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All Journal Dentika Dental Journal IDEAS: Journal on English Language Teaching and Learning, Linguistics and Literature Journal of Dentomaxillofacial Science Politeia: Jurnal Ilmu Politik Politeia: Jurnal Ilmu Politik Pendas : Jurnah Ilmiah Pendidikan Dasar SeBaSa: Jurnal Pendidikan Bahasa dan Sastra Indonesia Jurnal Ilmu Sosial dan Ilmu Politik Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) MDJ (Makassar Dental Journal) Jurnal Papatung : Jurnal Ilmu Administrasi Publik, Pemerintahan dan Politik Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Pendidikan, Sains, Geologi, dan Geofisika (GeoScienceEd Journal) Economics and Digital Business Review Miracle Journal Of Public Health (MJPH) Mitra Raflesia (Journal of Health Science) PRIMA : Portal Riset dan Inovasi Pengabdian Masyarakat International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET) Journal of Computer and Information System (J-CIS) AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Jurnal Ilmu dan Teknologi Peternakan Terpadu (JITPU) Jurnal Riset Pendidikan Matematika Jakarta International Journal of Public Health Excellence (IJPHE) JEUMPA Jurnal Pengabdian Masyarakat Tapis Berseri JUPADAI : Jurnal Pengabdian Kepada Masyarakat Kartika: Jurnal Studi Keislaman Journal of Sustainable Community Service JPLED Jurnal Abdimas Indonesia El-Adabi: Jurnal Studi Islam Jurnal Pendidikan Guru Sekolah Dasar Indonesia Journal of Engineering and Education Technology (IJEET) Media Farmasi JPIK - Jurnal Pengabdian Ilmu Kesehatan Jurnal Nyanadassana: Jurnal Penelitian Pendidikan, Sosial, dan Keagamaan The 1st Alifah Health Science College Symposium Proceeding JOURNAL OF COMMUNITY SERVICE AND APPLICATION SCIENCE (JCSAS) Beujroh : Jurnal Pemberdayaan dan Pengabdian pada Masyarakat RETORIKA : Jurnal Kajian Komunikasi dan Penyiaran Islam Journal in Teaching and Education Area Journal of Political and Government Issues Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) IECON: International Economics and Business Conference Action Research Journal Jurnal Riset Pendidikan dan Karakter Jurnal Pengembangan Profesi Guru dan Dosen Jurnal Bisnis Digital dan Enterpreneur (BISENTER) Menulis: Jurnal Penelitian Nusantara Gudang Jurnal Ilmu Kesehatan Jurnal Pengabdian Indonesia
Asmawati
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Journal : Media Farmasi

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Potensi Ekstrak Jahe Gajah (Zingiber officinale var. Roscoe) Sebagai Bahan Aktif Sediaan Gargarisma dalam Mencegah Pertumbuhan Streptococcus mutans Penyebab Karies Gigi Asmawati; Gunawan, Muh. Arfandy; Setiawan Jumain, Muhammad Asman; Dewi, Ratnasari
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.526

Abstract

Potential of Elephant Ginger Extract (Zingiber officinale var. Roscoe) as an active ingredient in Gargarisma preparation in inhibiting the growth of Strptococcus mutans which causes dental caries Ginger plants are known to contain chemical compounds in the form of phenols and flavonoids where these compounds have potential antibacterial power. This study aims to formulate elephant ginger extract into gargarisma preparations and determine the stability of the physical quality as well as to determine the antibacterial potential of gargarisma elephant ginger extract preparations optimally. Elephant ginger was extracted using the maceration method, then dried using a freeze-drying device. Then formulation into gargarisma preparations whit concentrations of 5%, 10%, and 20% elephant ginger extract followed by evaluation of the preparation including pH test, organoleptic test, and viscosity test as well as antibacterial power test. The results of each study have an average value before and after the Cycling test, namely the pH test with 5% concentration: 6.13 and 6.06; concentration 10%: 5.92 and 5.96; concentration 20%: 5.96 and 5.91, on the viscosity test 5% concentration: 1.86cps and 2.19cps; concentration 10%: 2.05cps and 2.45cps; concentration 20%: 2.55cps and 3.06cps, the organoleptic test did not change. From the results of the inhibition test, the average value was obtained at a concentration of 5%: 9mm; concentration 10%: 14.33mm; concentration 20%: 17.67mm. it can be concluded that 5%, 10%, and 20% concentrated ginger extract can be formulated into elephant ginger preparations with gargarisma constraint and fulfils the physical quality requirements of gargarisma preparations as well as for the antibacterial power test, the significance value (p<0,05) indicates a significant difference. Each concentration. At a concentration of 10%, it had an optimal effect in inhibiting the growth of Streptococcus mutans. Tanaman Jahe Gajah diketahui mengandung senyawa kimia berupa fenol, flavonoid dimana senyawa tersebut memiliki potensi daya antibakteri. Penelitian ini bertujuan untuk memformulasi ekstrak jahe gajah menjadi sediaan gargarisma dan mengetahui stabilitas mutu fisik serta untuk mengetahui potensi antibakteri dari sediaan gargarisma ekstrak jahe gajah secara optimal. Jahe gajah diekstraksi menggunakan metode maserasi, kemudian dikeringkan menggunakan alat freeze drying, lalu diformulasi menjadi sediaan gargarisma dengan konsentrasi ekstrak jahe gajah 5%, 10%, dan 20% dilanjutkan dengan evaluasi sediaan meliputi uji pH, uji organoleptik, dan uji viskositas serta uji daya antibakteri. Hasil penelitian masing-masing memiliki nilai rata-rata sebelum dan sesudah Cycling test yaitu pada uji pH konsentrasi 5%: 6,13 dan 6,06; konsentrasi 10%: 5,92 dan 5,96; konsentrasi 20%: 5,96 dan 5,91, pada uji viskositas konsentrasi 5%: 1,86cps dan 2,19cps; konsentrasi 10%: 2,05cps dan 2,45cps; konsentrasi 20%: 2,55cps dan 3,06cps, pada uji organoleptik tidak mengalami perubahan. Dari hasil pengujian daya hambat didapatkan nilai rata-rata pada konsentrasi 5%: 9mm, konsentrasi 10%: 14,33mm, konsentrasi 20%: 17,67mm. Dapat disimpulkan bahwa ekstrak jahe gajah dengan konsentrasi 5%, 10%, dan 20% dapat diformulasi menjadi sediaan gargarisma dan memenuhi syarat mutu fisik sediaan gargarisma serta untuk uj daya antibakteri diperoleh nilai Signifikansi (p<0,05) menunjukkan adanya perbedaan yang bermakna tiap konsentrasi. Pada konsentrasi 10% sudah memberikan efek yang optimal dalam menghambat pertumbuhan Streptococcus mutans.
Isolasi, Identifikasi, dan Uji Aktivitas Antibakteri Fungi Endofit Daun Bidara Arab (Ziziphus spina-christi L.) Terhadap Propionibacterium acnes Dan Staphylococcus epidermidis Salasa, Alfrida Monica; Layuksugi, Defline Apriliana; Pakadang, Sesilia Rante; Ratnah, St.; Asmawati
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.605

Abstract

Isolation, Identification, and Antibacterial Activity of Endophytic Fungi from Ziziphus spina-christi Leaves Against Propionibacterium acnes and Staphylococcus epidermidis Ziziphus spina-christi L. (Arabian bidara) has long been used in traditional medicine for preventing acne and enhancing skin health. Acne pathogenesis is closely associated with the proliferation of Propionibacterium acnes and Staphylococcus epidermidis. This study aimed to isolate endophytic fungi from bidara leaves and assess their ability to produce antibacterial secondary metabolites. Endophytes were isolated through surface sterilization and successive purification on Sabouraud Dextrose Agar, followed by fermentation on Potato Dextrose Agar and ethyl acetate extraction. Phytochemical profiling and antibacterial activity were evaluated using standard qualitative assays and the agar diffusion method on Mueller Hinton Agar, respectively.Six pure isolates were obtained: brown (Aspergillus niger), grey (Colletotrichum sp.), cream (Aspergillus terreus), green (Aspergillus flavus), turquoise (Aspergillus fumigatus), and white (Cylindrocladium sp.). Phytochemical screening revealed the presence of alkaloids, flavonoids, polyphenols, and tannins in varying combinations across isolates. Antibacterial testing showed that all isolates inhibited P. acnes and S. epidermidis, except the green isolate, which exhibited no bactericidal activity. These findings indicate that bidara leaf endophytes represent a promising source of antibacterial compounds with potential applications in acne management. Tanaman Bidara Arab (Ziziphus spina-christi L.) adalah tanaman tradisional yang diyakini secara empiris mencegah pertumbuhan jerawat dan menghaluskan kulit. Propionibacterium acnes dan Staphylococcus epidermidis merupakan jenis bakteri yang dapat menimbulkan jerawat. Penelitian ini bertujuan untuk memperoleh isolat fungi endofit Daun Bidara Arab yang berpotensi menghasilkan metabolit sekunder sebagai antibakteri Propinobacterum acnes dan Staphylococcus epidermidis. Fungi endofit diisolasi dengan cara sterilisasi Daun Bidara Arab, selanjutnya diinokulasi berulang pada media Sabouraud Dextrose Agar hingga diperoleh isolat murni. Dilakukan fermentasi pada media Potato Dextrose Agar diekstraksi dengan etil asetat. Skrining fitokimia ekstrak etil asetat dilakukan untuk mendapatkan metabolit sekunder digunakan untuk pengujian antibakteri dengan metode difusi agar pada media Mueller Hinton Agar. Hasil penelitian didapatkan 6 isolat murni, yaitu isolat coklat diduga Aspergillus niger, isolat abu-abu diduga Colletotrichum sp, isolat crem diduga Aspergillus terreus, isolat hijau diduga Aspergillus flavus, isolat toska diduga Aspergillus fumigatus, serta isolat putih diduga Cylindrocladium. Hasil skrining fitokimia menunjukkan isolat coklat mengandung alkaloid, polifenol, tannin, isolat crem mengandung alkaloid, flavonoid, polifenol dan tannin, isolat abu-abu mengandung polifenol dan tannin, isolat putih mengandung flavonoid, polifenol, tannin. Pengujian antibakteri didapatkan semua isolat pada Daun Bidara Arab berpotensi menghambat serta membunuh Propionibacterium acnes dan Staphylococcus epidermidis sedangkan isolat hijau tidak berpotensi dalam membunuh Propionibacterium acnes dan Staphylococcus epidermidis
Evaluasi In Silico Interaksi Senyawa Bioaktif Daun Serai Cymbopogon citratus Terhadap Protein Sortase A Streptococcus mutans Sebagai Target Potensial Pencegahan Karies Gigi Asmawati; Salasa, Alfrida Monica; St. Ratnah; Pakadang, Sesilia Rante; Jumain, Muhammad Asman Setiawan; Dinata, A. Moh. Whisnu Surya; Alfiana, Rizky; Gunawan, Muh. Arfandy
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2076

Abstract

Dental caries remains a major oral health problem with high prevalence and is primarily caused by the activity of Streptococcus mutans. One of the key virulence factors of this bacterium is Sortase A protein, which plays an essential role in bacterial adhesion and biofilm formation. This study aimed to evaluate the potential of bioactive compounds from Cymbopogon citratus as inhibitors of Sortase A from Streptococcus mutans using an in silico approach. The research method involved preparation of the Sortase A protein structure (PDB ID: 4TQX) and bioactive compounds of C. citratus, followed by molecular docking analysis using AutoDock Vina integrated with UCSF Chimera. Ligand–protein interaction analysis was performed to determine binding affinity and identify key amino acid residues involved, and the results were compared with a standard ligand (1QON). In addition, ADMET prediction was conducted to evaluate the absorption, distribution, metabolism, excretion, and toxicity profiles of the major compounds. The molecular docking results showed that luteolin and rutin exhibited strong binding affinities toward Sortase A, with binding energy values of -7.3 kcal/mol, comparable to the standard ligand (-7.2 kcal/mol). Luteolin demonstrated a similar interaction pattern with the standard ligand through the key residue Phe237, while rutin formed multiple hydrogen bonds around the active site. ADMET prediction indicated that luteolin possessed better oral absorption and a more favorable safety profile than rutin. In conclusion, luteolin is the most promising bioactive compound from Cymbopogon citratus for dental caries prevention through inhibition of Sortase A of Streptococcus mutans
Co-Authors Abd Haris Adelia Prameswari, Femy Adriana Hamsar Afiqah Jumatul Saadah afni, khairina Ahmad Muchlis Ahmad Muchlis Ahmad Rafiesa Guna Alfiana, Rizky Alqarama M. Thalib Andi Nirmala Sari Aqmal, Amal Argeto , Valentino Ariani, Zaenafi Ariansyah Aryanisila Ashifa Rozika Asman, Muhammad Asriadi Asriadi Athalla, Muhammad Radjab Ayu Safitri , Della Azizah, Tyara Nur Bahruddin Thalib Berliana, Eliya Br Saragih, Aminah Bucky Wibawa Karya Guna Chairul Adhim Choiriya, Nabila Conny Oktizulvia D., Hamidah Dawanto, Jirfan Depi Ratnasari Desi Fitria Dewi Rahmah Dewi Ratnasari Dg. Te’ne, Andi Syahraeni Dinata, A. Moh. Whisnu Surya Dwi Oktarini, Rahmi Dzaironi, Muhammad Edwar M Nur Efrianto Elfa Yeni Elin Hidayat Ellys Lestari Pambayun Emailijati, Kartika Ety Sofia Ramadhan Ety Sofia Ramadhan Fadhilsyah, Muhammad Fikriandi, Solihin Firmiaty, Sri Fitriani, Desy Gunawan, Muh. Arfandy Hamsar, Adriana Hartati, Lesi Hasna, Nabilah Sajidah HASYIM, ZOHRAH Helmayuni Hendarmin, Rum Herlinawati Herlinawati Hertati , Lesi Heryati, Agustina Holipah Husni Husnul Aini Husnul Hatimah Ida Ermiana Idris Indi Fatimah Az-Zahrah Indra indrayani, tri irfa Indriyanti Intan Aritoanng Intan Aritonang Irena, Angelina Irnanda, Tanti Irwan Safwadi Ismawati Jasril Jasril Julian Chandra Juliani K.T., Angelus Vecky Kadriani, Anisa Kalsum, Ummul Rabbayani Karina, Arihta Laeli Murod Solehani Laspida Harti Layuksugi, Defline Apriliana Lenni Indriani Lesi Hertati, Lesi Lestari Setia Ningrum, Ayu Lili Syafitri, Lili Linda Lusi Utama Lutfiah, Anisa Makmur, Malik Mayanti, Andi Meyi Yanti Moh. Rudini Mohammad NF. Taufik Muh. Khaerul Ummah BK Muhammad Ichsan Abda Muhammad Idrus Muhammad Idrus Muhammad Ryman Napirah Murjainah Mursalim Nohong Mutiara Puteri, Adinda Nabila Nur Uswatun Hasanah Netty Jojor Aritonang Nur Inayah Syar Nur Syabitha, Fidya Nur Syahra Nur, Nahya Nurhalizah, Nadila Nurhamidah Nurhamidah Nurhamidah Nurin Fahira Nurjannah Nurjannah Nursuhaela NURUL HIDAYAH Oktizulvia, Conny Padli Pakadang, Sesilia Rante Pardosi, Sariman Pawerangi, M. Harisa Putri Kumbara Putri Pratiwi Putri Zahara Putri, Dina Soes Ramadhan, Muh Syahru Ramli Ramli Rasmiati Ratnah, St. Renta Verawati Resky, Resky Reza, Rahmat Rezky Pangestu Aji Rifaat Nurrahma Rizki, Sutra Meilani Roikhan, Mohammad Rizal Romri, Arsi Sahrawati Salasa, Alfrida Monica Sanda, Elias Satriawan Septiyanti Sevindrajuta Sihombing, Kirana Patrolina Siti Zahara, Meisin Sitti Jahadiyah Sringati Suciyati Suharni Surmini Suryati Sutarto Sutarto Sutriati Syar, Nur Inayah Syarifuddin Syarifuddin Tati Murniati Terttiaavini Tsabita, Putri Utami Dewi Vidyanto Virma Nadia Safitri Wahyuni, Ningsih Weni Mailita Winda Azmi Yani, Sri Astri Yenny Lisbeth Siahaan Yenny Lisbeth Siahaan Yetti Lusiani Yofitri Heny Wahyuli Zuherna Mizwar