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All Journal ACTA VETERINARIA INDONESIANA Tekno - Pedagogi : Jurnal Teknologi Pendidikan JURNAL EMBA : JURNAL RISET EKONOMI, MANAJEMEN, BISNIS DAN AKUNTANSI LEX CRIMEN Majalah Kedokteran Bandung EGALITA Pixel : Jurnal Ilmiah Komputer Grafis Jurnal Ilmiah Teknik Industri Edufisika: Jurnal Pendidikan Fisika BERITA BIOLOGI Animal Production : Indonesian Journal of Animal Production Tekinfo | Scientific Journal of Industrial and Information Engineering Syntax Literate: Jurnal Ilmiah Indonesia Journal of Economic, Bussines and Accounting (COSTING) Buletin Farmatera Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Abadimas Adi Buana Journal of Health Policy and Management Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Litbang: Media Informasi Penelitian, Pengembangan dan IPTEK MAT-EDUKASIA JURNAL BIOCOLONY Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) JENIUS (Jurnal Ilmiah Manajemen Sumber Daya Manusia) Besaung : Jurnal Seni Desain dan Budaya Jurnal Manajemen Bisnis dan Kewirausahaan Community Development Journal: Jurnal Pengabdian Masyarakat Academia Open Majalah Ilmiah Pelita Ilmu Jurnal Cahaya Mandalika Keraton: Journal of History Education and Culture AEEJ : Journal of Automotive Engineering and Vocational Education ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Locus: Jurnal Konsep Ilmu Hukum Jurnal Kesehatan Kusuma Husada Al Jahiz: Journal of Biology Education Research Siginjai: Jurnal Sejarah MASALIQ: Jurnal Pendidikan dan Sains Borobudur Engineering Review Jurnal Ilmiah Ilmu Terapan Universitas Jambi Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Jurnal Abdimas: Pengabdian dan Pengembangan Masyarakat Indonesian Journal of Advanced Research (IJAR) Jurnal Kedokteran Hewan Healthcaring: Jurnal Ilmiah Kesehatan Prosiding Seminar Nasional Pascasarjana Proceeding of International Conference on Science, Education, and Technology Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Current Biomedicine Baileo: Jurnal Sosial Humaniora Jurnal PGSD Indonesia Jurnal Studi Islam dan Sosial Jurnal Pendidikan MIPA Indonesian Journal of History Education
Andriyanto Andriyanto
Jurusan Teknik Industri, Universitas Ahmad Dahlan Yogyakarta, Jl. Prof. Dr. Soepomo, Janturan, Umbul Harjo, Yogyakarta 55164
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Journal : Current Biomedicine

 1 
Toksisitas akut infusa daun pepaya Calina jantan (Carica papaya L.) pada mencit betina Sari, Nurma; Safika, Safika; Putra, Hamdika Yendri; Andriyanto, Andriyanto
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.46-53

Abstract

Latar belakang: Pepaya (Carica papaya L) merupakan salah satu tanaman yang berpotensi sebagai obat untuk beragam penyakit. Tujuan: Penelitian bertujuan menguji toksisitas akut ekstrak daun pepaya Calina (IPB 9) jantan pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif. Metode: Penelitian menggunakan 20 ekor mencit galur DDY yang dibagi secara acak ke dalam 4 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa daun pepaya Calina jantan masing-masing dengan dosis 5, 10, dan 15 g/kg BB secara per oral. Pengamatan dilakukan pada mortalitas, gejala klinis, respons fisiologis, bobot badan, dan bobot relatif organ. Hasil: Nilai LD50 menunjukkan pemberian infusa daun pepaya Calina jantan pada mencit betina bersifat tidak toksik. Pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Pemberian infusa daun pepaya Calina jantan dengan dosis 10 g/kg BB terbukti paling efektif dalam mempertahankan pertambahan bobot badan secara normal dan tidak bersifat toksik. Simpulan: Berdasarkan penelitian, pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB bersifat tidak toksik dan tidak memengaruhi organ tubuh mencit, dengan dosis efektif sebesar 10 g/kg BB.
Uji sitotoksik ekstrak cabai merah keriting (Capsicum annuum) pada sel WiDr secara in vitro Fadholly, Amaq; Sudjarwo, Sri Agus; Rantam, Fedik Abdul; Mustika, Aulia Andi; Andriyanto, Andriyanto; Pristihadi, Diah Nugrahani; Sutardi, Lina Noviyanti
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.70-75

Abstract

Latar belakang: Kanker masih menjadi salah satu penyebab kematian di dunia. Salah satu alternatif metode untuk mengobati kanker adalah dengan obat herbal yang mempunyai khasiat sebagai antikanker. Tujuan: Penelitian ini bertujuan untuk manganalisis efek sitotoksik esktrak Capsium annuum pada sel WiDr. Metode: Kemampuan sitotoksik ekstrak Capsium annuum diuji secara in vitro pada sel WiDr menggunakan metode MTT tetrazolium reduction assay. Hasil: Hasil uji MTT menunjukkan bahwa ekstrak Capsicum annuum menghambat proliferasi sel WiDr seiring dengan peningkatan konsentrasi (400, 800, dan 1600 ppm), dengan persentase penghambatan sel tertinggi diperoleh pada konsentrasi 800 ppm dari setiap kelompok terapi 24, 48, dan 72 jam. Nilai inhibitory concentration 50 (IC50) terendah dihasilkan oleh kelompok waktu terapi 48 jam, yaitu 651,18 ppm. Simpulan: Nilai IC50 ekstrak Capsicum annuum untuk sel WiDr memiliki nilai yang tinggi yang menunjukkan belum efektif sebagai obat antikanker. Penelitian lebih lanjut dibutuhkan untuk mendapatkan dosis terbaik agar dapat menghambat pertumbuhan sel WiDr secara maksimal.
Immunostimulatory activity of avocado oil in mice (Mus musculus) Jusuf, Elena Adjani; Mustika, Aulia Andi; Andriyanto, Andriyanto
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.95-102

Abstract

Avocado fruit contains bioactive compounds that have the potential to act as an immunomodulator. This study aims to identify the ability of avocado oil as an immunomodulator based on the macrophage phagocytic activity and index of mice injected with nonpathogenic Staphylococcus aureus and to determine the most effective dose as an immunomodulator. This study used 30 male Deutschland Denken Yoken (DDY) mice, which were divided into five groups: placebo as negative control (mineral water), positive control (commercial immunomodulator containing Echinacea purpurea extract), and avocado oil 1 g/kg BW, 3 g/kg BW, and 5 g/kg BW. The treatment was carried out orally once a day for 14 days. Mice were induced by nonpathogenic Staphylococcus aureus on day 15 intraperitoneally, and after one hour, mice were euthanized to collect the peritoneal fluid. Peritoneal fluid smear preparations were made before active macrophages and phagocytosed Staphylococcus aureus were observed under a microscope. Phagocytic activity and phagocytic index were calculated. Avocado oil 5 g/kg BW showed the highest phagocytic activity and phagocytic index results with values of 71.00% ± 5.40% and 2.79 ± 0.14, respectively. Avocado oil enhances non-specific immune responses through macrophagephagocytic activity and index, demonstrating its immunostimulatory potential.
Acute toxicity test of avocado (Persea americana) oil in mice Bhila, Aisya Salsa; Andriyanto, Andriyanto; Prasetyo, Bayu Febram
Current Biomedicine Vol. 2 No. 2 (2024): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.2.55-60

Abstract

Background: Avocado (Persea americana) fruit has a high oil content, so it is widely used in the pharmaceutical and cosmetic industries. Objective: This study aims to determine the toxicity of avocado oil in mice using the lethal dose (LD50) method so that it can be used as a reference for further testing. Methods: This study used a total of 20 DDY strain female mice, which were divided into 5 groups: one control group and four treatment groups that were fed with avocado oil with 5, 10, 15, and 20 g/kg BW doses orally. The mortalities of experimental mice were observed for 14 days after treatment. Other parameters observed in this study were physiological response, body weight, absolute organ weight, and relative organ weight. Results: There was a change in behavior, and the obtained LD50 value was 25.4 g/kg BW. Observation of physiological responses, body weight, absolute organ weights, and relative organ weights showed no significant differences. Conclusion: It was concluded that avocado oil is considered relatively harmless and safe to use.
Activity of arabica green coffee bean (Coffea arabica) extract as an immunomodulator in mice (Mus musculus) infected with Staphylococcus aureus Aurellia, Sharon; Subangkit, Mawar; Andriyanto, Andriyanto
Current Biomedicine Vol. 2 No. 1 (2024): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.1.29-35

Abstract

Arabica green coffee bean is the most widely produced coffee bean in Indonesia. Studies have shown that arabica green coffee beans are rich in polyphenols and antioxidants, stimulating immune cell proliferation. This study investigated the immunomodulatory activity of arabica green coffee beans (Coffea arabica). Thirty mice (Mus musculus) with an average body weight of 30 g were divided into five groups: negative control, positive control, and groups administered arabica green coffee bean powder extract at doses of 0.03, 0.06, and 0.18 mg/30 g BW. It was orally administered once daily for 14 days. On the 15th day, the mice were intraperitoneally injected with non-pathogenic Staphylococcus aureus. After an hour, mice were necropsied for peritoneal fluid collection. Peritoneal fluid was stained with a peripheral blood smear, and the number of macrophages and lymphocytes was observed under a microscope. Data were analyzed using one-way analysis of variance (ANOVA), followed by Tukey’s test. The group administered with 0.18 mg/30 g body weight (BW) dose showed the highest average of macrophage and lymphocytes compared to the negative control group and any other groups. Arabica green coffee bean powder extract was shown to have immunomodulatory activity, with the highest activity observed at a dosage of 0.18 mg/30 g BW.
Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice Husna, Hanifati; Andriyanto, Andriyanto; Manalu, Wasmen; Mohamad, Kusdiantoro
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.67

Abstract

Background Individuals experience varying levels of fatigue and stamina. Moringa oleifera Lam. Seed extract relieves fatigue due to its high levels of antioxidants and glucosinolate glucomoringin, which reduces intracellular oxidative stress. Objectives This study aimed to determine the effectiveness of infusion of M. oleifera seed as a stamina stimulator in mice. Methods This experiment used 25 male mice divided into five groups (five mice in each group), consisting of M. oleifera seed infusion at doses of 0, 1, 3, and 5 g/kg BW as the negative control and treatment groups, and caffeine at a dose of 6.5 mg/kg BW as the positive control group. Stamina effectiveness was evaluated using a swimming endurance test that measured swimming duration and physiological parameters every 15 min for 2 h after administration. Data were analyzed using analysis of variance (ANOVA) followed by Tukey’s test. Results M. oleifera seed infusion at a dose of 3 g/kg BW had the shortest swimming duration difference (Δ) value, with no difference compared to the 5 g/kg BW and caffeine groups, but was significantly different (P<0.05) compared to the 0 and 1 g/kg BW groups. M. oleifera seed infusion at a dose of 3 g/kg BW also showed a lower delta value for body surface temperature and heartbeat rate compared to the negative control, and a lower delta value for the respiratory rate compared to the 5 g/kg BW group. Conclusion M. oleifera seed infusion potentially maintains stamina performance in mice at a dose of 3 g/kg BW.
Co-Authors .Gandri Haryono, M A Winarto A.S. Satyaningtijas Abadi Sutisna Achmad Samsudin Agus Oman Sudrajat Agus Setiawan Agus Yulianto Ahmad Naufal, Ahmad Aji, Gilang Gusti Al Manan, Oesman Raliby Al-Fatihah, Inayah Altje L. Tumbel Amaq Fadholly Andriyanto Andy Suryadi Anggi Anggarini Anggraeni, Henny Endah Anjeliani, Restu Antonio, Marites Del Prado ARDI, ATIKAH Arifin, Mochammad Nur Arin Proborini, Christiana Armadi, Ali Asrori Asrori Astalini Astalini Aulia Andi Mustika Aurelia, Sharon Aurellia, Sharon Aziizah, Anisatul Azzahra, Miftahul Zannah Bambang Gunadi Bambang Tri Bawono Bangun, Dwi Agnes Natalia Bayu Febram Prasetyo Bhila, Aisya Salsa Br Kaban, Karmila Candra, Delfika Choirul Bariyah, Choirul Darmaji Darmaji Devi Fatmawati, Devi Dewi, Fitriana Dhanurseto Hadiprashada Diah Nugrahani Pristihadi Dian Wahyu Djoko Widodo Eko Soponyono Elpita Tarigan Eni Yulianti Erni Suparti, Erni Fedik Abdul Rantam Ferdy Roring Firda Agustin, Firda Firmansyah, Mas Agus Gandri Haryono, M. Giovani Siahaan, Fery GM Nugraha, GM Gosal, Ervina Hafid, Fernani Nur Haknowo, Dwi Hanif Hanif Haq, Ahmad Syaiful Haryanto Haryanto Henny Dwi Bhakti Herlina Herlina Hibban, Muhammad Farhan Ibnu Hidayat, Rezaldi Hidayatulloh, Muhammad Rizal Huber Yaspin Tandi Huda, Anam Miftahul Husna, Hanifati Igirisa, Silvia Febriyanti Ike Yuli Mestika Dewi Indrajayani, Galuh Gita Ira Pramudawardhani Irarang, Yusa Irwan Muhammad Ridwan Isnawati Isnawati Jamhari Jamhari JOKO SUSANTO Junaidi Junaidi Jusuf, Elena Adjani Kapelle, Imanuel B. D. Khairul Amri Kurniawan, Dwi Agus Kurniawan, Sofyan Kusdiantoro Mohamad Lailan Safina Nasution Leni Marlina Lina Noviyanti Sutardi Listyanda, R. Faiz Lumuan, Lumuan Madyastuti, Rini Mahardika, Dayu Maheni DK, MRR Tiyas Mansyur, Haris Mashdurohatun, Anies MD Darulfallah, MD Meillisa Carlen Mainassy MRR Tiyas Maheni DK, MRR Tiyas Maheni Muhammad Firdaus Muhammad Haikal Mumtaza Putri, Anne Muslikh Muslikh Muslikh Musthofa, Hajri Taqin Mustika, Aulia A. Napitupulu, Pesta Asni Natalie, Gabriela Neliana , Tri Ningsih, Dwi Aulia Nugroho, Deni Agung Nugroho, Dimas Satrio Laksono Nur Farida Haryanto, Lailin Nurfadhillah, Septy Nurma Sari, Nurma Oktavia, Sri Wina Perdana, Rahmat Pramudawardhani, Ira Pranoto, Rahmat Eko Purba, Elva Rini Puspitasari, Sendy Krisna Putra, Ghalyh Wardhana Putra, Hamdika Yendri R Arif, R R, Nofriyandi Rachmadita Dwi Pramesti Ramadhoni, Armando Ramdhan, Fadlatul Raya Agni Rayandra Asyhar Riantiarno, Edi Dwi Rivanol Chadry Rohasad, Rohasad Rosleini Ria Putri Zendrato Rozana Zuhri Rusmiyatun Rusmiyatun Safika S, Safika Sakti , Bima Sakti, Tegar Bima Sauri, Salsabila Selnia, Emika Septian, Dwi Nur Setianingrum, Vinda Maya Sirajuddin Sirajuddin Siti Aisyah Sofuan, Tazkia Kamila Subangkit, Mawar Suci, Yulia Suhandi*, Andi Sukmawati, Sindy Fitria Sunarti Supiyani, Atin Supriyadi, Supriyadi Suroto Munahar Suryadinata, Ningrum Suryanto, Esha Saraswati Susbiyanto, Susbiyanto Susilawati Tabrany Suwarta, Nyoman Syech Zainal Theresia Theresia Tony Wibowo, Tony TRIANI, ELZA W Manalu Warol, Khoirul Warol, Warol Wasmen Manalu Widi, Leliana Nugrahaning Wulan Dari, Wulan Wulandari, Eko Yendri, Hamdika Yuliantini Yuliantini Yuliarman Yuliarman Yusuf Yusuf Zilviana, Tengku Zulhendri Zulhendri Zylviana, Tengku