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Indra Kurniawan
Jurusan Manajemen Fakultas Ekonomi Universitas Sriwijaya
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Journal : Medical Scope Journal (MSJ)

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St. George’s Respiratory Questionnaire (SGRQ) sebagai Alat Bantu Diagnostik serta Prediktor Terjadinya Chronic Pulmonary Aspergillosis (CPA) pada Pasien Tuberkulosis Paru Pasca Terapi Wangko, William S.; Kurniawan, Indra; Wongkar, Maarthen C. P.; Nugroho, Agung; Polii, Efata B
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.32890

Abstract

Abstract: Patients of post therapy lung tuberculosis (TB) that still have permanent or worsened clinical signs might be caused by chronic pulmonary aspergillosis (CPA). Diagnosis of CPA is difficult to confirmed without complete supporting tests. This study was aimed to establish whether Saint George’s Respiratory Questionnaire (SGRQ) could be used as diagnostic tool and predictor of the occurence of CPA in post therapy lung TB patients. This was an analytical observational study with a cross sectional design. There were 72 patients who had negative Gene Xpert sputum; 34.7% with positive Aspergillus-specific IgG. Their clinical signs were evaluated with SGRQ. The results showed that there was a very significant relationship between clinical score and CPA (p<0.0001). The lower the clinical score the less the probability of CPA. In this analysis we determined the diagnosis value of clinical score with a probability cut-off point = 0.5 which led to clinical score cut-off point of 45.6 with further results, as follows: sensitivity 68.0%; specificity 95.7%; positive predictive value 89.5%; negative predictive value 84.9%; OR 47.8, and CI 95% (9,2-248,2). In conclusion, SGRQ could be used as diagnostic tool and predictor of the occurence of CPA in post therapy lung TB patients.Keywords: post therapy lung TB; chronic pulmonary aspergillosis; Saint George’s Respiratory Questionnaire (SGRQ)  Abstrak: Pasien TB paru pasca terapi yang masih memperlihatkan gejala klinis menetap atau bahkan memberat dapat disebabkkan oleh adanya chronic pulmonary aspergillosis (CPA). Diagnosis CPA sulit ditegakkan tanpa adanya pemeriksaan penunjang yang lengkap. Penelitian ini bertujuan untuk menentukan apakah Saint George’s Respiratory Questionnaire (SGRQ) dapat menjadi alat bantu diagnostik serta prediktor terjadinya CPA pada pasien TB paru pasca terapi. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Hasil penelitian mendapatkan 72 pasien dengan sputum Gene Xpert negatif (34,7% dengan positif IgG Aspergillus) dilakukan penilaian skor klinis menggunakan SGRQ. Hasil uji menunjukkan terdapat hubungan sangat bermakna antara skor klinis dengan terjadinya CPA (p<0,0001). Makin rendah skor klinis makin kecil peluang terjadinya CPA. Melalui analisis ini dapat ditentukan nilai diagnosis skor klinis SGRQ dengan mengambil titik potong peluang = 0,5. Nilai peluang = 0,5 memberikan titik potong skor klinis = 45,6.  Dengan titik potong skor klinis SGRQ = 45,6 diperoleh nilai-nilai diagnosis sebagai berikut: Sensitivitas = 68,0%; Spesifisitas = 95,7%; Nilai Prediksi Positif = 89,5%; Nilai Prediksi Negatif = 84,9%; OR = 47,8 dengan CI 95% (9,2-248,2). Simpulan penelitian ini ialah SGRQ dapat menjadi alat bantu diagnostik serta prediktor terjadinya CPA pada pasien TB paru pasca terapi.Kata kunci: tuberkulosis paru pasca terapi; chronic pulmonary aspergillosis; Saint George’s Respiratory Questionnaire (SGRQ)
Co-Authors A, Fery Rahmawan Abimanyu, Raditya Razindra Achmad Rusdi Adam, Muhammad Ibnu Adil Akhyar Adirianto, Bayu Ahmad Taufiq Aji, Wandha Atmaka Alfarisi, Achmad Hasan Amiroel Oemara Syarief Amrie Firmansyah Anasukha, Endah Wahyu Andi Nurkholis Andi Sadriani Anggastani, Novita Dia Anggreni, Veni Anwar, Resa Nurlaela Aprilian, Sulthan Arfat, Muhammad Fadilah Arfiandi, Joni Arif Fahmi Aristianingrum, Riska Dita Atmaka Aji , Wandha Aulia Ar Rakhman Awaludin Aulia, Ema Valy Ayu Ramadhani, Nandha Bahri, Saiful Batari, Denita Dea Bayu Hartanto, Naufal Bisma Arianto Cris Kuntadi David-Barrett, Tamas Dermawan, Chalvyn Rahmat Dewi, Yulida Intani Dona Katarina Dwi Retna Sulistyawati Edy Purwanto Edy Sulistiyawan, Edy Ek Ajeng Rahmi Pinahayu Ekawati, Christina Elan, Umi Elfantoro, Indra Elfatma, Olivia Endayanti, M Erdiansyah, Rezi Fadhilah, Ackbar Fadila Fitriana, Gita Fasdarsyah Fasdarsyah Fauzan Natsir Fitriana Destiawati Fitriana Destiawati Fitroh, Qorry Aina Gardenia, Nia Hananda Priyandaru Hanif, Muhammad Rafi Harnanik Harnanik, Harnanik Harry Dhika, Harry Hartono Hartono Hartuti, Purni Munah Hartuti, Purni Munah Hasan, Luthfi Helma Malini, Helma Herdiana, Mochamad Rafi Heri Setyawan HERI SETYAWAN Heriyati, Heriyati Hidayah, Muslihatul Ibad, Irsyadul Ibrahim, Abrar Hafidz Idum Satia Santi Iim Marfuah Imam Pujo Mulyatno Imam Sujadi Izni Shafie, Dalili Juanda, Syifa Ethika Julianto, Anang Khoirunnisa, Indah Rosewika Suryaning Khotimah, Alya Husnul Khuluq, Husnul Koko Setiawan, Koko Komalasari, Indah Krisdianto, Yusuf Kristian Tinduh, Yulio Kurniadhi, Adhitya Lailatul Qomariyah, Lailatul Latif, Riski Lina Nasihatun Nafidah Lisa Amriani Listianto, Herry Liza, Ahmad Luh Putu Widya Adnyani M. E. Winarno Mahatma Lanuru Maimon Sumo Maizuar Maizuar Maman Rachman Manto, Agus Marcellus S Kolopaking Marcellus Simadibrata Maryona Septiara Merina Pratiwi Mewa Zabeta, Mewa MIFTAKHUL JANNAH Mira Gusniwati Mubais, Ahmad Muhammad Choiru Zulfa Muhammad Muhaimin Mustikawati, Farida Musyarrofah, Musyarrofah Nabila, Riski Nadir, Fajriansyah Novianto, Esa Adelia Nugroho, Agung Nurali , Nurali Nurali, Nurali Nurcahyono Nurcahyono, Nurcahyono Nurianah, Nurianah Patricia, Sandra Uli Polii, Efata B Prada, Bagas Maulana Pasha Aditya Pradana, Alif Putra Pramalistyo, Arisca Prasojo, Rahman Azis Pratama, Andi Asriadi Pratiwi, Ni Made Indira Pristianto, Hendrik Purwoko, Hendro Purwono, Rudi Puspitasari, Wahyu Dwi Putra Jaya Abadi Putri, Hardiyani Eka Qifary, M. Ravi Al Rachmawati Chaldun, Evy Rahadyan, Andri RETNO NENGSIH Rina Martini Rini, Retno Puspa Rizal, Ahmad Khoiri Rizka Yulina, Rizka Rizki, Muhammad Agung Rizkianah, Diah Rudy Haryanto Said Jalalul Akbar, Said Jalalul Saloko, Subakho Aryo Samawi, Muhammad Farid Santi, Indyah Hartami Sari, Ilma Nopita Setiadi, Irawan Sholikah, Mar’atus Siti Munawaro, Siti Siti Nurrochmah Siti Samsiyah Siti Suprihatiningsih Sofwatunnisa, Sofwatunnisa Sri Gunawan Styawati, Styawati Suharwati, Nungky Suharyanto Sukmawati, Baiq Nadia Indra Sulaiman, Han Supardi, Mokhamad Sutjipto, Rachmat Syah, Danial Syahputri, Anggraini Syarifah Rahmah, Syarifah Tabrani, Muhamad Tatang Wahyudi, Tatang Tejo Murti, Theofilus Tri Atmojo Kusmayadi Ulfah, Sofia Untung Budiarto Utami, Aditya Dyah Vanessa Gaffar Wahyu Nur Cholifah Walim, Walim Welmart, Dylan Ritosa Theadiva Wenda Wahyu Christiyanto Wesli Wesli Widiastuti, Tri Cahyani William S. Wangko wisnu yudo untoro, wisnu Wiwin Winiati, Wiwin Wongkar, Maarthen C. P. Yuliana, Anita Yusuf, Khairullah Zuhroh, Siti