Methods: An experimental study employing quantitative and qualitative approaches was conducted. The research stages included material characterization, phytochemical screening, SPF testing of extract and formulations, physical quality evaluation (homogeneity, stability, adhesiveness), and in vivo skin hydration testing. Ethanolic Dayak onion extract samples were prepared at varying concentrations (100-1000 ppm). Results: The ethanolic extract was successfully formulated into stick blush meeting standard physical quality criteria. The extract demonstrated ultra SPF ratings (1000 ppm: SPF 32; 700 ppm: SPF 25; 500 ppm: SPF 21) to minimal protection (100 ppm: SPF 4). The 1000 ppm blush formulation showed ultra SPF 29, while the 700 ppm formula (F2) exhibited the highest skin moisturizing capacity. Conclusion: Dayak onion shows promise as both a natural colorant and active sunscreen agent in blush formulations. The developed product meets physical quality standards while offering dual functionality as a color cosmetic with UV protection.
Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Etanol Dedak Padi (Oryza sativa L.) terhadap Kebocoran Membran Bakteri Staphylococcus aureus Auza , Maharani; Nasution , Haris Munandar; Pulungan , Ainil Fithri; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.907

Abstract

Background: Rice bran is commonly utilized only as animal feed and is often regarded as a byproduct of rice milling. However, rice bran contains flavonoid compounds that exhibit antibacterial activity. This study aims to explore the potential of rice bran as an antibacterial agent, specifically against Staphylococcus aureus, through antibacterial activity testing and analysis of cell membrane leakage mechanisms. Objective: This research aims to utilize rice bran by evaluating its antibacterial activity and its mechanism of bacterial membrane leakage against Staphylococcus aureus. Methods: This experimental study involved the collection of rice bran samples, plant determination, simplicia characterization, and extraction using maceration with 96% ethanol. Phytochemical screening was conducted to identify active compounds, while antibacterial activity was tested using the disk diffusion method (Kirby-Bauer) at concentrations of 10%, 12.5%, 25%, 50%, 70%, and 80%. The membrane leakage mechanism was assessed by measuring nucleic acid and protein leakage (UV-Vis spectrophotometry) as well as Ca²⁺ and K⁺ ion release (atomic absorption spectrophotometry, AAS). Data were statistically analyzed using SPSS. Results: The ethanolic extract of rice bran yielded a 26.38% extraction yield and contained secondary metabolites, including alkaloids, flavonoids, tannins, saponins, triterpenoids/steroids, and glycosides. The antibacterial assay revealed inhibition zones classified as strong activity. Furthermore, rice bran extract induced membrane leakage in S. aureus, evidenced by increased mean absorbance values and standard deviations for DNA, protein (UV-Vis spectrophotometry), and Ca²⁺ and K⁺ ions (atomic absorption spectrophotometry) with rising extract concentrations. Conclusion: Rice bran exhibits potential as an antibacterial agent against Staphylococcus aureus through a membrane leakage mechanism. These findings support the utilization of rice bran not only as animal feed but also as a source of bioactive antimicrobial compounds.
Formulasi dan Uji Mutu Fisik Krim Antiperspirant dari Ekstrak Kunyit Putih (Curcuma zedoaria (Berg.) Roscoe) Syafira, Nona; Dalimunthe , Gabena Indrayani; Lubis, Minda Sari; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.916

Abstract

Background: Curcuma zedoaria (Berg.) Roscoe, commonly known as white turmeric, is a plant from the Zingiberaceae family that contains bioactive compounds such as curcumin, flavonoids, alkaloids, saponins, and tannins. These compounds have potential as natural antiperspirants due to their astringent and antimicrobial properties, which can reduce sweat production and prevent body odor. The use of synthetic antiperspirants containing aluminum chloride often causes skin irritation, highlighting the need for safer, natural alternatives. Objective: This study aims to formulate an antiperspirant cream using white turmeric (Curcuma zedoaria (Berg.) Roscoe) extract with good physical quality and to evaluate the effectiveness of various concentrations in inhibiting sweat production. Methods: This experimental study involved extracting white turmeric using 96% ethanol through maceration, followed by concentration with a rotary evaporator. The antiperspirant cream was formulated with varying extract concentrations. Physical quality evaluations included organoleptic testing, homogeneity, pH, stability, viscosity, adhesion, spreadability, cream type, as well as irritation and antiperspirant tests on volunteers. Results: Phytochemical screening showed that the white turmeric extract contains alkaloids, flavonoids, saponins, and tannins. The cream with a 17.5% extract concentration demonstrated the highest antiperspirant effectiveness compared to 7.5% and 12.5% concentrations. All formulations met physical quality standards, including pH (4.5–6.5), viscosity (2,700–23,020 cP), and 14-day stability without significant changes. Conclusion: The white turmeric-based antiperspirant cream met physical quality standards and exhibited significant antiperspirant effects, particularly at a 17.5% concentration. This study demonstrates the potential of white turmeric as a safe and effective natural active ingredient in antiperspirant formulations.
Uji Antibakteri Ekstrak Etanol Daun Mangga Golek (Mangifera indica L.) terhadap Bakteri Staphylococcus aureus: Antibacterial Test of Ethanol Extract of Golek Mango Leaves (Mangifera indica L.) Against Staphylococcus aureus Bacteria Yuniarti, Rafita; Rukmana, Siti; Nasution, Haris Munandar; Rani, Zulmai; Fauzi, Ziza Aisyia Putri
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2427

Abstract

Mango golek is among the numerous beneficial plants in the Mangifera genus. Mango leaves have antibacterial, antifungal, antiviral, and antiparasitic properties. The purpose of this research was to determine how effective an ethanol extract of mango golek leaves was against Staphylococcus aureus bacteria and what kind of secondary metabolites were present in the extract. This study employed laboratory experimental methods such as the maceration method with 70% ethanol solvent, phytochemical screening test, and Mango golek leaf extract (Mangifera indica L.) Staphylococcus aureus antimicrobial activity test at various concentrations of 100 mg/day. mL, 70, 50, 30, and 10 mg/mL using the agar diffusion method. Mango golek leaves ethanol extract included alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids, according to the screening results. values of 100 mg/mL and 70 mg/mL were considered high, while values of 50 and 30 mg/mL were considered moderate. Keywords:          cMangifera indica L., Staphylococcus aureus   Abstrak Salah satu tanaman dari genus Mangifera adalah mangga golek yang memiliki banyak manfaat. Salah satu keuntungan adalah sifat antiparasit, antijamur, antivirus, dan antibakterinya. Tujuan penelitian ini adalah untuk mengetahui seberapa efektif ekstrak daun mangga golek terhadap Bakteri Staphylococcus aureus dan mengidentifikasi metabolit sekundernya. Dalam penelitian ini, menggunakan metode eksperimental yang meliputi uji fitokimia, pembuatan pelarut etanol 70% dari ekstrak daun mangga golek (Mangifera indica L.), dan uji antibakteri Staphylococcus aureus dengan konsentrasi 100, 70, 50, 30, dan 10 mg/mL menggunakan metode difusi agar. Hasil skrining, ekstrak etanol daun mangga golek mengandung alkaloid, flavonoid, saponin, tanin, dan steroid/triterpenoid. Uji antibakteri, ekstrak daun mangga golek memiliki sifat antimikroba Staphylococcus aureus dengan kategori kuat 100 dan 70 mg/mL dan kategori sedang 50 dan 30 mg/mL. Kata Kunci:         Antibakteri, Mangifera indica L, Staphylococcus aureus
Determination of Total Alkaloid Content of Raru (Cotylelobium lanceolatum Craib) Bark Extract Using UV-ViS Spectrophotometry Method andriani, cici; Daulay, Anny Sartika; Ridwanto, Ridwanto; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i1.10

Abstract

The raru plant (Cotylelobium  lanceolatum Craib) comes from the Dipterocarpaceae family. Raru bark is usually added to the wine to enhance the taste of the wine. raru bark has antidiabetic compounds as a lowering of sugar levels in the blood. The purpose of this study was to determine the alkaloids in the Raru plant (Cotylelobium   lanceolatum  Craib) and to determine the total alkaloid content found in the Raru plant (Cotylelobium  lanceolatum  Craib). The extraction method used is the maceration extraction method using methanol solvent with various concentrations which is then evaporated with a rotary evaporator. Whereas the quantitative test was carried out by means of the viscous extract obtained by adding 2 mL of Phosphate buffer with a pH of 4.7, 2 mL of bromocresol green (BCG), and measured at a wavelength of 272.705 nm. The yield of the extract from a concentration of 95% was 23.0779%, a concentration of 70% was 21.2144%, a concentration of 50% was 20.3274%. The correlation equation obtained from the caffeine curve is y = 0.0508X + 0.008 and the value of r = 0.999, and the levels of alkaloids with different extract concentrations. Actual alkaloid content in raru bark methanol extract 95% was 14.9094 ± 0.3697 mg/g, actual alkaloid content in raru bark methanol extract 70% was 10.0472 ± 0.4594 mg/g, actual alkaloid content in extract 50% raru bark methanol was 6.6260 ± 0.803.
Co-Authors Adelia Ramadani Adjelie, Tiara Adyani Maulinda Ahmad Rasyid Ridho Alaina, Nadila Alfi Wahyudi Nasution Amaliana, Amaliana Ananda , Nadia Andjelie, Tiara Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Apmarja, Sarah Utami Aris Munandar Aryunda, Divia Asmarani, Asmarani Aulia Fitri, Aulia Aulia Sari Auza , Maharani Ayu , Tri Indah Pagar Azhar, Gustika Barutu, Liza Anisa Shevia Basaniah Basaniah Bilal, Mohd. BJ Sutrisna Cici Andriani Cindy Priscilia Cindy Widya Rosa Br Simarmata Cut Dian Mala Luthfia Cut Erika Maulydya D Elysa Putri Mambang D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang Daeng Elysa Putri Mambang Daulay , Anny Sartika Delvi Amira Hutagaol Dikki Miswanda Dina Agustia Parlin Dina Suciati Saragih Dinda Sari Utami Dini Rahmadani Dwi Jati, Fatma Ellyza, Chella Emmy Wiriandini Ercha Minanda Fahmi Fahmi Farida Yani Fathur Rahman Fatimah, Cut fatur Rahman, fatur Febiyani, Rica Fithri Pulungan, Ainil Fitri Mulyani, Fitri Fitri, Nurul Fitri, Raissa Friyani, Lilah Gabena Indrayani Dalimunthe Gultom, Syarifah Elena Hafizha, Putri Hasanah, Qori Hasibuan , Nabila Hasim Hasibuan, Supia Indah Hastri Kholifah Humaira, Yara Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Hutagaol, Delvi Amira Huzeila Nisa Siregar Ihsan Fadhilah Ika Yeni Siahaan Ilmi Widya Sari Imelda Natasia Br S Meliala Indah Nasution Indah Triutami Harahap Indrayani, Gabena Junia Fitri Hayani Khofifah , Nur Kiki Rawitri Krisna Juniharta Napitupulu Leni Safriani Lestari, Sri Indah Linda, Rosa Lubis, Minda Sari lubis, muhammad fauzan Lubis, Nadya Frestika Luthfianida, Arifna M Pandapotan Nasution M Pandapotan Nasution M Pandapotan Nasution M. Alfaruqi M. Pandapotan Nasution M. Pandapotan Nasution M. Pandapotan Nasution Mambang , D.Elysa Putri Mambang, D. Elsya Putri Mambang, Elysa Putri Maya Syafira Mayani, Nurhikma Meutia, Cut Miftahul Jannah Minda Sar Lubis Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Ari Mukhtizar Muhammad Hizbullah Muhammad Pandapotan Nasution Muhammad Wahyu Ikhsan, Muhammad Wahyu Ikhsan Munaziatul Jannah Munthe, Herlina Nasri Nasri, Nasri Nasution , Muhammad Amin Nasution, Kartika Zsaskia Nasution, M. Pandapotan Nasution, Nur Sahadah Nasution, Wardah Natasya, Siti Adinda Nazirah, Nazirah Nazuhra, Oca Nelsa Fahira Ningtias, Anggitha Niswa, Khairun Nofa Lismandaria Novika Utami Nur Hanifah Nuraida Nuraida Nuratika, Eli Nurliansyah, Nurliansyah Nursyafira, Arini Nurul Hasanah Ovalina Sylvia Br. Ginting Pandapotan Nasution, M. Pertiwi, Rahma Prasetyo , Healthy Aldriany Purba , Intan Sabila Putri Puteri, Cut Intan Annisa Putri , Adilla Putri Intan Sari Putri Khairani Putri Mambang, D. Elysa Putri Rahayu, Yayuk Putri, Nadya Iwani Rafika, Intan Maya Rafita Yuniari Rafita Yuniart Rafliza , Rista Rahayu , Yayuk Putri Rahmadani , Adevika Rapita Yuniarti Rati , Yuliandini Rawitri, Kiki Ridho, Ahmad Rasyid Ridwanto Ridwanto Ridwanto Ridwanto Ridwanto Rifqi, M. Ainur Rina Azhari Ritonga , Septi Ani Riza Syafira Rizki, Ayu Fadillah RR. Ella Evrita Hestiandari Rukmana, Siti Sabila , Anisa Safira , Liyuza Safitri , Nurhaliza sahrianti, Hikmah Sari, Syilvi Rinda Sarmadansyah Sarmadansyah Sartika Daulay, Anny Sasnita, Merida Satri Situmorang, Rati Selfia Lestary Sepriani, Ananda Sinaga, Novita Yulianti Siregar , Anisah Siti Aisyah Jamil Situmorang, Lusi Grasia Situmorang, Rati Satri Sony , Suyefri Sri Harti Sri Natalia Saragih Sri Ria Ranti Sri Wahyuni Sri Wahyuni Sri Wahyuni Suci, Nurul Sulwiyatul K Sani Supiyani, Supiyani Syafira, Nona Syaiful Bahri Syalsabila Putri Syara, Nurdiani Syarifah Elena Gultom Tawir Rina Rezeki Tri Damaiyanti Trizaldi, Asep Try Santi Kisria Darsih Ummi Khairani Rambe Vera Estefania Kaban Wahdaniati , Tri Widya Sari Widya Sari Widya, Rizka Yanti, Rahma Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Apriani Br.Lubis Yuniarti , Rafita Yuniarti, Rafita Zannah , Muhamad Zikra Maqfirah Ziza Putri Aisyia Fauzi Zulmai Rani