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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) International Journal of Public Health Science (IJPHS) Jurnal Ilmiah Farmasi Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Indonesian Journal of Biotechnology Global Medical and Health Communication Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Pharmacon INDONESIAN JOURNAL OF PHARMACY Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Public Health of Indonesia Jurnal Farmasi Sains dan Komunitas THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Medica Hospitalia Jurnal Farmagazine Jurnal Health Sains Journal of Holistics and Health Sciences (JHHS) Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Klinik dan Sains Borobudur Pharmacy Review Jurnal Permata Indonesia Sciences of Pharmacy Journal of Global Pharma Technology Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Farmasi Galenika Indonesian Journal of Pharmacology and Therapy
Dyah Aryani Perwitasari
Fakultas Farmasi, Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

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Evaluasi Toksisitas Hepatologi Akibat Penggunaan 6-Merkaptopurin dalam Fase Pemeliharaan pada Pasien Pediatri Kanker Leukimia Limfoblastik Akut di RS Kanker Dharmais Jakarta Nazhipah Isnani; Dyah Aryani Perwitasari; Rizka Andalusia; Haridini Intan Mahdi
Jurnal Pharmascience Vol 4, No 1 (2017): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5757

Abstract

ABSTRAK Merkaptopurin merupakan obat kemoterapi yang digunakan pada fase konsolidasi dan pemeliharaan pada pasien pediatri kanker leukimia limfoblastik akut (LLA). Merkaptopurin diduga memiliki hubungan erat dengan terjadinya toksisitas pada hepatologi. Penelitian ini bertujuan untuk mengetahui angka kejadian, derajat keparahan dan penatalaksanaan toksisitas serta faktor risiko yang mempengaruhi terjadinya toksisitas hepatologi penggunaan 6-MP dalam fase pemeliharaan pada pasien pediatri kanker leukimia limfoblastik akut di RS Kanker Dharmais Jakarta. Penelitian ini dilakukan dengan desain observasional cross sectional dengan mengambil data pasien secara retrokspetif dan prospektif selama periode Maret–April 2014. Subyek penelitian adalah pasien kanker LLA anak yang berobat di RS Kanker Dharmais Jakarta dari tahun 2013 sampai dengan periode Maret-April 2014 yang sedang dalam fase pemeliharaan. Subyek yang memenuhi kriteria inklusi adalah 23 pasien LLA yang mendapatkan 6-MP pada fase pemeliharaan. Pengumpulan data dilakukan dengan melihat rekam medik untuk mendapatkan data identitas pasien dan data hepatologi. Hasil penelitian menunjukkan bahwa angka kejadian toksisitas hepatologi paling banyak terjadi pada peningkatan SGPT sebesar 13,05%. Derajat keparahan pada toksisitas hepatologi paling banyak terjadi pada derajat 2 (8,70% dan 13,04%). Berdasarkan faktor-faktor yang mempengaruhi terjadinya toksisitas hepatologi, tidak terdapat perbedaan yang signifikan pada hasil penelitian. Kata kunci : 6-merkaptopurin, toksisitas, hepatologi, leukimia limfoblastik akut ABSTRACT Mercaptopurine is a chemotherapy drug that used in the consolidation and maintenance phase in pediatric patients with acute lymphoblastic leukemia (ALL). Mercaptopurine is supposed to have relationship with the occurrence of toxicity in hepatology. This study was aimed to determine the patient incidence, severity and management of toxicity and risk factors that affect the occurrence of hepatologic toxicity using of 6 - MP in the maintenance phase in pediatric patients with acute lymphoblastic leukemia in Dharmais Cancer Hospital Jakarta. This research was carried out by cross-sectional observational design with data was taken retrospectively and prospectively during the period from March to April 2014. The study subjects were patient who have been getting treatment of maintenace phase in Dharmais Cancer Hospital Jakarta from 2013 until March-April 2014. The Subjects who met the inclusion criteria were 23 patients of ALL received 6 - MP in the maintenance phase. Data was collected by looking at the medical records for getting of the patient's identity and data hepatology. The results showed that there the incidence of the increased of SGPT was the most prevalent (13, 05 %) . The severity of the most common hepatologic toxicity was at level 2 (8,70% and 13,04%). Based on the influence of the hepatology toxicity factors, there were not different significant of the result of research. Keywords : 6-mercaptopurine, toxicity, hepatology, acute lymphoblastic leukemia
Analisis Cost Of Illness Drug Reaction With Eosinophilia Systemic Symptoms Di RSUP Dr.Sardjito Yogyakarta Vicryanto Halid; Dyah Aryani Perwitasari; Sri Awalia Febriana
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8073

Abstract

ABSTRAK Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) adalah reaksi alergi kulit dengan demam, kenaikan eosinofil darah dan komplikasi organ. Sulitnya diagnosa dan lama terapi serta berpotensi kekambuhan membuat DRESS menjadi masalah karena mempengaruhi ekonomi. Cost of illness (COI) merupakan analisis menentukan beban ekonomi penyakit yang terdiri dari beberapa perspektif. Penelitian ini bertujuan mengetahui total COI dari perspektif Rumah sakit berdasarkan jenis DRESS, jenis obat, dan jumlah obat penyebab DRESS. Penelitian non-experimental dengan desain cross-sectional retrospektif. Subyek penelitian 21 pasien. Parameter biaya komponen biaya medis langsung yaitu biaya instalasi gawat darurat, pengobatan, monitoring, penunjang dan rawat jalan. Hasil analisis data berupa median (range). Median total COI DRESS dengan komplikasi organ adalah Rp.13.194.963 dan Rp.10.123.495 untuk pasien DRESS tanpa komplikasi organ. Antibiotik menjadi obat penyebab DRESS terbanyak (55,55%) dengan range total biaya tertingginya Rp.53.576.350. Kesimpulan: Total COI DRESS di RSUP Dr.Sardjito tahun 2014-2018 satu pasien adalah Rp.13.546.700.Kata Kunci: Drug Reaction with Eosinophilia and Systemic Symptom, Cost OF illness, biaya medis langsung, komplikasi organ, perspektif Rumah sakit.  ABSTRACT Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) are allergic skin reactions with fever, elevated blood eosinophils and organ complications. Difficult diagnosis and duration of therapy and potential recurrence make DRESS a problem because it affects the economy. Cost of illness (COI) is an analysis determining the economic burden of a disease consisting of several perspectives. This study aims to determine the total COI from the perspective of the hospital based on the type of DRESS, the amount and type of causative drug of DRESS. Non-experimental research with a retrospective cross-sectional design. Study subjects 21 patients. The cost parameters of the direct medical component costs are the costs of the emergency department, treatment, monitoring, support and outpatient care. The results of data analysis are in the form of a median (range). Results: The total median of COI DRESS with organ complications was Rp.13,194,963 and Rp.10,123,495 for DRESS patients without organ complications. Antibiotics became the most common drug causing DRESS (55.55%) with the highest total cost range of Rp.53,576,350. Conclusion: Total COI DRESS at Dr.Sardjito General Hospital in 2014-2018 one patient was Rp.13,546,700. Keywords: Drug Reaction with Eosinophilia and Systemic Symptom, Cost of Illness, direct medical costs, organ complications, perspective of the hospital.
Pengaruh Kemoterapi Pada Pasien Pediatri Leukimia Limfoblastik Akut Dengan Febrile Neutropenia di Rumah Sakit Kanker Dharmais Jakarta Muliyani Muliyani; Dyah Aryani Perwitasari; Rizka Andalusia; Mururul Aisyi
Jurnal Pharmascience Vol 4, No 1 (2017): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5750

Abstract

ABSTRAK Penelitian ini merupakan penelitian metode Observasional Crossectional dengan pengambilan data secara retrospektif dan prospektif di periode bulan Maret - April 2014. Data diambil dari rekam medik pasien kemudian dianalisis dengan dekskriptif. Subjek penelitian adalah episode febrile neutropenia yang terjadi pada pasien pediatri leukimia limfoblastik akut. Pada penelitian ini dapat diamati analisis faktor yang mempengaruhi tingkat keparahan febrile neutropenia berdasarkan beberapa karakteristik episode febrile neutropenia yaitu, jenis protokol, fase kemoterapi, penyakit penyerta dan fenotip tidak berbeda signifikan terhadap tingkat keparahan febrile neutropenia yang terjadi pada pasien pediatri leukimia limfoblastik akut secara statistik (p>0,05). Onset demam dan durasi febrile neutropenia tidak berpengaruh terhadap nilai ANC dimana signifikansinya menunjukkan (p>0,05). Drug Related Problems (DRPs) yang terjadi pada 25 episode febrile neutropenia (8 %). Kata kunci: febrile neutropenia, tingkat keparahan, leukimia limfoblastik akut ABSTRACT This research was carried out by cross-sectional design with data was collected retrospectively and prospectively during the period of March-April 2014. The data was taken from medical records of patient. The research subjects were febrile neutropenia that occurs pediatric patients with acute lymphoblastic leukemia. In this study, it can be observed analysis of factors affecting the severity of febrile neutropenia by some characteristic episodes of febrile neutropenia, namely, protocol type, phase of chemotherapy, concomitant diseases and phenotypes did not differ significantly to the severity of febrile neutropenia occurred in pediatric patients leukemia acute lymphoblastic statistically ( p> 0.05). Onset of fever and febrile neutropenia duration does not affect the value of the ANC which shows its significance (p> 0.05). Drug Related Problems (DRPs), which occurs in 25 episodes of febrile neutropenia (8%). Keywords: febrile neutropenia, severity, leukemia acute lymphoblastic
Analisis Cost of Illness Stevens Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) Qarriy Aina Urfiyya; Dyah Aryani Perwitasari; Sri Awalia Febriana
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8077

Abstract

ABSTRAK SJS/TEN merupakan reaksi yang melibatkan kulit dan mukosa yang berat dan mengancam jiwa. SJS dan TEN merupakan kejadian yang jarang terjadi, yaitu 1,4 – 12,7 kasus per 1 juta orang per tahun mengalami SJS dan TEN, dengan angka mortalitas 5% pada SJS dan 30-35% pada TEN. Obat merupakan penyebab utama SJS (50-80% dari kasus) dan TEN (80%). Tujuan: Mengetahui median total biaya per hari pasien SJS/TEN, serta pengaruh lama rawat inap terhadap total biaya SJS/TEN. Penelitian observasional analitik dengan sudut pandang masyarakat. Pengambilan data secara retrospektif menggunakan total sampling pasien rawat inap SJS dan TEN di RSUP Dr. Sardjito Yogyakarta tahun 2014-2018. Analisis data dengan menghitung median (range) dan regresi linear pada SPSS IBM versi 22.0 untuk mengetahui pengaruh lama rawat inap terhadap biaya SJS/TEN. Terdapat 29 pasien yang dianalisis. Median total biaya per hari pasien SJS/TEN Rp 1.139.963 (Rp 665.294-Rp 8.776.895), dengan Rp 1.139.963 (Rp 740.267-Rp 8.776.895) pada SJS dan Rp 1.166.084 (Rp 665.294-Rp 1.514.607) pada TEN. Hasil signifikansi uji regresi linear lama rawat inap terhadap total biaya SJS/TEN adalah 0,093 (p>0,05). Median biaya per hari SJS/TEN adalah Rp 1.139.963 (Rp 665.294-Rp 8.776.895), dan lama rawat inap tidak mempengaruhi total biaya SJS/TEN.  Kata Kunci—Stevens Johnson Syndrome, Toxic Epidermal Necrolysis, analisis biaya, cost of illness  ABSTRACT SJS/TEN is a reaction that involves heavy and life-threatening skin and mucosa. SJS and TEN are rare events, 1,4 – 12,7 cases per 1 million people per year experiencing SJS and TEN, with a mortality rate of 5% in SJS and 30-35% in TEN. Drugs are the main cause of SJS (50-80% of cases) and TEN (80%). Objective: To determine the median total cost per day of SJS and TEN patients, and the effect of length of stay on the total cost of SJS/TEN. This study used an observational analytic with cross sectional design and societal perspective. The data was collected retrospectively using total sampling of SJS and TEN inpatients at RSUP Dr. Sardjito Yogyakarta in 2014-1018. The data was analyzed by calculating the median (range) and linear regression in IBM SPSS version 22.0, to determine the effect of length of stay on SJS/TEN costs . There were 29 patients analysed. The median total cost per SJS/TEN patient was IDR 1.139.963 (IDR 665.294-8.776.895), with IDR 1.139.963 (IDR 740.267-8.776.895) on SJS and IDR 1.166.084 (IDR 665.294-1.514.607) on TEN patients. The significance linear regression of the length of stay in SJS/TEN was 0,093 (p> 0,05). The median cost per SJS/TEN day was IDR 1.139.963 (665.294-8.776.895), and the length of stay does not affect the total cost of SJS/TEN. Keywords— Stevens Johnson Syndrome, Toxic Epidermal Necrolysis, cost analysis, cost of illness
Co-Authors Abdi Wira Septama Adi Wira Septama Adnan Adnan Adnan Adnan Adnan Adnan Adnan, Adnan Adriyanto Rochmad Basuki Agung Permata Ahmad Azrul Zuniarto Aisyi, Mururul Ajeng Diantini Ajeng Diantini Akrom, Akrom Ambarwati, Sindy Cisna Anak Agung Gede Sugianthara Ananda Muhammad Naafi Ananda Muhammad Naafi, Ananda Muhammad Andalusia, Rizka Andriana Sari Andriana Sari Andriana Sari Andriana Sari Angella, Widi Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Annisa Annisa Awalia Rahma MH Sibadu Ardan Kensanovanto Arief Muttaqien Arief Rahman Afief Arifin, Bustanul Ariska Wigatiningtyas Astagiri Yusuf, Prasandhya Athika Darumas Putri Aulia Rahman B Simanjuntak, Lamhot Baiq Adelina Atbam Munawwarah Baiq Nurbaety Bambang Purwoko Barkah Djaka Purwanto Barkah Djaka Purwanto Baroroh, Faridah Bayu Prio Septiantoro Bayu Prio Septiantoro Bayu Prio Septiantoro Bayu Tri Murti Berry H Putra Boisi, Cici Feronika Bramadi Arya Bustanuddin As Suaidy Bustanul Arifin Bustanul Arifin Candradewi, Susan Fitria Cheung, Rocky Cut Fatia Ulfa Cut Fatia Ulfa Damayanti, Elok Dania Haafizah Darwis Darwis darwis darwis, darwis Denys Chichi Kusumastuti Desi Kusumawati, Desi Desty Kusumaningsih Dewi Wulandari Dewi Wulandari Dewi, Masita Sari Dian Prasasti Dian Prasasti Dias Ananda Sulistya Didi Rohadi Didik Setiawan Didik Setiawan Dwi Utami Eka Wuri Handayani Elli Nur Hayati Endang Darmawan Endang Darmawan Endang Darmawan Endang Yuniarti Endang Yuniarti Endang Yuniarti Esty Elvinda Farah Bidara Farida, Imaniar Noor Faridah Baroroh Faridah, Imaniar Fatimah Sri Kurniawati Fatimah, Salma Auliya Fatkhiya, Musa Fitri Febriana, Sri Awalia Febriana, Sri Awalia Fitri Nur Mahmudah Fredrick Dermawan Purba Gina Noor Djalilah Gugun Suhendra Gugun Suhendra Gurning, Sri Handayani Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Hadiq, Shabran Handayani, Eka Wuri Haridini Intan Mahdi Haridini Intan Mahdi Haridini Intan Mahdi Hasniah Hasniah Hazena Misgi Damayanti, Hazena Misgi Hendrik Hendrik Hendy Ristiono, Hendy Herjanti Ratnawiningsih Herjanti Ratnawiningsih Herjuna Hardiyanto Herlina, Tetie Hidayah Karuniawati Ikrimah Nisa Utami Imaniar Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Intan Fatah Kumara Irma Risdiana Irma Risdiana Irma Risdiana, Irma Iskak, Iskak Islami, Safira Nur Jamhari Jamhari Jarir At Thobari Juwita, Dina Ratna Kania Agustina Kaptein, A.A Khuluq, Husnul Kiki Lukman Kintoko, Kintoko Kodriati, Nurul Kuluq, Muhammad Husnul Kurniawan, Nurcholid Umam Kurniawati, Fatimah Sri Kurniyati, . Kurniyati, . Lalu M Irham Lalu Muhammad Irham Lamhot B Simanjuntak Lamhot B Simanjuntak Lamhot B Simanjuntak Lestari, Mardiana Puji Lianawati Lianawati Like Efriani Lisza Niarisessa Lutfi Sukma Pratiwi Luthfiah Luthfiah M Rifqi Rokhman M. Rifqi Rokhman M. Rifqi Rokhman M. Rifqi Rokhman Made Ary Sarasmita Mahdi, Haridini Intan Mahfudh , Nurkhasanah Maliza, Rita Marwin Marwin Marwin Marwin Masita Sari Dewi Meki Pranata Melinda Widianingrum Melinda Widianingrum Melodia Rezadhini Melodia Rezadhini Menit Ardhiani Menit Ardhiani Muamala, Anisa Muh. Deni Kurniawan Muhammad AR Saputra Muhammad Ardhani Muhammad Dwi Suprobo Muhammad Fathurrahman Muhammad Thesa Ghozali Mukti A Berlian Muliyani Muliyani Muliyani Muliyani Muliyani, Muliyani muliyani, muliyani muliyani Mulyani, Sri Mumfasiroh Saputri Mururul Aisyi Mururul Aisyi mustika muthaharah Mustika Muthaharah Mustofa Mustofa muthaharah, mustika Mutmainnah Siradjuddin Muttaqien, Arief Nabial Chiekal Gibran Nabilah Nabilah Nabilah Nabilah Nadia Utami Noor Naili Ra fi'ah Nanik Sulistyani Nasriyah, Chotijatun Nazhipah Isnani Nguyen, Thang Ni Made Ary Sarasmita Nidia Yuni Lestari Nidia Yuni Lestari, Nidia Ninda Sari Wahyuningtyas Noerhidayati, Elly Novi Milasari Novitasari, Putri Rachma Nuni Ihsana Nur Aida Nur Azizah Nur Mahdi Nur Rahmi Hidayati, Nur Rahmi Nurcholid Umam Nurcholid Umam Kurniawan Nurcholid Umam Kurniawan Nurcholid Umam, Nurcholid Nurfadilasari, Ulfa Mustofa Nurkhasanah Mahfudh Nurul Kodriati Nyoman Kertia Oni Yulianta Wilisa P.D. Pratiwi Pandanwangi , Siti Pendicho Eko Yuliyanto Permatasari, Anggraeni Pradika, Jaka Pradipta, Indra Prasasti, Dian Pratama, Kharisma Pratiwi, P.D. Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Putri Pertiwi Qarriy 'Aina Urfiyya Qarriy Aina Urfiyya Ra fi'ah, Naili Ra fi'ah, Naili Rachma Greta Putri Ratu Matahari Ratu Matahari Retno Murwanti Reza Aditya Nugroho Rezadhini, Melodia Riana Prastiwi Handayani Rini, Vina Angga Rizka Andalusia Rizka Andalusia Rizka Andalusia Rizka Novia Atmadani Rizky, Muhammad Arif Robi’ah Adawiyah Rocky Cheung Rocky Cheung Rocky Cheung RR. Ella Evrita Hestiandari Rr. Erni Kusuma Putri Sabaan, Wahid Sabaan, Wahid Saidah Rauf Santoso, Setiyo Budi Satibi Satibi Sawitri Sawitri Sawitri Sawitri Septiantoro, Bayu Prio Setiyati Jatiningsih Simanjuntak, LB Sindy Cisna Ambarwati Siswandi Siswandi Siswandi Siswandi Siswandi Siswandi Siswandi, Siswandi Siti Pandanwangi Siti Urbayatun Solikhah Sri Awalia Febriana Sri Handayani Gurning Sri Mulyani Suhendra, Gugun Suin Rina Dewi Sulastri Sulastri Sulastri Sulastri Supadmi, Woro Woro Supadmi Susan Fitri Candradewi Susan Fitri Candradewi Susan Fitria Candradewi Susilo, Rinto Suwijiyo Pramono Syifa Imelda Teguh Uji Sungkowo Tomi . Triantoro Safaria Triantoro Safaria Tuty Lia Syahfitri Ully Adhie Mulyani Ully Adhie Mulyani Vicryanto Halid Vina Angga Rini Wahyu Rahmatulloh Wahyu Widyaningsih Wahyudi, Andrey Wilisa, Oni Yulianta Wilisa, Oni Yulianta Wirawan Adikusuma Woro Supadmi Woro Supadmi Woro Supadmi Woro Supadmi Woro Supadmi Wulandari, D Yeni Alfiana Ratnasari Yudha Rizky Nuari Yuli Rachmawati Yuli Rachmawati Yusuf, Prasandhya Astagiri Zulkarnain Zulkarnain Zulkarnain Zulkarnain Zuniarto, Ahmad Azrul