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Journal : Makara Journal of Science

Phytochemical Analysis, Antioxidant Activity, and Cytotoxic Effects of Physalis angulata and Moringa oleifera Leaf Extracts on Cancer and Normal Cells In Vitro Priyandoko, Didik; Widowati, Wahyu; Sholihah, Ika Adhani; Zahira, Nurul Zahra; Bangun, Adityana Arta; Kusdianti, Kusdianti; Hernawati, Hernawati; Surakusumah, Wahyu; Juansah, Rahadian Deden
Makara Journal of Science Vol. 29, No. 1
Publisher : UI Scholars Hub

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Abstract

Physalis angulata and Moringa oleifera have long been the key ingredients of traditional medicine. This study aimed to obtain the metabolite profiles of the ethanolic leaf extracts of P. angulata (ELP) and M. oleifera (ELM), evaluate their antioxidant activity, and assess their toxicity against normal and cancer cells. The leaves were sourced from Balittro, West Java. The extraction used 70% ethanol and continued for 3 days. The metabolites were identified using Gas Chromatography-Mass Spectrometry (GC-MS), antioxidant activity was ascertained via the DPPH assay, and cytotoxicity was evaluated employing the PrestoBlue assay. GC-MS identified 23 compounds in ELP and 15 in ELM. The DPPH assay showed that ELM, ELP, or their combination exhibited marked antioxidant activity, with inhibition ranging from 50% to 90%. The toxicity assay against MCF-7 cancer cells demonstrated that ELP at 1,500 µg/mL and ELM at 1,200 µg/mL induced cytotoxicity. The ELP + ELM formulation exhibited stronger cytotoxic effects than the positive control. In contrast, ELM or ELP did not induce toxicity in normal CV-1 cells and, stimulated viability com-pared to the control. Thus, the phytochemical contents of ELM and ELP exhibited enhanced antioxidant activity, in-duced toxicity in cancer cells, and were safe for normal cells.
Co-Authors , Rizal - Lindayani AA Sudharmawan, AA Afifah Bambang Sutjiatmo, Afifah Bambang Afifah, Ervi Agung Novianto, Agung Agus Susanto Ahmad Faried Alexandro, Garry Annaba, Aziz Arif, Julio Arinta, Yukko Armansyah, Adek Arrahmani, Betharie Cendera Aryenti, Aryenti Ayuni, Vini Azis, Rizal Bangun, Adityana Arta Batubara, Lilian Ch. Retnaningsih, Ch. Chandra Risdian Chiuman, Linda Damayanti, Ndaru Andri Dani Dani Dewi Nurul, Dewi Dewi, Intan Keumala Dewi, Nindia Salsabila Mia Didik Priyandoko Djaja Rusmana Edriayani, Novi Edwin Setiabudi Edy Fachrial Eka Yudha Rahman Elisabeth, Mariska Eltania, The Fransiska Elvira, Cut Endah Purnamasari Esti Mumpuni, Esti Euis Reni Yuslianti, Euis Fahrauk, M. Fanny Rahardja Fauziyah, Nida Firyal Ferdiansyah, Rival Ferdinand, Sahna Ferry Sandra Fibrina, Dewi Fioni, Fioni Geeta, Ginting, Chrismis Novalinda Girsang, Ermi Gosandra, Sherrina O. Gunadi, Michael Sebastian Gunanegara, Rimonta Febby Hadiprasetyo, Dhanar Septyawan Halim, Nathanael HANA RATNAWATI Handayani, Rr. Anisa Siwianti Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Hartini Tiono Haryanti, Mathelda Weni Hernawati Hernawati Irfan Syarif, Irfan Irwan, Mulia Jeffrey ., Jeffrey Jo Suherman Johan Lucianus Joko Raharjo, Sentot Juansah, Rahadian Deden Julio Arif Jusri, Ridza Khainir Akbar, Khainir Khie Khiong Ksatrianto, Faris Kusdianti Kusdianti Liana Liana Lindayani, . Lister, I Nyoman Ehrich Lusiana Darsono MADE PHARMAWATI Malau, Reghita Claudia Manurung, Mian Maranata Br Marisca Evalina Gondokesumo, Marisca Evalina Marpaung, Hans Hotma Mars, Nicholas Mawarni, Evi Mulyasari, Tira Endang Muthmainnah, Anis Syabani Nafik, Said Nainggolan, Ita Margaretha Nasution, Ali Napiah Natadilandes, Reyhan Ngurah Intan Wiratmini Nia Kania Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Novilla, Arina Nunung Ainur Rahmah Nurjamil, Aris Muhammad Nursanti, Okta Obeng, Selonan Philips Onggowidjaja Pradipta, Regina Purwoko, Agus Qamarani, audina Qlintang, Sandy Qodariah, Rismawati Laila Qodriah, Rahmatul R. Sapto Hendri Boedi Soesatyo Rahma Micho Widyanto RAHMAT, DENI Rita Tjokropranoto Rizal Aziz, Rizal Rizal Rizal Sabrina, Adilah Hafizha Nur Sachrowardi, Qomariyah Romadhiyani Salfa Nindya, Faradhina Salsabila, Nindia Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sholihah, Ika Adhani Sijani Prahastuti Sinaga, Ade Putra Fratama Siregar, Irma Dolsyeria Solihat, Ananda Khairunisa Sormin, Delores Elisabeth Sosiawan, Insan Sri Utami Suci Nar Vikasari, Suci Nar Sugiaman, Vinna Kurniwati Suhantoa, Deviana Lavender Sukandar, Elin Y. Susi Endrini Susy Tjahyani Sutjiatmo, Afifah B Syamsi, Lusi Nursilawati Syamsudin Syamsudin Takasenserang, Oktaviana Teddy Marcus Zakaria Teresa Liliana Wargasetia Tjandrawati Mozef Tri Suciati Triharsiwi, Dwi Nur Udju D. Rusdi Utomo, Herry S Utoyo, Frederick Surya vera vera, vera Vinna K. Sugiaman Vinna Kurniawati Sugiaman, Vinna Kurniawati Vrianty, Dela Wahyu Surakusumah WAHYU WINARNO Wangguai, Vannia Wibowo, Satrio Haryo Benowo Widodo, Wahyu Setia Widya Kusuma, Hanna Sari Widya Kusuma Yuninda, Viranda Andria Yusuf, Lydia Zahira, Nurul Zahra Zahiroh, Fadhilah Haifa