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Journal : Universa Medicina

Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Marbun, Yohan Pamuji
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.805 KB) | DOI: 10.18051/UnivMed.2020.v39.74-80

Abstract

BackgroundThe polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.MethodsThis cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. ResultsMean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. ConclusionExpression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.
Effect of hypnotherapy on prolactin level in women after cesarean section Supriyadi Hari Respati; Risang Bhaskoro; Eric Edwin Yuliantara; Uki Retno Budihastuti; Debree Septiawan
Universa Medicina Vol. 42 No. 1 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.6-11

Abstract

BackgroundPostpartum depression occurs in women after cesarean section, due to increased cortisol and decreased prolactin levels, leading to delayed breast milk production. Hypnotherapy is one of the most effective and efficient complementary therapy options for reducing postpartum depression. Hypnotherapy increases oxytocin secretion from the paraventricular nucleus of the anterior pituitary gland, decreases cortisol levels, and increases prolactin, thereby increasing breast milk production. This study evaluates hypnotherapy’s effect on prolactin levels after a cesarean section. MethodsThis study was an experimental non-blinded randomized controlled trial with a post-test-only control group design conducted at Dr. Moewardi General Hospital and UNS hospital. A total of 20 post-cesarean -section women were included in the study. They were randomized into two groups, a group I: given hypnotherapy, and group 2: the control group (without hypnotherapy). Both groups were tested for prolactin levels. Group I received hypnotherapy 6 to 12 hours post-cesarean section, and study participants were confirmed to be unaffected by the anesthetic. Data analysis used the independent t-test and p<0.05. ResultsAt baseline, there was no significant difference in age, parity, and indication for cesarean section between the hypnotherapy and the control groups (p>0.05). After intervention, the mean prolactin level was higher in the hypnotherapy group (247.6 ± 81.1 ng/mL) compared to the control group (120.1 ± 55.4 ng/mL) (p<0.001). ConclusionHypnotherapy increases post-cesarean prolactin levels compared to the controls. Our findings open up a wide range of potential hypnotic applications among women with postpartum depression.
Co-Authors -, Kartika ., Darto Abdurahman Laqif Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Adhimukti, Fahmi Agung Sari Wijayanti Agustina, Devita Alfi Marita Tristiarti Alfi Marita Tristiarti Alfi Marita Tristiarti Ali Djamhuri Alifa, Rosita Ambar Mudigdo Amir, Nikmah Ayu Ramadhani Angelia Ratnasari, Affi Anggraeni, Asih Anik Lestari Anik Lestari Annang Giri Moelyo Argyo Demartoto, Argyo Arianty, Meike Arifiana, Ratna Arifin, Ayu Kusuma Puspasari Aris Sudiyanto Armadhani, Riska Asih Anggraeni Astuti, Susiana Yuni Bachnas, Muhammad Adrianes Bachtiar, Harrys Besar, Dwi Sakti Berlian Bhisma Murti Cahyono Hadi Chintya, Shally Ayu Cut Sheira Elnita Damalita, Annisa Fitriana Damayanti, Siti Darto Darto Darto Darto - Darto . Darto . Darto Darto Debree Septiawan Dewanto Suryoningrat Dewi, Rizqa Kartika Dewi, Yulia Lanti Ratna Dewi, Yulia Lanti Ratna Dian Asih Ning Utami Dian Kusumawardani Dian Kusumawardani Dian Rahmawati Diani Octaviyanti Handajani Didik Gunawan Tamtomo Didik Tamtomo, Didik Dwi Apriyanti Endang Sutisna Endang Sutisna Sulaeman Eriana Melinawati Eric Edwin Yuliantara Erin Rizkiana Ermawati, Dwi Hesti Ertiana, Dwi Eti Poncorini Pamungkasari Fahsan, Fatmiyanti Farras Wahdan, Arib Fatmawati, Zeny Fauzia, Raina Lola Fazrina, Gina Firdausia, Shalsabilla Tiara Fitria Wulandari Frafitasari, Dika Yanuar Habibatullah, Afifa Intifadha Hadi, Cahyono Hadianti, Ayunita Dwi Hafi Nurinasari Hafiizha, Attahira Amalia Hafiizha, Atthahira Amalia Handriani, Winei Haniah, Alfi Zamilul Hanifah, Rofi'atul Hanifah, Rofi’atul Harsono Salimo Harsono Salimo Hastuti, Tri Ari Hermawan Udiyanto Heru Priyanto Heru Priyanto Hidayah, Fristyaningrum Ida Nurwati Ilmiyah, Desy Eka Indradewa, Rhian Jannah, Ahadyah Miftahul Jannah, Ahadyah Miftahul Jatiningtyas, Abida Zuhra Jayanti, Saktryana Endang Ragil Juhrotun Nisa, Juhrotun Kunaryanti, Kunaryanti Kunaryanti, Kunaryanti Kusnandar Kusnandar Laqif, Abdurahman Lunardhi Susanto Lutfiana Puspita Sari Maghfiroh, Ainul Mahendra Wijaya Mahendra Wijaya Marbun, Yohan Pamuji Marliana, Wiwit Martaningrum, Herlina Ika Metanolia Sukmawati Mufidah, Amatullah Muhammad Adrianes Bachnas Mulyoto Pangestu Murdikawati, Dayang Fitri Murdikawati, Dayang Fitri Mushthafa, Mufti Mutiara, Bunga Ngudi Insan Ksyatria, Yudhistira Ningrum, Sintia Ayu Ningsih, Hepti Widia Nugrahani, Rosi Rizqi Nurul Qomariah Nurul Wahidah Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Ode, Diana Oktaviani, Anisa Sevi Pamungakasari, Eti Poncorini Pawito -, Pawito Pertiwi, Mumpuni Intan Poncorini, Eti Prasetya, Hanung Prastyoningsih, Aris Prisasanti, Dympna Prameilita Puspita, Ita Fijanah Putriarsih, Ryanawati Qadrijati, Isna Qomariah, Nur Laili Quinita M. J. Noronha Rahardjo, Setyo Sri Rahayu, Baiq Zulvita Rahayu, Putu Sri Rahmadani, Latifah Nur Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratih Sakti Prastiwi Ratih Sakti Prastiwi, Ratih Sakti Ratna Dewi Permatasari Ratnasari, Affi Angelia Regita, Immanuela Maria Reso, Mulya Cunda Ratu Reso, Mulya Cunda Ratu Retno, Yulia Lanti Ria, Matilda Bupu Riawati, Meida Siwi Risang Bhaskoro Rita Adriani Benya Adriani Rizkiani, Inne Rofi’atul Hanifah Saputra, Ricky Bernadi Sari, Arum Dessy Rahma Sari, Lutfiana Puspita Sari, Prafista Wulan Satria, Yohanes Aditya Adhi Selvia Febrianti Septiana, Yesika Cahya Simarmata, Imelda Dearni Simarmata, Imelda Dearni SITI KHOLIFAH Siti Munawaroh Siti Nur Hidayati Soetrisno Soetrisno Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Widarti, Sri Sringatin, Sringatin Suci Arsita Sari Sulistyoningrum, Indah SUMIYATI SUMIYATI Sunarta, Elfania Arumma Suparno, Amalia Ulfah Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Tanti Arianti Teguh Prakosa, Teguh Teha, Zadia Dara Cynintya Tri Nugraha Susilawati Verasita, Prissy Vitri Widyaningsih Wardana, Aisyah Puspa Wardhani, Anindyah Tri Lhaksmi Kusuma Wasyanto, Trisulo Wesliaprilius, Todung Antony Wijayanti, Agung Sari Wisnu Prabowo WISNU PRABOWO Wulandari, Rizqi Amalia Wulandari, Umianita Risca yulia lanti retno dewi Yulyanti, Yulyanti