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Efek Andrographolide terhadap Gambaran Histopatologi Sel Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karbon Tetraklorida (CCl4): Hasil Penelitian Sanjaya, Vincent; Andriani; Ilmiawan, Muhammad In’am
Cermin Dunia Kedokteran Vol 52 No 10 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i10.1010

Abstract

Introduction: Andrographolide is a group of diterpene lactone isolates from the Andrographis paniculata plant with hepatoprotective properties. Andrographolide gives a hydrogen ion to pair with a free electron from a free radical to form a stable chemical compound and thus decrease liver damage. Methods: This experimental research used a post-test only with a control group design. The samples were mouse's liver (Rattus norvegicus).Twenty-four mice (Rattus norvegicus) were divided into 6 groups: a normal group, a curcumin-treated group as a positive control, a carbon tetrachloride-only group as a negative control, and the treatment group with the dose an andrographolide 50 mg/kgBW group, an andrographolide 100 mg/kgBW group, and an andrographolide 200 mg/kgBW group with 4 mice in each group. Mice were induced with carbon tetrachloride on the first day, then treated with curcumin and andrographolide for 7 days. Liver organs were dissected on day 9 to prepare a specimen for assessing hepatocyte damage (necrosis and hydropic degeneration). Results: Andrographolide showed a hepatoprotective effect on hepatocyte damage after induction by CCl4. The injury score in the normal group is 16.84; the negative control group is 34.36; the positive control group is 11.48; the dose 1 group is 24.92; the dose 2 group is 19.96; and dose 3 is 19.52. In the LSD test, the 50 mg/kgBW and 100 mg/kgBW andrographolide dose groups showed significant differences in hepatocyte damage compared to the normal group. There was no significant difference in liver histopathologic injury score between the normal group and the andrographolide 200 mg/kgBW group (ANOVA, p > 0.05). Conclusion: The best hepatoprotective effect was provided by andrographolide 200 mg/kgBW because the degree of damage is similar to that in the normal group.
Co-Authors Abbiyu Dwi Rizki Abdul Ghofir Abdul Hadi Abdul Hakam Abdul, Hakam Achmad Mieka Husaeini Pinem Adhi Purba, Ilyas Afandi, Asrul Afida Wahid Ahmad Pujiono Akbar. H. Anr, Riyadlul Alanti Alfaina Karem, Nahdya Alya Amat Damuri Anita Satriani Antika Zahrotul Kamalia Anwar Arbi Apriandini, Wani Aprillita, Rizky Ardi, Abdullah ARIF SUSILO Arista Ardilla Arwan Sulaeman, Asep Arwan, Asep Asmaul Husna Aulia, Wilna Ayuri Wahyu Azdkia Al-Mazaya Azwar, Yessi Baitulloh, Sabit Basyirah Ainun Batubara, Hamidah Sari Binti Mutafarida Bustamin Cahya Intanesia, Indah Chamdan Purnama Cipta Bakti Gama Citra Feriana PUTRI Cut Aja Nuraskin Cut Ratna Keumala Destria Efliani Dewi Fatmala Putri Dhea Maulana Dhian Septiana, Eka Edi Priyo, Basuki Efridayani Eka Lestari Eka Pratiwi Estiningtias Elfi Zahara Erfina Erwin Akib Eva Santi H. Fadhillah, Rizky Fahmi, Moh Farih Fairus Nurhasriati Faricha Lita Nabbila FARICHA LITA NABBILA - Fatmah, Dinda Fitrianingsih, Julia FITRIYAH Fitriyah, Aidatul Ghofur, Muh. Abdul Hamidah Sari Batubara Hamrul, Heliawati Handayani, Rika Hariyanti, Sri Hartian, Tengku Hasani, Syaiful Hasibuan, Sarmita Hasniar Herlina M Herman, Sriyana Hutasoit, Eva Santi Ibnu Hajar Ika Permanasari Ikhsan Andi Syahputra Ikmal Muhammad Ilmiawan, Muhammad In’am Ilyas Adhi Purba Indri Ariestiana Intan Liana Intan Wardyna Irma Niawati Istifadah, Miftahul Iwan Mulyana Junaidi Junaidi Kamila, Saadatul Karem, Nahdya Alfaina Keumala, Cut Ratna Khairul Wahid Kiswantoro, Agus Kumalasari, Inci Saputri Kusrini S. Kadar Liana, Intan Lilik Purwanti Linda Suryani Lita Nabbila, Faricha luttadinata, zefry M. Fadli Ma'ruf, Amar Madyasari, Arlupi Yulia Mardelita, Sisca Mardhatillah Maria Ulfa Marzila, Mariani Millatuz Zahroh, Millatuz Moch. Zainuddin, Moch. Mochamad Ali Muchtar Muhtajuddin Danny Mumtaza Alfahdy Mustaqim Mustika Hana Harahap Mutafarida , Binti Mutafarida, Binti Mutiara Sadewa, Manik N. Dhiya, Almassyah Nabila Zharifah Nada Kusuma Nadhifah, Siti Nurun Naning Fatmawatie, Naning Nashwa Juliani Naya, Candra Niawati, Irma Nisa Zakiati Umami Novianita Rulandari NOVIYANTI Nur Hikmah Nur, Arnela Nurdin Nurmalawati Nurmaulid Nuzuri, Eka Putra Opep Cahya Nugraha Prartama, Amal Primatika, Roza Puji Astuti Purwitasri, Aulya Putra, Robby Eldy Eka Putri, Dewi Fatmala Rachma Wati, Rachma Rahendra Herlianto, Hemdani Rahmadani Rahmah, Mirhamida Rahmah, Yusriyah Rahmah, Zakiyah Zulfa Rahmati, Lina Ratna Wilis Reca Rimadeni, Yeni Rindi Genesa Hatika Roza Azizah Primatika, Roza Azizah Rozikin, Zaenur Rusli Salmaria, Elsa Syahrika Sanjaya, Vincent Sari, Dian Megah Sari, Widya Rarta Sarmadan Sifa', Moh Agus Sisca Mardelita Siska Mulyani Siswandi, Arif Siti Jumra Agma Sobri, Sawal Sri Rahayuningsih Sudarwati Sugiarto Cokrowibowo sukmawati Suni Hariati, Suni Surojudin, Nurhadi Suryani, Linda Syafitri, Puspa Rosiana Syakila Syamsuriati Syarif, Sitti Hatija T. Muntazar Tangkonda, Elisabet Turmud Zy, Ahmad Tuti Marjan Fuadi Ulfasari , Putri Virhan Novianry Wahid, Khairul Wahyu Budiana Wahyuni, Rika Sri Widia Tamara Widodo Suwito Widya Ratna Sari Wulandari Wulandari Yamonaha Halaw Yosi Ramadona Yusna Zahara, Elfi Zulfa Rahmah, Zakiyah ‘Alamiah, Fawallia ‘Ansyarril